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List of works by Frank A Middleton

167. Changes in Frontothalamic Connectivity are Associated With Prodromal Psychosis in Young Adults With 22q11.2 Deletion Syndrome.

scientific article

A Comparative Review of microRNA Expression Patterns in Autism Spectrum Disorder.

scientific article

A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease

scientific article

A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study

scientific article published on December 2008

A role for genes in the 'caregiver stress process'?

article

A splicing-regulatory polymorphism in DRD2 disrupts ZRANB2 binding, impairs cognitive functioning and increases risk for schizophrenia in six Han Chinese samples

scientific article published on 8 September 2015

Accuracy of self-reported medical problems in patients with alcohol dependence and co-occurring schizophrenia or schizoaffective disorder

scientific article

Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation

scientific article

Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain

scientific article published on 5 September 2015

Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophrenia

scientific article published in May 2005

An Adaptive Multivariate Two-Sample Test With Application to Microbiome Differential Abundance Analysis

scientific article published on 24 April 2019

Analysis of SHIP1 expression and activity in Crohn's disease patients

scientific article

Analysis of Shared Haplotypes amongst Palauans Maps Loci for Psychotic Disorders to 4q28 and 5q23-q31.

scientific article published on 12 October 2016

Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse

scientific article

Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function

scientific article

Application of genomic technologies: DNA microarrays and metabolic profiling of obesity in the hypothalamus and in subcutaneous fat.

scientific article published on January 2004

Association and linkage analyses of RGS4 polymorphisms in schizophrenia

scientific article published on June 2002

Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes

scientific article

Associations between neurodevelopmental genes, neuroanatomy, and ultra high risk symptoms of psychosis in 22q11.2 deletion syndrome.

scientific article published on 31 January 2017

Autism-related behavioral phenotypes in an inbred rat substrain

scientific article

Basal ganglia and cerebellar loops: motor and cognitive circuits

scientific article published on 01 March 2000

Basal ganglia and cerebellar output influences non-motor function

scientific article published in December 1996

Basal ganglia output and cognition: evidence from anatomical, behavioral, and clinical studies

scientific article (publication date: March 2000)

Basal-ganglia 'projections' to the prefrontal cortex of the primate

scientific article

Case-Control Genome-Wide Association Study of Attention-Deficit/Hyperactivity Disorder ⬇️

scientific article published on August 5, 2010

Cerebellar Output Channels ⬇️

scientific article published on January 1, 1997

Cerebellar output: motor and cognitive channels

scientific article published on 01 September 1998

Cerebellar projections to the prefrontal cortex of the primate.

scientific article published in January 2001

Characterization of a Novel Mutation in SLC1A1 Associated with Schizophrenia

scientific article

Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats

scientific article published on 11 July 2007

Characterizing runs of homozygosity and their impact on risk for psychosis in a population isolate

scientific article published on July 2014

Comparison of serum and saliva miRNAs for identification and characterization of mTBI in adult mixed martial arts fighters

scientific article published in PLoS ONE

Complete maternal uniparental isodisomy of chromosome 4 in a subject with major depressive disorder detected by high density SNP genotyping arrays

scientific article

Connective tissue growth factor and insulin-like growth factor 2 show upregulation in early growth plate radiorecovery response following irradiation

scientific journal article

Contrast sensitivity to spatial gratings in moderate and dim light conditions in patients with diabetes in the absence of diabetic retinopathy.

scientific article published on 8 August 2017

Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees

scientific article published on 7 October 2011

Cortical-amygdala volumetric ratios predict onset of symptoms of psychosis in 22q11.2 deletion syndrome.

scientific article published on 25 November 2016

Crizotinib induces apoptosis and gene expression changes in ALK+ anaplastic large cell lymphoma cell lines; brentuximab synergizes and doxorubicin antagonizes

scientific article

Cyclosporine inhibition of angiogenesis involves the transcription factor HESR1.

scientific article

Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family

scientific article published on 22 January 2013

Delineating novel signature patterns of altered gene expression in schizophrenia using gene microarrays.

scientific article

Dentate output channels: motor and cognitive components

scientific article published on January 1997

Depolarization and Ca(2+) down regulate CB1 receptors and CB1-mediated signaling in cerebellar granule neurons

scientific article published on 18 January 2006

Diagnosing mild traumatic brain injury using saliva RNA compared to cognitive and balance testing

scientific article published on 1 October 2020

Differential expression of SLC9A9 and interacting molecules in the hippocampus of rat models for attention deficit/hyperactivity disorder

scientific article

Differential expression of miRNAs in acute myeloid leukemia quantified by Nextgen sequencing of whole blood samples

scientific article published on 20 March 2019

Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia

scientific article published on May 2001

Distance running alters peripheral microRNAs implicated in metabolism, fluid balance, and myosin regulation in a sex-specific manner

scientific article published on 08 June 2018

Diurnal oscillations in human salivary microRNA and microbial transcription: Implications for human health and disease

scientific article published on 18 July 2018

Effect of lesion proximity on the regenerative response of long descending propriospinal neurons after spinal transection injury

scientific article published on 18 March 2019

Effects of Acute Prenatal Exposure to Ethanol on microRNA Expression are Ameliorated by Social Enrichment

scientific article

Effects of omega-3 fatty acid supplementation on tumor-bearing rats

scientific article published in November 2004

Environmental risk factors for attention-deficit hyperactivity disorder

scientific article published on September 2007

Epstein-Barr virus genetic variation in lymphoblastoid cell lines derived from Kenyan pediatric population

scientific article published on May 2015

Ethanol-induced methylation of cell cycle genes in neural stem cells.

scientific article published on 27 July 2010

Evaluation of cell proliferation, apoptosis, and DNA-repair genes as potential biomarkers for ethanol-induced CNS alterations

scientific article

Familial transmission of schizophrenia in Palau: A 20-year genetic epidemiological study in three generations

scientific article published on 3 February 2011

Functional and biochemical characterization of soleus muscle in Down syndrome mice: insight into the muscle dysfunction seen in the human condition

scientific article published on 31 October 2012

Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches

article

Gene expression profiles of intact and regenerating zebrafish retina.

scientific article

Gene expression profiles post Roux-en-Y gastric bypass

scientific article published on 01 August 2004

Gene expression profiling reveals a lingering effect of prenatal alcohol exposure on inflammatory-related genes during adolescence and adulthood

scientific article published on 03 June 2020

Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia.

scientific article

Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disorders.

scientific article

Genetic architecture of Wistar-Kyoto rat and spontaneously hypertensive rat substrains from different sources

scientific article

Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia

scientific article

Genetic linkage of bipolar disorder to chromosome 6q22 is a consistent finding in Portuguese subpopulations and may generalize to broader populations

scientific article

Genetic overlap of schizophrenia and bipolar disorder in a high-density linkage survey in the Portuguese Island population

scientific article published on 27 March 2012

Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3.

scientific article published on February 2012

Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder

scientific article

Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder

scientific article published on December 2008

Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder

scientific article

Genomewide linkage analysis of bipolar disorder by use of a high-density single-nucleotide-polymorphism (SNP) genotyping assay: a comparison with microsatellite marker assays and finding of significant linkage to chromosome 6q22.

scientific article

Genomic investigation of alpha-synuclein multiplication and parkinsonism

scientific article published on June 2008

Gestational ethanol exposure alters the behavioral response to ethanol odor and the expression of neurotransmission genes in the olfactory bulb of adolescent rats

scientific article published on 19 November 2008

Growth plate zonal microarray analysis shows upregulation of extracellular matrix genes and downregulation of metalloproteinases and cathepsins following irradiation

scientific journal article

HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE.

scientific article

Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus

scientific article published on 01 February 2008

Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia

scientific article published on 01 December 2004

Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder.

scientific article

Hierarchical clustering of gene expression patterns in the Eomes + lineage of excitatory neurons during early neocortical development

scientific article

Hormone-response genes are direct in vivo regulatory targets of Brahma (SWI/SNF) complex function

scientific article published on 21 September 2006

Identification of stage-specific gene modulation during early thymocyte development by whole-genome profiling analysis after aryl hydrocarbon receptor activation

scientific article

Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects

scientific article published on 27 March 2012

Integrating genetic, functional genomic, and bioinformatics data in a systems biology approach to complex diseases: application to schizophrenia

scientific article

Is obesity an inflammatory disease?

scientific article published in August 2003

Isolation and confirmation of a calcium excretion quantitative trait locus on chromosome 1 in genetic hypercalciuric stone-forming congenic rats

scientific article published on 12 April 2006

Linkage disequilibrium and haplotype structure of five GABAA receptor subunit genes investigated for association with schizophrenia

article

Long descending cervical propriospinal neurons differ from thoracic propriospinal neurons in response to low thoracic spinal injury

scientific article

Loss of vacuolar proton-translocating ATPase activity in yeast results in chronic oxidative stress

scientific article published on 10 January 2007

Meta-Analysis of Genome-Wide Association Studies of Attention-Deficit/Hyperactivity Disorder ⬇️

scientific article published on August 1, 2010

Methylphenidate normalizes elevated dopamine transporter densities in an animal model of the attention-deficit/hyperactivity disorder combined type, but not to the same extent in one of the attention-deficit/hyperactivity disorder inattentive type

scientific article published on 6 March 2010

Microarray analysis of perichondral and reserve growth plate zones identifies differential gene expressions and signal pathways

scientific article

Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways

scientific article published in December 2004

Microarray cluster analysis of irradiated growth plate zones following laser microdissection

scientific journal article

Mitochondrial carrier protein overloading and misfolding induce aggresomes and proteostatic adaptations in the cytosol

scientific article published on 20 March 2019

Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex

scientific article (publication date: October 2000)

Molecular substrates of social avoidance seen following prenatal ethanol exposure and its reversal by social enrichment

scientific article published on 8 May 2012

New concepts about the organization of basal ganglia output

scientific article published on January 1, 1997

Oral microbiome activity in children with autism spectrum disorder

scientific article published on 14 August 2018

Oxytocin receptor gene (OXTR) links to marital quality via social support behavior and perceived partner responsiveness

scientific article published on 29 November 2018

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease

scientific article

Parent Perspectives Towards Genetic and Epigenetic Testing for Autism Spectrum Disorder

scientific article published on 22 March 2019

Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication

scientific article

Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants ⬇️

scientific article

Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine

scientific article published on 11 May 2009

Quantification of SARS-CoV-2 and cross-assembly phage (crAssphage) from wastewater to monitor coronavirus transmission within communities

scientific article published on 24 May 2020

Reduced Slc1a1 expression is associated with neuroinflammation and impaired sensorimotor gating and cognitive performance in mice: Implications for schizophrenia

scientific article published on 8 September 2017

Regulating the availability of transforming growth factor ß1 in B104 neuroblastoma cells

scientific article

Reviewer selection biases editorial decisions on manuscripts

scientific article published on 27 January 2018

SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction.

scientific article

SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder

scientific article

Saliva MicroRNA Differentiates Children With Autism From Peers With Typical and Atypical Development

scientific article published on 27 March 2019

Saliva microRNA Biomarkers of Cumulative Concussion

scientific article published on 20 October 2020

Salivary miRNA profiles identify children with autism spectrum disorder, correlate with adaptive behavior, and implicate ASD candidate genes involved in neurodevelopment

scientific article

Support for involvement of neuregulin 1 in schizophrenia pathophysiology

scientific article published on 01 April 2005

Support for involvement of neuregulin 1 in schizophrenia pathophysiology

The Transcriptional Signature of a Runner's High

scientific article published on 01 May 2019

The cerebellum: an overview

scientific article published in September 1998

The cerebellum: an overview

scientific article published on 01 September 1998

The de novo autism spectrum disorder RELN R2290C mutation reduces Reelin secretion and increases protein disulfide isomerase expression

scientific article published on 17 April 2017

The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI study

scientific article

The effects of strain and prenatal nicotine exposure on ethanol consumption by adolescent male and female rats

scientific article

The human genome: gene expression profiling and schizophrenia

scientific article published on 01 September 2001

The oral microbiome of early stage Parkinson's disease and its relationship with functional measures of motor and non-motor function

scientific article published on 27 June 2019

The spontaneously hypertensive rat model of ADHD--the importance of selecting the appropriate reference strain

scientific article

The temporal lobe is a target of output from the basal ganglia

scientific article published on August 1996

Thrombospondin-1 differentially regulates microRNAs in vascular smooth muscle cells

scientific article published on 4 January 2016

Thrombospondin-1: a proatherosclerotic protein augmented by hyperglycemia

scientific article published on 29 March 2010

Trajectory of Change in Brain Complement Factors from Neonatal to Young Adult Humans

scientific article published on 15 November 2020

Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing

scientific article

Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa

scientific article published on 26 September 2006

Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms

scientific article published in August 2005

Transcriptional profiling of depolarization-dependent phenotypic alterations in primary cultures of developing granule neurons

scientific article published on 20 September 2006

Transcriptome-wide gene expression in a rat model of attention deficit hyperactivity disorder symptoms: rats developmentally exposed to polychlorinated biphenyls

scientific article published on 14 September 2011

Transcriptomic analysis of postmortem brain identifies dysregulated splicing events in novel candidate genes for schizophrenia

scientific article

Transforming growth factor beta1 and ethanol affect transcription and translation of genes and proteins for cell adhesion molecules in B104 neuroblastoma cells

scientific journal article

Validation of a Salivary RNA Test for Childhood Autism Spectrum Disorder

scholarly article by Steven D Hicks et al published 2018 in Frontiers in Genetics

Weight regain after Roux-en-Y: a significant 20% complication related to PYY.

scientific article published on September 2008

White matter abnormalities in 22q11.2 deletion syndrome: preliminary associations with the Nogo-66 receptor gene and symptoms of psychosis

scientific article published on 08 December 2013

White matter microstructural abnormalities of the cingulum bundle in youths with 22q11.2 deletion syndrome: associations with medication, neuropsychological function, and prodromal symptoms of psychosis

scientific article

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