List of works - David A Gillespie

AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11.

scientific article published on 2 October 2017

ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.

scientific article

Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.

scientific article

Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability ⬇️

scientific article published on March 15, 2012

An oncogenic mutation uncouples the v-Jun oncoprotein from positive regulation by the SAPK/JNK pathway in vivo

scientific article published on 01 January 1998

Analysing the DNA damage and replication checkpoints in DT40 cells.

scientific article published on January 2006

Analysis of the interaction between c-Jun and c-Jun N-terminal kinase in vivo

scientific article published on 01 December 1998

Analysis of the variations in proviral cytosine methylation that accompany transformation and morphological reversion in a line of Rous sarcoma virus-infected Rat-1 cells

scientific article published on July 1984

Autophagy is critically required for DNA repair by homologous recombination.

scientific article published on 2 October 2015

Cancer therapy. Targeting the poison within

scientific article

Cdk phosphorylation of Chk1 regulates efficient Chk1 activation and multiple checkpoint proficiency ⬇️

scientific article published on September 30, 2011

Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage ⬇️

scientific article published on July 18, 2011

Cell transformation by v-Jun deactivates ERK MAP kinase signalling.

scientific article

Centrifugal elutriation as a means of cell cycle phase separation and synchronisation.

scientific article

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity.

scientific article

Chk1 KA1 domain auto-phosphorylation stimulates biological activity and is linked to rapid proteasomal degradation

scientific article published in Scientific Reports

Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis.

scientific article published in August 2011

Chk1 regulates the density of active replication origins during the vertebrate S phase.

scientific article published on 10 May 2007

Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil.

scientific article published on 17 April 2006

Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase.

scientific article published on 6 August 2007

Claspin - checkpoint adaptor and DNA replication factor

scientific article published on 29 June 2018

DNA damage control: regulation and functions of checkpoint kinase 1

scientific article

DNA mismatch repair and Chk1-dependent centrosome amplification in response to DNA alkylation damage.

scientific article published on 5 April 2007

DNA replication in Physarum polycephalum. Analysis of replicating nuclear DNA using the electron microscope

scientific article published on May 1, 1980

Estrogen receptor activation function 2 (AF-2) is essential for hormone-dependent transactivation and cell transformation induced by a v-Jun DNA binding domain-estrogen receptor chimera.

scientific article published in August 2003

Expression of integrated Rous sarcoma viruses: DNA rearrangements 5' to the provirus are common in transformed rat cells but not seen in infected but untransformed cells

scientific article published on April 1986

Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation

scientific article

Gene-regulatory properties of Myc helix-loop-helix/leucine zipper mutants: Max-dependent DNA binding and transcriptional activation in yeast correlates with transforming capacity.

scientific article published in July 1993

Inhibition of adipocyte differentiation by cMyc is not accompanied by alterations in cell cycle control.

scientific article

Insulin-stimulated expression of c-fos, fra1 and c-jun accompanies the activation of the activator protein-1 (AP-1) transcriptional complex.

scientific article published on October 1998

Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX

scientific article (publication date: 13 February 2003)

Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53.

scientific article

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage

scientific article

Lethal errors in checkpoint control--life without Chk1.

scientific article

Loss of autophagy causes a synthetic lethal deficiency in DNA repair.

scientific article

Microarray analysis identifies Autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun.

scientific article published in March 2004

Microbubbles in replicating nuclear deoxyribonucleic acid from Physarum polycephalum ⬇️

scientific article published on November 1, 1979

Mitogenesis by v-Src: fluctuations throughout G1 of classical immediate early AP-1 and mitogen-activated protein kinase responses that parallel the need for the oncoprotein.

scientific article

Mitotic index determination by flow cytometry

scientific article published on 01 January 2006

Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor.

scientific article

Mutant p53 drives invasion by promoting integrin recycling

scientific article

PARP inhibitor olaparib increases the oncolytic activity of dl922-947 in in vitro and in vivo model of anaplastic thyroid carcinoma

scientific article published on 2 August 2014

PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1.

scientific article published on 4 July 2016

Phosphorylation at serine 331 is required for Aurora B activation.

scientific article

Phosphorylation of HuR by Chk2 regulates SIRT1 expression

scientific article

Properties of middle-repeat sequences in nuclear deoxyribonucleic acid from baby-hamster kidney cells (BHK-21/C13) [proceedings]

scientific article published in August 1979

Protein phosphatase 2A reverses phosphorylation of c-Jun specified by the delta domain in vitro: correlation with oncogenic activation and deregulated transactivation activity of v-Jun

scientific article published on November 1, 1991

Regulation of AP-1/DNA complex formation in vitro

scientific article published on 01 February 1991

Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein.

scientific article

Short-circuiting the cell cycle for cancer therapy.

scientific article published in August 2012

Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function.

scientific article published on March 1995

The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer

scientific article

The Secret Life of Histones ⬇️

scientific article published on September 19, 2003

The leucine zipper domain of avian cMyc is required for transformation and autoregulation

scientific article published on 01 May 1990

The v-Jun oncoprotein replaces p39 c-Jun as the predominant AP-1 constituent in ASV17-transformed fibroblasts: implications for SAPK/JNK-mediated signal transduction.

scientific article published on June 1996

Transcription activation by Myc and Max: flanking sequences target activation to a subset of CACGTG motifs in vivo.

scientific article published in December 1993

Transcriptional activation by the v-Jun oncoprotein is independent of positive regulatory phosphorylation

scientific article published on 01 August 1994

Transformation by v-Jun prevents cell cycle exit and promotes apoptosis in the absence of serum growth factors

scientific article published on 01 April 1997

Viral mutations enhance the Max binding properties of the vMyc b-HLH-LZ domain.

scientific article

c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.

scientific article published on October 2004

c-Myc inhibits myogenic differentiation and myoD expression by a mechanism which can be dissociated from cell transformation.

scientific article published on December 1994

v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity.

scientific article

v-Jun represses c-jun proto-oncogene expression in vivo through a 12-O-tetradecanoylphorbol-13-acetate-responsive element in the proximal gene promoter.

scientific article published on August 1998

v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release

scientific article published on 01 November 2000

List of works by David A Gillespie

AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11.

ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.

Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.

Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability ⬇️

An oncogenic mutation uncouples the v-Jun oncoprotein from positive regulation by the SAPK/JNK pathway in vivo

Analysing the DNA damage and replication checkpoints in DT40 cells.

Analysis of the interaction between c-Jun and c-Jun N-terminal kinase in vivo

Analysis of the variations in proviral cytosine methylation that accompany transformation and morphological reversion in a line of Rous sarcoma virus-infected Rat-1 cells

Autophagy is critically required for DNA repair by homologous recombination.

Cancer therapy. Targeting the poison within

Cdk phosphorylation of Chk1 regulates efficient Chk1 activation and multiple checkpoint proficiency ⬇️

Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage ⬇️

Cell transformation by v-Jun deactivates ERK MAP kinase signalling.

Centrifugal elutriation as a means of cell cycle phase separation and synchronisation.

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity.

Chk1 KA1 domain auto-phosphorylation stimulates biological activity and is linked to rapid proteasomal degradation

Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis.

Chk1 regulates the density of active replication origins during the vertebrate S phase.

Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil.

Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase.

Claspin - checkpoint adaptor and DNA replication factor

DNA damage control: regulation and functions of checkpoint kinase 1

DNA mismatch repair and Chk1-dependent centrosome amplification in response to DNA alkylation damage.

DNA replication in Physarum polycephalum. Analysis of replicating nuclear DNA using the electron microscope

Estrogen receptor activation function 2 (AF-2) is essential for hormone-dependent transactivation and cell transformation induced by a v-Jun DNA binding domain-estrogen receptor chimera.

Expression of integrated Rous sarcoma viruses: DNA rearrangements 5' to the provirus are common in transformed rat cells but not seen in infected but untransformed cells

Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation

Gene-regulatory properties of Myc helix-loop-helix/leucine zipper mutants: Max-dependent DNA binding and transcriptional activation in yeast correlates with transforming capacity.

Inhibition of adipocyte differentiation by cMyc is not accompanied by alterations in cell cycle control.

Insulin-stimulated expression of c-fos, fra1 and c-jun accompanies the activation of the activator protein-1 (AP-1) transcriptional complex.

Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX

Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53.

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage

Lethal errors in checkpoint control--life without Chk1.

Loss of autophagy causes a synthetic lethal deficiency in DNA repair.

Microarray analysis identifies Autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun.

Microbubbles in replicating nuclear deoxyribonucleic acid from Physarum polycephalum ⬇️

Mitogenesis by v-Src: fluctuations throughout G1 of classical immediate early AP-1 and mitogen-activated protein kinase responses that parallel the need for the oncoprotein.

Mitotic index determination by flow cytometry

Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor.

Mutant p53 drives invasion by promoting integrin recycling

PARP inhibitor olaparib increases the oncolytic activity of dl922-947 in in vitro and in vivo model of anaplastic thyroid carcinoma

PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1.

Phosphorylation at serine 331 is required for Aurora B activation.

Phosphorylation of HuR by Chk2 regulates SIRT1 expression

Properties of middle-repeat sequences in nuclear deoxyribonucleic acid from baby-hamster kidney cells (BHK-21/C13) [proceedings]

Protein phosphatase 2A reverses phosphorylation of c-Jun specified by the delta domain in vitro: correlation with oncogenic activation and deregulated transactivation activity of v-Jun

Regulation of AP-1/DNA complex formation in vitro

Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein.

Short-circuiting the cell cycle for cancer therapy.

Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function.

The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer

The Secret Life of Histones ⬇️

The leucine zipper domain of avian cMyc is required for transformation and autoregulation

The v-Jun oncoprotein replaces p39 c-Jun as the predominant AP-1 constituent in ASV17-transformed fibroblasts: implications for SAPK/JNK-mediated signal transduction.

Transcription activation by Myc and Max: flanking sequences target activation to a subset of CACGTG motifs in vivo.

Transcriptional activation by the v-Jun oncoprotein is independent of positive regulatory phosphorylation

Transformation by v-Jun prevents cell cycle exit and promotes apoptosis in the absence of serum growth factors

Viral mutations enhance the Max binding properties of the vMyc b-HLH-LZ domain.

c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.

c-Myc inhibits myogenic differentiation and myoD expression by a mechanism which can be dissociated from cell transformation.

v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity.

v-Jun represses c-jun proto-oncogene expression in vivo through a 12-O-tetradecanoylphorbol-13-acetate-responsive element in the proximal gene promoter.

v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release