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List of works by David B Savage

31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle.

scientific article published on 7 January 2016

A Pharmacogenetic Approach to the Treatment of Patients with PPARG Mutations.

scientific article published on 5 April 2018

A clinical approach to severe insulin resistance

scientific article published on January 2007

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

scientific article published on 13 May 2012

A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice

scientific article

A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia.

scholarly article

Acquired generalized lipodystrophy associated with peripheral T cell lymphoma with cutaneous infiltration.

scientific article published on 29 October 2013

Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters

scientific article

An amino acid profile to predict diabetes? ⬇️

scientific article published on April 1, 2011

An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy

scientific article

Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis

scientific article published on October 2016

Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors

scientific article published on 01 December 2018

Association of Genetically Enhanced Lipoprotein Lipase-Mediated Lipolysis and Low-Density Lipoprotein Cholesterol-Lowering Alleles With Risk of Coronary Disease and Type 2 Diabetes

scientific article

Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity

scientific article

Complement abnormalities in acquired lipodystrophy revisited

scientific article published on 14 October 2008

Compositional marker in vivo reveals intramyocellular lipid turnover during fasting-induced lipolysis.

scientific article published on 9 February 2018

Congenital syndromes of severe insulin resistance.

scientific article published on March 2011

Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3

scientific article

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

scholarly article

Correction: A Prevalent Variant in PPP1R3A Impairs Glycogen Synthesis and Reduces Muscle Glycogen Content in Humans and Mice.

scientific article published on 23 December 2008

Corrigendum: Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

scientific article

Digenic inheritance of severe insulin resistance in a human pedigree

scientific article

Disordered lipid metabolism and the pathogenesis of insulin resistance

scientific article

Dual binding motifs underpin the hierarchical association of perilipins1-3 with lipid droplets

scientific article published on 16 January 2019

Early Diagnosis of Werner's Syndrome Using Exome-Wide Sequencing in a Single, Atypical Patient

scientific article published in 2011

Energy expenditure and adaptive responses to an acute hypercaloric fat load in humans with lipodystrophy

scientific article published on 21 December 2004

European paediatric non-alcoholic fatty liver disease registry (EU-PNAFLD): Design and rationale

scientific article published on 05 November 2018

Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis

scientific article

Fatty acid metabolism in patients with PPARgamma mutations

scientific article

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

scientific article published on 10 January 2019

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

scientific article

Genetic Syndromes of Severe Insulin Resistance

scientific article (publication date: August 2011)

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

scientific article published on 26 June 2011

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

scientific article

Human congenital perilipin deficiency and insulin resistance

scientific article published on February 2013

Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5)

scientific article

Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma

scientific article published in April 2003

Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization

scientific article published on March 2002

Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice

scientific article

Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations

scientific article published on 20 October 2016

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.

scientific article

Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals

scientific article published on 2 May 2013

Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRalpha

scientific article

Lipase tug of war: PNPLA3 sequesters ABHD5 from ATGL

scientific article published on 01 May 2019

Lipid droplet-organelle interactions: emerging roles in lipid metabolism

scientific article published on 15 May 2015

Lipodystrophy: metabolic insights from a rare disorder ⬇️

scientific article published on September 24, 2010

Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy

scientific article published on 12 April 2018

Mechanisms of insulin resistance in humans and possible links with inflammation

scientific article

Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes

scientific article published on 28 June 2015

Metabolic insights from extreme human insulin resistance phenotypes

scientific article published on April 2012

Mitochondrial dysfunction in patients with primary congenital insulin resistance

scientific article

Mitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophy

scientific article

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

scientific article

Mouse models of inherited lipodystrophy

scientific article

Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease

scientific article

New susceptibility loci associated with kidney disease in type 1 diabetes

scientific article

PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress.

scientific article

PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy

PPAR gamma as a metabolic regulator: insights from genomics and pharmacology

scientific article

Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC

scientific article

Perilipin deficiency and autosomal dominant partial lipodystrophy

scientific article published on February 2011

Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis

scientific article

Plasma Adiponectin as a Marker of Insulin Receptor Dysfunction: Clinical utility in severe insulin resistance

scientific article published on 25 February 2008

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis

scientific article published on 26 January 2009

Prospective functional classification of all possible missense variants in PPARG.

scientific article published on 17 October 2016

Proteinuric nephropathy in acquired and congenital generalized lipodystrophy: baseline characteristics and course during recombinant leptin therapy

scientific article published in July 2004

Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial

scientific article

Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance

scientific article published on August 2010

Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia

scientific article

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

scientific article published on 16 February 2006

Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma

scientific article published in May 2005

Roux-en-Y Gastric Bypass Surgery in the Management of Familial Partial Lipodystrophy Type 1.

scientific article published on 26 July 2017

Seipin is required for converting nascent to mature lipid droplets

scientific article

Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using (31)P magnetic resonance spectroscopy

scientific article

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

scientific journal article

Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.

scientific article published on 16 May 2018

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

scientific article published on 06 April 2007

The genetics of lipid storage and human lipodystrophies

scientific article published on 12 May 2015

The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation

scientific article

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

scholarly article

Truncation of POC1A associated with short stature and extreme insulin resistance

scientific article

Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.

scientific article published on 4 December 2003

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