Search filters

List of works by Stefan Wölfl

1,25(OH)2D3 disrupts glucose metabolism in prostate cancer cells leading to a truncation of the TCA cycle and inhibition of TXNIP expression

scientific article

7,7'-Diazaindirubin--a small molecule inhibitor of casein kinase 2 in vitro and in cells

scientific article published on 25 November 2013

A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway

scientific article published in 2018

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.

scientific article published on 25 September 2014

A crucial role for primary cilia in cortical morphogenesis

scientific journal article

A deadly organometallic luminescent probe: anticancer activity of a ReI bisquinoline complex.

scientific article published on 24 January 2014

A fast and efficient polymerase chain reaction‐based method for the preparation of in situ hybridization probes ⬇️

scientific article published on March 28, 2012

A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.

scientific article published on 23 June 2016

A multi-target gold(I) complex induces cytotoxicity related to aneuploidy in HCT-116 colorectal carcinoma cells

scientific article published on 12 June 2020

Acidic stress induced G1 cell cycle arrest and intrinsic apoptotic pathway in Jurkat T-lymphocytes

scientific article published on 21 November 2016

Activation of pro-survival metabolic networks by 1,25(OH)2D3 does not hamper the sensitivity of breast cancer cells to chemotherapeutics

scientific article published on 30 August 2018

Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex.

scientific article published on 30 December 2015

Antileukemic activity and cellular effects of rhodium(III) crown thiaether complexes

scientific article published on 28 January 2011

Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis

scientific article published on 23 December 2020

Author Correction: Essential role of mitochondrial Stat3 in p38MAPK mediated apoptosis under oxidative stress.

scientific article published on 12 April 2018

BMP2 Transfer to Neighboring Cells and Activation of Signaling

scientific article published on 16 June 2016

Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties

scientific article published on 17 November 2010

Cellular Selectivity and Biological Impact of Cytotoxic Rhodium(III) and Iridium(III) Complexes Containing Methyl‐Substituted Phenanthroline Ligands ⬇️

scientific article published on February 17, 2011

Cellular impact and selectivity of half-sandwich organorhodium(III) anticancer complexes and their organoiridium(III) and trichloridorhodium(III) counterparts

scientific article

Cellular uptake, cytotoxicity, and metabolic profiling of human cancer cells treated with ruthenium(II) polypyridyl complexes [Ru(bpy)2(N--N)]Cl2 with N--N=bpy, phen, dpq, dppz, and dppn

scientific article

Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type.

scientific article

Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3 ⬇️

scientific article published on June 13, 2010

Correction to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

article

Cytotoxicity and cellular impact of dinuclear organoiridium DNA intercalators and nucleases with long rigid bridging ligands ⬇️

scientific article published on March 14, 2012

Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform

scientific article published on 3 February 2017

Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.

scientific article published on September 2014

Di (2-Ethylhexyl) Phthalate and Its Role in Developing Cholestasis: An In Vitro Study on Different Liver Cell Types

scientific article published on 01 February 2018

Differences in p53 status significantly influence the cellular response and cell survival to 1,25-dihydroxyvitamin D3-metformin cotreatment in colorectal cancer cells.

scientific article published on 15 June 2017

Differential expression of cancer-related genes by single and permanent exposure to bone morphogenetic protein 2.

scientific article published on 30 April 2008

Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain ⬇️

scientific article published on July 2, 2012

Effects of 1,25(OH)₂D₃ on Cancer Cells and Potential Applications in Combination with Established and Putative Anti-Cancer Agents.

scientific article published on 23 January 2017

Enhanced cellular uptake and cytotoxicity studies of organometallic bioconjugates of the NLS peptide in Hep G2 cells

scientific article

Essential role of mitochondrial Stat3 in p38MAPK mediated apoptosis under oxidative stress.

scientific article published on 13 November 2017

Ethanol sensitizes hepatocytes for TGF-β-triggered apoptosis

scientific article published on 19 January 2018

Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4.

scientific article published on 5 July 2015

Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules

scientific article published on 14 November 2012

Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts

scientific article

Expression of TXNIP in Cancer Cells and Regulation by 1,25(OH)₂D₃: Is It Really the Vitamin D₃ Upregulated Protein?

scientific article published on 10 March 2018

FeIII(salophene)Cl, a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells ⬇️

scientific article published on December 4, 2010

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction

scientific article published on 25 June 2018

From catalysts to bioactive organometallics: do Grubbs catalysts trigger biological effects?

scientific article

Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae

scientific article

Fusion of a Short HA2-Derived Peptide Sequence to Cell-Penetrating Peptides Improves Cytosolic Uptake, but Enhances Cytotoxic Activity

scientific article published on 25 September 2009

Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators

scientific article published on 6 May 2014

Golgi stress mediates redox imbalance and ferroptosis in human cells

scientific article published on 28 November 2018

Guidelines and recommendations on yeast cell death nomenclature.

scientific article published in January 2018

Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells.

scientific article published on 21 April 2011

Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling

scientific article

Human microRNA-299-3p decreases invasive behavior of cancer cells by downregulation of Oct4 expression and causes apoptosis

scientific article

Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers

scientific article published on 7 May 2015

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

scientific article

In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells

scientific article published on 21 October 2015

In vitro metabolic activation of vitamin D3 by using a multi-compartment microfluidic liver-kidney organ on chip platform

scientific article published on 15 March 2019

Indirubin derivatives modulate TGFβ/BMP signaling at different levels and trigger ubiquitin-mediated depletion of nonactivated R-Smads

scientific article published in November 2012

Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

article

Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites

scientific article published on 04 December 2017

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis

scientific article published on 28 April 2022

Metabolic response to MMS-mediated DNA damage in Saccharomyces cerevisiae is dependent on the glucose concentration in the medium

scientific article

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

scientific article published on 04 February 2016

Microfluidic devices for stem-cell cultivation, differentiation and toxicity testing

scientific article

Modified STAP conditions facilitate bivalent fate decision between pluripotency and apoptosis in Jurkat T-lymphocytes

scientific article published on 10 March 2016

Monitoring cytochrome P450 activity in living hepatocytes by chromogenic substrates in response to drug treatment or during cell maturation.

scientific article

Multimodal Eph/Ephrin signaling controls several phases of urogenital development

scientific article published on 22 June 2016

Mutational analysis of fructose-1,6-bis-phosphatase FBP1 indicates partially independent functions in gluconeogenesis and sensitivity to genotoxic stress

scientific article published on February 2017

NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice

scientific article published on 03 January 2020

On the biological properties of alkynyl phosphine gold(I) complexes.

scientific article published on 29 July 2012

Procarcinogens - Determination and Evaluation by Yeast-Based Biosensor Transformed with Plasmids Incorporating RAD54 Reporter Construct and Cytochrome P450 Genes

scientific article

Proliferation and cilia dynamics in neural stem cells prospectively isolated from the SEZ.

scientific article published on 22 January 2014

Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonists ⬇️

scientific article published on October 17, 2012

Real-Time Monitoring of Cisplatin-Induced Cell Death ⬇️

scientific article published on May 16, 2011

Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling

scientific article published on 23 November 2015

SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability

scientific article published in April 2010

Structure-activity relationship of trifluoromethyl-containing metallocenes: electrochemistry, lipophilicity, cytotoxicity, and ROS production

scientific article published on 18 May 2014

Synthesis and cellular impact of diene-ruthenium(II) complexes: a new class of organoruthenium anticancer agents

scientific article

Synthesis, biological activity, and structure-activity relationships for potent cytotoxic rhodium(III) polypyridyl complexes

scientific article

The new facile and straightforward method for the synthesis of 4H-1,2,3-thiadiazolo[5,4-b]indoles and determination of their antiproliferative activity

scientific article published on 11 November 2015

The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.

scientific article published on 19 September 2014

Vesicular disruption of lysosomal targeting organometallic polyarginine bioconjugates

scientific article published in February 2015

Vitamin D as a Novel Regulator of Tumor Metabolism: Insights on Potential Mechanisms and Implications for Anti-Cancer Therapy

scientific article published on 19 October 2017

Zonation of nitrogen and glucose metabolism gene expression upon acute liver damage in mouse

scientific article

[N,N'-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties

scientific article

[NiII(3-OMe-salophene)]: a potent agent with antitumor activity

scientific article published on August 2010

p53-Dependent Anti-Proliferative and Pro-Apoptotic Effects of a Gold(I) N-Heterocyclic Carbene (NHC) Complex in Colorectal Cancer Cells.

scientific article published on 29 May 2019

Paulina is supported by:

About Paulina

Help