List of works by Andrew P Cope

22nd European Workshop for Rheumatology Research, Leiden, The Netherlands, 28 February-3 March 2002

scientific article

3D Bayesian cluster analysis of super-resolution data reveals LAT recruitment to the T cell synapse

scientific article

A Bayesian cluster analysis method for single-molecule localization microscopy data

scientific article

A rare mediastinal tumour presenting with systemic effects due to IL-6 and tumour necrosis factor (TNF) production

article

A subset of memory effector T cells in peripheral blood defined by differential expression of the TCR-ζ chain

A systematic review and meta-analysis of infection risk with small molecule JAK inhibitors in rheumatoid arthritis

scientific article published on 01 October 2019

ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial

scientific article published on 16 January 2014

Adding new perspectives to the kaleidoscope of remission criteria in rheumatoid arthritis

scientific article published in April 2013

Addisonian crisis induced by treatment with rifampicin

scientific article published on 01 March 1989

Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.

scientific article

Aging, autoimmunity and arthritis: an introduction

scientific article published in 2003

Altered signalling thresholds in T lymphocytes cause autoimmune arthritis

scientific article

An approach to the analysis of gene expression in chronically activated T Lymphocytes.

scientific article published on 4 February 2002

An unusual case of ankle arthropathy.

scientific article published on April 2004

Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?

scientific article published on January 2004

Anti-tuberculous therapy-induced crystal arthropathy

scientific article published on 29 June 2006

Autoantibodies targeting TLR and SMAD pathways define new subgroups in systemic lupus erythematosus.

scientific article published on 22 March 2018

Bayesian cluster identification in single-molecule localization microscopy data

scientific article

CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner.

scientific article published on 03 July 2013

CD3ζ-chain expression of human T lymphocytes is regulated by TNF via Src-like adaptor protein-dependent proteasomal degradation

scientific article published on 13 July 2012

CYTOKINE MEASUREMENTS IN BIOLOGICAL FLUIDS

scientific article published on 01 November 1992

Cell therapy for autoimmune diseases

scientific article published in January 2007

Chronic exposure to TNF activates distinct TNF-R signaling pathways favouring cell survival in T lymphocytes.

scientific article published on 4 February 2002

Clinical and serological predictors of remission in rheumatoid arthritis are dependent on treatment regimen

scientific article published in July 2014

Clostridium difficile toxin-induced reactive arthritis in a patient with chronic Reiter's syndrome

scientific article published on January 1, 1992

Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells

scientific article

Correction. Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus.

scientific article

Correction: Predicting the Risk of Rheumatoid Arthritis and Its Age of Onset through Modelling Genetic Risk Variants with Smoking.

scientific article

Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus

scientific article published on 01 August 1993

Corrigendum: The RA-MAP Consortium: a working model for academia-industry collaboration

scientific article published in January 2018

Cortical Actin Flow in T Cells Quantified by Spatio-temporal Image Correlation Spectroscopy of Structured Illumination Microscopy Data

scientific article

Determination of glutamic acid decarboxylase 65 peptides presented by the type I diabetes-associated HLA-DQ8 class II molecule identifies an immunogenic peptide motif

scientific article published on 01 December 1999

Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.

scientific article published on May 1993

Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?

scientific article published on 15 May 2015

Does sustained downregulation of the TCRzeta chain define the transition from antigen mode to inflammation mode in effector T lymphocytes?

scientific article published on 12 September 2003

EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis

scientific article published on 2 March 2012

Emerging approaches for the therapy of autoimmune and chronic inflammatory disease

scientific article

Emerging therapies for pre-RA.

scientific article published in February 2017

Engagement of the p55 TNF-R for different periods of time induces qualitatively distinct pathways of tumour necrosis factor signalling and gene expression profiles in murine T cells.

scientific article

Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints

scientific article published on July 1, 1992

Enhancing PET Signal at Target Tissue in Vivo: Dendritic and Multimeric Tris(hydroxypyridinone) Conjugates for Molecular Imaging of αvβ3 Integrin Expression with Gallium-68.

scientific article published on 14 December 2016

Erratum: Corrigendum: Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events

article

Evaluating candidate autoantigens in rheumatoid arthritis

scientific article published on 01 January 1998

Evaluation of the role of cytokines in autoimmune disease: the importance of TNF alpha in rheumatoid arthritis

scientific article published on January 1, 1992

Expansion of T-Cell Receptor ζ dim Effector T Cells in Acute Coronary Syndromes

scientific article published on 11 September 2008

Expectations of new treatment in rheumatoid arthritis: developing a patient-generated questionnaire

scientific article published on 25 April 2013

Exploring the pathogenesis of rheumatoid arthritis in transgenic and mutant mice.

scientific article

Exploring the reciprocal relationship between immunity and inflammation in chronic inflammatory arthritis.

scientific article

Exploring the signalling pathways promoting T cell effector responses in chronic inflammation

scientific article published on June 2002

Expression profiling of lymphocyte plasma membrane proteins

scientific article published on 21 October 2003

Flares in Rheumatoid Arthritis Patients with Low Disease Activity: Predictability and Association with Worse Clinical Outcomes

scientific article published on 01 September 2018

Genetic and environmental risk factors for rheumatoid arthritis in a UK African ancestry population: the GENRA case-control study

scientific article published on 12 April 2017

HLA class II transgenic mice: models of the human CD4+ T-cell immune response.

scientific article

Harmful waste products as novel immune modulators for treating inflammatory arthritis?

scientific article

High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis?

scientific article published on 24 July 2008

How does tumour necrosis factor uncouple T-cell receptor-induced IL-2 gene expression in murine T cells?

scientific article published on 17 February 2005

Humanized mice as a model for rheumatoid arthritis

scientific article

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.

scientific article

Immune-mediated pathways in chronic inflammatory arthritis

scientific article published on April 2008

Immunoglobulin kappa variable region gene selection during early human B cell development in health and systemic lupus erythematosus.

scientific article published on 17 February 2015

Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus.

scientific article published on 02 June 2015

Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

scientific article published on January 2007

Improving medication adherence in rheumatoid arthritis (RA): a pilot study.

scientific article

Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases

scientific article published on 01 October 1992

Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells

scientific article

Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness.

scientific article published on 17 November 2013

Integration of lyoplate based flow cytometry and computational analysis for standardized immunological biomarker discovery.

scientific article

Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45RO+CD25+CD127low regulatory T cells

scientific article published on 28 November 2012

Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells

scientific article published on March 2013

Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation

scientific article published on 05 December 2013

Investigation of association between the TRAF family genes and RA susceptibility

scientific article

Is there a role of synovial biopsy in drug development?

scientific article

Isolating the molecular suspect: HLA transgenic mice in the study of human autoimmune disease.

scientific article

Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.

scientific article

Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines.

scientific article published on August 1994

Mental health, fatigue and function are associated with increased risk of disease flare following TNF inhibitor tapering in patients with rheumatoid arthritis: an exploratory analysis of data from the Optimizing TNF Tapering in RA (OPTTIRA) trial.

scientific article published on 17 May 2018

Molecular flow quantified beyond the diffraction limit by spatiotemporal image correlation of structured illumination microscopy data

scientific article

Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation

scientific article

Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells

scientific article published on 01 February 2000

New tumour necrosis factor inhibitors for rheumatoid arthritis: are there benefits from extending choice?

scientific article published in June 2009

Nitric oxide differentially regulates T-cell function in rheumatoid arthritis and systemic lupus erythematosus.

scientific article

Nitric oxide production of T lymphocytes is increased in rheumatoid arthritis.

scientific article published on 19 March 2008

Nitric oxide, chronic inflammation and autoimmunity

scientific article published on 25 May 2007

Optimizing treatment with tumour necrosis factor inhibitors in rheumatoid arthritis-a proof of principle and exploratory trial: is dose tapering practical in good responders?

scientific article published on 17 August 2017

Pathways of T cell activation and terminal differentiation in chronic inflammation

scientific article

Placebo Response in Rheumatoid Arthritis Clinical Trials

scientific article published on 01 May 2019

Polymorphisms in the CD3Z Gene Influence TCR Expression in Systemic Lupus Erythematosus Patients and Healthy Controls

article

Polypharmacy and Unplanned Hospitalizations in Patients with Rheumatoid Arthritis

scientific article

Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking

scientific article

Prolonged exposure of T cells to TNF down-regulates TCR zeta and expression of the TCR/CD3 complex at the cell surface.

scientific article published on May 2001

Prolonged stimulation by TNF uncouples T cell receptor (TCR) signalling pathways at many levels

scientific article published on 4 February 2002

Protein clustering and spatial organization in T-cells

scientific article published on June 2015

Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

scientific article published on 17 October 2017

Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice.

scientific article

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses

article

Proteomic analysis of the lymphocyte plasma membrane using cell surface biotinylation and solution-phase isoelectric focusing

scientific article

Proteomic characterisation of cell contact-dependent macrophage activation

Psychometric properties of a new treatment expectation scale in rheumatoid arthritis: an application of item response theory

scientific article

RAPIDS, RAFTS, AND RATS

scientific article published in The Lancet

Regulation of autoimmunity by proinflammatory cytokines

scientific article published on 01 December 1998

Rheumatoid arthritis: a disease of chronic, low-amplitude signals transduced through T cell antigen receptors?

scientific article

Selective immunosuppression of tumour necrosis factor-alpha in rheumatoid arthritis.

scientific article published on January 1995

Shedding kinetics of soluble tumor necrosis factor (TNF) receptors after systemic TNF leaking during isolated limb perfusion. Relevance to the pathophysiology of septic shock.

scientific article published on February 1998

Signal transduction pathways in chronic inflammatory rheumatic diseases

scientific article published on 7 September 2012

Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF

scientific article published on 01 January 1995

Soluble tumor necrosis factor receptors and soluble interleukin-6 receptor in fetal and maternal sera, coelomic and amniotic fluids in normal and pre-eclamptic pregnancies

scientific article published on 01 July 1995

Soluble tumor necrosis factor receptors in arthritis

scientific article published on 01 March 1995

Stabilization of IFN- mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells

scientific article published on 02 September 2004

Strontium can increase some osteoblasts without increasing hematopoietic stem cells.

scientific article published on 30 October 2007

Studies of T-cell activation in chronic inflammation

scientific article

Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity.

scientific article

Sustained downregulation of the TCRζ chain defines a transition from antigen mode to inflammation mode during terminal T-cell differentiation

T cell receptor zeta reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor alpha

scholarly article

T cells in arthritis.

scientific article published in March 1999

T cells in rheumatoid arthritis

scientific article published on 15 October 2008

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

scientific article

T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man.

scientific article published on March 2012

TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues

scientific article published on 25 January 2007

TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action.

scientific article published on July 1995

TNF suppresses CD4+ T-CELL responses by attenuating calcium/NFAT-dependent but not ERK-dependent signal transduction pathways.

scientific article published on 24 February 2003

TNF-inhibitor drugs regulate human pathogenic Th17 cells through induction of IL-10

TNF-α blockade induces IL-10 expression in human CD4+ T cells

scientific article published on January 2014

The 2013 BSR and BHPR guideline for the use of intravenous tocilizumab in the treatment of adult patients with rheumatoid arthritis.

scientific article published on 12 May 2014

The RA-MAP Consortium: a working model for academia-industry collaboration. ⬇️

scientific article published on 7 December 2017

The Relationship Between Mental Health, Disease Severity and Genetic Risk for Depression in Early Rheumatoid Arthritis

scientific article

The Th1 life cycle: molecular control of IFN-γ to IL-10 switching

scientific article published on 30 April 2011

The antiproliferative effect of mesenchymal stem cells is a fundamental property shared by all stromal cells

scientific article published on September 2007

The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life

scientific article published on 28 December 2018

The protective effect of alcohol on developing rheumatoid arthritis: a systematic review and meta-analysis

scientific article published on 03 January 2013

The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens

scientific article published in Scientific Reports

The role of TNF alpha and related cytokines in the development and function of the autoreactive T-cell repertoire

scientific article published on June 1997

The role of tumour necrosis factor (TNF-alpha) in experimental autoimmune uveoretinitis (EAU).

scientific article published in November 2004

The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain

scientific article published in June 2001

The ying and yang of fever in rheumatic disease.

scientific article published on June 2015

Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production

scientific article published on 13 July 2010

Topographic prominence as a method for cluster identification in single-molecule localisation data

scientific article

Tracking antigen-experienced effector T cells in vitro and in vivo

scientific article published in January 2010

Treg cells suppress osteoclast formation: a new link between the immune system and bone

article

Turning the immune system on

scientific article published on 01 April 1999

Two-stage affinity purification for inducibly phosphorylated membrane proteins

scientific article

Variable impacts of different remission states on health-related quality of life in rheumatoid arthritis

scientific article published on 23 October 2017

What does it take to be healthy? Investigating immune-deficiency in non-immunodeficient scenarios

scientific article

What does the immunogenetic basis of rheumatoid arthritis teach us about the immunobiology of the disease?

scientific article published on September 2006

What does tumour necrosis factor excess do to the immune system long term?

scientific article

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

scientific article

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