List of works - Arjan Kortholt

Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis

scientific article

Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis

scientific article

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

scientific article published on June 11, 2012

Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

scientific article published on December 1, 2011

A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected].

scientific article

Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation

scientific article published on 05 May 2014

Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling

scientific article

Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC.

scientific article published on 14 August 2008

Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis

scientific article

Ras activation and symmetry breaking duringDictyosteliumchemotaxis

scientific article published on July 25, 2013

Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

scientific article published on 7 January 2016

Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement

scientific article

Revisiting the Roco G-protein cycle

scientific article published on January 1, 2015

A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells

scientific article (publication date: 2016)

Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility

scientific article published on 7 November 2012

GxcC connects Rap and Rac signaling during Dictyostelium development

scientific article

Multiple regulatory mechanisms for the Dictyostelium Roco protein GbpC.

scientific article

Rap1-dependent pathways coordinate cytokinesis in Dictyostelium

scientific article

Function and Regulation of Heterotrimeric G Proteins during Chemotaxis

scientific article published on January 14, 2016

Roco Proteins: GTPases with a Baroque Structure and Mechanism

scientific article published on 03 January 2019

GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis.

scientific article published on 6 November 2017

Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection.

scientific article

Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein

scientific article published on 07 January 2019

Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization.

scientific article

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

scientific article published on 17 March 2022

Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis

scientific article published on 04 August 2021

List of works by Arjan Kortholt

Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis

Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected].

Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation

Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling

Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC.

Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis

Ras activation and symmetry breaking duringDictyosteliumchemotaxis

Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement

Revisiting the Roco G-protein cycle

A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells

Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility

GxcC connects Rap and Rac signaling during Dictyostelium development

Multiple regulatory mechanisms for the Dictyostelium Roco protein GbpC.

Rap1-dependent pathways coordinate cytokinesis in Dictyostelium

Function and Regulation of Heterotrimeric G Proteins during Chemotaxis

Roco Proteins: GTPases with a Baroque Structure and Mechanism

GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis.

Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection.

Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein

Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization.

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis

PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner