List of works - Georgios Pissas

A comparative analysis between proteasome and immunoproteasome inhibition in cellular and humoral alloimmunity

scientific article published on 16 June 2017

Activation of general control nonderepressible 2 kinase protects human glomerular endothelial cells from harmful high-glucose-induced molecular pathways

scientific article published on 27 July 2016

Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction.

scientific article

Angiogenin is upregulated during the alloreactive immune response and has no effect on the T-cell expansion phase, whereas it affects the contraction phase by inhibiting CD4+ T-cell apoptosis

scientific article published on 06 October 2016

Asymptomatic hyperuricemia and chronic kidney disease: Narrative review of a treatment controversial.

scientific article published on 5 May 2017

CD8+ T-cell auto-reactivity is dependent on the expression of the immunoproteasome subunit LMP7 in exposed to lipopolysaccharide antigen presenting cells and epithelial target cells.

scientific article published on 14 June 2013

Cell Death Patterns Due to Warm Ischemia or Reperfusion in Renal Tubular Epithelial Cells Originating from Human, Mouse, or the Native Hibernator Hamster

scientific article published on 15 November 2018

Comparison of the effect of the aerobic glycolysis inhibitor dichloroacetate and of the Krebs cycle inhibitor LW6 on cellular and humoral alloimmunity.

scientific article published on 11 September 2017

Correction to: Tryptophan depletion under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through reactive oxygen species-dependent and independent pathways

scientific article

Cytochrome c as a Potentially Clinical Useful Marker of Mitochondrial and Cellular Damage

scientific article

Damage-associated molecular patterns derived from mitochondria may contribute to the hemodialysis-associated inflammation

scientific article published on 21 March 2013

Differential effects of the two amino acid sensing systems, the GCN2 kinase and the mTOR complex 1, on primary human alloreactive CD4⁺ T-cells.

scientific article published in April 2016

Energy handling in renal tubular epithelial cells of the hamster, a native hibernator, under warm anoxia or reoxygenation

scientific article published on 12 October 2018

Factors affecting effectiveness of vaccination against hepatitis B virus in hemodialysis patients

scientific article

Hepatitis C virus core+1/ARF protein decreases hepcidin transcription through an AP1 binding site.

scientific article published on 11 April 2013

Hepatitis C virus modulates lipid regulatory factor Angiopoietin-like 3 gene expression by repressing HNF-1α activity.

scientific article published on 23 August 2013

IDO decreases glycolysis and glutaminolysis by activating GCN2K, while it increases fatty acid oxidation by activating AhR, thus preserving CD4+ T‑cell survival and proliferation.

scientific article

In human alloreactive CD4⁺ T-cells, dichloroacetate inhibits aerobic glycolysis, induces apoptosis and favors differentiation towards the regulatory T-cell subset instead of effector T-cell subsets.

scientific article

In human cell cultures, everolimus is inferior to tacrolimus in inhibiting cellular alloimmunity, but equally effective as regards humoral alloimmunity.

scientific article

Increased plasma angiogenin level is associated and may contribute to decreased T-cell zeta-chain expression in hemodialysis patients

scientific article published on 30 October 2012

Increased visfatin in hemodialysis patients is associated with decreased demands for recombinant human erythropoietin.

scientific article published on 21 August 2013

Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells.

scientific article

Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation.

scientific article published on 26 July 2014

Indoleamine 2,3-dioxygenase, by degrading L-tryptophan, enhances carnitine palmitoyltransferase I activity and fatty acid oxidation, and exerts fatty acid-dependent effects in human alloreactive CD4+ T-cells.

scientific article published on 23 September 2016

Indoleamine 2,3‑dioxygenase downregulates T‑cell receptor complex ζ‑chain and c‑Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T‑cells.

scientific article published on 20 November 2015

Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells.

scientific article

Inhibition of indoleamine 2,3-dioxygenase not only blocks autoreactive B cell activation, but it also reduces production of antibodies in general: comment on the article by Pigott and Mandik-Nayak

scientific article published on 01 July 2013

Kynurenine, by activating aryl hydrocarbon receptor, decreases erythropoietin and increases hepcidin production in HepG2 cells: A new mechanism for anemia of inflammation

scientific article published on 29 August 2015

Late onset of clinically apparent central vein stenosis due to previous central venous catheter in a patient with inherited thrombophilia.

scientific article

Late-onset Pompe's disease in a hemodialysis patient: A first case report.

scientific article

Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells.

scientific article

Perilipin-1 in hemodialyzed patients: association with history of coronary heart disease and lipid profile

scientific article published on 07 June 2012

Plasma indoleamine 2,3-dioxygenase and arginase type I may contribute to decreased blood T-cell count in hemodialysis patients

scientific article published on 17 August 2012

Plasma vascular endothelial growth factor and angiogenin are positively related to erythropoietin dose in hemodialysis patients.

scientific article published in January 2013

Preconditioning of primary human renal proximal tubular epithelial cells without tryptophan increases survival under hypoxia by inducing autophagy.

scientific article published on 17 April 2017

Proteasome or immunoproteasome inhibitors cause apoptosis in human renal tubular epithelial cells under normoxic and hypoxic conditions

scientific article published on 26 February 2016

Quiz: Nine Years of Persistent, Disabling Foot Pain in a Kidney Transplant Recipient

scientific article published on 01 August 2017

Serum copper and ferroportin in monocytes of hemodialysis patients are both decreased but unassociated

scientific article published on 8 May 2014

Serum osteoprotegerin is markedly increased and may contribute to decreased blood T cell count in hemodialysis patients

scientific article published on 08 January 2013

Sternal instability in a hemodialysis patient with secondary hyperparathyroidism

scientific article published on 04 April 2014

The contribution of genetic variants of SLC2A1 gene in T2DM and T2DM-nephropathy: association study and meta-analysis

article

Toll-like receptors and their role in renal pathologies.

scientific article published on December 2012

Tryptophan depletion under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through reactive oxygen species-dependent and independent pathways.

scientific article published on 4 February 2017

Urate crystals directly activate the T-cell receptor complex and induce T-cell proliferation

scientific article published on 4 August 2017

Uric acid and cellular and humoral alloimmunity

scientific article published on 08 August 2018

Uric acid increases cellular and humoral alloimmunity in primary human peripheral blood mononuclear cells.

scientific article

Xanthine oxidase inhibitors may prevent or slow chronic kidney disease even in the absence of hyperuricemia

scientific article published on 01 October 2018

List of works by Georgios Pissas

A comparative analysis between proteasome and immunoproteasome inhibition in cellular and humoral alloimmunity

Activation of general control nonderepressible 2 kinase protects human glomerular endothelial cells from harmful high-glucose-induced molecular pathways

Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction.

Angiogenin is upregulated during the alloreactive immune response and has no effect on the T-cell expansion phase, whereas it affects the contraction phase by inhibiting CD4+ T-cell apoptosis

Asymptomatic hyperuricemia and chronic kidney disease: Narrative review of a treatment controversial.

CD8+ T-cell auto-reactivity is dependent on the expression of the immunoproteasome subunit LMP7 in exposed to lipopolysaccharide antigen presenting cells and epithelial target cells.

Cell Death Patterns Due to Warm Ischemia or Reperfusion in Renal Tubular Epithelial Cells Originating from Human, Mouse, or the Native Hibernator Hamster

Comparison of the effect of the aerobic glycolysis inhibitor dichloroacetate and of the Krebs cycle inhibitor LW6 on cellular and humoral alloimmunity.

Correction to: Tryptophan depletion under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through reactive oxygen species-dependent and independent pathways

Cytochrome c as a Potentially Clinical Useful Marker of Mitochondrial and Cellular Damage

Damage-associated molecular patterns derived from mitochondria may contribute to the hemodialysis-associated inflammation

Differential effects of the two amino acid sensing systems, the GCN2 kinase and the mTOR complex 1, on primary human alloreactive CD4⁺ T-cells.

Energy handling in renal tubular epithelial cells of the hamster, a native hibernator, under warm anoxia or reoxygenation

Factors affecting effectiveness of vaccination against hepatitis B virus in hemodialysis patients

Hepatitis C virus core+1/ARF protein decreases hepcidin transcription through an AP1 binding site.

Hepatitis C virus modulates lipid regulatory factor Angiopoietin-like 3 gene expression by repressing HNF-1α activity.

IDO decreases glycolysis and glutaminolysis by activating GCN2K, while it increases fatty acid oxidation by activating AhR, thus preserving CD4+ T‑cell survival and proliferation.

In human alloreactive CD4⁺ T-cells, dichloroacetate inhibits aerobic glycolysis, induces apoptosis and favors differentiation towards the regulatory T-cell subset instead of effector T-cell subsets.

In human cell cultures, everolimus is inferior to tacrolimus in inhibiting cellular alloimmunity, but equally effective as regards humoral alloimmunity.

Increased plasma angiogenin level is associated and may contribute to decreased T-cell zeta-chain expression in hemodialysis patients

Increased visfatin in hemodialysis patients is associated with decreased demands for recombinant human erythropoietin.

Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells.

Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation.

Indoleamine 2,3-dioxygenase, by degrading L-tryptophan, enhances carnitine palmitoyltransferase I activity and fatty acid oxidation, and exerts fatty acid-dependent effects in human alloreactive CD4+ T-cells.

Indoleamine 2,3‑dioxygenase downregulates T‑cell receptor complex ζ‑chain and c‑Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T‑cells.

Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells.

Inhibition of indoleamine 2,3-dioxygenase not only blocks autoreactive B cell activation, but it also reduces production of antibodies in general: comment on the article by Pigott and Mandik-Nayak

Kynurenine, by activating aryl hydrocarbon receptor, decreases erythropoietin and increases hepcidin production in HepG2 cells: A new mechanism for anemia of inflammation

Late onset of clinically apparent central vein stenosis due to previous central venous catheter in a patient with inherited thrombophilia.

Late-onset Pompe's disease in a hemodialysis patient: A first case report.

Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells.

Perilipin-1 in hemodialyzed patients: association with history of coronary heart disease and lipid profile

Plasma indoleamine 2,3-dioxygenase and arginase type I may contribute to decreased blood T-cell count in hemodialysis patients

Plasma vascular endothelial growth factor and angiogenin are positively related to erythropoietin dose in hemodialysis patients.

Preconditioning of primary human renal proximal tubular epithelial cells without tryptophan increases survival under hypoxia by inducing autophagy.

Proteasome or immunoproteasome inhibitors cause apoptosis in human renal tubular epithelial cells under normoxic and hypoxic conditions

Quiz: Nine Years of Persistent, Disabling Foot Pain in a Kidney Transplant Recipient

Serum copper and ferroportin in monocytes of hemodialysis patients are both decreased but unassociated

Serum osteoprotegerin is markedly increased and may contribute to decreased blood T cell count in hemodialysis patients

Sternal instability in a hemodialysis patient with secondary hyperparathyroidism

The contribution of genetic variants of SLC2A1 gene in T2DM and T2DM-nephropathy: association study and meta-analysis

Toll-like receptors and their role in renal pathologies.

Tryptophan depletion under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through reactive oxygen species-dependent and independent pathways.

Urate crystals directly activate the T-cell receptor complex and induce T-cell proliferation

Uric acid and cellular and humoral alloimmunity

Uric acid increases cellular and humoral alloimmunity in primary human peripheral blood mononuclear cells.

Xanthine oxidase inhibitors may prevent or slow chronic kidney disease even in the absence of hyperuricemia