List of works by Pierre-Olivier Couraud

A functional in vitro model of rat blood-brain barrier for molecular analysis of efflux transporters

scientific article published on 12 March 2007

A multi-system approach assessing the interaction of anticonvulsants with P-gp

scientific article

Activated leukocyte cell adhesion molecule (ALCAM) facilitates trafficking of HTLV-1 infected lymphocytes through the blood brain barrier

scientific article published on 28 August 2015

Adenosine receptors regulate gap junction coupling of the human cerebral microvascular endothelial cells hCMEC/D3 by Ca2+ influx through cyclic nucleotide-gated channels

scientific article published on 11 January 2017

Alteration of blood-brain barrier integrity by retroviral infection

scientific article published in November 2008

Angiotensin II facilitates breast cancer cell migration and metastasis

scientific article

Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

scientific article published in Scientific Reports

Aryl hydrocarbon receptor regulates CYP1B1 but not ABCB1 and ABCG2 in hCMEC/D3 human cerebral microvascular endothelial cells after TCDD exposure

scientific article

Astrocytes facilitate melanoma brain metastasis via secretion of IL-23.

scientific article published on 12 February 2015

CCL2 disrupts the adherens junction: implications for neuroinflammation

scientific article

Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling

scientific article

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

scientific article

Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells

scientific article published on June 2003

Characterization of genetically modified human retinal pigment epithelial cells developed for in vitro and transplantation studies

scientific article

Contribution of pannexin 1 and connexin 43 hemichannels to extracellular calcium-dependent transport dynamics in human blood-brain barrier endothelial cells.

scientific article

Correction: The Brain Microvascular Endothelium Supports T Cell Proliferation and Has Potential for Alloantigen Presentation.

scientific article published on 22 April 2013

Design of fluorescently tagged poly(alkyl cyanoacrylate) nanoparticles for human brain endothelial cell imaging

scientific article

Development and characterization of immortalized cerebral endothelial cell lines

scientific article published on January 2003

Development of a solvent-free analytical method for paracetamol quantitative determination in Blood Brain Barrier in vitro model

scientific article

Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models

scientific article published on 14 May 2011

Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier

scientific article published on 7 February 2008

Differential expression of the bone and the liver tissue non-specific alkaline phosphatase isoforms in brain tissues

scientific article published on 31 December 2010

Differential permissivity of human cerebrovascular endothelial cells to enterovirus infection and specificities of serotype EV-A71 in crossing an in vitro model of the human blood-brain barrier

scientific article

Drug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin C

scientific article (publication date: 2014)

Edaravone protects against methylglyoxal-induced barrier damage in human brain endothelial cells

scientific article

Effect of Long-term In Vitro Lithium Exposure on mRNA Levels of Claudin-3, CYP1A1, ABCG2 and GSTM3 Genes in the hCMEC/D3 Human Brain Endothelial Cell Line

scientific article

Effects of Aggregatibacter actinomycetemcomitans leukotoxin on endothelial cells

scientific article published on 9 May 2013

Effects of HIV-1 Tat and Methamphetamine on Blood-Brain Barrier Integrity and Function In Vitro

scientific article published on 11 September 2017

Endothelin-1, angiotensin II and cancer

scientific article

Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown

scientific article

Expression and localization of claudins-3 and -12 in transformed human brain endothelium

scientific article

Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment

scientific article published on 25 March 2009

Fonctions de la protéine prion PrPc

Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model

scientific article published on 26 January 2013

Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide

scientific article

Guanine nucleotide-binding protein Gαi2: a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cells

scientific article

Hepatitis C virus infects the endothelial cells of the blood-brain barrier

scientific article published on December 2011

High-density lipoprotein-based therapy reduces the hemorrhagic complications associated with tissue plasminogen activator treatment in experimental stroke

scientific article published on 19 February 2013

How do extracellular pathogens cross the blood-brain barrier?

scientific article

Human T-Lymphotropic Virus Type 1-Induced Overexpression of Activated Leukocyte Cell Adhesion Molecule (ALCAM) Facilitates Trafficking of Infected Lymphocytes through the Blood-Brain Barrier

scientific article published on June 2016

Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: a new target cell type for the immunodeficiency virus-1?

scientific article published on 21 June 2002

Human blood-brain barrier disruption by retroviral-infected lymphocytes: role of myosin light chain kinase in endothelial tight-junction disorganization

scientific article

Human brain endothelial cells are responsive to adenosine receptor activation

scientific article

Hyperosmotic stress induces Axl activation and cleavage in cerebral endothelial cells

scientific article

IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells

scientific article published on 18 April 2010

Identification of peptide ligands for targeting to the blood-brain barrier

scientific article

Immature mesenchymal stem cell-like pericytes as mediators of immunosuppression in human malignant glioma

scientific article published on 20 September 2013

Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans

scientific article published on 18 September 2009

Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies

scientific article

Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier

scientific article published on 13 October 2012

In vitro modeling of the neurovascular environment by coculturing adult human brain endothelial cells with human neural stem cells

scientific article

Induced secretion of beta-hexosaminidase by human brain endothelial cells: a novel approach in Sandhoff disease?

scientific article

Insights into the putative catechin and epicatechin transport across blood-brain barrier

scientific article

Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration

scientific article

Invading basement membrane matrix is sufficient for MDA-MB-231 breast cancer cells to develop a stable in vivo metastatic phenotype

scientific article

Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis

scientific article published on 08 July 2018

JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation

scientific article published on 08 December 2008

Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes

scientific article published on 24 October 2006

Lamotrigine is a substrate for OCT1 in brain endothelial cells

scientific article published on 29 December 2011

Localization microscopy (SPDM) reveals clustered formations of P-glycoprotein in a human blood-brain barrier model

scientific article

Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier

scientific article

Lymphocyte trafficking through the blood-brain barrier is dependent on endothelial cell heterotrimeric G-protein signaling

scientific article published on August 2002

Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells

scientific article

Metabolic acidosis induced by Plasmodium falciparum intraerythrocytic stages alters blood-brain barrier integrity

scientific article published on 4 August 2010

Microvilli-like structures are associated with the internalization of virulent capsulated Neisseria meningitidis into vascular endothelial cells.

scientific article published on March 2002

Modulation of blood-brain barrier permeability by neutrophils: in vitro and in vivo studies

scientific article

New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator

scientific article published on 3 April 2017

Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?

scientific article

PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells

scientific journal article

Paracrine signalling of inflammatory cytokines from an in vitro blood brain barrier model upon exposure to polymeric nanoparticles

scientific article published on 5 November 2013

Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization

scientific article published on June 2014

Pcbs and tight junction expression

scientific article published on March 2008

Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line

scientific article

Permeability of PEGylated immunoarsonoliposomes through in vitro blood brain barrier-medulloblastoma co-culture models for brain tumor therapy

scientific article published on 19 September 2014

Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release

scientific article published on 13 March 2015

Primary angiitis of the central nervous system: description of the first fifty-two adults enrolled in the French cohort of patients with primary vasculitis of the central nervous system.

scientific article published in May 2014

Purine receptors and Ca(2+) signalling in the human blood-brain barrier endothelial cell line hCMEC/D3

scientific article published on 29 September 2011

Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model

scientific article

Rat brain endothelial cell lines for the study of blood-brain barrier permeability and transport functions

scientific article

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling

scientific article

Regulation of Tight-Junction Integrity by Insulin in an In Vitro Model of Human Blood-Brain Barrier

scientific article

Role of KCNMA1 gene in breast cancer invasion and metastasis to brain

scientific article published on 29 July 2009

Role of astrocytic leptin receptor subtypes on leptin permeation across hCMEC/D3 human brain endothelial cells ⬇️

scientific article published on October 26, 2010

Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells

scientific article published on 14 February 2008

Somatostatin preserved blood brain barrier against cytokine induced alterations: possible role in multiple sclerosis

scientific article published on 13 June 2013

Surface characteristics of nanoparticles determine their intracellular fate in and processing by human blood-brain barrier endothelial cells in vitro

scientific article

Synthesis and in vitro evaluation of BBB permeability, tumor cell uptake, and cytotoxicity of a series of carboranylporphyrin conjugates

scientific article

TAL-1/SCL and its partners E47 and LMO2 up-regulate VE-cadherin expression in endothelial cells

scientific article published on 22 January 2007

TWEAK/Fn14 pathway modulates properties of a human microvascular endothelial cell model of blood brain barrier

scientific article published on 15 January 2013

Temozolomide down-regulates P-glycoprotein in human blood-brain barrier cells by disrupting Wnt3 signaling

scientific article published on 15 June 2013

Temporal profile of matrix metalloproteinases and their inhibitors in a human endothelial cell culture model of cerebral ischemia

scientific article published on 25 June 2013

The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

scientific article published on 31 October 2016

The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells

scientific article published on 18 December 2013

The angiogenic gene profile of circulating endothelial progenitor cells from ischemic stroke patients

scientific article published on 6 February 2013

The blood-brain barrier in brain homeostasis and neurological diseases

scientific article

The brain microvascular endothelium supports T cell proliferation and has potential for alloantigen presentation

scientific article

The hCMEC/D3 cell line as a model of the human blood brain barrier

scientific article published on 26 March 2013

The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies

scientific article

The involvement of a Na⁺- and Cl⁻-dependent transporter in the brain uptake of amantadine and rimantadine

scientific article published in March 2012

The metastatic microenvironment: Brain-derived soluble factors alter the malignant phenotype of cutaneous and brain-metastasizing melanoma cells

scientific article published on 12 April 2012

The metastatic microenvironment: brain-residing melanoma metastasis and dormant micrometastasis

scientific article published on 2 December 2011

The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family

scientific article published on 26 August 2014

Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation

scientific article

Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier

scientific article

Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP

scientific article

Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro

scientific article

Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels

scientific article published on 8 July 2011

Transthyretin participates in beta-amyloid transport from the brain to the liver--involvement of the low-density lipoprotein receptor-related protein 1?

scientific article published on 3 February 2016

Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium

scientific article

Uptake and cytotoxicity of citrate-coated gold nanospheres: Comparative studies on human endothelial and epithelial cells

scientific article

Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line

scientific article published on 29 November 2010

Vemurafenib resistance selects for highly malignant brain and lung-metastasizing melanoma cells

scientific article

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