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List of works by Georg M Lauer

A multi-ancestry sex stratified genome-wide association study of spontaneous clearance of hepatitis C virus

scientific article published on 29 October 2020

A prophylactic hepatitis C virus vaccine: a distant peak still worth climbing.

scientific article

A simple strategy to identify acute hepatitis C virus infection among newly incarcerated injection drug users ⬇️

scientific article published on February 15, 2013

ADCC-Mediated CD56DIM NK Cell Responses Are Associated with Early HBsAg Clearance in Acute HBV Infection

scientific article published on 19 February 2018

Acute hepatitis C infection in correctional settings

scientific article published on 03 May 2009

Acute hepatitis C infection lowers serum lipid levels

scientific article published on 08 February 2011

Acute hepatitis C virus infection in incarcerated injection drug users

scientific article

Analysis of resistance-associated substitutions in acute hepatitis C virus infection by deep sequencing across six genotypes and three continents.

scientific article

Antibody dynamics and spontaneous viral clearance in patients with acute hepatitis C infection in Rio de Janeiro, Brazil.

scientific article

Breadth of the HCV-specific CD4+ T-cell response in spontaneous resolvers is independent of the IL-28 haplotype

scientific article published on 27 June 2016

Broad Specificity of Virus-Specific CD4+ T-Helper-Cell Responses in Resolved Hepatitis C Virus Infection

scientific article (publication date: December 2002)

Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes

scientific article

Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence ⬇️

scientific article published on January 2, 2012

Bystander chronic infection negatively impacts development of CD8(+) T cell memory.

scientific article published on May 2014

CD8 Epitope Escape and Reversion in Acute HCV Infection

scientific article

Cellular immune responses against hepatitis C virus: the evidence base 2002

scientific article (publication date: May 2002)

Characterization of full-length hepatitis C virus genotype 4 sequences.

scientific article published in May 2007

Chronic HCV infection affects the NK cell phenotype in the blood more than in the liver.

scientific article

Cohort profile: the international collaboration of incident HIV and hepatitis C in injecting cohorts (InC3) study.

scientific article

Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase

scientific article published on 31 August 2011

Comprehensive Analysis of CD8+-T-Cell Responses against Hepatitis C Virus Reveals Multiple Unpredicted Specificities

scientific article (publication date: June 2002)

Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C.

scientific article published on July 2005

Correction: Multi-ancestry fine mapping of interferon lambda and the outcome of acute hepatitis C virus infection

scientific article published on 23 November 2020

Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection

scientific article published on 18 July 2016

Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus

scientific article

Defining the directionality and quality of influenza virus?specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus.

scientific article published in March 2011

Detection of Diverse Hepatitis C Virus (HCV)-Specific Cytotoxic T Lymphocytes in Peripheral Blood of Infected Persons by Screening for Responses to All Translated Proteins of HCV

scientific article (publication date: February 2001)

Differentiation of exhausted CD8<sup>+</sup> T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

scientific article published on 26 July 2021

Distinct Escape Pathway by Hepatitis C Virus Genotype 1a from a Dominant CD8+ T Cell Response by Selection of Altered Epitope Processing.

scientific article published on 7 October 2015

Do antiviral CD8+ T cells select hepatitis C virus escape mutants? Analysis in diverse epitopes targeted by human intrahepatic CD8+ T lymphocytes.

scientific article published in February 2006

Dynamic Changes in Innate Immune Responses During Direct Acting Antiviral Therapy for HCV Infection

article

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection

scientific article published in October 2017

Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16

scientific article published on 09 March 2016

Epigenetic scars of CD8<sup>+</sup> T cell exhaustion persist after cure of chronic infection in humans

scientific article published on 26 July 2021

Escape from HLA-B*08-Restricted CD8 T Cells by Hepatitis C Virus Is Associated with Fitness Costs

scientific article (publication date: December 2008)

Evolution of the innate and adaptive immune response in women with acute Zika virus infection

scientific article published on 02 December 2019

Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers

scientific article

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

scientific article published on 20 November 2017

Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy

scientific article

Genetic and structural insights into broad neutralization of hepatitis C virus by human V1-69 antibodies

scientific article published on 02 January 2019

Genetic basis for variation in plasma IL-18 levels in persons with chronic hepatitis C virus and human immunodeficiency virus-1 infections

scientific article published on 16 March 2017

Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis

scientific article

Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts

scientific article

Genomic characterization of hepatitis C virus transmitted founder variants with deep sequencing

scientific article published on 08 March 2019

Genomic variability of within-host hepatitis C variants in acute infection

scientific article published on 22 January 2019

Genotype 1 and global hepatitis C T-cell vaccines designed to optimize coverage of genetic diversity.

scientific article published on 6 January 2010

HLA-B*27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope

scientific article published on 23 August 2013

HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs.

scientific article published on 12 April 2017

Hepatitis B virus infection and the immune response: The big questions

scientific article

Hepatitis B virus infection: A strong case against ageism ⬇️

scientific article published on October 1, 2011

Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution

scientific article (publication date: February 2010)

Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution

scientific article

Hepatitis C virus clearance, reinfection, and persistence, with insights from studies of injecting drug users: towards a vaccine

scientific article published on May 2012

Hepatitis C virus infection

scientific article (publication date: 5 July 2001)

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8 and CD4 T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

scientific article published in May 2011

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

scientific article

High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection

scientific article published on September 2004

Historical Trends in the Hepatitis C Virus Epidemics in North America and Australia

scientific article published on 28 August 2016

Human Immunodeficiency Virus Type 1-Hepatitis C Virus Coinfection: Intraindividual Comparison of Cellular Immune Responses against Two Persistent Viruses

scientific article (publication date: March 2002)

Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells

scientific article published on 15 November 2011

Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations

scientific article

Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution

scientific article published in August 2007

Hurdles to the Development of Effective HBV Immunotherapies and HCV Vaccines

scientific article

IFN-free therapy is associated with restoration of type I IFN response in HIV-1 patients with acute HCV infection who achieve SVR.

scientific article

Immune responses to hepatitis C virus (HCV) infection and the prospects for an effective HCV vaccine or immunotherapies.

scientific article published on March 2013

Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non genotype 1 infection

scientific article (publication date: September 2007)

Immunological biomarker discovery in cure regimens for chronic hepatitis B virus infection

scientific article published on 05 March 2022

Impaired Hepatitis C Virus-Specific T Cell Responses and Recurrent Hepatitis C Virus in HIV Coinfection

scientific article

Innocent spectators, helping hands or a fifth column? Acute hepatitis A infection reveals important insights into bystander T cells

scientific article published on 05 February 2019

Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative

scientific article published on January 2016

Interferon lambda 3 genotype predicts hepatitis C virus RNA levels in early acute infection among people who inject drugs: the InC(3) study

scientific article

Limited naturally occurring escape in broadly neutralizing antibody epitopes in hepatitis C glycoprotein E2 and constrained sequence usage in acute infection

scientific article published on 5 January 2017

Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140

scientific article published on 3 March 2017

Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus

scientific article published on 26 December 2018

Multi-ancestry fine mapping of interferon lambda and the outcome of acute hepatitis C virus infection

scientific article published on 28 October 2020

Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients

scientific article (publication date: December 2008)

Outcomes and Treatment of Acute Hepatitis C Virus Infection in a United States Population

scientific article (publication date: October 2006)

Pathogenesis of HIV-HCV Coinfection

scientific article published on 01 July 2007

Patterns of hepatitis C virus RNA levels during acute infection: the InC3 study

scientific article

Phenotype and function of HBV-specific T cells is determined by the targeted epitope in addition to the stage of infection.

scientific article published on 22 December 2018

Phylogenetic analysis of full-length, early infection, hepatitis C virus genomes among people with intravenous drug use: the InC3 Study.

scientific article

Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.

scientific article published on November 2012

Prospective follow-up of patients with acute hepatitis C virus infection in Brazil.

scientific article published on May 2010

Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope

scientific article

Rare birds in North America: acute hepatitis C cohorts

scientific article

Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy.

scientific article

Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance.

scientific article published on 17 December 2010

Serum interleukin 4 and interleukin 10 levels in patients with chronic hepatitis C virus infection.

scientific article published on March 1997

Simultaneous Analysis of HCV-Specific CD4+ and CD8+ T Cells by Multicolor Flow Cytometry

scientific article published on 01 January 2019

Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes

scientific article

Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus

scientific article

T cell failure in hepatitis C virus infection

scientific article

Temporal Dynamics of a Predominant Protease Inhibitor–Resistance Mutation in a Treatment-Naive, Hepatitis C Virus–Infected Individual

scientific article (publication date: March 2009)

The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design

scientific article

The effect of female sex on hepatitis C incidence among people who inject drugs: results from the international multi-cohort InC3 Collaborative.

scientific article published on 24 August 2017

The effects of alcohol on spontaneous clearance of acute hepatitis C virus infection in females versus males.

scientific article published on 26 October 2016

The epigenetic landscape of T cell exhaustion.

scientific article

Underascertainment of acute hepatitis C virus infections in the U.S. surveillance system: a case series and chart review

scientific article published on 30 June 2015

Up-regulation of circulating miR-20a is correlated with hepatitis C virus-mediated liver disease progression.

scientific article published on 23 July 2013

Vaccine-induced T-cell responses against HCV: one step taken, more to follow

scientific article published on 01 April 2007

Viral Sequence Evolution in Acute Hepatitis C Virus Infection

scientific article (publication date: November 2007)

Whole recombinant yeast-based immunotherapy induces potent T cell responses targeting HCV NS3 and Core proteins.

scientific article published on 10 November 2006

p53 and K-RAS alterations in pancreatic epithelial cell lesions

scientific article published on 01 February 1993

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