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List of works by Brian Popko

A G-coupled receptor protein critical for peripheral nerve myelination

scientific article published on 14 December 2009

A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination.

scientific article

A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation.

scientific article published in August 2002

A subgenomic segment of Theiler's murine encephalomyelitis virus RNA causes demyelination

scientific article published on 9 April 2008

Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice

scientific article

Activation of the Integrated Stress Response and Metabolic Dysfunction in a Murine Model of Sleep Apnea

scientific article published on 8 June 2017

Adenomatous polyposis coli regulates radial axonal sorting and myelination in the PNS

scientific article published on 25 May 2016

An enhanced integrated stress response ameliorates mutant SOD1-induced ALS.

scientific article published on 23 December 2013

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

scientific article (publication date: March 2003)

Animal models in the study of the unfolded protein response.

scientific article published on January 2011

Autosomal recessive neuromuscular disorder in a transgenic line of mice

scientific article published on 01 January 1994

Biochemistry and neuropathology of mice doubly deficient in synthesis and degradation of galactosylceramide.

scientific article

Cholesterol crystals impede nerve repair

scientific article published in February 2018

Cis-Acting Human ApoE Tissue Expression Element is Associated with Human Pattern of Intraneuronal ApoE in Transgenic Mice ⬇️

scientific article published on January 1, 1998

Cloning and characterization of a cDNA encoding a novel fatty acid binding protein from rat brain

scientific journal article

Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis

scientific article

Connexin23 deletion does not affect lens transparency.

scientific article published on 30 March 2016

DNA Sequence, genomic organization, and chromosomal localization of the mouse peripheral myelin protein zero gene: Identification of polymorphic alleles ⬇️

scientific article published on April 1, 1991

Detecting Demyelination by PET: The Lesion as Imaging Target

scientific article published on 01 January 2018

Developing and mature oligodendrocytes respond differently to the immune cytokine interferon-gamma ⬇️

scientific article published on April 15, 1998

Development of a PET radioligand for potassium channels to image CNS demyelination.

scientific article published on 12 January 2018

Disruption of the mouse Large gene in the enr and myd mutants results in nerve, muscle, and neuromuscular junction defects.

scientific article published in April 2005

Downregulating DR6 to drive remyelination ⬇️

scientific article published on 07 July 2011

Drastically abnormal gluco- and galactosylceramide composition does not affect ganglioside metabolism in the brain of mice deficient in galactosylceramide synthase.

scientific article published in April 1999

ER Chaperone BiP/GRP78 Is Required for Myelinating Cell Survival and Provides Protection during Experimental Autoimmune Encephalomyelitis.

scientific article

Effects of galactolipid elimination on oligodendrocyte development and myelination.

scientific article published in June 2000

Endoplasmic reticulum stress and the unfolded protein response in disorders of myelinating glia

scientific article published on 4 April 2016

Endoplasmic reticulum stress in disorders of myelinating cells.

scientific article

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma

scientific journal article

Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma

scientific article published on 25 September 2008

Epigenetic control of myelin repair.

scientific article published on September 2008

Expression and demethylation of germinally-transmitted BALB/c mouse mammary tumor virus DNA in Abelson MuLV B-lymphoid cell lines.

scientific article published in January 1984

Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype.

scientific article published in February 1987

Expression of major histocompatibility complex class I antigens in the demyelinating twitcher CNS and PNS

scientific article published on 01 March 1997

Galactolipids in the formation and function of the myelin sheath

scientific article published on 01 June 1998

Genetic analysis of myelin galactolipid function.

scientific article

Genetic dissection of myelin galactolipid function.

scientific article

Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination.

scientific article

Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis.

scientific article

Harnessing the integrated stress response for the treatment of multiple sclerosis.

scientific article published on 9 February 2016

Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.

scientific article published on January 1996

Impaired peripheral nerve regeneration in a mutant strain of mice (Enr) with a Schwann cell defect

scientific article published in November 1995

In situ analysis of myelin basic protein gene expression in myelin-deficient oligodendrocytes: antisense hnRNA and readthrough transcription ⬇️

scientific article published on November 1, 1990

Induced reciprocal translocation in transgenic mice near sites of transgene integration

scientific article published on January 1, 1992

Inducible production of interferon-gamma in the developing brain causes cerebellar dysplasia with activation of the Sonic hedgehog pathway.

scientific article published in December 2004

Integrated stress response activation by sleep fragmentation during late gestation in mice leads to emergence of adverse metabolic phenotype in offspring

scientific article published on 21 January 2017

Interferon-gamma induced medulloblastoma in the developing cerebellum.

scientific article published in November 2004

Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress

scientific article published on 27 February 2006

Interferon-gamma protects against cuprizone-induced demyelination.

scientific article published in October 2000

Interferon-gamma-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis

scientific article published on 01 February 2007

Isolation, characterization, and expression of cDNA clones that encode rat UDP-galactose: ceramide galactosyltransferase

scientific journal article

Major histocompatibility complex heavy chain accumulation in the endoplasmic reticulum of oligodendrocytes results in myelin abnormalities

scientific article published on 01 January 2000

Molecular characterization of the murine mutation myelin deficient

scientific article published on January 1, 1991

Morphometric analysis of normal, mutant, and transgenic CNS: correlation of myelin basic protein expression to myelinogenesis

scientific article published on 01 January 1992

Myelin abnormalities in mice deficient in galactocerebroside and sulfatide.

scientific article published in September 1998

Myelin basic protein and myelinogenesis: morphometric analysis of normal, mutant and transgenic central nervous system

scientific article published on January 1, 1990

Myelin galactolipids are essential for proper node of Ranvier formation in the CNS.

scientific article

Myelin maintenance: axonal support required

scientific article published on 01 March 2010

Myelin repair: developmental myelination redux?

scientific article published in March 2005

Myelin: not just a conduit for conduction

scientific article published on 01 March 2003

Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.

scientific article published in July 1996

Neonatal Hypoxia Results in Peripheral Nerve Abnormalities.

scientific article published on 2 January 2017

Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice

scientific journal article

New perspectives on the function of myelin galactolipids.

scientific article

Nodal sodium channel domain integrity depends on the conformation of the paranodal junction, not on the presence of transverse bands

scientific article published on 01 February 2003

Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization

scientific article

Notch signaling: a rheostat regulating oligodendrocyte differentiation?

scientific article published in November 2003

Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS

scientific article

Oligodendrocyte death results in immune-mediated CNS demyelination.

scientific article published on 14 December 2015

Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis

scientific article published on April 2013

Oligodendrocytes assist in the maintenance of sodium channel clusters independent of the myelin sheath.

scientific article published in August 2004

Organization and expression of mouse mammary tumor virus sequences in normal and neoplastic C3Hf/HeSed mouse tissues.

scientific article published on November 1984

Paranodal junction formation and spermatogenesis require sulfoglycolipids

scientific journal article

Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic

scientific article

Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation.

scientific article published in May 2018

Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts

scientific article published on 03 August 2016

Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 gene

scientific article

Quantitative analysis of myelin protein gene expression during development in the rat sciatic nerve.

scientific article published in August 1990

Remyelination therapy goes to trial for multiple sclerosis

scientific article

Repetitive DNA (TGGA)n 5′ to the human myelin basic protein gene: A new form of oligonucleotide repetitive sequence showing length polymorphism ⬇️

scientific article published on January 1, 1990

Rewiring enervated: thinking LARGEr than myodystrophy.

scientific article

Spinal glioma: platelet-derived growth factor B-mediated oncogenesis in the spinal cord.

scientific article

Suppressor of cytokine signaling 1 expression protects oligodendrocytes from the deleterious effects of interferon-gamma.

scientific article published in May 2006

Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development

scientific article published on 01 May 1996

Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids.

scientific article published in June 1996

Tellurium-induced neuropathy: A model for reversible reductions in myelin protein gene expression ⬇️

scientific article published on August 1, 1990

The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination

scientific journal article

The effects of interferon-gamma on the central nervous system.

scientific article published on February 1997

The integrated stress response in hypoxia-induced diffuse white matter injury

scientific article published on 18 July 2017

The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage

scientific article published on February 2007

The neuronal adhesion protein TAG-1 is expressed by Schwann cells and oligodendrocytes and is localized to the juxtaparanodal region of myelinated fibers.

scientific article published in April 2002

The unfolded protein response in familial amyotrophic lateral sclerosis ⬇️

scientific article published on December 15, 2010

Thyroid-specific and hormone-dependent expression of rat thyroglobulin promoter fused with bacterial chloramphenicol acetyltransferase gene in transgenic mice

scientific article published on 01 December 1992

Transcriptional Fingerprint of Hypomyelination in Zfp191null and Shiverer (Mbpshi) Mice

scientific article published on 28 September 2016

Twitcher mice with only a single active galactosylceramide synthase gene exhibit clearly detectable but therapeutically minor phenotypic improvements

scientific article published on 01 January 2000

WDR81 is necessary for purkinje and photoreceptor cell survival

scientific article

ZFP191 is required by oligodendrocytes for CNS myelination

scientific journal article

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