Search filters

List of works by Andre J van Wijnen

1alpha,25-dihydroxy vitamin D(3) induces nuclear matrix association of the 1alpha,25-dihydroxy vitamin D(3) receptor in osteoblasts independently of its ability to bind DNA

scientific article

1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex

scientific journal article

A Combination of a Polycaprolactone Fumarate Scaffold with Polyethylene Terephthalate Sutures for Intra-Articular Ligament Regeneration

scientific article published on 20 May 2017

A Drug Eluting Scaffold for the Treatment of Arthrofibrosis

scientific article published on 01 September 2018

A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation

scientific article

A Runx2 threshold for the cleidocranial dysplasia phenotype

scientific article

A Simple Dynamic Strategy to Deliver Stem Cells to Decellularized Nerve Allografts

scientific article published on 01 August 2018

A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model

scientific article published on 01 April 2019

A Versatile Protocol for Studying Calvarial Bone Defect Healing in a Mouse Model

scientific article published on 24 May 2017

A central dinucleotide within vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands

scientific article

A conserved interaction that is essential for the biogenesis of histone locus bodies

scientific article

A current review of molecular mechanisms regarding osteoarthritis and pain

scientific article

A functional N-terminal domain in C/EBPβ-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts

scientific article

A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation

scientific article published on 30 June 2013

A microRNA signature for a BMP2-induced osteoblast lineage commitment program

scientific article

A multi-chamber tissue culture device for load-dependent parallel evaluation of tendon explants

scientific article published on 18 November 2019

A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program

scientific article

A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2

scientific journal article

ATF1 and CREB Trans-Activate a Cell Cycle Regulated Histone H4 Gene at a Distal Nuclear Matrix Associated Promoter Element ⬇️

scientific article published on November 25, 1997

Absence of VEGFR-1/Flt-1 signaling pathway in mice results in insensitivity to discogenic low back pain in an established disc injury mouse model

scientific article published on 25 December 2019

Acquired Idiopathic Stiffness After Total Knee Arthroplasty: A Systematic Review and Meta-Analysis

scientific article published on 01 July 2019

Activation of the bone-related Runx2/Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton

scientific article published in June 2002

Acute-phase protein serum amyloid A3 is a novel paracrine coupling factor that controls bone homeostasis

scientific article

Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia

scientific article published on 09 September 2016

Affinity Selection of FGF2-Binding Heparan Sulfates for Ex Vivo Expansion of Human Mesenchymal Stem Cells

scientific article

Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model

scientific article

Alterations in genetic and protein content of swine adipose tissue-derived mesenchymal stem cells in the metabolic syndrome.

scientific article published on 18 March 2019

Alterations in intranuclear localization of Runx2 affect biological activity

scientific article published on December 2006

Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network

scientific article

Altered spinal microRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints

scientific article

An architectural genetic and epigenetic perspective

scientific article published on 24 December 2010

An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition.

scientific article published on December 2006

An architectural perspective of vitamin D responsiveness.

scientific article published on 8 January 2007

Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate

scientific article published on 12 January 2016

Analysis of in vivo gene expression using epitope-tagged proteins

scientific article published on 01 January 2004

Animal models for studying the etiology and treatment of low back pain.

scientific article

Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells

scientific article published on 12 October 2016

Anti-fibrotic effects of the antihistamine ketotifen in a rabbit model of arthrofibrosis

scientific article published on 01 June 2020

Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information

scientific article

Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments

scientific article

Author Correction: Sustained perfusion of revascularized bioengineered livers heterotopically transplanted into immunosuppressed pigs

scientific article published on 05 November 2019

Autogenous Arteriovenous Bundle Implantation Maintains Viability Without Increased Immune Response in Large Porcine Bone Allotransplants

scientific article published on 18 September 2020

Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease.

scientific article published on 08 April 2017

BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network.

scientific article published on 23 October 2006

Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes

scientific article published on 27 August 2007

Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes.

scientific article published on 31 October 2009

Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes

scientific article

Bioactive lipids lysophosphatidic acid and sphingosine 1-phosphate mediate breast cancer cell biological functions through distinct mechanisms.

scientific article published in January 2009

Biological Effects of Gyrophoric Acid and Other Lichen Derived Metabolites, on Cell Proliferation, Apoptosis and Cell Signaling pathways

scientific article published in January 2022

Biological Functions of Chromobox (CBX) Proteins in Stem Cell Self-Renewal, Lineage-Commitment, Cancer and Development

scientific article published on 23 September 2020

Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis.

scientific article published on 28 December 2017

Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells

scientific article published in October 2012

Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation

scientific article published on 02 April 2009

Biological strategies for improved osseointegration and osteoinduction of porous metal orthopedic implants

scientific article

Bipartite structure of the proximal promoter of a human H4 histone gene ⬇️

scientific article published on July 1, 1995

Blockade of Vascular Endothelial Growth Factor Receptor-1 (Flt-1), Reveals a Novel Analgesic For Osteoarthritis-Induced Joint Pain.

scientific article published on 8 March 2018

Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2)

scientific article

Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells

scientific journal article

Bookmarking target genes in mitosis: a shared epigenetic trait of phenotypic transcription factors and oncogenes?

scientific article published on 09 January 2014

Bookmarking the genome: maintenance of epigenetic information.

scientific article

Bovine lactoferricin induces TIMP-3 via the ERK1/2-Sp1 axis in human articular chondrocytes

scientific article published on 11 January 2013

Bovine lactoferricin is anti-inflammatory and anti-catabolic in human articular cartilage and synovium

scientific article

Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes

scientific article published on January 2006

C/EBPβ binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells

scientific article published on November 2011

CBFβ and the leukemogenic fusion protein CBFβ-SMMHC associate with mitotic chromosomes to epigenetically regulate ribosomal genes

scientific article

CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P

scientific article

CORR® ORS Richard A. Brand Award: Disruption in Peroxisome Proliferator-Activated Receptor-γ (PPARG) Increases Osteonecrosis Risk Through Genetic Variance and Pharmacologic Modulation

scientific article published on 01 August 2019

Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility ⬇️

scientific article

Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene Expression

scientific article published in Journal of Biological Chemistry

Cell Cycle Regulation of Histone H4 Gene Transcription Requires the Oncogenic Factor IRF-2 ⬇️

scientific article published on January 2, 1998

Cell cycle dependent phosphorylation and subnuclear organization of the histone gene regulator p220(NPAT) in human embryonic stem cells.

scientific article published on October 2007

Cell cycle related modulations in Runx2 protein levels are independent of lymphocyte enhancer-binding factor 1 (Lef1) in proliferating osteoblasts

scientific article published on 21 September 2007

Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts ⬇️

scientific article published on September 1, 2003

Challenges in the Measurement and Interpretation of Serum Titanium Concentrations

scientific article published on 06 November 2019

Characterization of a new animal model for evaluation and treatment of back pain due to lumbar facet joint osteoarthritis

scientific article

Chondrocyte Attachment, Proliferation, and Differentiation on Three-Dimensional Polycaprolactone Fumarate Scaffolds

scientific article published on 31 March 2017

Chromatin dynamics regulate mesenchymal stem cell lineage specification and differentiation to osteogenesis

scientific article published on 8 January 2017

Chromatin immunoprecipitation

scientific article published on 01 January 2004

Chromatin immunoprecipitation assays: application of ChIP-on-chip for defining dynamic transcriptional mechanisms in bone cells.

scientific article

Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells

scientific article

Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease

scientific article published on 31 March 2015

Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity

scientific article

Chromatin remodeling by SWI/SNF results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter

scientific article published on February 2007

Circulating microRNA-23b as a new biomarker for rheumatoid arthritis

scientific article published on 06 June 2019

Clinical Factors, Disease Parameters, and Molecular Therapies Affecting Osseointegration of Orthopedic Implants

scientific article published on 29 June 2016

Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats)

scientific article

Cobalt and Chromium Ion Release in Metal-on-Polyethylene and Ceramic-on-Polyethylene THA: A Simulator Study With Cellular and Microbiological Correlations

scientific article published on 27 November 2019

Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer

scientific article

Comparative proteomic analysis of extracellular vesicles isolated from porcine adipose tissue-derived mesenchymal stem/stromal cells

scientific article published on 27 October 2016

Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine.

scientific article published on 26 October 2017

Contribution of transposable elements in the plant's genome

scientific article published on 22 April 2018

Control of 1,25-dihydroxyvitamin D3 receptor-mediated enhancement of osteocalcin gene transcription: effects of perturbing phosphorylation pathways by okadaic acid and staurosporine ⬇️

scientific article published on 01 December 1995

Control of bone development by P2X and P2Y receptors expressed in mesenchymal and hematopoietic cells

scientific article published on 14 June 2015

Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2.

scientific article

Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.

scientific article

Coordinate control and selective expression of the full complement of replication-dependent histone H4 genes in normal and cancer cells

scientific article published on 29 August 2005

Core binding factor β (CBFβ) is retained in the midbody during cytokinesis

scientific article

Corrigendum to "Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells" [Gene. 2013 Jul. 25; 524(2):282-91].

scientific article

Corrigendum to "Mir-202-3p regulates interleukin-1β-induced expression of matrix metalloproteinase 1 in human nucleus pulposus" [Gene 687 (2019) 156-165]

scientific article published on 13 February 2019

Corrigendum to "Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain" [GENE 655 (2018) 1-12]

scientific article published on 12 June 2018

Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells

scientific article

Cytotoxic Effects of Nonionic Iodinated Contrast Agent on Human Adipose-Derived Mesenchymal Stem Cells

scientific article published on 01 June 2018

Cytotoxicity of Local Anesthetics in Mesenchymal Stem Cells

scientific article published in January 2018

Decreased local and systemic levels of sFRP3 protein in osteosarcoma patients

scientific article published on 19 June 2018

Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.

scientific article

Development of an In Vivo Mouse Model of Discogenic Low Back Pain.

scientific article published on 18 November 2017

Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse

scientific article

Dickkopf-1 reduces hypertrophic changes in human chondrocytes derived from bone marrow stem cells

scientific article published on 14 November 2018

Differences in cytotoxicity of lidocaine, ropivacaine, bupivacaine on the viability and metabolic activity of human adipose-derived mesenchymal stem cells

scientific article published on 09 July 2020

Differential gene expression analysis using paraffin-embedded tissues after laser microdissection

scientific article published in December 2003

Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma

scientific article

Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene.

scientific article published on October 2004

Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression

scientific article published on 18 August 2009

Effect of Lidocaine on Viability and Gene Expression of Human Adipose-derived Mesenchymal Stem Cells: An in vitro Study

scientific article published on 30 May 2019

Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells

scientific article

Efficacy of intervertebral disc regeneration with stem cells - a systematic review and meta-analysis of animal controlled trials

scientific article published on 19 March 2015

Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma.

scientific article

Engineering Cartilage Tissue by Co-culturing of Chondrocytes and Mesenchymal Stromal Cells

scientific article published on 01 January 2021

Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice

scientific article published on 10 October 2016

Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice

scientific article published on 13 June 2018

Enhancing the Efficacy of Stem Cell Therapy with Glycosaminoglycans

scientific article published on 02 January 2020

Environmental disruption of circadian rhythm predisposes mice to osteoarthritis-like changes in knee joint

scientific article published on September 2015

Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2

scientific article

Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B.

scientific article published on 9 October 2015

Epigenetic control of cell cycle-dependent histone gene expression is a principal component of the abbreviated pluripotent cell cycle.

scientific article

Epigenetic mechanisms in leukemia

scientific article published on 24 May 2012

Epigenetic modifications and canonical wingless/int-1 class (WNT) signaling enable trans-differentiation of nonosteogenic cells into osteoblasts

scientific article

Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex

scientific article

Epigenetics as a New Frontier in Orthopedic Regenerative Medicine and Oncology

scientific article published on 25 April 2019

Epithelial-to-mesenchymal transition and cancer stem cells contribute to breast cancer heterogeneity

scientific article published on 03 July 2018

Erratum to: RNA sequencing reveals a depletion of collagen targeting microRNAs in Dupuytren's disease.

scientific article published on 13 July 2016

Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells

scientific article published in February 2007

Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.

scientific article published on 29 January 2013

Expression of Runx2 transcription factor in non-skeletal tissues, sperm and brain

scientific article

Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2

scientific article published on 19 June 2018

Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha

scientific article

Extracellular matrix protein production in human adipose-derived mesenchymal stem cells on three-dimensional polycaprolactone (PCL) scaffolds responds to GDF5 or FGF2

scientific article published on 28 December 2017

Extracellular vesicles from osteosarcoma cell lines contain miRNAs associated with cell adhesion and apoptosis

scientific article published on 06 June 2019

FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors p21(Waf1) and p27(Kip1).

scientific article published in December 2013

FSTL1 promotes nitric oxide-induced chondrocyte apoptosis via activating the SAPK/JNK/caspase3 signaling pathway

scientific article published on 09 January 2020

Fabrication of polycaprolactone-silanated β-tricalcium phosphate-heparan sulfate scaffolds for spinal fusion applications.

scientific article published on 18 December 2017

Fibrin glue mediated delivery of bone anabolic reagents to enhance healing of tendon to bone

scientific article published in February 2018

Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes

scientific article published on 11 August 2011

Fidelity of histone gene regulation is obligatory for genome replication and stability

scientific article

Flyingfish (Exocoetidae) species diversity and habitats in the eastern tropical Pacific Ocean

scientific article published on 09 March 2017

Follistatin-like protein 1 induction of matrix metalloproteinase 1, 3 and 13 gene expression in rheumatoid arthritis synoviocytes requires MAPK, JAK/STAT3 and NF-κB pathways

scientific article published on 01 January 2018

Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells

scientific article

Four novel RUNX2 mutations including a splice donor site result in the cleidocranial dysplasia phenotype.

scientific article published in April 2006

Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair.

scientific article published on November 2003

Functional characterization of a human histone gene cluster duplication

scientific article

Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development.

scientific article

Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells

scientific article published on 04 February 2020

Gene Wiki Reviews: marrying crowdsourcing with traditional peer review

scientific article published on 5 September 2013

Gene Wiki Reviews—Raising the quality and accessibility of information about the human genome

scientific article (publication date: November 2016)

Gene profiling of cell cycle progression through S-phase reveals sequential expression of genes required for DNA replication and nucleosome assembly

scientific article

Gene regulation through dynamic actin control of nuclear structure

scientific article published on 13 May 2019

Genetic Background Dependent Modifiers of Craniosynostosis Severity

scientific article published on 22 September 2020

Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility

scientific journal article

Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer

scientific article published on August 2008

Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells

scientific article published on 17 April 2015

Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation.

scientific article published on 09 February 2011

Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene

scientific article published on February 2013

Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis.

scientific article published on 21 March 2014

Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility

scientific article published on 9 December 2011

Global epigenetic alterations of mesenchymal stem cells in obesity: The role of vitamin C reprogramming

scientific article published on 06 September 2020

Glycosaminoglycans modulate RANKL-induced osteoclastogenesis

scientific article

HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes.

scientific article published on 26 February 2007

Heparan sulfate enhances the self-renewal and therapeutic potential of mesenchymal stem cells from human adult bone marrow

scientific article

Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity

scientific article

Heparan sulfate regulates the anabolic activity of MC3T3-E1 preosteoblast cells by induction of Runx2.

scientific article published on January 2007

HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.

scientific article

HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription

scientific article

High-resolution molecular validation of self-renewal and spontaneous differentiation in clinical-grade adipose-tissue derived human mesenchymal stem cells.

scientific article

Higher order genomic organization and regulatory compartmentalization for cell cycle control at the G1/S-phase transition

scientific article published on 10 May 2018

Histone Deacetylase 3 Deletion in Mesenchymal Progenitor Cells Hinders Long Bone Development

scientific article published on 7 August 2017

Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1α-TAZ Signaling Pathway in Osteoblasts

scientific article

Histone Deacetylases in Bone Development and Skeletal Disorders.

scientific article

Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation

scientific article published on 9 November 2016

Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription

scientific article

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

scientific article

Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells

scientific article

Histone deacetylase inhibition promotes osteoblast maturation by altering the histone H4 epigenome and reduces Akt phosphorylation.

scientific article published on 12 August 2013

Histone deacetylase inhibitors reduce differentiating osteoblast-mediated protection of acute myeloid leukemia cells from cytarabine

scientific article published on 10 October 2017

Human Adipose-Derived Mesenchymal Stromal/Stem Cells Remain Viable and Metabolically Active Following Needle Passage.

scientific article published on 27 January 2016

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions

scientific article published on 18 April 2015

Human Fibrosis: Is There Evidence for a Genetic Predisposition in Musculoskeletal Tissues?

scientific article published on 04 June 2020

Human Mesenchymal Stem Cells Retain Multilineage Differentiation Capacity Including Neural Marker Expression after Extended In Vitro Expansion

scientific article published on 10 September 2015

Human embryonic stem cells are pre-mitotically committed to self-renewal and acquire a lengthened G1 phase upon lineage programming

scientific article

Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2

scientific article published on 9 June 2012

Hypothermia and nutrient deprivation alter viability of human adipose-derived mesenchymal stem cells

scientific article published on 05 September 2019

Hypoxia-related microRNA-210 is a diagnostic marker for discriminating osteoblastoma and osteosarcoma

scientific article published on 21 June 2016

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production

scientific article published on 11 August 2016

Identification of HiNF-P, a Key Activator of Cell Cycle-Controlled Histone H4 Genes at the Onset of S Phase ⬇️

scientific article published on November 1, 2003

Identification of RUNX3 as a component of the MST/Hpo signaling pathway

scientific article published on February 2012

Identification of Three Early Phases of Cell-Fate Determination during Osteogenic and Adipogenic Differentiation by Transcription Factor Dynamics

scientific article published on 16 March 2017

Identification of differentially methylated regions in new genes associated with knee osteoarthritis.

scientific article

Identification of novel protein/DNA interactions within the promoter of the bone-related transcription factor Runx2/Cbfa1.

scientific article published on January 2002

Identification of osteolineage cell-derived extracellular vesicle cargo implicated in hematopoietic support

scientific article published on 21 February 2020

Identifying Nuclear Matrix-Attached DNA Across the Genome

scientific article published on 14 September 2016

Immobilization of vitronectin-binding heparan sulfates onto surfaces to support human pluripotent stem cells.

scientific article published on 20 September 2017

Immunofluorescence analysis using epitope-tagged proteins: in vitro system

scientific article published on 01 January 2004

Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells

scientific article

Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.

scientific article

Improved Post-Thaw Function and Epigenetic Changes in Mesenchymal Stromal Cells Cryopreserved Using Multicomponent Osmolyte Solutions.

scientific article published on 8 February 2017

In Vivo Survival of Mesenchymal Stromal Cell-Enhanced Decellularized Nerve Grafts for Segmental Peripheral Nerve Reconstruction

scientific article published on 06 October 2018

In situ immunofluorescence analysis: analyzing RNA synthesis by 5-bromouridine-5'-triphosphate labeling

scientific article

In situ immunofluorescence analysis: immunofluorescence microscopy

scientific article published on 01 January 2004

In situ nuclear organization of regulatory machinery

scientific article published on 01 January 2008

In vivo assessment of high-molecular-weight polyethylene core suture tape for intra-articular ligament reconstruction: an animal study

scientific article published on 01 October 2019

Induction of chondrogenic or mesenchymal stem cells from human periodontal ligament cells through inhibition of Twist2 or Klf12

scientific article published on 01 January 2019

Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells

scientific article published on 11 March 2017

Inhibition of COX-2 Pathway as a Potential Prophylaxis Against Arthrofibrogenesis in a Rabbit Model of Joint Contracture

scientific article published on 26 August 2019

Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status

scientific article published on 02 December 2019

Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines.

scientific article

Inhibition of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses

scientific article published on 19 July 2020

Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2

scientific article published on 24 April 2020

Inhibitory Effects of Insulin-like Growth Factor-1 and Osteogenic Protein-1 on Fibronectin Fragment- and Interleukin-1β-stimulated Matrix Metalloproteinase-13 Expression in Human Chondrocytes ⬇️

scientific article published on May 6, 2003

Injectable Biologics: What is the Evidence?

scientific article published on 19 March 2020

Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc cells

scientific article

Integrated transcriptomic and proteomic analysis of the molecular cargo of extracellular vesicles derived from porcine adipose tissue-derived mesenchymal stem cells

scientific article

Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites

scientific article

Interaction of the 1alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling

scientific journal article

Interrelationships of nuclear structure and transcriptional control: Functional consequences of being in the right place at the right time ⬇️

scientific article published on August 1, 1998

Intra-articular Injection of a Substance P Inhibitor Affects Gene Expression in a Joint Contracture Model.

scientific article

Intra-renal delivery of mesenchymal stem cells attenuates myocardial injury after reversal of hypertension in porcine renovascular disease

scientific article published on 19 January 2015

Intraarticular slow-release triamcinolone acetate reduces allodynia in an experimental mouse knee osteoarthritis model

scientific article published on 26 June 2016

Intranuclear Actin Structure Modulates Mesenchymal Stem Cell Differentiation.

scientific article published on 3 April 2017

Intranuclear Trafficking: Organization and Assembly of Regulatory Machinery for Combinatorial Biological Control

scientific article (publication date: 23 July 2004)

Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer.

scientific article

Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer

scientific article

Intranuclear targeting of AML/CBFα regulatory factors to nuclear matrix-associated transcriptional domains ⬇️

scientific article published on February 17, 1998

Intranuclear trafficking of transcription factors: Requirements for vitamin D-mediated biological control of gene expression.

scientific article

Intrarenal Delivery of Mesenchymal Stem Cells and Endothelial Progenitor Cells Attenuates Hypertensive Cardiomyopathy in Experimental Renovascular Hypertension

scientific article published on 21 November 2014

Intricate gene regulatory networks of helix-loop-helix (HLH) proteins support regulation of bone-tissue related genes during osteoblast differentiation

scientific article published on October 2008

Introducing human adipose-derived mesenchymal stem cells to AvanceⓇ nerve grafts and NeuraGenⓇ nerve guides

scientific article published on 11 April 2020

Joint contracture is reduced by intra-articular implantation of rosiglitazone-loaded hydrogels in a rabbit model of arthrofibrosis

scientific article published on 13 July 2018

Knockdown of formin mDia2 alters lamin B1 levels and increases osteogenesis in stem cells

scientific article published on 06 November 2019

Lactoferricin mediates anabolic and anti-catabolic effects in the intervertebral disc

scientific article

Lactoferricin mediates anti‐inflammatory and anti‐catabolic effects via inhibition of IL‐1 and LPS activity in the intervertebral disc ⬇️

scientific article published on September 1, 2013

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

scientific article published in January 2018

Ligament Tissue Engineering Using a Novel Porous Polycaprolactone Fumarate Scaffold and Adipose Tissue-Derived Mesenchymal Stem Cells Grown in Platelet Lysate.

scientific article published on 28 September 2015

Light chain amyloidosis induced inflammatory changes in cardiomyocytes and adipose-derived mesenchymal stromal cells

scientific article published on 03 December 2019

Live cell imaging of the cancer-related transcription factor RUNX2 during mitotic progression

scientific article

Local Cellular Responses to Titanium Dioxide from Orthopedic Implants

scientific article published on July 2017

Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development

scientific article published in Journal of Biological Chemistry

Lumbar intervertebral disc mRNA sequencing identifies the regulatory pathway in patients with disc herniation and spondylolisthesis

scientific article published on 30 March 2020

Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts

scientific article published in April 2006

Lysine-Specific Demethylase 1 (LSD1) epigenetically controls osteoblast differentiation

scientific article published on 07 March 2022

Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells

scientific article

Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes

scientific article published in Nature Communications

Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos

scientific article

Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2

scientific article published on 16 January 2020

Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal os

scientific article published on 26 January 2017

Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve the Renal Microvasculature in Metabolic Renovascular Disease in Swine

scientific article published on 28 June 2018

Mesenchymal stem cell-derived extracellular vesicles attenuate kidney inflammation

scientific article published on 24 February 2017

Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem Cells

scientific article published on 01 June 2019

Metabolic syndrome alters expression of insulin signaling-related genes in swine mesenchymal stem cells

scientific article

MiR-202-3p regulates interleukin-1β-induced expression of matrix metalloproteinase 1 in human nucleus pulposus

scientific article published on 17 November 2018

MicroRNA Levels as Prognostic Markers for the Differentiation Potential of Human Mesenchymal Stromal Cell Donors

scientific article

MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells

scientific article

MicroRNA control of bone formation and homeostasis

scientific article published on 31 January 2012

MicroRNA functions in osteogenesis and dysfunctions in osteoporosis

scientific article published on June 2013

MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis

scientific article

MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc.

scientific article published on 12 October 2014

MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

scientific article published on 29 May 2013

MicroRNAs 221 and 222 bypass quiescence and compromise cell survival

scientific article

Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2.

scientific article published on February 2006

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

scientific article published on 23 November 2018

Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells.

scientific article published on 7 September 2015

Mitotic bookmarking of genes: a novel dimension to epigenetic control.

scientific article

Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells

scientific article published on April 2007

Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2.

scientific article

Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells

scientific journal article

Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2.

scholarly article

Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts

scientific article published on 07 September 2018

Molecular Validation of Chondrogenic Differentiation and Hypoxia Responsiveness of Platelet-Lysate Expanded Adipose Tissue-Derived Human Mesenchymal Stromal Cells

scientific article published on 21 July 2016

Molecular characterization of human osteoblast-derived extracellular vesicle mRNA using next-generation sequencing.

scientific article published on 24 March 2017

Molecular characterization of physis tissue by RNA sequencing

article

Molecular landscape of arthrofibrosis: Microarray and bioinformatic analysis of the temporal expression of 380 genes during contracture genesis

scientific article published on 03 February 2017

Molecular pathology of adverse local tissue reaction caused by metal-on-metal implants defined by RNA-seq

scientific article published on 21 September 2018

Molecular pathology of human knee arthrofibrosis defined by RNA sequencing

scientific article published on 05 March 2020

Molecular pathology of total knee arthroplasty instability defined by RNA-seq

scientific article published on 22 November 2017

Molecular signatures of multiple myeloma progression through single cell RNA-Seq

scientific article published on 03 January 2019

Molecular switches involving homeodomain proteins, HOXA10 and RUNX2 regulate osteoblastogenesis

scientific article published on 14 August 2008

Multi-disciplinary antimicrobial strategies for improving orthopaedic implants to prevent prosthetic joint infections in hip and knee

scientific article

Multiphasic scaffold for scapholunate interosseous ligament reconstruction: a study in the rabbit knee

scientific article published on 24 June 2020

Multiple levels of steroid hormone-dependent control of osteocalcin during osteoblast differentiation: Glucocorticoid regulation of basal and vitamin D stimulated gene expression ⬇️

scientific article published on May 1, 1998

Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins

scientific article

Neo-Angiogenesis, Transplant Viability, and Molecular Analyses of Vascularized Bone Allotransplantation Surgery in a Large Animal Model

scientific article published on 06 October 2019

Networks and hubs for the transcriptional control of osteoblastogenesis.

scientific article published on June 2006

Nicotinamide Phosphoribosyltransferase Inhibitor APO866 Prevents IL-1β-Induced Human Nucleus Pulposus Cell Degeneration via Autophagy

scientific article published on 27 September 2018

Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation

scientific journal article

Nomenclature for Runt-related (RUNX) proteins

scientific article

Nuclear Structure - Skeletal Gene Expression Interrelationships ⬇️

scientific article published on August 1, 1998

Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing

scientific article

Nuclear matrix associated DNA-binding proteins of ocular lens epithelial cells

scientific article published on January 1, 1998

Nuclear microenvironments in biological control and cancer.

scientific article published on June 2007

Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation

scientific article published on February 2004

Nuclear microenvironments support physiological control of gene expression

scientific article published in January 2003

Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequence

scientific article published on August 2007

Obesity-induced mitochondrial dysfunction in porcine adipose tissue-derived mesenchymal stem cells.

scientific article published on 15 December 2017

Office-Based Mesenchymal Stem Cell Therapy for the Treatment of Musculoskeletal Disease: A Systematic Review of Recent Human Studies

scientific article published on 01 August 2019

Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells

scientific article published on August 2013

Organization of transcriptional regulatory machinery in nuclear microenvironments: implications for biological control and cancer

scientific article published on 23 March 2007

Organization of transcriptional regulatory machinery in osteoclast nuclei: compartmentalization of Runx1.

scientific article published in September 2005

Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer

scientific article published on February 2009

Osteoarthritic tissues modulate functional properties of sensory neurons associated with symptomatic OA pain

scientific article published on 16 February 2011

Osteoblasts protect AML cells from SDF-1-induced apoptosis.

scientific article

Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells

scientific article published on 02 September 2016

Osteogenic Stimulation of Human Adipose-Derived Mesenchymal Stem Cells Using a Fungal Metabolite That Suppresses the Polycomb Group Protein EZH2.

scientific article published on 27 December 2017

Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium

scientific article published on 13 January 2016

Osteoporosis and osteoarthritis. Preface

scientific article published on 01 January 2015

Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development

scientific journal article

PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth

scientific article published on 18 January 2016

Pain assessment in animal models of osteoarthritis

scientific article published on 10 December 2013

Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors

scientific article

Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain.

scientific article published on 20 February 2018

Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation

scientific article

Phenotypic transcription factors epigenetically mediate cell growth control.

scholarly article

Phenotypic, Transcriptional, and Functional Analysis of Liver Mesenchymal Stromal Cells and Their Immunomodulatory Properties

scientific article published on 04 March 2020

Phosphorylation at serine 208 of the 1alpha,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators

scientific article published on March 2007

Phylogenetics and biogeography of the two-wing flyingfish (Exocoetidae: Exocoetus).

scientific article

Planar cell polarity aligns osteoblast division in response to substrate strain

scientific article

Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype.

scientific article

Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus

scientific article published on 20 May 2016

Population Genetic Structure of the Tropical Two-Wing Flyingfish (Exocoetus volitans)

scientific article (publication date: 2016)

Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer.

scientific article published on 24 July 2009

Primary mouse embryonic fibroblasts: A model of mesenchymal cartilage formation

article

Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing

scientific article

Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis

scientific article published on February 2009

Prostate cancer regulatory networks

scientific article

Protein-deoxyribonucleic acid interactions linked to gene expression: DNase I digestion.

scientific article published on January 2004

Protein-deoxyribonucleic acid interactions linked to gene expression: electrophoretic mobility shift assay

scientific article published on 01 January 2004

Protein-deoxyribonucleic acid interactions linked to gene expression: ligation-mediated polymerase chain reaction

scientific article published on 01 January 2004

Proteomic Analysis of Exosomes and Exosome-Free Conditioned Media From Human Osteosarcoma Cell Lines Reveals Secretion of Proteins Related to Tumor Progression.

scientific article published on 30 June 2016

Quantitative signature for architectural organization of regulatory factors using intranuclear informatics.

scientific article published on 14 September 2004

RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues.

scientific article published on 11 December 2017

RNA sequencing reveals a depletion of collagen targeting microRNAs in Dupuytren's disease

scientific article

RNA-seq analysis of clinical-grade osteochondral allografts reveals activation of early response genes.

scientific article published on 22 February 2016

RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.

scientific article published on 8 August 2016

RUNX1-dependent mechanisms in biological control and dysregulation in cancer

scientific article published on 04 December 2018

RUNX3 facilitates growth of Ewing sarcoma cells

scientific article published on December 2014

Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation

scientific article published on February 2007

Reduced CpG methylation is associated with transcriptional activation of the bone-specific rat osteocalcin gene in osteoblasts

scientific article

Reduction of arthrofibrosis utilizing a collagen membrane drug-eluting scaffold with celecoxib and subcutaneous injections with ketotifen

scientific article published on 05 March 2020

Regulation and biological roles of the multifaceted miRNA-23b (MIR23B).

scientific article published on 31 October 2017

Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity

scientific journal article

Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors

scientific article

Relative mRNA and Protein Stability of Epigenetic Regulators in Musculoskeletal Cell Culture Models

scientific article published on 06 August 2020

Reprogramming the pluripotent cell cycle: restoration of an abbreviated G1 phase in human induced pluripotent stem (iPS) cells

scientific article

Response to Letter to the Editor on "Cobalt and Chromium Ion Release in Metal-on-Polyethylene and Ceramic-on-Polyethylene THA: A Simulator Study With Cellular and Microbiological Correlations"

scientific article published on 20 December 2019

Ribonucleoprotein immunoprecipitation (RNP-IP): a direct in vivo analysis of microRNA-targets

scientific article published in July 2010

Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

scientific article

Runx1 Activities in Superficial Zone Chondrocytes, Osteoarthritic Chondrocyte Clones and Response to Mechanical Loading

scientific article published on February 2015

Runx1 is associated with breast cancer progression in MMTV-PyMT transgenic mice and its depletion in vitro inhibits migration and invasion

scientific article published on October 2015

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

scientific article published on May 2004

Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential.

scholarly article

Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice.

scientific article

Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation

scientific article

Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice

scientific article published on 7 January 2013

Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors

scientific article

Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells

scientific article published on October 2008

Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1).

scientific article published on December 2009

Runx2/Cbfa1 functions: diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions

scientific article

SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells

scientific article published on 19 July 2016

SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation

scientific journal article

SWI/SNF-independent nuclease hypersensitivity and an increased level of histone acetylation at the P1 promoter accompany active transcription of the bone master gene Runx2.

scientific article published on August 2009

Safety Studies for Use of Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells in a Rabbit Model for Osteoarthritis to Support a Phase I Clinical Trial

scientific article

Safety of Intra-Articular Implantation of Oligo[Poly(ethylene glycol) Fumarate] Scaffolds into the Rabbit Knee.

scientific article published on 27 September 2016

Seeding decellularized nerve allografts with adipose-derived mesenchymal stromal cells: An in vitro analysis of the gene expression and growth factors produced

scientific article published on 09 May 2019

Selective expression of specific histone H4 genes reflects distinctions in transcription factor interactions with divergent H4 promoter elements ⬇️

scientific article published on October 23, 1998

Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase

scientific article published on December 2006

Sequence‐specific DNA binding activities of nuclear matrix proteins of mammalian lens epithelial cells ⬇️

scientific article published on 01 May 1995

Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription.

scientific article

Species-specific biological effects of FGF-2 in articular cartilage: implication for distinct roles within the FGF receptor family

scientific article

Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation.

scientific article published on 26 August 2008

Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells

scholarly article

Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal.

scientific article

Subcellular partitioning of transcription factors during osteoblast differentiation: Developmental association of the AML/CBFα/PEBP2α-related transcription factor-NMP-2 with the nuclear matrix ⬇️

scientific article published on July 1, 1997

Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response

scientific article

Subnuclear localization and intranuclear trafficking of transcription factors

scientific article published on January 2010

Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1.

scientific article published on November 2005

Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes.

scientific article

Sulfated glycosaminoglycans mediate the effects of FGF2 on the osteogenic potential of rat calvarial osteoprogenitor cells

scientific journal article

Surgical angiogenesis modifies the cellular environment of processed nerve allografts in a rat sciatic nerve defect model

scientific article published on 27 April 2020

Survival responses of human embryonic stem cells to DNA damage

scientific article

Sustained perfusion of revascularized bioengineered livers heterotopically transplanted into immunosuppressed pigs

scientific article published on 14 October 2019

Synergism between Wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase/Akt/RUNX2 pathway

scientific article

TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone

scientific article published on 22 March 2019

TGF-β1 modifications in nuclear matrix proteins of osteoblasts during differentiation ⬇️

scientific article published on 01 June 1998

TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts

scientific article

Targeting deregulated epigenetic control in cancer ⬇️

scientific article published on November 1, 2013

Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease

scientific article

Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy

scientific article published on 23 July 2015

The 1alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene

scientific article

The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation

scientific article

The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes

scientific article

The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells

scientific journal article

The Rapidly Assessed Predictor of Intraoperative Damage (RAPID) Score: An In-Clinic Predictive Model for High-Grade Acetabular Chondrolabral Disruption

The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion

scientific article

The Runx2 transcription factor plays a key role in the 1alpha,25-dihydroxy Vitamin D3-dependent upregulation of the rat osteocalcin (OC) gene expression in osteoblastic cells

scientific article published in May 2004

The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation

scientific article

The architectural organization of human stem cell cycle regulatory machinery

scientific journal article

The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cells

scientific article

The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts

scientific article

The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells.

scientific article

The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis

scientific article published on 13 January 2019

The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines

scientific article published on April 2013

The cleidocranial dysplasia-related R131G mutation in the Runt-related transcription factor RUNX2 disrupts binding to DNA but not CBF-beta

scientific article

The dynamic architectural and epigenetic nuclear landscape: developing the genomic almanac of biology and disease.

scientific article published on June 2014

The dynamic organization of gene-regulatory machinery in nuclear microenvironments

scientific article

The epigenetic reader Brd4 is required for osteoblast differentiation

scientific article published on 23 December 2019

The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues

scientific article

The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis.

scientific article published on September 2009

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

scientific article

The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss

scientific article

The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles

scientific journal article

The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif

scientific article

The histone gene transcription factor HiNF-P stabilizes its cell cycle regulatory co-activator p220NPAT.

scientific article published on December 2006

The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes

scientific article

The influence of collagen and hyaluronan matrices on the delivery and bioactivity of bone morphogenetic protein-2 and ectopic bone formation

scientific article published on 19 July 2013

The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes

scientific article published on January 1, 1998

The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing

scientific article

The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes.

scientific article

The metabolic syndrome modifies the mRNA expression profile of extracellular vesicles derived from porcine mesenchymal stem cells.

scientific article published on 21 July 2018

The osteocalcin gene: a model for multiple parameters of skeletal-specific transcriptional control

scientific article published on August 1, 1997

The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts

scientific article

The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts

scientific article published on 02 April 2009

The polypyrimidine/polypurine motif in the mouse mu opioid receptor gene promoter is a supercoiling-regulatory element

scientific article published on 31 July 2011

The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain

scientific article published on 13 October 2011

The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types

scientific article

The synovial microenvironment of osteoarthritic joints alters RNA-seq expression profiles of human primary articular chondrocytes

scientific article published on July 2016

The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter

scientific article published on 5 May 2003

Therapeutic Effect of Adipose Derived Mesenchymal Stem Cell Transplantation in Reducing Restenosis in a Murine Angioplasty Model

scientific article published on 25 June 2020

Tissue-Nonspecific Alkaline Phosphatase Is Required for MC3T3 Osteoblast-Mediated Protection of Acute Myeloid Leukemia Cells from Apoptosis

scientific article published on 18 June 2018

Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disk homeostasis: in vitro, ex vivo studies

scientific article published on 10 June 2012

Topical vancomycin for treatment of methicillin-resistant Staphylococcus epidermidis infection in a rat spinal implant model

scientific article published on 20 February 2020

Total Protein Staining is Superior to Classical or Tissue-Specific Protein Staining for Standardization of Protein Biomarkers in Heterogeneous Tissue Samples

scientific article published on 06 March 2020

Towards understanding pre-mRNA splicing mechanisms and the role of SR proteins

scientific article published on 3 May 2016

Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer

scientific article

Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

scientific article published on February 2009

Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition

scientific article

Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes

scientific article

Transcriptomic Analysis of Cellular Pathways in Healing Flexor Tendons of Plasminogen Activator Inhibitor 1 (PAI-1/Serpine1) Null Mice

scientific article published on 01 September 2019

Transplant Chimerism in Porcine Structural Vascularized Bone Allotransplants

scientific article published on 26 March 2020

Treatment of Pediatric Osteoid Osteomas Not Amenable to Radiofrequency Ablation: A Retrospective Review of Surgical Outcomes

scientific article published on 01 January 2018

Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

scientific article published on 12 February 2004

Validation of Osteogenic Properties of Cytochalasin D by High-Resolution RNA-Sequencing in Mesenchymal Stem Cells Derived from Bone Marrow and Adipose Tissues

scholarly article by Rebekah M Samsonraj et al published 15 August 2018 in Stem Cells and Development

Validation of a dynamic joint contracture measuring device in a live rabbit model of arthrofibrosis

scientific article published on 23 February 2018

Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery

scientific article published on January 2008

Vitamin-D Supplementation: A Low-Risk, High-Gain Therapy to Prevent PJI?: Commentary on an article by Vishal Hegde, MD, et al.: "Single-Dose, Preoperative Vitamin-D Supplementation Decreases Infection in a Mouse Model of Periprosthetic Joint Infecti

scientific article published in October 2017

Wnt/β-Catenin Signaling Activates Expression of the Bone-Related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types

scientific article published on 28 March 2017

hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3.

scientific article

miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells

scientific article

miR-219a-5p Regulates Rorβ During Osteoblast Differentiation and in Age-related Bone Loss

scientific article published on 15 October 2018

microRNA-mediated survivin control of pluripotency

scientific article

p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency

scientific article

p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation

scientific article

β-Catenin Preserves the Stem State of Murine Bone Marrow Stromal Cells Through Activation of EZH2

scientific article published on 05 February 2020

Paulina is supported by:

About Paulina

Help