List of works - Petri T Kovanen

ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model

scientific article

Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future.

scientific article

An emerging role of mast cells in cerebral ischemia and hemorrhage

scientific article

Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: an angiotensin II type 2 receptor-mediated effect.

scientific article

Apolipoprotein composition and particle size affect HDL degradation by chymase: effect on cellular cholesterol efflux.

scientific article

C-reactive protein binds to the 3beta-OH group of cholesterol in LDL particles

scientific journal article

Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

scientific article (publication date: November 2014)

Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice

scientific article

Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation

scientific article

Chronic intermittent psychological stress promotes macrophage reverse cholesterol transport by impairing bile acid absorption in mice

scientific article

Combination of Intracerebral Haemorrhage and Familial Hypercholesterolemia in the Acute Hospital Setting – A Challenge for Statin Treatment?

scientific article published on 01 June 2015

Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL.

scientific article

Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro.

scientific article

Decreasing the Cholesterol Burden in Heterozygous Familial Hypercholesterolemia Children by Dietary Plant Stanol Esters

article

Depicting new pharmacological strategies for familial hypercholesterolaemia involving lipoprotein (a).

scientific article published on 3 October 2017

Depletion of pre-beta-high density lipoprotein by human chymase impairs ATP-binding cassette transporter A1- but not scavenger receptor class B type I-mediated lipid efflux to high density lipoprotein

scientific article published on 29 December 2003

Do statins reduce the incidence of stroke in familial hypercholesterolemia? ⬇️

scientific article published on March 1, 2011

Enhanced vascular permeability facilitates entry of plasma HDL and promotes macrophage-reverse cholesterol transport from skin in mice.

scientific article

Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion

scientific article

FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.

scientific article

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

scientific article

Familial hypercholesterolemia and COVID-19: triggering of increased sustained cardiovascular risk

scientific article published on 03 April 2020

Food allergy alters jejunal circular muscle contractility and induces local inflammatory cytokine expression in a mouse model

scientific article

Functional LCAT is not required for macrophage cholesterol efflux to human serum

scientific article

HDL functionality in reverse cholesterol transport--Challenges in translating data emerging from mouse models to human disease

scientific article

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

scientific article

Hypolipidemic treatment of heterozygous familial hypercholesterolemia: a lifelong challenge

scientific article published on May 2004

Hypoxia-induced expression of bradykinin type-2 receptors in endothelial cells triggers NO production, cell migration, and angiogenesis

scientific journal article

IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe–/– mice ⬇️

scientific article published on August 8, 2011

Inhibition of hepatic microsomal triglyceride transfer protein - a novel therapeutic option for treatment of homozygous familial hypercholesterolemia

scientific article

Initiation of PCSK9 inhibition in patients with heterozygous familial hypercholesterolaemia entering adulthood: a new design for living with a high-risk condition?

scientific article published on 6 February 2016

Lipid exchange mechanism of the cholesteryl ester transfer protein clarified by atomistic and coarse-grained simulations

scientific article

Lipoprotein lipase in the arterial wall: linking LDL to the arterial extracellular matrix and much more.

scientific article

Lipoprotein(a) as a cardiovascular risk factor: current status

scientific article

Lipoprotein(a) as a risk factor for calcific aortic valvulopathy in heterozygous familial hypercholesterolemia

scientific article published on 07 December 2018

Lowering Low-Density Lipoprotein Cholesterol Concentration with Plant Stanol Esters to Reduce the Risk of Atherosclerotic Cardiovascular Disease Events at a Population Level: A Critical Discussion

scientific article published on 06 August 2020

Lysosomal Enzymes Are Released From Cultured Human Macrophages, Hydrolyze LDL In Vitro, and Are Present Extracellularly in Human Atherosclerotic Lesions ⬇️

scientific article (publication date: August 2003)

Mast Cells as Potential Accelerators of Human Atherosclerosis-From Early to Late Lesions

scientific article published on 11 September 2019

Mast cell activation in vivo impairs the macrophage reverse cholesterol transport pathway in the mouse

scientific article published on 6 January 2011

Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux

scientific article (publication date: September 2002)

Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions

scientific journal article

Modified lipoprotein-derived lipid particles accumulate in human stenotic aortic valves.

scientific article

OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages

scientific article

Pharmacological evidence for a role of liver X receptors in atheroprotection

scientific article

Prevention of endothelial dysfunction and thrombotic events in COVID-19 patients with familial hypercholesterolemia

scientific article published on 15 June 2020

Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells.

scientific article

Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2 group V and secretory sphingomyelinase

scientific article

Rescue therapy with PCSK9 inhibitors for patients with delayed diagnosis of heterozygous familial hypercholesterolemia: Redressing the balance of missed opportunities.

scientific article published on 20 July 2016

Resolvins: Emerging Players in Autoimmune and Inflammatory Diseases

scientific article published on 01 February 2020

Rupture of the atherosclerotic plaque: does a good animal model exist?

scientific article

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway ⬇️

scientific article (publication date: June 2011)

Statin treatment of children with familial hypercholesterolemia--trying to balance incomplete evidence of long-term safety and clinical accountability: are we approaching a consensus?

scientific article published on 12 October 2012

Statins for children with familial hypercholesterolemia

scientific article (published 2014-07-23)

Statins for children with familial hypercholesterolemia

scientific article (published 2010-07-07)

Statins for children with familial hypercholesterolemia

scientific article

Statins for children with familial hypercholesterolemia

scientific article published on 7 July 2017

Statins for children with familial hypercholesterolemia

scientific article published on 07 November 2019

The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice

scientific article

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

scientific article

Three-dimensional cryoEM reconstruction of native LDL particles to 16Å resolution at physiological body temperature

scientific article published in 2011

Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathology

scientific article

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management ⬇️

scientific article

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health

scientific article

List of works by Petri T Kovanen

ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model

Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future.

An emerging role of mast cells in cerebral ischemia and hemorrhage

Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: an angiotensin II type 2 receptor-mediated effect.

Apolipoprotein composition and particle size affect HDL degradation by chymase: effect on cellular cholesterol efflux.

C-reactive protein binds to the 3beta-OH group of cholesterol in LDL particles

Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice

Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation

Chronic intermittent psychological stress promotes macrophage reverse cholesterol transport by impairing bile acid absorption in mice

Combination of Intracerebral Haemorrhage and Familial Hypercholesterolemia in the Acute Hospital Setting – A Challenge for Statin Treatment?

Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL.

Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro.

Decreasing the Cholesterol Burden in Heterozygous Familial Hypercholesterolemia Children by Dietary Plant Stanol Esters

Depicting new pharmacological strategies for familial hypercholesterolaemia involving lipoprotein (a).

Depletion of pre-beta-high density lipoprotein by human chymase impairs ATP-binding cassette transporter A1- but not scavenger receptor class B type I-mediated lipid efflux to high density lipoprotein

Do statins reduce the incidence of stroke in familial hypercholesterolemia? ⬇️

Enhanced vascular permeability facilitates entry of plasma HDL and promotes macrophage-reverse cholesterol transport from skin in mice.

Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion

FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

Familial hypercholesterolemia and COVID-19: triggering of increased sustained cardiovascular risk

Food allergy alters jejunal circular muscle contractility and induces local inflammatory cytokine expression in a mouse model

Functional LCAT is not required for macrophage cholesterol efflux to human serum

HDL functionality in reverse cholesterol transport--Challenges in translating data emerging from mouse models to human disease

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

Hypolipidemic treatment of heterozygous familial hypercholesterolemia: a lifelong challenge

Hypoxia-induced expression of bradykinin type-2 receptors in endothelial cells triggers NO production, cell migration, and angiogenesis

IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe–/– mice ⬇️

Inhibition of hepatic microsomal triglyceride transfer protein - a novel therapeutic option for treatment of homozygous familial hypercholesterolemia

Initiation of PCSK9 inhibition in patients with heterozygous familial hypercholesterolaemia entering adulthood: a new design for living with a high-risk condition?

Lipid exchange mechanism of the cholesteryl ester transfer protein clarified by atomistic and coarse-grained simulations

Lipoprotein lipase in the arterial wall: linking LDL to the arterial extracellular matrix and much more.

Lipoprotein(a) as a cardiovascular risk factor: current status

Lipoprotein(a) as a risk factor for calcific aortic valvulopathy in heterozygous familial hypercholesterolemia

Lowering Low-Density Lipoprotein Cholesterol Concentration with Plant Stanol Esters to Reduce the Risk of Atherosclerotic Cardiovascular Disease Events at a Population Level: A Critical Discussion

Lysosomal Enzymes Are Released From Cultured Human Macrophages, Hydrolyze LDL In Vitro, and Are Present Extracellularly in Human Atherosclerotic Lesions ⬇️

Mast Cells as Potential Accelerators of Human Atherosclerosis-From Early to Late Lesions

Mast cell activation in vivo impairs the macrophage reverse cholesterol transport pathway in the mouse

Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux

Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions

Modified lipoprotein-derived lipid particles accumulate in human stenotic aortic valves.

OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages

Pharmacological evidence for a role of liver X receptors in atheroprotection

Prevention of endothelial dysfunction and thrombotic events in COVID-19 patients with familial hypercholesterolemia

Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells.

Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2 group V and secretory sphingomyelinase

Rescue therapy with PCSK9 inhibitors for patients with delayed diagnosis of heterozygous familial hypercholesterolemia: Redressing the balance of missed opportunities.

Resolvins: Emerging Players in Autoimmune and Inflammatory Diseases

Rupture of the atherosclerotic plaque: does a good animal model exist?

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway ⬇️

Statin treatment of children with familial hypercholesterolemia--trying to balance incomplete evidence of long-term safety and clinical accountability: are we approaching a consensus?

Statins for children with familial hypercholesterolemia

Statins for children with familial hypercholesterolemia

Statins for children with familial hypercholesterolemia

Statins for children with familial hypercholesterolemia

Statins for children with familial hypercholesterolemia

The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

Three-dimensional cryoEM reconstruction of native LDL particles to 16Å resolution at physiological body temperature

Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathology

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management ⬇️

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health