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List of works by Mauro Perretti

'Annexins' themed section

scientific article published in April 2015

21-NO-prednisolone is a novel nitric oxide-releasing derivative of prednisolone with enhanced anti-inflammatory properties

scientific article

A novel anti-inflammatory peptide from human lipocortin 5 ⬇️

scientific article published on June 1, 1991

A novel biological activity for galectin-1: inhibition of leukocyte-endothelial cell interactions in experimental inflammation.

scientific article published on October 2003

A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils.

scientific article

A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones

scientific article

A novel effect for annexin 1-derived peptide ac2-26: reduction of allergic inflammation in the rat.

scientific article published on 22 March 2005

A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5

scientific article

A novel murine model of allergic inflammation to study the effect of dexamethasone on eosinophil recruitment

scientific article

A novel peptide agonist of formyl-peptide receptor-like 1 (ALX) displays anti-inflammatory and cardioprotective effects

scientific article published on 20 November 2008

A role for MC3R in modulating lung inflammation

scientific article published on 17 October 2008

A role for endogenous histamine in interleukin‐8‐induced neutrophil infiltration into mouse air‐pouch: investigation of the modulatory action of systemic and local dexamethasone ⬇️

scientific article published on July 1, 1994

A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation

scientific article published on 03 June 2013

Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse

scientific journal article

Actions of SPM in regulating host responses in arthritis.

scientific article published on 26 April 2017

Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling

scientific article published in January 2012

Activation of PPARbeta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release.

scientific article published on 23 April 2009

Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis.

scientific article published in October 2002

Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation

scientific article published on 22 February 2007

Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes

scientific article

Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1.

scientific article published on March 1996

Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3)

scientific article published on 22 October 2011

Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory function

scientific article

Agonism at melanocortin receptor type 3 on macrophages inhibits neutrophil influx

scientific article published on 01 December 1999

Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo

scientific article published on 19 August 2015

Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response

scientific article published on 15 September 2015

Alteration of neutrophil trafficking by a lipocortin 1 N-terminus peptide

scientific article published on 01 June 1995

Alterations in the profile of blood neutrophil membrane receptors caused by in vivo adrenocorticotrophic hormone actions

scientific article published on 02 September 2014

An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouse.

scientific article published on 16 August 2010

An immunocytochemical and in situ hybridization analysis of annexin 1 expression in rat mast cells: modulation by inflammation and dexamethasone

scientific journal article

An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis

scientific article published on 4 February 2013

An isocratic HPLC method for the quantitation of eicosanoids in human platelets.

scientific article

An orally administered butyrate-releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium-induced murine colitis.

scientific article published on 29 September 2016

An overview of the effects of annexin 1 on cells involved in the inflammatory process

scientific article

Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin

scientific article published on 10 August 2014

Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4- CD8- T cells.

scientific article published on 7 April 2010

Analysis of the protection afforded by annexin 1 in ischaemia–reperfusion injury: focus on neutrophil recruitment ⬇️

scientific article published on October 19, 2001

Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement.

scientific article published on 8 November 2005

Annexin 1 and neutrophil apoptosis

scientific article published on June 2004

Annexin 1 and the biology of the neutrophil

scientific article published on 13 February 2004

Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3.

scientific article published on 6 August 2007

Annexin 1 localisation in tissue eosinophils as detected by electron microscopy

scientific journal article

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles

scientific article published on 01 July 2008

Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model

scientific article published on August 2002

Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: analysis of their mechanism of action.

scientific article published in October 2001

Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro

scientific article published on 6 July 2005

Annexin 1: an endogenous anti-inflammatory protein

scientific article

Annexin A1 Contained in Extracellular Vesicles Promotes the Activation of Keratinocytes by Mesoglycan Effects: An Autocrine Loop Through FPRs

scientific article published on 19 July 2019

Annexin A1 Is a Physiological Modulator of Neutrophil Maturation and Recirculation Acting on the CXCR4/CXCL12 Pathway

scientific article

Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System

scientific article published on 04 December 2018

Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils

scientific article published on 28 February 2012

Annexin A1 Released in Extracellular Vesicles by Pancreatic Cancer Cells Activates Components of the Tumor Microenvironment, through Interaction with the Formyl-Peptide Receptors

scientific article published on 18 December 2020

Annexin A1 and glucocorticoids as effectors of the resolution of inflammation

scientific article

Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation

scientific article published on 01 March 2020

Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling

scientific article

Annexin A1 mediates hydrogen sulfide properties in the control of inflammation

scientific article

Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice

scientific article published on 10 April 2015

Annexin A1 regulates intestinal mucosal injury, inflammation, and repair

scientific journal article

Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow ⬇️

scientific article published on September 28, 2011

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair ⬇️

scientific article published on December 17, 2012

Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.

scientific article

Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst

scientific article published on 11 May 2020

Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis

scientific article published on 01 January 2000

Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors

scientific article published on 4 May 2006

Annexin-1 modulates T-cell activation and differentiation

scientific article

Annexin-1 modulates repair of gastric mucosal injury

scientific article

Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation.

scientific article published on 24 November 2008

Annexin-A1 protein and its relationship to cortisol in human saliva

scientific article published on 25 September 2012

Annexin-A1: a pivotal regulator of the innate and adaptive immune systems

scientific article published on 21 July 2008

Anti-Inflammatory Lipocortin-Derived Peptides ⬇️

scientific article published on January 1, 1995

Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid

scientific article published on 02 October 2020

Anti-inflammatory actions of an N-terminal peptide from human lipocortin 1.

scientific article

Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis

scientific article published on 11 August 2010

Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation

scientific article

Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization

scientific article

Antiflammin-2 activates the human formyl-peptide receptor like 1

scientific article published on 25 October 2006

Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment.

scholarly article

AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice

scientific article published on 12 September 2014

Are the lipocortins the second messengers of the anti-inflammatory action of glucocorticoids?

scientific article published on January 1990

Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities

scientific article published on 26 October 2007

Aspirin and steroids: new mechanistic findings and avenues for drug discovery

scientific article (publication date: August 2005)

Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3.

scientific article

Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)

scientific article published on 23 October 2018

Attenuation of plasma annexin A1 in human obesity

scientific article

Author Correction: Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo

scientific article published on 02 May 2018

Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects.

scientific article published on 27 February 2015

Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 expression

scientific article published on 28 May 2013

Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment

scientific article

CFTR inhibition provokes an inflammatory response associated with an imbalance of the annexin A1 pathway.

scientific article

Calcitonin and prednisolone display antagonistic actions on bone and have synergistic effects in experimental arthritis

scientific article published on March 2007

Carbon Monoxide-Releasing Molecules Modulate Leukocyte-Endothelial Interactions under Flow

scientific article published on 08 February 2007

Cell barrier function of resident peritoneal macrophages in post-operative adhesions

scientific article published on 14 April 2021

Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells

scientific article published on 7 September 2012

Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study.

scientific article published on 5 February 2009

Characterization of a Synovial B Cell-Derived Recombinant Monoclonal Antibody Targeting Stromal Calreticulin in the Rheumatoid Joints

scientific article published on 25 July 2018

Characterizing the anti-inflammatory and tissue protective actions of a novel Annexin A1 peptide

scientific article

Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23.

scientific article published on 3 September 2013

Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets ⬇️

scientific article published on October 23, 2010

Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5.

scientific article published in January 1993

Connections in pharmacology: innovation serving translational medicine

scientific article (publication date: July 2014)

Contrasting roles for RANTES and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in a murine model of allergic peritonitis

scientific article published on August 1999

Control of myeloid cell trafficking in resolution.

scientific article published on 30 April 2013

Controlling inflammation: a fat chance?

scientific article

Corrections: Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation

article

Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation.

scientific article published on June 2005

Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides

scientific article published on 7 May 2013

Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing

scientific article

Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry.

scientific article

Cytokine modulation of liver annexin 1 expression during experimental endotoxemia

scientific article

Cytokines, glucocorticoids and lipocortins in the control of neutrophil migration

scientific article published on 01 July 1994

D-Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine-γ-lyase

scientific article published on 18 February 2016

Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation

scientific article

Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature

scientific article published on 12 August 2010

Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC

scientific journal article

Dexamethasone inhibits leukocyte emigration in rat mesenteric post-capillary venules: an intravital microscopy study ⬇️

scientific article published on 01 September 1997

Dexamethasone reduces cell surface levels of CD11b on human eosinophils.

scientific article

Differential modulation of annexin I binding sites on monocytes and neutrophils

scientific article published on January 1999

Distinct localization of T cell Agrin during antigen presentation - evidence for the expression of Agrin receptor(s) in antigen-presenting cells

scientific article published on 21 May 2012

Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain

scientific article published in 2022

Down-regulation of the anti-inflammatory protein annexin A1 in cystic fibrosis knock-out mice and patients

scientific article published on 12 July 2005

Downstream gene activation of the receptor ALX by the agonist annexin A1.

scientific article

Editorial: To resolve or not to resolve: Annexin A1 pushes resolution on track ⬇️

scientific article published on 01 August 2012

Effect of interleukin-1 beta on the release of substance P from rat isolated spinal cord

scientific article published on 01 March 1996

Endogenous Annexin-A1 Negatively Regulates Mast Cell-Mediated Allergic Reactions

scientific article published on 13 November 2019

Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo.

scientific article published on 30 November 2017

Endogenous Galectin-1 Exerts Tonic Inhibition on Experimental Arthritis ⬇️

scientific article published on May 29, 2013

Endogenous annexin A1 (AnxA1) modulates early phase gestation and offspring sex-ratio skewing

scientific article published on 8 November 2017

Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis.

scientific article

Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice.

scientific article

Endogenous corticosteroids mediate the neutrophilia caused by platelet-activating factor in the mouse

scientific article published on 01 September 1995

Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect.

scientific article

Endogenous galectins and the control of the host inflammatory response

scientific article published on 20 January 2009

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor

scientific article (publication date: November 2002)

Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model ⬇️

scientific article published on January 1, 1998

Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: involvement of NK-1 receptors

scientific article published on 01 September 1993

Eotaxin-induced eosinophil migration in the peritoneal cavity of ovalbumin-sensitized mice: mechanism of action ⬇️

scientific article published on 01 August 1997

Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature

scientific article published on 11 March 2011

Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice

scientific article published on January 1, 1992

Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma.

scientific article published on 24 November 2017

Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics

scientific article published on October 2009

Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca2+/MAPK signalling transduction pathway

scientific article published on 23 September 2019

FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis.

scientific article

Formyl peptide receptor 1 signalling promotes experimental colitis in mice

scientific article published on 31 January 2019

Formyl peptide receptor as a novel therapeutic target for anxiety-related disorders

scientific article published on 17 December 2014

Formyl peptide receptor type 2 agonists to kick-start resolution pharmacology

scientific article published on 20 September 2020

Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides

scientific article published on 11 January 2007

Formyl-Peptide Receptor 2/3/Lipoxin A4 Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in Cardiovascular Disease

scientific article

Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in murine acute myocardial infarct.

scientific article published on 26 October 2004

Functional and ultrastructural analysis of annexin A1 and its receptor in extravasating neutrophils during acute inflammation

scientific journal article

Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation.

scientific article published on 24 April 2017

Gapdh gene expression is modulated by inflammatory arthritis and is not suitable for qPCR normalization

scientific article

Generation of innovative anti-inflammatory and anti-arthritic glucocorticoid derivatives that release NO: the nitro-steroids

scientific article published in May 2003

Glucocorticoid receptor activation reduces CD11b and CD49d levels on murine eosinophils: characterization and functional relevance

scientific article published on 01 June 2000

Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands

scientific article published in September 2003

Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cells.

scientific article

Glucocorticoid upregulation of the annexin-A1 receptor in leukocytes

scientific article published on 7 September 2006

Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids

scientific article

H and L Chain Affinity Maturation and/or Fab N-Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones

scientific article published on 27 March 2020

Heparan sulfate binds the extracellular Annexin A1 and blocks its effects on pancreatic cancer cells

scientific article published on 27 September 2020

Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties

scientific article published on 08 May 2013

Human RCAN3 gene expression and cell growth in endothelial cells

scientific article published on December 2010

Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo

scientific article published on April 2010

Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways

scientific article published on 12 April 2017

IL-17A increases ADP-induced platelet aggregation.

scientific article

Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates

scientific article

Identification of a novel recycling sequence in the C-tail of FPR2/ALX receptor: association with cell protection from apoptosis.

scientific article published on 17 October 2014

Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: a potential involvement of immune cell cross-talk

scientific article published on 04 April 2019

Identification of novel predictor classifiers for inflammatory bowel disease by gene expression profiling

scientific article

Imbalance of pro-resolving lipid mediators in persistent allodynia dissociated from signs of clinical arthritis

scientific article published on 04 May 2020

Immune Cell Plasticity in Inflammation: Insights into Description and Regulation of Immune Cell Phenotypes

scientific article published in 2022

Immune resolution mechanisms in inflammatory arthritis

scientific article published on 5 January 2017

Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells

scientific article published on 29 February 2020

Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells

scientific article published in November 2007

Impaired phagocytic mechanism in annexin 1 null macrophages

scientific article published on 24 April 2006

In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation.

scientific article published on February 2005

Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice

scientific article

Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I)

scientific article published on 01 March 2000

Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion

scientific article published on 29 August 2008

Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis.

scientific article published on 22 January 2010

Inflammatory resolution: new opportunities for drug discovery

scientific article published on May 2004

Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1.

scientific article published on March 1997

Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects

scientific article

Inhibitory control of TGF-beta1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes.

scientific article published on 3 March 2005

Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking

scientific article published on 26 October 2007

Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo.

scientific article published on October 2004

Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3

scientific article published on 10 March 2006

Interleukin 17 sustains rather than induces inflammation.

scientific article

Investigation of the functional role played by the chemokine monocyte chemoattractant protein-1 in interleukin-1-induced murine peritonitis

scientific article published on September 1998

Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression

scientific article published on 24 October 2013

Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics

scientific article published in June 2001

IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD.

scientific article published on 6 May 2016

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

scientific article (publication date: July 2015)

Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis

scientific article published on 6 August 2009

Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms

scientific article

Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule. Involvement of endogenous lipocortin 1 ⬇️

scientific article published on 01 July 1995

Ligand Bias and Its Association With Pro-resolving Actions of Melanocortin Drugs

article

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses.

scientific article published on 09 October 2013

Ligand-specific glucocorticoid receptor activation in human platelets

scientific article published on 30 August 2005

Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function

scientific article

Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat.

scientific article

Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration ⬇️

scientific article published on November 15, 1997

Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment

scientific article published on 01 October 2000

Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody.

scientific article published on October 1993

Loss of 15-lipoxygenase disrupts T<sub>reg</sub> differentiation altering their pro-resolving functions

scientific article published on 27 May 2021

MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct

scientific article published on 26 July 2004

Macrophage biology in the Anx-A1-/- mouse.

scientific article

Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: modulation by glucocorticoids and inflammation

scientific article published on June 1996

Mediators of the Resolution of the Inflammatory Response

scientific article published on 13 February 2019

Melanocortin 3 receptors control crystal-induced inflammation

scientific article published on 01 November 2006

Melanocortin Control of Cell Trafficking in Vascular Inflammation ⬇️

scientific article published on January 1, 2010

Melanocortin Receptors as Novel Effectors of Macrophage Responses in Inflammation ⬇️

scientific article published on September 13, 2011

Melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection.

scientific article published on 17 August 2016

Melanocortin receptor signaling in RAW264.7 macrophage cell line

scientific article published on 15 November 2005

Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2

scientific article published on 07 December 2020

Mesoglycan induces keratinocyte activation by triggering syndecan-4 pathway and the formation of the annexin A1/S100A11 complex

scientific article published on 08 April 2019

Mesoglycan induces the secretion of microvesicles by keratinocytes able to activate human fibroblasts and endothelial cells: A novel mechanism in skin wound healing

scientific article published on 26 December 2019

Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis

scientific article published on 15 December 2013

Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration

scientific article published on 01 November 1996

Modulation of ICAM-1 levels on U-937 cells and mouse macrophages by interleukin-1 beta and dexamethasone

scientific article published on June 1996

Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1

scientific article published on 01 February 1993

Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions

scientific article published on 01 May 1999

Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1.

scientific article published on 13 November 2009

Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis.

scientific article published in March 2004

Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26)

scientific article published on 01 March 2005

Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins ⬇️

scientific article published on 01 October 1997

Molecular engineering of short half-life small peptides (VIP, αMSH and γ₃MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics

scientific article

Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain

scientific article published on 17 April 2014

NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice

scientific article

Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages

scientific article published on 7 February 2018

Neutrophil accumulation induced by bacterial lipopolysaccharide: effects of dexamethasone and annexin 1

scientific article published on 01 January 2001

Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo

scientific journal article

Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post-ischemia/reperfusion injury

scientific article published on 22 March 2019

Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression

scientific article published on February 2001

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis.

scientific article published in November 2015

Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy.

scientific article published on 12 December 2016

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.

scientific article

Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation

scientific article published on 03 June 2019

Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow

scientific article published on 27 March 2008

Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3

scientific article

POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation

scientific article published on 01 June 1999

Peptide 204–212 of lipocortin 5 inhibits the generation of a prostacyclin-like factor from rat aorta preparations in vitro ⬇️

scientific article published on 01 November 1992

Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet

scientific article

Pharmacology of interleukin-1-induced neutrophil migration

scientific article published on 01 January 1993

Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes

scientific article published on 28 June 2019

Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis

scientific article

Prednisolone exerts exquisite inhibitory properties on platelet functions ⬇️

scientific article published on February 16, 2012

Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1

scientific article published on November 1998

Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1.

scientific article

Proresolving and Tissue-Protective Actions of Annexin A1–Based Cleavage-Resistant Peptides Are Mediated by Formyl Peptide Receptor 2/Lipoxin A4 Receptor ⬇️

scientific article published on May 17, 2013

Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis

scientific article

Proresolving lipid mediators enhance PMN-mediated bacterial clearance

scientific article published on 16 April 2020

Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection

scientific article

Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance

scientific article published on 04 March 2019

Purification and biological activity of human lipocortin 2.

scientific article

Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor

scientific article published in March 2003

Regulation of leukocyte-endothelial interactions by glucocorticoids.

scientific article

Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC)

scientific article published on 01 April 1996

Resident mast cells are important for eotaxin-induced eosinophil accumulation in vivo ⬇️

scientific article published on August 1, 1998

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation.

scientific article

Resolution of Inflammation: What Controls Its Onset?

scientific article

Resolution of inflammation: examples of peptidergic players and pathways

scientific article published on 29 May 2014

Resolution of inflammation: state of the art, definitions and terms

scientific article

Resolution of inflammation: targeting GPCRs that interact with lipids and peptides

scientific article published on 30 June 2014

Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions

scientific article

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

scientific article

Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation

scientific article

Resolvins suppress tumor growth and enhance cancer therapy.

scientific article published on 30 November 2017

Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection

scientific journal article

Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation

scientific article published on 01 December 1998

Role of lipocortin‐1 in the anti‐hyperalgesic actions of dexamethasone ⬇️

scientific article published on July 1, 1997

Role of melanocortin receptors in the regulation of gouty inflammation.

scientific article published on April 2011

Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10.

scientific article published in February 1999

Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves.

scientific article

Selective inhibition of neutrophil function by a peptide derived from lipocortin 1 N-terminus

scientific article

Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.

scientific article

Senescence under appraisal: hopes and challenges revisited

publication published in 2021

Serum corticosterone, interleukin-1 and tumour necrosis factor in rat experimental endotoxaemia: comparison between Lewis and Wistar strains

scientific article

Smooth muscle cells in human atherosclerosis: Proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease

scientific article published on 12 November 2012

Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis.

scientific article

Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo.

scientific article

Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model

scientific article published on 27 December 2011

Stimulus-dependent specificity for annexin 1 inhibition of the inflammatory nociceptive response: the involvement of the receptor for formylated peptides.

scientific article

Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages.

scientific article published on 14 June 2004

Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice.

scientific article

Subacute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes

scientific article published on February 1997

Suppression by dexamethasone of inducible nitric oxide synthase protein expression in vivo: a possible role for lipocortin 1

scientific article published on 01 February 1998

Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin

scientific article

Switching on resolution to treat RA moves closer to reality

scientific article published on 30 November 2020

Synthesis of nitro esters of prednisolone, new compounds combining pharmacological properties of both glucocorticoids and nitric oxide

scientific article

Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

scientific article published on February 2015

Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody

scientific article published on 14 February 2020

The Annexin A1/FPR2 pathway controls the inflammatory response and bacterial dissemination in experimental pneumococcal pneumonia

scientific article published on 26 December 2019

The Atlas of Inflammation Resolution (AIR)

scientific article published on 29 August 2020

The Atlas of Inflammation Resolution (AIR)

scientific article published on 03 September 2020

The Melanocortin Agonist AP214 Exerts Anti-Inflammatory and Proresolving Properties ⬇️

scientific article published on May 10, 2011

The ability of murine leukocytes to bind lipocortin 1 is lost during acute inflammation

scientific article published on 01 April 1993

The annexin-1 knockout mouse: what it tells us about the inflammatory response.

scientific article

The calcitonin and glucocorticoids combination: mechanistic insights into their class-effect synergy in experimental arthritis

scientific article

The cardio-protective properties of Ncx-6550, a nitric oxide donating pravastatin, in the mouse.

scientific article published on August 2010

The distinct alterations produced in cardiovascular functions by prednisolone and nitro-prednisolone (NCX-1015) in the rat highlight a causal role for endothelin-1.

scientific article published on 27 April 2004

The effect of galectins on leukocyte trafficking in inflammation: sweet or sour?

scientific article published on 18 January 2012

The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation

scientific article published on 01 November 2018

The formyl peptide fMLF primes platelet activation and augments thrombus formation

scientific article published on 24 May 2019

The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis

scientific article published on 5 May 2012

The impact of environmental enrichment on the murine inflammatory immune response

scientific article published on 06 April 2017

The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner.

scientific article

The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage.

scientific article published on 25 January 2006

The peritoneal tumour microenvironment of high-grade serous ovarian cancer.

scientific article published on 18 April 2012

The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1.

scientific article

The role of neutrophils in inflammation resolution

scientific article published on 24 March 2016

The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil

scientific article published on 21 January 2016

Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists

scientific article

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

scientific article published on 06 February 2020

Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation

scientific article

Uneven modulation of the annexin 1 system in osteoblast-like cells by dexamethasone

scientific article (publication date: 9 March 2007)

Up-regulation of Annexin-A1 and lipoxin A(4) in individuals with ulcerative colitis may promote mucosal homeostasis

scientific article

[D-Trp8]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse)

scientific article published on 07 September 2006

microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression

scientific article published on 17 December 2020

n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis

scientific article published on 01 November 2018

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