List of works by Johan Bussink

(64)Cu-ATSM and (18)FDG PET uptake and (64)Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry

scientific article published on 15 June 2012

111In-cetuximab-F(ab')2 SPECT and 18F-FDG PET for prediction and response monitoring of combined-modality treatment of human head and neck carcinomas in a mouse model

scientific article published on 31 December 2014

111In-cetuximab-F(ab')2 SPECT imaging for quantification of accessible epidermal growth factor receptors (EGFR) in HNSCC xenografts

scientific article published on 7 August 2013

18F-FDG PET early response evaluation of locally advanced non-small cell lung cancer treated with concomitant chemoradiotherapy

scientific article published on 17 July 2013

18F-FDG and 18F-FLT do not discriminate between reactive and metastatic lymph nodes in oral cancer.

scientific article published on 17 February 2009

18F-FLT PET does not discriminate between reactive and metastatic lymph nodes in primary head and neck cancer patients.

scientific article published in May 2007

18F-FLT PET during radiotherapy or chemoradiotherapy in head and neck squamous cell carcinoma is an early predictor of outcome.

scientific article

18F-FLT PET/CT for early response monitoring and dose escalation in oropharyngeal tumors

scientific article published on 19 May 2010

18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)-Radiomics of metastatic lymph nodes and primary tumor in non-small cell lung cancer (NSCLC) - A prospective externally validated study.

scientific article published in March 2018

A practical approach to assess clinical planning tradeoffs in the design of individualized IMRT treatment plans

scientific article published on 11 November 2010

ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker

scientific article published on 07 December 2019

ARCON: a novel biology-based approach in radiotherapy

scientific article

Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck.

scientific article

Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer

scientific article published on March 2008

Adverse effect of smoking on prognosis in human papillomavirus-associated oropharyngeal carcinoma.

scientific article

Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia.

scientific article

Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptors

scientific article published on 27 May 2010

Balancing radiation pneumonitis versus locoregional tumor control in non-small-cell lung cancer

scientific article published in May 2013

Biology of hypoxia.

scientific article published in March 2015

CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models

scientific article published on 11 December 2019

Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?

scientific article published on 2 September 2009

Cardiac comorbidity is an independent risk factor for radiation-induced lung toxicity in lung cancer patients

scientific article published on 14 September 2013

Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage.

scientific article

Changes in DNA Damage Repair Gene Expression and Cell Cycle Gene Expression Do Not Explain Radioresistance in Tamoxifen-Resistant Breast Cancer

scientific article published on 18 April 2019

Clinical evidence on PET-CT for radiation therapy planning in head and neck tumours

scientific article published on 12 August 2010

Clinical studies of hypoxia modification in radiotherapy

scientific article published in July 2004

Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines

scientific article

Combretastatin A-4 phosphate affects tumor vessel volume and size distribution as assessed using MRI-based vessel size imaging

scientific article

Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

scientific article published on 17 October 2019

Comparison of different methods of CAIX quantification in relation to hypoxia in three human head and neck tumor lines

scientific article

Comparison of toxicity and outcome in advanced stage non-small cell lung cancer patients treated with intensity-modulated (chemo-)radiotherapy using IMRT or VMAT.

scientific article

Concurrent celecoxib versus placebo in patients with stage II-III non-small cell lung cancer: a randomised phase II trial

scientific article published on 25 May 2007

Constitutive expression of γ-H2AX has prognostic relevance in triple negative breast cancer

scientific article

Correlation of [18F]FMISO autoradiography and pimonidazole [corrected] immunohistochemistry in human head and neck carcinoma xenografts

scientific article published on 18 April 2008

Correlation of [18F]FMISO autoradiography and pimonidazole immunohistochemistry in human head and neck carcinoma xenografts

scientific article published on 20 November 2008

Correlation of segmented metabolic tumor volume with outcome--letter

scientific article published on 9 March 2010

Corrigendum: Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach

scientific article published on 7 August 2014

Dasatinib Inhibits DNA Repair after Radiotherapy Specifically in pSFK-Expressing Tumor Areas in Head and Neck Xenograft Tumors.

scientific article published on August 2013

Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach

scientific article

Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study

scientific article published on 30 November 2018

Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions

scientific article published on 23 December 2019

Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice

scientific article published on 13 March 2019

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

scientific article published on 12 June 2011

Differences in metabolism between adeno- and squamous cell non-small cell lung carcinomas: spatial distribution and prognostic value of GLUT1 and MCT4.

scientific article published on 6 December 2011

Diffusion-weighted MR imaging in liver metastases of colorectal cancer: reproducibility and biological validation.

scientific article

Distributed learning on 20 000+ lung cancer patients - The Personal Health Train

scientific article published on 03 January 2020

Distributed radiomics as a signature validation study using the Personal Health Train infrastructure

scientific article published on 22 October 2019

Downregulation of matrix Gla protein is a biomarker for tamoxifen-resistant and radioresistant breast cancer

scientific article published on 18 July 2019

Dynamics of hypoxia, proliferation and apoptosis after irradiation in a murine tumor model

scientific article

Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers

scientific article published on February 2007

EBUS and EUS guided fine needle aspirations for molecular diagnostic analysis in lung cancer.

scientific article published in August 2012

EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival

scientific article published on 25 July 2013

Early response monitoring with 18F-FDG PET and cetuximab-F(ab')2-SPECT after radiotherapy of human head and neck squamous cell carcinomas in a mouse model

scientific article published on 18 September 2014

Effect of carbogen breathing on the radiation response of a human glioblastoma xenograft: analysis of hypoxia and vascular parameters of regrowing tumors.

scientific article published in July 2006

Effect of hypoxia on the expression of αB-crystallin in head and neck squamous cell carcinoma

scientific article

Effects of nicotinamide and carbogen in different murine colon carcinomas: immunohistochemical analysis of vascular architecture and microenvironmental parameters

scientific article

Engineered microparticles delivering oxygen to enhance radiotherapy efficacy.

scientific article published on 7 December 2016

Epidermal growth factor receptor expression in laryngeal cancer predicts the effect of hypoxia modification as an additive to accelerated radiotherapy in a randomised controlled trial

scientific article published on 15 July 2013

Epidermal growth factor receptor imaging in human head and neck cancer xenografts

scientific article published on 06 August 2015

Erratum: "Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers" [Med. Phys. 45 (7), 3449-3459 (2018)]

scientific article published on 07 January 2019

Esophageal wall dose-surface maps do not improve the predictive performance of a multivariable NTCP model for acute esophageal toxicity in advanced stage NSCLC patients treated with intensity-modulated (chemo-)radiotherapy

scientific article published on 5 April 2017

Evaluating the use of optimally respiratory gated 18F-FDG-PET in target volume delineation and its influence on radiation doses to the organs at risk in non-small-cell lung cancer patients.

scientific article published on 5 October 2015

Exploratory Study to Identify Radiomics Classifiers for Lung Cancer Histology

scientific article published on 30 March 2016

Expression of E-cadherin and vimentin correlates with metastasis formation in head and neck squamous cell carcinoma patients

scientific article published on 22 June 2011

Expression of EGFR under tumor hypoxia: identification of a subpopulation of tumor cells responsible for aggressiveness and treatment resistance.

scientific article

External validation of an NTCP model for acute esophageal toxicity in locally advanced NSCLC patients treated with intensity-modulated (chemo-)radiotherapy

scientific article published on 18 September 2018

GABARAPL1 is required for increased EGFR membrane expression during hypoxia

scientific article published on 8 July 2015

Generation of multicellular tumor spheroids of breast cancer cells: how to go three-dimensional

scientific article published on 19 February 2013

Glucose and glutamine metabolism in relation to mutational status in NSCLC histological subtypes

scientific article published on 30 October 2019

Glucose metabolism in NSCLC is histology-specific and diverges the prognostic potential of 18FDG-PET for adenocarcinoma and squamous cell carcinoma.

scientific article published in October 2014

Histopathologic validation of 3'-deoxy-3'-18F-fluorothymidine PET in squamous cell carcinoma of the oral cavity

scientific article published on 15 April 2010

Hypoxia regulation of phosphokinases and the prognostic value of pAKT in breast cancer.

scientific article

Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

scientific article

Hypoxia, metabolism, and growth factor signaling in head and neck squamous cell carcinoma: correlation between primary and xenograft tumors

scientific article published on 06 November 2013

Hypoxic cell turnover in different solid tumor lines

scientific article

Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer.

scientific article published on 11 February 2011

Hypoxic regulation of the PERK/ATF4/LAMP3-arm of the unfolded protein response in head and neck squamous cell carcinoma.

scientific article published on 27 June 2014

Identification of residual metabolic-active areas within NSCLC tumours using a pre-radiotherapy FDG-PET-CT scan: a prospective validation

scientific article published on 22 July 2011

Image-guided adaptive radiotherapy in patients with locally advanced NSCLC: the art of PET

scientific article published on 04 June 2018

Imaging hypoxia after oxygenation-modification: comparing [18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors.

scientific article published on 14 August 2006

Imaging hypoxia in xenografted and murine tumors with 18F-fluoroazomycin arabinoside: a comparative study involving microPET, autoradiography, PO2-polarography, and fluorescence microscopy

scientific article

Imaging integrin αvβ3 on blood vessels with 111In-RGD2 in head and neck tumor xenografts.

scientific article published on 9 January 2014

Imaging of epidermal growth factor receptor expression in head and neck cancer with SPECT/CT and 111In-labeled cetuximab-F(ab')2.

scientific article published on 17 October 2013

Improved evaluation of antivascular cancer therapy using constrained tracer-kinetic modeling for multi-agent dynamic contrast-enhanced MRI.

scientific article published on 9 January 2018

Improved recurrence-free survival with ARCON for anemic patients with laryngeal cancer

scientific article

Improving chemoradiation efficacy by PI3-K/AKT inhibition

scientific article

Inclusion of Incidental Radiation Dose to the Cardiac Atria and Ventricles Does Not Improve the Prediction of Radiation Pneumonitis in Advanced-Stage Non-Small Cell Lung Cancer Patients Treated With Intensity Modulated Radiation Therapy

scientific article published on 19 April 2017

Individualized Dose Prescription for Hypofractionation in Advanced Non-Small-Cell Lung Cancer Radiotherapy: An in silico Trial

scientific article published on 13 January 2012

Inhibition of CDK4/CDK6 Enhances Radiosensitivity of HPV Negative Head and Neck Squamous Cell Carcinomas

scientific article published on 02 July 2019

Innovations in radiotherapy planning of head and neck cancers: role of PET.

scientific article published on 15 December 2009

Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer

scientific article published on 04 July 2019

Interaction between hypoxia, AKT and HIF-1 signaling in HNSCC and NSCLC: implications for future treatment strategies

scientific article published on 29 January 2016

Interaction of EGFR with the tumour microenvironment: implications for radiation treatment

scientific article published on 05 June 2013

Interferon-Stimulated Genes Are Involved in Cross-resistance to Radiotherapy in Tamoxifen-Resistant Breast Cancer

scientific article published on 16 April 2018

Interleukin-12 has no effect on vascular density, perfusion, hypoxia and proliferation of an implanted human squamous cell carcinoma xenograft tumour despite up-regulation of ICAM-1.

scientific article

Intratumoral Spatial Distribution of Hypoxia and Angiogenesis Assessed by 18F-FAZA and 125I-Gluco-RGD Autoradiography

article

Irradiation combined with SU5416: microvascular changes and growth delay in a human xenograft glioblastoma tumor line.

scientific article published on February 2005

LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy.

scientific article published on 16 January 2014

Learning from scanners: Bias reduction and feature correction in radiomics

scientific article published on 16 July 2019

Longitudinal radiomics of cone-beam CT images from non-small cell lung cancer patients: Evaluation of the added prognostic value for overall survival and locoregional recurrence

scientific article published on 11 April 2019

Low phosphorylated AKT expression in laryngeal cancer: indications for a higher metastatic risk

scientific article published on 23 July 2013

Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers

scientific article published on 13 June 2018

Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4 ⬇️

scientific article

Microenvironmental transformations by VEGF- and EGF-receptor inhibition and potential implications for responsiveness to radiotherapy

scientific article published on 4 December 2006

Molecular PET imaging for biology-guided adaptive radiotherapy of head and neck cancer

scientific article published on 05 September 2013

Molecular aspects of tumour hypoxia

scientific article published on 27 March 2008

Multivariable normal-tissue complication modeling of acute esophageal toxicity in advanced stage non-small cell lung cancer patients treated with intensity-modulated (chemo-)radiotherapy.

scientific article published on 2 September 2015

Observer variation in target volume delineation of lung cancer related to radiation oncologist-computer interaction: a 'Big Brother' evaluation.

scientific article published on 26 October 2005

PD-L1 microSPECT/CT Imaging for Longitudinal Monitoring of PD-L1 Expression in Syngeneic and Humanized Mouse Models for Cancer

scientific article published on 20 November 2018

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

scientific article published on 7 March 2013

PET Imaging in Head and Neck Cancer Patients to Monitor Treatment Response: A Future Role for EGFR-Targeted Imaging

scientific article published on 30 April 2015

PET in the management of locally advanced and metastatic NSCLC.

scientific article published on 28 April 2015

PET of EGFR with (64) Cu-cetuximab-F(ab')2 in mice with head and neck squamous cell carcinoma xenografts

scientific article published on 4 August 2015

PET of hypoxia with 89Zr-labeled cG250-F(ab')2 in head and neck tumors.

scientific article

PET-CT for radiotherapy treatment planning and response monitoring in solid tumors

scientific article published on 25 January 2011

PET-CT for response assessment and treatment adaptation in head and neck cancer

scientific article published on 10 March 2010

Parametric mapping of immunohistochemically stained tissue sections; a method to quantify the colocalization of tumor markers.

scientific article

Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial

scientific article published on 26 May 2013

Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome: in regard to Evans et al. (Int J Radiat Oncol Biol Phys 2007;69:1024-1031).

scientific article published in April 2008

Performance of automatic image segmentation algorithms for calculating total lesion glycolysis for early response monitoring in non-small cell lung cancer patients during concomitant chemoradiotherapy.

scientific article published on 10 May 2016

Pharmacology and toxicity of nicotinamide combined with domperidone during fractionated radiotherapy

scientific article

Photons or protons for reirradiation in (non-)small cell lung cancer: Results of the multicentric ROCOCO in silico study

scientific article published on 20 December 2019

Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.

scientific article published in December 2002

Poor outcome in hypoxic endometrial carcinoma is related to vascular density

scientific article published on 23 April 2019

Poor prognosis of constitutive γ-H2AX expressing triple-negative breast cancers is associated with telomere length.

scientific article

Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: An ESTRO-ASTRO consensus statement

scientific article published on 24 April 2020

Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging

scientific article

Preclinical validation of 111In-girentuximab-F(ab')2 as a tracer to image hypoxia related marker CAIX expression in head and neck cancer xenografts

scientific article published on 5 August 2017

Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers

scientific article published on 14 May 2013

Predictive value of hypoxia, proliferation and tyrosine kinase receptors for EGFR-inhibition and radiotherapy sensitivity in head and neck cancer models.

scientific article published on 28 February 2013

Prognostic value of the proliferation marker Ki-67 in laryngeal carcinoma: results of the accelerated radiotherapy with carbogen breathing and nicotinamide phase III randomized trial

scientific article published on 12 February 2014

Quantitative Imaging of the Hypoxia-Related Marker CAIX in Head and Neck Squamous Cell Carcinoma Xenograft Models

scientific article published on 31 December 2018

Radiation Promptly Alters Cancer Live Cell Metabolic Fluxes: An In Vitro Demonstration.

scientific article published on 29 April 2016

Radiation-induced rib fractures after stereotactic body radiation therapy: Predict to prevent?

scientific article published on 27 March 2017

Radiolabeled cetuximab: dose optimization for epidermal growth factor receptor imaging in a head-and-neck squamous cell carcinoma model.

scientific article published in December 2010

Radiomic feature clusters and prognostic signatures specific for Lung and Head & Neck cancer

scientific article

Radiomics integration into a picture archiving and communication system

publication published on 09 October 2021

Radiotherapy and cGAS/STING signaling: Impact on MDSCs in the tumor microenvironment

scientific article published in 2021

Reduction of observer variation using matched CT-PET for lung cancer delineation: a three-dimensional analysis

scientific article

Regulation of TRIB3 mRNA and protein in breast cancer

scientific article

Reproducibility of functional volume and activity concentration in 18F-FDG PET/CT of liver metastases in colorectal cancer

scientific article published on 4 September 2012

Secretion of pro-angiogenic extracellular vesicles during hypoxia is dependent on the autophagy-related protein GABARAPL1

scientific article published on 01 December 2021

Semiautomatic methods for segmentation of the proliferative tumour volume on sequential FLT PET/CT images in head and neck carcinomas and their relation to clinical outcome.

scientific article published on 18 December 2013

Spatial relationship of phosphorylated epidermal growth factor receptor and activated AKT in head and neck squamous cell carcinoma.

scientific article

Stereotactic versus conventional radiotherapy for pain reduction and quality of life in spinal metastases: study protocol for a randomized controlled trial

scientific article published on 2 February 2016

Survival prediction of non-small cell lung cancer patients using radiomics analyses of cone-beam CT images.

scientific article published on 12 May 2017

Systematic analysis of 18F-FDG PET and metabolism, proliferation and hypoxia markers for classification of head and neck tumors

scientific article

TRIB3 protein denotes a good prognosis in breast cancer patients and is associated with hypoxia sensitivity.

scientific article

Targeting glucose and glutamine metabolism combined with radiation therapy in non-small cell lung cancer

scientific article published on 15 October 2018

Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy.

scientific article published on October 2012

Targeting oxidative phosphorylation to increase the efficacy of radio- and immune- combination therapy

scientific article published on 08 January 2021

The Impact of Optimal Respiratory Gating and Image Noise on Evaluation of Intratumor Heterogeneity on 18F-FDG PET Imaging of Lung Cancer

scientific article published on 9 June 2016

The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response.

scientific article published on 25 July 2013

The PI3-K/AKT-pathway and radiation resistance mechanisms in non-small cell lung cancer

scientific article published on June 2009

The Predictive Value of Early In-Treatment 18F-FDG PET/CT Response to Chemotherapy in Combination with Bevacizumab in Advanced Nonsquamous Non-Small Cell Lung Cancer

scientific article published on 23 March 2017

The Role of Hypoxia and the Immune System in Tumor Radioresistance

scientific article published on 14 October 2019

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

scientific article published on 9 July 2013

The mechanical microenvironment in cancer: How physics affects tumours

scientific article published on 04 September 2015

The potential of hyperpolarized 13C magnetic resonance spectroscopy to monitor the effect of combretastatin based vascular disrupting agents

scientific article published on 25 August 2017

The role of (18)F-FDG PET in the differentiation between lung metastases and synchronous second primary lung tumours

scientific article

The unfolded protein response as a target for cancer therapy

scientific article published on 25 July 2014

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

scientific article

Therapeutic targeting of autophagy in cancer. Part I: molecular pathways controlling autophagy.

scientific article published on 29 May 2014

Therapeutic targeting of autophagy in cancer. Part II: pharmacological modulation of treatment-induced autophagy

scientific article

Toll-like receptor 4 in bone marrow-derived cells as well as tissue-resident cells participate in aggravating autoimmune destructive arthritis

scientific article published on 03 January 2013

Tracers for non-invasive radionuclide imaging of immune checkpoint expression in cancer

scientific article published on 06 November 2019

Treatment outcome and toxicity of intensity-modulated (chemo) radiotherapy in stage III non-small cell lung cancer patients

scientific article

Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response.

scientific article published on 24 August 2011

Tumor Delineation and Quantitative Assessment of Glucose Metabolic Rate within Histologic Subtypes of Non-Small Cell Lung Cancer by Using Dynamic 18F Fluorodeoxyglucose PET.

scientific article published on 15 November 2016

Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers

scientific article

Tumor microenvironment in head and neck squamous cell carcinomas: predictive value and clinical relevance of hypoxic markers. A review

scientific article published on June 2007

Tumor microenvironmental changes induced by the sulfamate carbonic anhydrase IX inhibitor S4 in a laryngeal tumor model

scientific article

Undertreatment of tracheal carcinoma: multidisciplinary audit of epidemiologic data.

scientific article

Vascular architecture, hypoxia, and proliferation in first-generation xenografts of human head-and-neck squamous cell carcinomas

scientific article published in September 2002

Vascular responses to radiotherapy and androgen-deprivation therapy in experimental prostate cancer

scientific article

αB-crystallin expression is correlated with phospho-ERK1/2 expression in human breast cancer.

scientific article published on October 2013

αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma

scientific article

γ-H2AX foci in peripheral blood lymphocytes to quantify radiation-induced DNA damage after 177Lu-DOTA-octreotate peptide receptor radionuclide therapy

scientific article published on 26 February 2015

Paulina is supported by:

About Paulina

Help