List of works by Toshiko Tanaka

52 Genetic Loci Influencing Myocardial Mass

scientific article

A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function

scientific article published on 15 December 2020

A brain proteomic signature of incipient Alzheimer's disease in young <i>APOE</i> ε4 carriers identifies novel drug targets

scientific article published on 10 November 2021

A double blind placebo controlled randomized trial of the effect of acute uric acid changes on inflammatory markers in humans: A pilot study.

scientific article

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

scientific article published on 13 May 2012

A genome-wide association analysis of serum iron concentrations

scientific article

A genome-wide association search for type 2 diabetes genes in African Americans

scientific article published on 4 January 2012

A genome-wide association study of aging

scientific article

A genome-wide association study of depressive symptoms

scientific journal article

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels

scientific article

A higher adherence to a Mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women

scientific article

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

scientific article

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

scientific article

A network-based approach to prioritize results from genome-wide association studies

scientific article

Adherence to a Mediterranean Diet Protects from Cognitive Decline in the Invecchiare in Chianti Study of Aging

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

scientific article published on 8 December 2016

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.

scientific article published on 13 June 2019

Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging

scientific article published on 5 July 2012

Association Between Accelerated Multimorbidity and Age-Related Cognitive Decline in Older Baltimore Longitudinal Study of Aging Participants without Dementia

scientific article published on 30 April 2016

Association Between The Multidimensional Prognostic Index And Mortality Over 15 Years Of Follow-Up In The Inchianti Study

scientific article published on 17 September 2020

Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies

scientific article published on 23 December 2011

Association of Methylation Signals With Incident Coronary Heart Disease in an Epigenome-Wide Assessment of Circulating Tumor Necrosis Factor α.

scientific article

Association of hippocampal volume polygenic predictor score with baseline and change in brain volumes and cognition among cognitively healthy older adults

scientific article published on 21 May 2020

BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism

scientific article

Biological, clinical and population relevance of 95 loci for blood lipids

scientific article

Blood DNA Methylation and Aging: A Cross-Sectional Analysis and Longitudinal Validation in the InCHIANTI Study

scientific article published on 09 March 2020

Blood DNA methylation sites predict death risk in a longitudinal study of 12, 300 individuals

scientific article published on 22 July 2020

Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease

scientific article published on 19 August 2019

Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study of Aging (BLSA) and the Tsuruoka Metabolomics Cohort Study (TMCS)

scientific article published on 13 February 2020

Blood Metabolite Signatures of Metabolic Syndrome in Two Cross-Cultural Older Adult Cohorts

scientific article published on 16 February 2020

CUBN is a gene locus for albuminuria

scientific article

Caffeine and alcohol intakes and overall nutrient adequacy are associated with longitudinal cognitive performance among U.S. adults

scientific article

Cardiovascular Health Is Associated With Disability Among Older Community Dwelling Men and Women

scientific article published on 31 May 2018

Cardiovascular Health Is Associated With Physical Function Among Older Community Dwelling Men and Women

scientific article published on 10 February 2017

Change in Epigenome-Wide DNA Methylation Over 9 Years and Subsequent Mortality: Results From the InCHIANTI Study

scientific article published on 9 September 2015

Changes in splicing factor expression are associated with advancing age in man.

scientific article published on 06 June 2013

Characterization of the plasma proteomic profile of frailty phenotype

scientific article published on 17 November 2020

Chronic Low-Calorie Sweetener Use and Risk of Abdominal Obesity among Older Adults: A Cohort Study

scientific article

Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals

scientific article

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease

scientific article

Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium

scientific article published on 8 November 2011

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

scientific article

Common variants at 30 loci contribute to polygenic dyslipidemia

scientific article

Common variants in Mendelian kidney disease genes and their association with renal function

scientific article published on 12 September 2013

Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study

scientific article published on 29 January 2009

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study

scientific article

Correction: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution.

scientific article published on 27 July 2009

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 7 July 2017

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

scientific article published on November 2016

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

scientific article published on 12 December 2016

DNA methylation-based measures of biological age: meta-analysis predicting time to death

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Dietary pattern trajectories in middle age and physical function in older age

scientific article published on 20 November 2020

Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations

scientific article

Discovery and refinement of loci associated with lipid levels

scientific article

Elevated Plasma Growth and Differentiation Factor 15 Is Associated With Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults

scientific article published on 01 January 2020

Elevated plasma growth and differentiation factor 15 predicts incident anemia in older adults aged 60 years and older

scientific article published on 28 December 2020

Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

scientific article

Erratum: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

article

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article published in May 2010

Extracellular RNA profiles with human age

scientific article published on 24 May 2018

FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.

scientific article

Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans

scientific article

GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium

scientific article

GWAS of epigenetic aging rates in blood reveals a critical role for TERT.

scientific article published on 26 January 2018

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy

scientific article

Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site

scientific article

GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease

scientific article published on 20 March 2014

Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry

scientific article

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

scientific article

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

scientific article

Genetic diversity is a predictor of mortality in humans

scientific article

Genetic insights into biological mechanisms governing human ovarian ageing

scientific article

Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium

scientific article

Genetic loci influencing kidney function and chronic kidney disease

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes

scientific article (publication date: 14 November 2012)

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

scientific article published on 18 April 2016

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genetic variation associated with circulating monocyte count in the eMERGE Network

scientific article published on 12 January 2013

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

scientific journal article

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin

scientific article (publication date: July 2014)

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

scientific article

Genome-wide Association Study of Parental Life Span

scientific article

Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations.

scientific article published in May 2009

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis

scientific article published on 19 December 2016

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

scientific article published in February 2013

Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data

scientific article

Genome-wide association and functional follow-up reveals new loci for kidney function

scientific article

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts.

scientific article published on 13 December 2017

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

scientific article published in June 2009

Genome-wide association scan of trait depression

scientific journal article

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

scientific article

Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology [...]

scientific article

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

scientific article

Genome-wide association study of circulating retinol levels

scientific article published on 30 August 2011

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium

scientific article

Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study

scientific article

Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations

scientific article

Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene

scientific article

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

scientific article

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

scientific article

Genome-wide meta-analysis of common variant differences between men and women

scientific article published on 27 July 2012

Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium

scientific article published on 09 July 2018

Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

scientific article

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium

scientific article

Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD.

scientific article

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits ⬇️

scientific article published on 21 June 2016

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

scientific article published on 23 September 2016

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

scientific article published on 24 April 2017

Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants

scientific article

Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory

scientific article published on 15 May 2014

Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies

scientific article

Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels

scientific article

Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density

scientific article

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Identification of nine novel loci associated with white blood cell subtypes in a Japanese population

scientific article

Impact of ancestry and common genetic variants on QT interval in African Americans

scientific article

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

scientific article published on 12 September 2017

Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation

scientific article

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

scientific article published on 8 September 2012

Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium

scientific article

Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair

scientific article published in December 2015

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

scientific article published in November 2015

Loss of Weight in Obese Older Adults: A Biomarker of Impending Expansion of Multimorbidity?

scientific article

Measures of autozygosity in decline: globalization, urbanization, and its implications for medical genetics

scientific article

Measuring biological aging in humans: A quest

scientific article published on 12 December 2019

Mediterranean diet and mobility decline in older persons

scientific article

Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts

scientific article

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

scientific article published on 11 September 2015

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

scientific article

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

scientific article

Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations

scientific article

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels

scientific article

Modulation of genetic associations with serum urate levels by body-mass-index in humans

scientific article

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

scientific article (publication date: 17 September 2013)

Multiple loci are associated with white blood cell phenotypes

scientific article

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

scientific article

NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality

scientific article published on 30 March 2017

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

New loci associated with kidney function and chronic kidney disease

scientific article

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

scientific article published on February 2016

No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects

scientific article

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

scientific article published on 13 March 2012

Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels

scientific article

Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Nutritional determinants of mobility ⬇️

scientific article published on November 1, 2010

Overall Cardiovascular Health Is Associated With All-Cause and Cardiovascular Disease Mortality Among Older Community-Dwelling Men and Women

scientific article published on April 2016

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

scientific article published in Nature Communications

PRKCZ methylation is associated with sunlight exposure in a North American but not a Mediterranean population

scientific article

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

scientific article

Plasma proteomic biomarker signature of age predicts health and life span

scientific article published on 19 November 2020

Plasma proteomic signature of age in healthy humans

scientific article published on 11 July 2018

Plasma proteomic signatures predict dementia and cognitive impairment

scientific article published on 09 May 2020

Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions

scientific article published on 05 December 2012

Relationship of Circulating Growth/Differentiation Factors 8 and 11 and Their Antagonists as Measured Using Liquid Chromatography-Tandem Mass Spectrometry with Age and Skeletal Muscle Strength in Healthy Adults

scientific article published on 01 January 2019

SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits ⬇️

scientific article published on 24 October 2012

SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.

scientific article

Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging

scientific article published in October 2009

Seventy-five genetic loci influencing the human red blood cell

scientific article published on 5 December 2012

Sex-Dependent Associations of Serum Uric Acid with Brain Function During Aging

scientific article published on 8 September 2017

Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level

scientific article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging.

scientific article published on 21 January 2018

State- and trait-dependent associations of vitamin-D with brain function during aging

scientific article published on 18 November 2015

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 10 January 2017

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

scientific article published on 14 March 2012

Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis

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Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin

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Trans-ethnic meta-analysis of white blood cell phenotypes

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Underlying features of epigenetic aging clocks in vivo and in vitro

scientific article published on 15 September 2020

Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples

scientific article

Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults

scientific article published on 14 December 2011

Vitamin D receptor and megalin gene polymorphisms are associated with central adiposity status and changes among US adults

scientific article

Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes

scientific article

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