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List of works by Zhe-Xiong Lian

A Mouse Model of Autoimmune Cholangitis via Syngeneic Bile Duct Protein Immunization

scientific article published on 10 November 2017

AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers

scientific article published in February 2007

Adaptive immune cells are necessary for the enhanced therapeutic effect of sorafenib-loaded nanoparticles

scientific article

Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice

scientific article published on June 2008

Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice

scientific article published in January 2002

Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis

scientific article

Analysis of TCR antagonism and molecular mimicry of an HLA-A0201-restricted CTL epitope in primary biliary cirrhosis

scientific article published on October 2002

Animal Models of Autoimmune Liver Diseases: a Comprehensive Review

scientific article published on 01 April 2020

Anti-drug Antibodies Against a Novel Humanized Anti-CD20 Antibody Impair Its Therapeutic Effect on Primary Biliary Cholangitis in Human CD20- and FcγR-Expressing Mice

Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice

scientific article published in August 2006

Appearance of human plasma cells following differentiation of human B cells in NOD/SCID mouse spleen

scientific article published on June 2003

B cells and autoimmune liver diseases

scientific article published on 20 March 2006

B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis

scientific article

B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis.

scientific article published on 19 November 2008

B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice

scientific article

Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis

scientific article published on February 2005

Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid

scientific article published on February 2012

Block of both TGF-β and IL-2 signaling impedes Neurophilin-1+ regulatory T cell and follicular regulatory T cell development

scientific article published on 27 October 2016

CD4+ CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice

scientific article published on 01 November 2008

CD4- plasmacytoid dendritic cells (pDCs) migrate in lymph nodes by CpG inoculation and represent a potent functional subset of pDCs.

scientific article published in March 2005

CD8 T Cells Mediate Direct Biliary Ductule Damage in Nonobese Diabetic Autoimmune Biliary Disease ⬇️

scientific article published on December 17, 2010

CD8+ T cells and IFN-γ induce autoimmune myelofibrosis in mice

scientific article published on 4 January 2018

Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8+ T cell activation

scientific article published on 24 January 2017

Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity

scientific article published on 29 October 2021

Clonality, activated antigen-specific CD8(+) T cells, and development of autoimmune cholangitis in dnTGFβRII mice

scientific article published on 24 July 2013

Comparative analysis of portal cell infiltrates in antimitochondrial autoantibody-positive versus antimitochondrial autoantibody-negative primary biliary cirrhosis

scientific article published on 4 April 2012

Comprehensive mapping of HLA-A0201-restricted CD8 T-cell epitopes on PDC-E2 in primary biliary cirrhosis

scientific article (publication date: November 2002)

Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis

scientific article

Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice

scientific article

Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice

scientific article

Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis

scientific article

Development of autoantibodies precedes clinical manifestations of autoimmune diseases: A comprehensive review

scientific article

Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha(-/-) mice

scientific article published on January 2009

Differential modulation by IL-17A of Cholangitis versus Colitis in IL-2Rα deleted mice

scientific article

Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Rα(-/-) mice

scientific article published on 17 March 2014

Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride

scientific article published on May 2009

Dysregulation of peritoneal cavity B1a cells and murine primary biliary cholangitis

scientific article published on 20 April 2016

Elevated C-met in thymic dendritic cells of New Zealand Black mice

scientific article published in March 2002

Epigenetics and Primary Biliary Cirrhosis: a Comprehensive Review and Implications for Autoimmunity

scientific article published on 13 August 2015

Expansion of bone marrow IFN-alpha-producing dendritic cells in New Zealand Black (NZB) mice: high level expression of TLR9 and secretion of IFN-alpha in NZB bone marrow

scientific article

Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis

scientific article

Forkhead Box O1 Regulates Macrophage Polarization Following Staphylococcus aureus Infection: Experimental Murine Data and Review of the Literature

scientific article

FoxO1 is a regulator of MHC-II expression and anti-tumor effect of tumor-associated macrophages

scientific article published on 14 December 2017

Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis

scientific article published in June 2005

Gut microbiota translocation promotes autoimmune cholangitis

scientific article published on 17 October 2018

Hepatic IL-17 responses in human and murine primary biliary cirrhosis

scientific article published on 19 December 2008

Heterogeneity of dendritic cells in the mouse liver: identification and characterization of four distinct populations.

scientific article published in March 2003

IFN-γ-STAT1-iNOS Induces Myeloid Progenitors to Acquire Immunosuppressive Activity

scientific article published on 22 September 2017

IL-2 receptor alpha deficiency and features of primary biliary cirrhosis

scientific article published on 10 August 2006

IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis

scientific article published in November 2006

Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells

scientific article

Increased frequency of pre-pro B cells in the bone marrow of New Zealand Black (NZB) mice: implications for a developmental block in B cell differentiation

scientific article published on March 2002

Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis

scientific article published on 26 May 2006

Increased levels of chemokine receptor CXCR3 and chemokines IP-10 and MIG in patients with primary biliary cirrhosis and their first degree relatives

scientific article

Intra-bone marrow injection of donor bone marrow cells suspended in collagen gel retains injected cells in bone marrow, resulting in rapid hemopoietic recovery in mice

scientific article published on 3 July 2008

Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis.

scientific article published in April 2006

Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease

scientific article published on August 2008

Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFβ receptor II.

scientific article

Modulation of liver regeneration via myeloid PTEN deficiency

scientific article published on 25 May 2017

Murine thymic plasmacytoid dendritic cells

scientific article published in April 2003

Myeloid STAT3 inhibits T cell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production

scientific article published on 15 August 2009

Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis

scientific article published in February 2008

Overexpression of microRNA-21 is associated with elevated pro-inflammatory cytokines in dominant-negative TGF-β receptor type II mouse

scientific article published on 8 February 2013

Plasmacytoid dendritic cells of different origins have distinct characteristics and function: studies of lymphoid progenitors versus myeloid progenitors

scientific article published in December 2005

Proteasome is required for class I-restricted presentation by Fcgamma receptor-mediated endocytosis in primary biliary cirrhosis

scientific article published in September 2003

Prss16 is not required for T-cell development

scientific article

Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis

scientific article

Regulatory T cells ameliorate acetaminophen-induced immune-mediated liver injury

scientific article published on 14 February 2015

Regulatory T cells: development, function and role in autoimmunity

scientific article

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation

scientific article

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation.

scientific article published in December 2014

STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib

scientific article published on 13 August 2013

Sorafenib inhibits macrophage-mediated epithelial-mesenchymal transition in hepatocellular carcinoma

scientific article published on 18 May 2016

Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy

scientific article published on 29 September 2015

Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis

scientific article published on 17 February 2015

The CXC Chemokine Receptor 3 Inhibits Autoimmune Cholangitis via CD8+ T Cells but Promotes Colitis via CD4+ T Cells.

scientific article published on 17 May 2018

The current immune function of hepatic dendritic cells.

scientific article published on October 2007

The immunobiology of colitis and cholangitis in interleukin-23p19 and interleukin-17A deleted dominant negative form of transforming growth factor beta receptor type II mice

scientific article

The influence of cyclosporin A on lymphocyte attenuator expression

scientific article published on 20 April 2007

The intestinal microbiota and microenvironment in liver

scientific article

The molecular basis of immune regulation in autoimmunity

scientific article published on 5 January 2018

Thymic B cells promote thymus-derived regulatory T cell development and proliferation

scientific article

Traditional Chinese Medicine and Immune Regulation ⬇️

scientific article published on June 1, 2013

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