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List of works by Lionel Opie

2013 ESC guidelines on the management of stable coronary artery disease

scientific article published on 30 August 2013

A Proposal to Incorporate Trial Data Into a Hybrid American College of Cardiology/American Heart Association Algorithm for the Allocation of Statin Therapy in Primary Prevention

scientific article published in September 2015

A challenge to the metabolic approach to myocardial ischaemia

scientific article

A new mutation, R563Q, of the beta subunit of the epithelial sodium channel associated with low-renin, low-aldosterone hypertension ⬇️

scientific article published on May 1, 2003

AMPK activation represses the human gene promoter of the cardiac isoform of acetyl-CoA carboxylase: Role of nuclear respiratory factor-1.

scientific article published on July 2010

Acknowledgement

Acute heart failure: Can modern therapy delay or prevent death?

scientific article published on 16 December 2015

Acute myocardial infarction and diabetes

scientific article

Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts.

scientific article published in February 2006

Angina pectoris: the evolution of concepts

scientific article published in September 2004

Angiotensin receptor blockers and myocardial infarction: direct comparative studies are needed

scientific article published in May 2005

Antihypertensive effects of angiotensin converting enzyme inhibition by lisinopril in post-transplant patients

scientific article published in October 2002

Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution.

scientific article published on 11 May 2016

Beta-blockade should not be among several choices for initial therapy of hypertension

scientific article published on 01 February 2008

Beta-blockers and the treatment of hypertension: it is time to move on

scientific article

Beta-blockers for hypertension

scientific article

Beta-blockers for hypertension

scientific article (published 2012-11-14)

Beta-blockers for hypertension

scientific article (published 2007-01-24)

Beta-blockers for hypertension.

scientific article

Body-mass index and mortality.

scientific article

COMPARISON OF METABOLIC ABNORMALITIES IN DIABETES MELLITUS INDUCED BY STREPTOZOTOCIN OR BY ALLOXAN

scientific article published in The Lancet

Can dementia be lessened by statins?

scientific article published in September 2014

Cancer and cardiovascular disease: more tightly linked than by chance

scientific article published in March 2015

Cardioprotection from metabolism to molecules to certainties.

scientific article

Cardiovascular disease in sub-Saharan Africa

scientific article published in December 2005

Cardiovascular disease prevention with a multidrug regimen in the developing world: a cost-effectiveness analysis

scientific article (publication date: 19 August 2006)

Cardiovascular remodelling in coronary artery disease and heart failure

scientific article

Cellular basis for therapeutic choices in heart failure

scientific article published in October 2004

Ceramide attenuates hypoxic cell death via reactive oxygen species signaling

scientific article published on January 2006

Ceramide-induced preconditioning involves reactive oxygen species

scientific article published on 15 November 2005

Cognitive decline: mechanisms and proposed role of the renin-angiotensin-aldosterone system

scientific article published on July 2014

Controversies in atrial fibrillation

scientific article

Controversies in hypertension

scientific article

Controversies in stable coronary artery disease

scientific article (publication date: 7 January 2006)

Controversies in the cardiovascular management of type 2 diabetes

scientific article

Controversies in ventricular remodelling

scientific article

Cost-effectiveness analysis of hypertension guidelines in South Africa: absolute risk versus blood pressure level

scientific article published in December 2005

Delayed postconditioning: cardioprotection at the limit?

scientific article published on 01 September 2011

Diabetic nephropathy: can renoprotection be extrapolated to cardiovascular protection?

scientific article published on 01 August 2002

Diazoxide-induced respiratory inhibition - a putative mitochondrial K(ATP) channel independent mechanism of pharmacological preconditioning

scientific article published on 29 November 2006

Dietary patterns need emphasising

scientific article published in November 2014

Diets and the heart. So many to choose from, but which work?

scientific article published in December 2014

Digitalis reappraised: Still here today, but gone tomorrow?

scientific article published on 15 December 2014

Digitalis, yesterday and today, but not forever

scientific article published on 10 September 2013

Dissociating HDL cholesterol from cardiovascular risk

scientific article published on 23 July 2010

Donepezil for severe Alzheimer's disease

scientific article published in July 2006

Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning

scientific journal article

Effect of losartan versus candesartan on uric acid, renal function, and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics

scientific article published in February 2006

Effects of Sphingosine-1-Phosphate on Acute Contractile Heart Failure (ACHF) ⬇️

scientific article published on December 1, 2010

Efficacy of indapamide SR compared with enalapril in elderly hypertensive patients with type 2 diabetes

scientific article

Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: the NESTOR Study

scientific article published in August 2004

Errors: incompetence, ineptitude or failure

scientific article published in August 2003

Ethanolamine is a novel STAT-3 dependent cardioprotective agent ⬇️

scientific article published on October 12, 2010

Evidence-based evaluation of calcium channel blockers for hypertension: equality of mortality and cardiovascular risk relative to conventional therapy

scientific article published on 01 January 2002

Exercise-induced Myalgia may Limit the Cardiovascular Benefits of Statins ⬇️

scientific article published on December 1, 2013

Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure

scientific article published on 6 November 2006

Free radicals trigger TNF alpha-induced cardioprotection

scientific article published in January 2005

Generic substitution--is it safe in patients at high cardiovascular risk?

scientific article published in August 2002

Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning

scientific article published on 01 September 2004

Glucose-insulin-potassium revived: current status in acute coronary syndromes and the energy-depleted heart

scientific article published on March 2013

Glucose-insulin-potassium therapy in patients with STEMI

scientific article published on 01 May 2008

Guía de Práctica Clínica de la ESC 2013 sobre diagnóstico y tratamiento de la cardiopatía isquémica estable

scientific article published in February 2014

H-89, a non-specific inhibitor of protein kinase A, promotes post-ischemic cardiac contractile recovery and reduces infarct size

scientific article

HDL protects against ischemia reperfusion injury by preserving mitochondrial integrity ⬇️

scientific article published on February 19, 2013

HIV/AIDS in South Africa

scientific article published in July 2005

Heart disease in Africa

scientific article published on 01 August 2006

How strong is the evidence for use of beta-blockers as first-line therapy for hypertension? Systematic review and meta-analysis

scientific article published on November 2006

Hypertension in sub-Saharan African populations

scientific article

Identification of a novel role for sphingolipid signaling in TNF alpha and ischemic preconditioning mediated cardioprotection

scientific article

Influence of Tumour Necrosis Factor Alpha on the Outcome of Ischaemic Postconditioning in the Presence of Obesity and Diabetes ⬇️

scientific article published on October 17, 2012

Inhibition of the Cerebral Renin-Angiotensin System to Limit Cognitive Decline in Elderly Hypertensive Persons ⬇️

scientific article published on August 1, 2011

Interplay Between SAFE and RISK Pathways in Sphingosine-1-Phosphate–Induced Cardioprotection ⬇️

scientific article published on June 1, 2012

Introduction to JMCC symposium on myocardial energy metabolism in health and disease

scientific article published in September 2002

Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol‐ and melatonin‐induced cardioprotection ⬇️

scientific article published on February 23, 2011

Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway

scientific article published on 7 August 2009

Left Ventricular Systolic Dysfunction in Asymptomatic Black Hypertensive Subjects

scientific article

Letter by Opie and Selker regarding article, "Reperfusion starts in the ambulance"

scientific article published on 01 December 2006

Lifestyle and diet

scientific article

Loss of Cardioprotection With Ischemic Preconditioning in Aging Hearts: Role of Sirtuin 1? ⬇️

scientific article published on September 6, 2012

Marketing ALLHAT

scientific article published on 01 January 2004

Medicine and conflict

scientific article

Mediterranean diet for primary prevention of cardiovascular disease

Comment by Opie, published in August 2013

Melatonin has multiorgan effects

scientific article

Melatonin, the new partner to aspirin?

scientific article published in February 2015

Metabolic management of acute myocardial infarction comes to the fore and extends beyond control of hyperglycemia

scientific article published in April 2008

Metabolic mechanisms in heart failure

scientific article published on July 2007

Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning

scientific article

Metabolic syndrome

scientific article published on 01 January 2007

Metabolic therapy for heart failure

scientific article published in October 2004

Myocardial perfusion in type 2 diabetes with left ventricular hypertrophy: normalisation by acute angiotensin-converting enzyme inhibition

scientific article

Old antihypertensives and new diabetes

scientific article published in August 2004

Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial

scientific article

PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibition ⬇️

scientific article published on September 1, 2011

Perindopril (Coversyl) prevents cardiovascular death and MI in coronary disease patients regardless of their cardiovascular risk

scientific article published on 01 September 2003

Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase).

scientific article

Positron emission tomographic evaluation of regulation of myocardial perfusion in physiological (elite athletes) and pathological (systemic hypertension) left ventricular hypertrophy

scientific article published on 28 October 2005

Postconditioning for protection of the infarcting heart

scientific article published on 01 February 2006

Postconditioning: a simple, clinically applicable procedure to improve revascularization in acute myocardial infarction

scientific article

Preconditioning and metabolic anti-ischaemic agents ⬇️

scientific article published on October 1, 2003

Predisposing factors and incidence of newly diagnosed atrial fibrillation in an urban African community: insights from the Heart of Soweto Study

scientific article

Present status of statin therapy

scientific article published on 24 December 2014

Professor Andries Jacob Brink: 29 August 1923--17 October 2012

scientific article published on March 1, 2013

Recording of smoking history in death notification ⬇️

scientific article published on August 24, 2013

Relationship between left ventricular geometry and soluble ST2 in a cohort of hypertensive patients

scientific article

Response to Letter Regarding Article, “Trimetazidine, a Metabolic Modulator, Has Cardiac and Extracardiac Benefits in Idiopathic Dilated Cardiomyopathy”

Response to Letters Regarding Article, “Free Fatty Acid Depletion Acutely Decreases Cardiac Work and Efficiency in Cardiomyopathic Heart Failure”

Role of melatonin, melatonin receptors and STAT3 in the cardioprotective effect of chronic and moderate consumption of red wine

scientific article published on 18 August 2015

Role of toll-like receptor 4 in melatonin-induced cardioprotection

scientific article

Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion

scientific article

Sphingosine-1-phosphate (S1P) activates STAT3 to protect against de novo acute heart failure (AHF).

scientific article published on 23 January 2018

Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: A double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary

scientific article

TNFalpha is required to confer protection in an in vivo model of classical ischaemic preconditioning

scientific article published on 30 January 2007

TNFalpha-induced cytoprotection requires the production of free radicals within mitochondria in C2C12 myotubes

scientific article

TNFα protects cardiac mitochondria independently of its cell surface receptors ⬇️

scientific article published on August 1, 2010

Tedisamil in Coronary Disease: Additional Benefits in the Therapy of Atrial Fibrillation? ⬇️

scientific article published on June 1, 2003

The PGE2-Stat3 interaction in doxorubicin-induced myocardial apoptosis

scientific article published on 20 June 2008

The acute coronary syndrome revisited: effects and therapeutic modulation of excess metabolic fuel supply

scientific article published on 01 May 2020

The adrenergic-fatty acid load in heart failure

scientific article published on October 2009

The chest radiograph. A useful investigation in the evaluation of hypertensive patients.

scientific article published in June 2004

The metabolic vicious cycle in heart failure

scientific article

The neuroendocrinology of congestive heart failure

scientific article published on 01 July 2002

The proposed role of plasma NT pro-brain natriuretic peptide in assessing cardiac remodelling in hypertensive African subjects

scientific article

The red wine hypothesis: from concepts to protective signalling molecules

scientific article

Trials, tribulations and speculation! Report from the 7th Biennial Hatter Cardiovascular Institute Workshop

scientific article published on 25 September 2012

Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humans

scientific article published on 31 July 2011

Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy

scientific article

Very early administration of glucose-insulin-potassium by emergency medical service for acute coronary syndromes: Biological mechanisms for benefit in the IMMEDIATE Trial.

scientific article published on 2 June 2016

Warfarin in non-valvular atrial fibrillation

scientific article published on 11 October 2013

What is good for the circulation also lessens cancer risk

scientific article

What is the need for another new journal?

scientific article

β-Blocker therapy for patients with hypertension--reply

scientific article published in February 2014

β-Blockers as initial therapy for hypertension.

scientific article

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