List of works - Hiroshi Suemizu

A basolateral sorting motif in the MICA cytoplasmic tail.

scientific article

A novel Css-MRTpo approach to simulate oral plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers

scientific article published on 22 November 2019

A versatile technique for the in vivo imaging of human tumor xenografts using near-infrared fluorochrome-conjugated macromolecule probes

scientific article

Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry.

scientific article published on 27 July 2016

Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment.

scientific article published on 30 January 2017

Chimeric Mice with Humanized Liver as a Model for Testing Organophosphate and Carbamate Pesticide Exposure.

scientific article published on 13 December 2017

Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice

scientific article published on 25 January 2019

Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology.

scientific article published on 23 June 2016

Decreased expression of liver glutathione peroxidase in Long-Evans cinnamon mutant rats predisposed to hepatitis and hepatoma

scientific article published on 01 March 1994

Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice

scientific article published on 31 December 2019

Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rγnull mice is attributed to a lack of CD11c+B220+CD122+ cells

scientific article published on 26 September 2012

Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice.

scientific article published on 25 July 2015

Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice

scientific article published on 07 October 2008

Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised livers

scholarly article by Shotaro Uehara et al published 4 October 2018 in Xenobiotica

Expression profiling of placentomegaly associated with nuclear transplantation of mouse ES cells.

scientific article published in January 2003

Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers.

scientific article published on 11 December 2014

Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes.

scientific article published on 2 January 2016

Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice

scientific article published on 2 February 2018

Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway

scientific article published on 22 January 2020

Hepatocytes buried in the cirrhotic livers of patients with biliary atresia proliferate and function in the livers of urokinase-type plasminogen activator-NOG mice

scientific article

Higher susceptibility of NOG mice to xenotransplanted tumors

scientific article published on 01 February 2009

Highly efficient induction of primate iPS cells by combining RNA transfection and chemical compounds

scientific article published on 17 June 2019

Human Aldehyde Oxidase 1-mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes

scientific article published on 01 May 2020

Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling.

scientific article published on 20 March 2015

Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice.

scientific article

Human hepatocytes depletion in the presence of HIV-1 infection in dual reconstituted humanized mice.

scientific article published on 22 January 2018

Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling.

scientific article

Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.

scientific article published on 10 July 2014

Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling.

scientific article published on 21 March 2015

Immunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted mice

article

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

scientific article

In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.

scientific article

In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits

scientific article published on 02 January 2020

Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity.

scientific article published on 13 July 2015

Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse

scientific article published on 8 December 2017

Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice.

scientific article

Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes

scientific article published on 12 November 2019

Mutation analysis of vinyl carbamate or urethane induced lung tumors in rasH2 transgenic mice.

scientific article published in April 2003

Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes.

scientific article

Plasma and Hepatic Concentrations of Acetaminophen and Its Primary Conjugates after Oral Administrations Determined in Experimental Animals and Humans and Extrapolated by Pharmacokinetic Modeling

scientific article published on 12 November 2020

Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.

scientific article published on 5 February 2013

Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice

scientific article published on 24 July 2015

Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver

scientific article published on 21 June 2019

Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver

scientific article published on 25 November 2019

Predominant development of mature and functional human NK cells in a novel human IL-2-producing transgenic NOG mouse.

scientific article

Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6

scientific article published on 14 June 2019

Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice.

scientific article

Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver

scientific article published on 9 June 2016

Sox17 is Essential for Proper Formation of the Marginal Zone of Extraembryonic Endoderm Adjacent to a Developing Mouse Placental Disk.

scientific article published on 4 April 2018

Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate

scientific article published on 05 February 2019

Study on AAV-mediated gene therapy for diabetes in humanized liver mouse to predict efficacy in humans

scientific article published on 18 August 2016

Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor

scientific article published on 5 February 2014

The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice. ⬇️

scientific article published on 14 December 2015

The adult livers of immunodeficient mice support human hematopoiesis: evidence for a hepatic mast cell population that develops early in human ontogeny.

scientific article

The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice.

scientific article published on 25 September 2013

The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.

scientific article published on 14 January 2011

List of works by Hiroshi Suemizu

A basolateral sorting motif in the MICA cytoplasmic tail.

A novel Css-MRTpo approach to simulate oral plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers

A versatile technique for the in vivo imaging of human tumor xenografts using near-infrared fluorochrome-conjugated macromolecule probes

Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry.

Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment.

Chimeric Mice with Humanized Liver as a Model for Testing Organophosphate and Carbamate Pesticide Exposure.

Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice

Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology.

Decreased expression of liver glutathione peroxidase in Long-Evans cinnamon mutant rats predisposed to hepatitis and hepatoma

Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice

Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rγnull mice is attributed to a lack of CD11c+B220+CD122+ cells

Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice.

Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice

Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised livers

Expression profiling of placentomegaly associated with nuclear transplantation of mouse ES cells.

Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers.

Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes.

Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice

Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway

Hepatocytes buried in the cirrhotic livers of patients with biliary atresia proliferate and function in the livers of urokinase-type plasminogen activator-NOG mice

Higher susceptibility of NOG mice to xenotransplanted tumors

Highly efficient induction of primate iPS cells by combining RNA transfection and chemical compounds

Human Aldehyde Oxidase 1-mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes

Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling.

Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice.

Human hepatocytes depletion in the presence of HIV-1 infection in dual reconstituted humanized mice.

Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling.

Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.

Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling.

Immunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted mice

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.

In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits

Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity.

Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse

Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice.

Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes

Mutation analysis of vinyl carbamate or urethane induced lung tumors in rasH2 transgenic mice.

Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes.

Plasma and Hepatic Concentrations of Acetaminophen and Its Primary Conjugates after Oral Administrations Determined in Experimental Animals and Humans and Extrapolated by Pharmacokinetic Modeling

Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.

Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice

Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver

Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver

Predominant development of mature and functional human NK cells in a novel human IL-2-producing transgenic NOG mouse.

Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6

Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice.

Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver

Sox17 is Essential for Proper Formation of the Marginal Zone of Extraembryonic Endoderm Adjacent to a Developing Mouse Placental Disk.

Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate

Study on AAV-mediated gene therapy for diabetes in humanized liver mouse to predict efficacy in humans

Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor

The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice. ⬇️

The adult livers of immunodeficient mice support human hematopoiesis: evidence for a hepatic mast cell population that develops early in human ontogeny.

The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice.

The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.