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List of works by Brian Huntly

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.

scientific article

A Polycythemia Vera Updated: Diagnosis, Pathobiology, and Treatment.

scientific article

A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients.

scientific article

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression

scientific article

A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation.

scientific article published on 14 October 2016

A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients ⬇️

scientific article published on August 2, 2010

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

scientific article (publication date: April 2005)

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

scientific article published on 17 January 2013

Acute myeloid leukemia: leukemia stem cells write a prognostic signature.

scientific article

An acquired translocation in JAK2 Val617Phe-negative essential thrombocythemia associated with autosomal spread of X-inactivation.

scientific article published in August 2006

BET bromodomain inhibitors in leukemia.

scientific article published on 08 July 2015

BETs Need Greens: Folate Deficiency and Resistance to MYC-Targeted Therapies

scientific article published on 01 December 2020

Blasts from the past: new lessons in stem cell biology from chronic myelogenous leukemia

scientific article published on 01 September 2004

Cancer biology: summing up cancer stem cells.

scientific article published in June 2005

Cancer stem cell definitions and terminology: the devil is in the details

scientific article published on 11 October 2012

Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis

scientific article published on 21 May 2010

Characterization of the imprinted polycomb gene L3MBTL, a candidate 20q tumour suppressor gene, in patients with myeloid malignancies

scientific article

Chromosome 20 deletions in myeloid malignancies: reduction of the common deleted region, generation of a PAC/BAC contig and identification of candidate genes

article

Clinical utility of routine MPL exon 10 analysis in the diagnosis of essential thrombocythaemia and primary myelofibrosis.

scientific article published on 11 February 2010

Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias ⬇️

scientific article published on April 19, 2011

Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation.

scientific article published on 22 March 2005

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML

scientific article published on 19 March 2019

Cytogenetics of chronic myeloid leukaemia.

scientific article

Deletions of the derivative chromosome 9 do not account for the poor prognosis associated with Philadelphia-positive acute lymphoblastic leukemia

scientific article published on 01 March 2002

Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia

scientific article published on 01 September 2001

Derivative chromosome 9 deletions in chronic myeloid leukemia: poor prognosis is not associated with loss of ABL-BCR expression, elevated BCR-ABL levels, or karyotypic instability.

scientific article published in June 2002

Detection of cytoplasmic nucleophosmin expression by imaging flow cytometry.

scientific article published on 11 September 2012

Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis

scientific article published on 27 June 2011

Disordered signaling in myeloproliferative neoplasms.

scientific article published on 25 August 2012

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

scientific article published on 16 March 2020

Does isochromosome 7q mandate bone marrow transplant in children with Shwachman-Diamond syndrome?

scientific article

Double jeopardy from a single translocation: deletions of the derivative chromosome 9 in chronic myeloid leukemia.

scientific article

Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

scientific article published on 31 August 2020

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.

scientific article

Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia

scientific article

Erratum: Corrigendum: Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

scientific article published in Nature

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors

scientific article published in February 2018

FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model.

scientific article published in November 2005

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

scientific article (publication date: 26 January 2007)

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

scientific article published on 31 August 2016

Functional interdependence of BRD4 and DOT1L in MLL leukemia

scientific article published on 13 June 2016

Genetic modification of primary human B cells to model high-grade lymphoma

scientific article published on 04 October 2019

Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia

scientific article

Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

scientific article published on 20 February 2018

HOX gene regulation in acute myeloid leukemia: CDX marks the spot?

scientific article published on 29 June 2007

HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias.

scientific article published on 27 May 2013

Hematopoietic stem cells made BETter by inhibition

scientific article published on 01 June 2018

Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions.

scientific article published on 15 May 2003

Immunosuppressive drug therapy as a potentiator of anal carcinoma in a patient with relapsing lymphoma

scientific article published on 01 January 2000

Independence of epigenetic and genetic diversity in AML

scientific article published on 01 July 2016

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

scientific article

Intratumoral Heterogeneity: Tools to Understand and Exploit Clone Wars in AML

article

KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements

scientific article published on 06 August 2020

Kinase Networks Regulate Metabolism: I'D(H1) Never Have Guessed!

scientific article published on 01 June 2019

Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia

scientific article published on 01 February 2000

Leukaemia stem cells and the evolution of cancer-stem-cell research.

scientific article published in April 2005

Leukemia stem cells in acute myeloid leukemia.

scientific article published on August 2008

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

scientific article

Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development

scientific article published on 6 July 2016

Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice.

scientific article

Molecular cytogenetics of polycythaemia vera: lack of occult rearrangements detectable by 20q LSP screening, CGH, and M-FISH

scientific article published on 01 July 2003

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

scientific article

Mutation and methylation analysis of the transforming growth factor beta receptor II gene in polycythaemia vera

scientific article published on 01 December 2001

Myeloproliferative disorders

scientific article published on 01 September 2001

Network properties derived from deep sequencing of human B-cell receptor repertoires delineate B-cell populations

scientific article published on 06 June 2013

Novel epigenetic therapies in hematological malignancies: Current status and beyond

scientific article

Population dynamics of normal human blood inferred from somatic mutations

scientific article published in Nature

Prognostic models turn the Heat(IT)up on FLT3ITD-mutated AML

scientific article published on 02 November 2018

Recent advances in acute myeloid leukemia stem cell biology

scientific article published on 17 April 2012

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

scientific article published on 13 November 2013

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

scientific article

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

scientific article published in Nature Communications

Size matters: the prognostic implications of large and small deletions of the derivative 9 chromosome in chronic myeloid leukemia.

scientific article published in July 2006

Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2

scientific article

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/-) leukemia

scientific article published on 13 August 2015

Survival implications of molecular heterogeneity in variant Philadelphia-positive chronic myeloid leukaemia

scientific article published on 01 May 2003

Targeting cancer stem cells.

scientific article published on July 2007

Targeting epigenetic readers in cancer.

scientific article published on August 2012

The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

scientific article

The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors

scientific article

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

scientific article published on 20 April 2015

The incidences of trisomy 8, trisomy 9 and D20S108 deletion in polycythaemia vera: an analysis of blood granulocytes using interphase fluorescence in situ hybridization

scientific article published on 01 September 2000

The role of BET epigenetic readers in acute myeloid leukaemia and other haematological malignancies.

scientific article published on 19 August 2013

The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells.

scientific article

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

scientific article published on 07 May 2018

Variant Philadelphia translocations in chronic myeloid leukaemia can mimic typical blast crisis chromosome abnormalities or classic t(9;22): a report of two cases

scientific article published on 01 May 2001

Visual information processing during controlled hypoglycaemia in humans.

scientific article

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