List of works - Stig Linder

A close association between alteration in growth kinetics by neoadjuvant chemotherapy and survival outcome in primary breast cancer

scientific article published on August 2004

A natural anticancer agent thaspine targets human topoisomerase IB.

scientific article published in February 2013

A novel high-through-put assay for screening of pro-apoptotic drugs

scientific article

Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA

article

Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition

scientific article published on March 2017

Alterations in the cellular immune compartment of patients treated with third-party mesenchymal stromal cells following allogeneic hematopoietic stem cell transplantation

scientific article published in August 2013

Autophagy is a protective mechanism for human melanoma cells under acidic stress

scientific article

Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis

scientific article published on May 2002

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

scientific article published on 28 December 2017

Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells

scientific article published on 16 March 2013

Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II

scientific article

Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis

scientific article published on 09 February 2010

Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling

scientific article

Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation

scientific article

Clinical cancer proteomics: promises and pitfalls

scientific article

Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts

scientific article

Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis

scientific article

Corrigendum: The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

scientific article published on 29 July 2016

Cytokeratin markers come of age.

scientific article published on 23 August 2007

Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy

scientific article

Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action

scientific article published on 7 December 2017

Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line

scientific article published on October 2003

Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker

scientific article published in October 2004

Deubiquitinase inhibition as a cancer therapeutic strategy

scientific article

Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer

Dienone Compounds: Targets and Pharmacological Responses

scientific article published on 04 November 2020

Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18.

scientific article

Elevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases

scientific article

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

scientific article published on 20 November 2012

Handling of misconduct in Swedish research must be improved. More strict investigative procedures, tougher punishments and withdrawals are required

scientific article published on 15 December 2015

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

scientific article

Identification of agents that induce apoptosis of multicellular tumour spheroids: enrichment for mitotic inhibitors with hydrophobic properties

scientific article

Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570 ⬇️

scientific article published on 04 July 2020

Induction of endoplasmic reticulum stress by ellipticine plant alkaloids

scientific article published on April 2004

Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis

scientific article

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

scientific article

Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system

scientific article

Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress

scientific article

Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?

scientific article published on 06 July 2015

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

scientific article

Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response

scientific article published on March 2012

Interleukin-15 potentiates human natural killer cells to resist tumor-induced suppression through mTOR-regulated metabolic control.

scientific article published on 4 November 2015

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.

scientific article published in February 2018

Is translational research compatible with preclinical publication strategies?

scientific article

Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

scientific article published on 14 October 2013

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

scientific article

Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin.

scientific article

Lysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy

scientific article

Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?

scientific article published on October 2007

Molecular pathways: translational potential of deubiquitinases as drug targets

scientific article published on August 2014

Novel activity of acriflavine against colorectal cancer tumor cells

scientific article

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

scientific article published on 10 June 2019

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

scientific article

Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis

scientific article

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

scientific article published on 11 January 2013

Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir

scientific article published in July 2008

Processing of pulmonary surfactant protein B by napsin and cathepsin H

scientific article

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors

scientific article

Proteasome deubiquitinases as novel targets for cancer therapy

scientific article published on 20 July 2012

Proteasome-associated deubiquitinases and cancer

scientific article published on 14 November 2017

Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model

scientific article

Screening for compounds that induce apoptosis of cancer cells grown as multicellular spheroids

scientific article published on 26 November 2007

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

scientific article

Screening of natural products for therapeutic activity against solid tumors

scientific article published on March 1, 2010

Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses

scientific article

Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System

scientific article published in 2021

Serum efficacy biomarkers for oncology

scientific article published on February 2009

Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15

scientific article (publication date: November 2015)

Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells

scientific article

Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2019

The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity

scientific article published on 14 January 2008

The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival

scientific article

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.

scientific article published on 7 December 2011

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

scientific article published on 24 April 2015

Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1.

scientific article published on 9 March 2006

Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin

scientific article published on January 2009

Utilization of cytokeratin-based biomarkers for pharmacodynamic studies

scientific article published on April 2010

Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines

scientific article

List of works by Stig Linder

A close association between alteration in growth kinetics by neoadjuvant chemotherapy and survival outcome in primary breast cancer

A natural anticancer agent thaspine targets human topoisomerase IB.

A novel high-through-put assay for screening of pro-apoptotic drugs

Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA

Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition

Alterations in the cellular immune compartment of patients treated with third-party mesenchymal stromal cells following allogeneic hematopoietic stem cell transplantation

Autophagy is a protective mechanism for human melanoma cells under acidic stress

Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells

Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II

Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis

Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling

Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation

Clinical cancer proteomics: promises and pitfalls

Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts

Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis

Corrigendum: The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

Cytokeratin markers come of age.

Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy

Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action

Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line

Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker

Deubiquitinase inhibition as a cancer therapeutic strategy

Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer

Dienone Compounds: Targets and Pharmacological Responses

Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18.

Elevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

Handling of misconduct in Swedish research must be improved. More strict investigative procedures, tougher punishments and withdrawals are required

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

Identification of agents that induce apoptosis of multicellular tumour spheroids: enrichment for mitotic inhibitors with hydrophobic properties

Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570 ⬇️

Induction of endoplasmic reticulum stress by ellipticine plant alkaloids

Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system

Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress

Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response

Interleukin-15 potentiates human natural killer cells to resist tumor-induced suppression through mTOR-regulated metabolic control.

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.

Is translational research compatible with preclinical publication strategies?

Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin.

Lysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy

Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?

Molecular pathways: translational potential of deubiquitinases as drug targets

Novel activity of acriflavine against colorectal cancer tumor cells

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir

Processing of pulmonary surfactant protein B by napsin and cathepsin H

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors

Proteasome deubiquitinases as novel targets for cancer therapy

Proteasome-associated deubiquitinases and cancer

Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model

Screening for compounds that induce apoptosis of cancer cells grown as multicellular spheroids

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Screening of natural products for therapeutic activity against solid tumors

Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses

Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System

Serum efficacy biomarkers for oncology

Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15

Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells

Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer ⬇️

The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity

The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1.

Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin

Utilization of cytokeratin-based biomarkers for pharmacodynamic studies

Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines