List of works - Leah E Cowen

A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae

scientific article published on 01 October 2012

A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase

scientific article published on 22 October 2021

A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis

scientific article

Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance

scientific article

Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance

scientific article published on 11 February 2022

Advances in fungal chemical genomics for the discovery of new antifungal agents

scientific article published on 28 August 2020

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

scientific article published on 22 December 2020

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

scientific article published on 22 May 2020

Antifungal Drugs: The Current Armamentarium and Development of New Agents

scientific article

Antifungal drug resistance: evolution, mechanisms and impact.

scientific article published on 12 March 2018

Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29.

scientific article published on 10 October 2016

Candida albicans Is Resistant to Polyglutamine Aggregation and Toxicity

scientific article published on 2 November 2016

Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans ⬇️

scientific article published on November 16, 2011

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling

scientific article

Elucidating drug resistance in human fungal pathogens

scientific article

Evolution of drug resistance in experimental populations of Candida albicans.

scientific article

Extensive functional redundancy in the regulation of Candida albicans drug resistance and morphogenesis by lysine deacetylases Hos2, Hda1, Rpd3 and Rpd31.

scientific article

Fitness Trade-Offs Associated with the Evolution of Resistance to Antifungal Drug Combinations

scientific article published on 4 February 2015

Functional Divergence of Hsp90 Genetic Interactions in Biofilm and Planktonic Cellular States

scientific article

Functional Genomic Analysis of Candida albicans Adherence Reveals a Key Role for the Arp2/3 Complex in Cell Wall Remodelling and Biofilm Formation.

scientific article

Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans.

scientific article

Functional divergence of a global regulatory complex governing fungal filamentation

scientific article published on 07 January 2019

Genetic Analysis of Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance

scientific article published on 29 January 2019

Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations

scientific article

Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation

scientific article (publication date: November 2015)

Global analysis of fungal morphology exposes mechanisms of host cell escape

scientific article

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs.

scientific article published on 27 April 2018

Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata

scientific article

Global gene deletion analysis exploring yeast filamentous growth

scientific article published on 01 September 2012

Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen

scientific article published on 08 July 2019

High-Throughput Screening Identifies Genes Required for Induction of Macrophage Pyroptosis

article

Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans.

scientific article

Hsp90 orchestrates stress response signaling governing fungal drug resistance

scientific article

Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling

scientific article published on 26 March 2009

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast

scientific article

Hsp90-dependent regulatory circuitry controlling temperature-dependent fungal development and virulence.

scientific article published on 14 February 2014

Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans.

scientific article

Inhibiting Protein Prenylation with Benzoxaboroles to Target Fungal Plant Pathogens

scientific article published on 23 June 2020

Insights into the host-pathogen interaction: manipulation of macrophage pyroptosis

scientific article published on 12 November 2018

Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes.

scientific article

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets

scientific article published on 11 November 2021

Lysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance.

scientific article

Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular Stress

scientific article

Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry

scientific article

Mechanisms of Antifungal Drug Resistance

scientific article

Membrane fluidity and temperature sensing are coupled via circuitry comprised of Ole1, Rsp5, and Hsf1 in Candida albicans.

scientific article published on 20 June 2014

Metabolic control of antifungal drug resistance.

scientific article published on 10 July 2009

Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis

scientific article

Molecular Evolution of Antifungal Drug Resistance

scientific article published on September 2017

Multilocus genotyping indicates that the ability to invade the bloodstream is widespread among Candida albicans isolates

scientific article

Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies

scientific article

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90

scientific article

Pho85, Pcl1, and Hms1 signaling governs Candida albicans morphogenesis induced by high temperature or Hsp90 compromise.

scientific article published on 23 February 2012

Population genomics of drug resistance in Candida albicans.

scientific article

Predicting the emergence of resistance to antifungal drugs.

scientific article

Progress and prospects for targeting Hsp90 to treat fungal infections

scientific article published on 20 February 2014

Regulation of the heat shock transcription factor Hsf1 in fungi: implications for temperature-dependent virulence traits.

scientific article

Regulatory circuitry governing fungal development, drug resistance, and disease.

scientific article

Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues.

scientific article

Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A.

scientific article published on March 2017

Stress Adaptation.

scientific article published in July 2017

Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance

scientific article published on 28 March 2008

Surviving the Heat of the Moment: A Fungal Pathogens Perspective ⬇️

scientific article published on March 7, 2013

The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferation

scholarly article

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

scientific article published on 11 September 2017

The Hsp90 Chaperone Network Modulates Candida Virulence Traits.

scientific article

The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance

scientific article

The Proteasome Governs Fungal Morphogenesis via Functional Connections with Hsp90 and cAMP-Protein Kinase A Signaling

scientific article published on 21 April 2020

The Rise of Fungi: A Report on the CIFAR Program Fungal Kingdom: Threats & Opportunities Inaugural Meeting

scientific article published on 01 June 2020

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.

scientific article published on March 2008

The fungal Achilles' heel: targeting Hsp90 to cripple fungal pathogens.

scientific article published on 13 April 2013

Thermal control of microbial development and virulence: molecular mechanisms of microbial temperature sensing.

scientific article published on 02 October 2012

Treatment strategies for cryptococcal infection: challenges, advances and future outlook

scientific article published in 2021

Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space.

scientific article published on 28 March 2018

Uncovering cellular circuitry controlling temperature-dependent fungal morphogenesis ⬇️

scientific article published on June 22, 2012

Using combination therapy to thwart drug resistance.

scientific article

Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2.

scientific article published on 2 October 2017

List of works by Leah E Cowen

A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae

A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase

A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis

Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance

Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance

Advances in fungal chemical genomics for the discovery of new antifungal agents

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Antifungal Drugs: The Current Armamentarium and Development of New Agents

Antifungal drug resistance: evolution, mechanisms and impact.

Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29.

Candida albicans Is Resistant to Polyglutamine Aggregation and Toxicity

Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans ⬇️

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling

Elucidating drug resistance in human fungal pathogens

Evolution of drug resistance in experimental populations of Candida albicans.

Extensive functional redundancy in the regulation of Candida albicans drug resistance and morphogenesis by lysine deacetylases Hos2, Hda1, Rpd3 and Rpd31.

Fitness Trade-Offs Associated with the Evolution of Resistance to Antifungal Drug Combinations

Functional Divergence of Hsp90 Genetic Interactions in Biofilm and Planktonic Cellular States

Functional Genomic Analysis of Candida albicans Adherence Reveals a Key Role for the Arp2/3 Complex in Cell Wall Remodelling and Biofilm Formation.

Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans.

Functional divergence of a global regulatory complex governing fungal filamentation

Genetic Analysis of Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance

Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations

Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation

Global analysis of fungal morphology exposes mechanisms of host cell escape

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs.

Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata

Global gene deletion analysis exploring yeast filamentous growth

Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen

High-Throughput Screening Identifies Genes Required for Induction of Macrophage Pyroptosis

Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans.

Hsp90 orchestrates stress response signaling governing fungal drug resistance

Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast

Hsp90-dependent regulatory circuitry controlling temperature-dependent fungal development and virulence.

Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans.

Inhibiting Protein Prenylation with Benzoxaboroles to Target Fungal Plant Pathogens

Insights into the host-pathogen interaction: manipulation of macrophage pyroptosis

Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes.

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets

Lysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance.

Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular Stress

Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry

Mechanisms of Antifungal Drug Resistance

Membrane fluidity and temperature sensing are coupled via circuitry comprised of Ole1, Rsp5, and Hsf1 in Candida albicans.

Metabolic control of antifungal drug resistance.

Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis

Molecular Evolution of Antifungal Drug Resistance

Multilocus genotyping indicates that the ability to invade the bloodstream is widespread among Candida albicans isolates

Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90

Pho85, Pcl1, and Hms1 signaling governs Candida albicans morphogenesis induced by high temperature or Hsp90 compromise.

Population genomics of drug resistance in Candida albicans.

Predicting the emergence of resistance to antifungal drugs.

Progress and prospects for targeting Hsp90 to treat fungal infections

Regulation of the heat shock transcription factor Hsf1 in fungi: implications for temperature-dependent virulence traits.

Regulatory circuitry governing fungal development, drug resistance, and disease.

Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues.

Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A.

Stress Adaptation.

Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance

Surviving the Heat of the Moment: A Fungal Pathogens Perspective ⬇️

The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferation

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

The Hsp90 Chaperone Network Modulates Candida Virulence Traits.

The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance

The Proteasome Governs Fungal Morphogenesis via Functional Connections with Hsp90 and cAMP-Protein Kinase A Signaling

The Rise of Fungi: A Report on the CIFAR Program Fungal Kingdom: Threats & Opportunities Inaugural Meeting

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.

The fungal Achilles' heel: targeting Hsp90 to cripple fungal pathogens.

Thermal control of microbial development and virulence: molecular mechanisms of microbial temperature sensing.

Treatment strategies for cryptococcal infection: challenges, advances and future outlook

Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space.

Uncovering cellular circuitry controlling temperature-dependent fungal morphogenesis ⬇️

Using combination therapy to thwart drug resistance.

Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2.