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List of works by Alastair G McEwan

A Glutathione-Dependent Detoxification System Is Required for Formaldehyde Resistance and Optimal Survival of Neisseria meningitidis in Biofilms

scientific article

A Molecular Mechanism for Bacterial Susceptibility to Zinc

scientific article

A Novel, Molybdenum-Containing Methionine Sulfoxide Reductase Supports Survival of Haemophilus influenzae in an In vivo Model of Infection

scientific article

A Sco homologue plays a role in defence against oxidative stress in pathogenic Neisseria

scientific article published on 01 July 2003

A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae

scientific article

A genetic screen reveals a periplasmic copper chaperone required for nitrite reductase activity in pathogenic Neisseria

scientific article published in June 2015

A glutathione-based system for defense against carbonyl stress in Haemophilus influenzae.

scientific article

A mechanistic and electrochemical study of the interaction between dimethyl sulfide dehydrogenase and its electron transfer partner cytochrome c2.

scientific article published on 8 July 2008

A novel nickel responsive MerR-like regulator, NimR, from Haemophilus influenzae

scientific article published on 23 September 2011

A periplasmic thioredoxin-like protein plays a role in defense against oxidative stress in Neisseria gonorrhoeae.

scientific article published on 17 August 2009

A recombinant diheme SoxAX cytochrome - implications for the relationship between EPR signals and modified heme-ligands.

scientific article published in April 2005

A role for lactate dehydrogenases in the survival of Neisseria gonorrhoeae in human polymorphonuclear leukocytes and cervical epithelial cells

scientific article

A system for the heterologous expression of complex redox proteins in Rhodobacter capsulatus: characterisation of recombinant sulphite:cytochrome c oxidoreductase from Starkeya novella

scientific article published on 01 October 2002

Access to highly specialized growth substrates and production of epithelial immunomodulatory metabolites determine survival of Haemophilus influenzae in human airway epithelial cells

scientific article published in 2022

Accumulation of manganese in Neisseria gonorrhoeae correlates with resistance to oxidative killing by superoxide anion and is independent of superoxide dismutase activity

scientific article published on 01 June 2001

An Antimicrobial Role for Zinc in Innate Immune Defense Against Group A Streptococcus

scientific article published on 20 January 2014

An antioxidant role for catecholate siderophores in Salmonella.

scientific article published on September 2013

Antimicrobial action of copper is amplified via inhibition of heme biosynthesis.

scientific article published on 22 August 2013

Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action

scientific article published on April 2014

Asymmetric reduction of racemic sulfoxides by dimethyl sulfoxide reductases from Rhodobacter capsulatus, Escherichia coli and Proteus species

scientific article published on 01 August 1998

Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae.

scientific article

Characterisation of the mob locus from Rhodobacter sphaeroides required for molybdenum cofactor biosynthesis.

scientific article

Characterisation of the pterin molybdenum cofactor in dimethylsulfoxide reductase of Rhodobacter capsulatus

scientific article published on 01 May 1997

Characterization of DorC from Rhodobacter capsulatus, a c-type cytochrome involved in electron transfer to dimethyl sulfoxide reductase

scientific article published on 01 April 1999

Characterization of an ntrX mutant of Neisseria gonorrhoeae reveals a response regulator that controls expression of respiratory enzymes in oxidase-positive proteobacteria

scientific article published on 5 April 2013

Characterization of the OxyR regulon of Neisseria gonorrhoeae

scientific article

Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance

scientific article published on 11 December 2018

Cobalt hexaamine mediated electrocatalytic voltammetry of dimethyl sulfoxide reductase: driving force effects on catalysis

scientific article published on October 27, 2010

Conjugative plasmid transfer and adhesion dynamics in an Escherichia coli biofilm

scientific article published on 28 August 2009

Copper Ions and Coordination Complexes as Novel Carbapenem Adjuvants.

scientific article published on 13 November 2017

Copper sensitivity of cueO mutants of Escherichia coli K-12 and the biochemical suppression of this phenotype.

scientific article published in March 2005

Copper(II)-Bis(Thiosemicarbazonato) Complexes as Antibacterial Agents: Insights into Their Mode of Action and Potential as Therapeutics.

scientific article

Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents.

scientific article published on September 2017

Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus

scientific article published on 01 May 2006

Cytochrome c2 is essential for electron transfer to nitrous oxide reductase from physiological substrates in Rhodobacter capsulatus and can act as an electron donor to the reductase in vitro. Correlation with photoinhibition studies

scientific article published on 01 August 1991

Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?

scientific article published on 23 December 2015

Defenses against oxidative stress in Neisseria gonorrhoeae: a system tailored for a challenging environment

scientific article

Detection of c-type cytochromes using enhanced chemiluminescence

scientific article published on 01 March 1993

Detection of the optical bands of molybdenum(V) in DMSO reductase (Rhodobacter capsulatus) by low-temperature MCD spectroscopy

scientific article published on 01 July 1992

Dietary zinc and the control of Streptococcus pneumoniae infection

scientific article published on 22 August 2019

Dimethylsulfide:acceptor oxidoreductase from Rhodobacter sulfidophilus. The purified enzyme contains b-type haem and a pterin molybdenum cofactor.

scientific article

Dimethylsulphoxide reductase from purple phototrophic bacteria: structures and mechanism(s)

scientific article published on 01 August 1998

Direct electrochemistry of a bacterial sulfite dehydrogenase

scientific article published on 01 January 2003

Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach

scientific article published on 30 March 2015

Domain structure, oligomeric state, and mutational analysis of PpsR, the Rhodobacter sphaeroides repressor of photosystem gene expression.

scientific article published on April 2000

Draft Genome Sequences of Three Nontypeable Strains of Haemophilus influenzae, C188, R535, and 1200, Isolated from Different Types of Disease.

scientific article published on 23 March 2017

Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model ⬇️

scientific article published on 11 January 2022

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

scientific article

Electrochemically mediated enantioselective reduction of chiral sulfoxides.

scientific article published on 20 November 2014

Electron flow to dimethylsulphoxide or trimethylamine-N-oxide generates a membrane potential in Rhodopseudomonas capsulata

scientific article published on 01 December 1983

Evidence for distinctive mechanisms of S-nitrosoglutathione metabolism by AdhC in two closely related species, Neisseria gonorrhoeae and Neisseria meningitidis.

scientific article published on 12 January 2007

Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae

scientific article

Formaldehyde Stress Responses in Bacterial Pathogens

scientific article

Functional analysis of an feoB mutant in Clostridium perfringens strain 13.

scientific article published on 10 May 2016

Functional analysis of the multi-copper oxidase from Legionella pneumophila

scientific article published on 25 January 2008

Glutathione-dependent alcohol dehydrogenase AdhC is required for defense against nitrosative stress in Haemophilus influenzae.

scientific article

Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress

scientific article published on 14 February 2019

Handling of nutrient copper in the bacterial envelope

scientific article published on 01 January 2019

Identification and in vivo characterization of PpaA, a regulator of photosystem formation in Rhodobacter sphaeroides.

scientific article

Identification of type 3 fimbriae in uropathogenic Escherichia coli reveals a role in biofilm formation

scientific article

Imperfect coordination chemistry facilitates metal ion release in the Psa permease

scientific article

Inhibition of respiratory complex I by copper(ii)-bis(thiosemicarbazonato) complexes.

scientific article published on 4 November 2014

Interplay between manganese and iron in pneumococcal pathogenesis: role of the orphan response regulator RitR

scientific article published on 26 November 2012

Interplay between tolerance mechanisms to copper and acid stress in Escherichia coli

scientific article published on 13 June 2017

Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay

scientific article

Iron metabolism in Rhodobacter capsulatus. Characterisation of bacterioferritin and formation of non-haem iron particles in intact cells

scientific article published on 01 August 1994

Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence

scientific article published on 24 March 2015

Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae

scientific article

Manganous ions suppress photosynthesis gene expression in Rhodobacter sphaeroides

scientific article published on 01 August 1998

Maturation of molybdoenzymes and its influence on the pathogenesis of non-typeable Haemophilus influenzae.

scientific article

Membrane-associated NADH dehydrogenase activities in Rhodobacter capsulatus: purification of a dihydrolipoyl dehydrogenase

scientific article published on 01 August 1993

Metabolic versatility in Haemophilus influenzae: a metabolomic and genomic analysis

scientific article published on 04 March 2014

Metal binding specificity of the MntABC permease of Neisseria gonorrhoeae and its influence on bacterial growth and interaction with cervical epithelial cells

scientific article published on 21 April 2008

Microbial dimethylsulfoxide and trimethylamine-N-oxide respiration.

scientific article

Molecular analysis of dimethyl sulphide dehydrogenase from Rhodovulum sulfidophilum: its place in the dimethyl sulphoxide reductase family of microbial molybdopterin-containing enzymes.

scientific article

Molecular analysis of the psa permease complex of Streptococcus pneumoniae.

scientific article

Molecular analysis of type 3 fimbrial genes from Escherichia coli, Klebsiella and Citrobacter species

scientific article published in 2010

Molecular ecology of a facultative swine waste lagoon.

scientific article

Multiple states of the molybdenum centre of dimethylsulphoxide reductase from Rhodobacter capsulatus revealed by EPR spectroscopy

scientific article published on 01 October 1994

New Insights into the Role of Zinc Acquisition and Zinc Tolerance in Group A Streptococcal Infection

scientific article published on 22 May 2018

New insights into the protective effect of manganese against oxidative stress.

scientific article published on 27 April 2009

NmlR of Neisseria gonorrhoeae: a novel redox responsive transcription factor from the MerR family.

scientific article published in September 2005

PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae

scientific article published on April 2006

Phenotypic Characterization of acopAMutant of Neisseria gonorrhoeae Identifies a Link between Copper and Nitrosative Stress ⬇️

scientific article published on December 19, 2011

Phenotypic and genetic characterization of cytochrome c2 deficient mutants of Rhodobacter sphaeroides

scientific article published on 01 March 1988

Preliminary crystallographic studies of dimethylsulfoxide reductase from Rhodobacter capsulatus

scientific article published on 01 January 1996

Probing the archaeal diversity of a mixed thermophilic bioleaching culture by TGGE and FISH

scientific article (publication date: October 2009)

Proton motive force generation from stored polymers for the uptake of acetate under anaerobic conditions

scientific article published on 04 July 2007

PrrC from Rhodobacter sphaeroides, a homologue of eukaryotic Sco proteins, is a copper-binding protein and may have a thiol-disulfide oxidoreductase activity.

scientific article published in May 2002

PrrC, a Sco homologue from Rhodobacter sphaeroides, possesses thiol-disulfide oxidoreductase activity

scientific article published on 04 September 2007

Regulation of photosynthetic gene expression in purple bacteria ⬇️

scientific article published on February 1, 1998

Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages

scientific article published on 2 February 2016

Site-directed mutagenesis of dimethyl sulfoxide reductase from Rhodobacter capsulatus: characterization of a Y114 --> F mutant.

scientific article

Spectroscopic and kinetic studies of Y114F and W116F mutants of Me2SO reductase from Rhodobacter capsulatus.

scientific article published on 5 October 2007

Spectroscopic studies of Rhodobacter capsulatus cytochrome c' in the isolated state and in intact cells

scientific article published on 01 May 1992

Stopped-flow studies on dimethylsulphoxide reductase from Rhodobacter capsulatus: kinetic competence of the dimethylsulphide-reduced intermediate

scientific article published on 01 August 1998

Structural and functional characterization of three DsbA paralogues from Salmonella enterica serovar Typhimurium

scientific article

Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region

scientific article

Sulfite:Cytochrome c oxidoreductase from Thiobacillus novellus. Purification, characterization, and molecular biology of a heterodimeric member of the sulfite oxidase family

scientific article (publication date: 5 May 2000)

Survey of ferroxidase expression and siderophore production in clinical isolates of Pseudomonas aeruginosa

scientific article published on June 2004

The Composition and Metabolic Phenotype of Neisseria gonorrhoeae Biofilms

scientific article

The PerR-Regulated P1B-4-Type ATPase (PmtA) Acts as a Ferrous Iron Efflux Pump in Streptococcus pyogenes

scientific article published on 3 April 2017

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

scientific article

The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection.

scientific article published on 21 October 2016

The first non-turnover voltammetric response from a molybdenum enzyme: direct electrochemistry of dimethylsulfoxide reductase from Rhodobacter capsulatus.

scientific article published on 14 May 2002

The high resolution crystal structure of DMSO reductase in complex with DMSO

scientific article

The multicopper oxidase of Pseudomonas aeruginosa is a ferroxidase with a central role in iron acquisition

scientific article published in September 2002

The role of c-type cytochromes in the photosynthetic electron transport pathway of Rhodobacter capsulatus

scientific article published on 01 August 1990

Thioredoxin reductase is essential for protection of Neisseria gonorrhoeae against killing by nitric oxide and for bacterial growth during interaction with cervical epithelial cells.

scientific article published on January 2009

Trade-off between iron uptake and protection against oxidative stress: deletion of cueO promotes uropathogenic Escherichia coli virulence in a mouse model of urinary tract infection

scientific article published on 22 August 2008

Transcriptional profiling identifies the metabolic phenotype of gonococcal biofilms.

scientific article published on 15 June 2009

Transition Metal Homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae

scientific article published on 20 February 2017

Xanthine dehydrogenase from the phototrophic purple bacterium Rhodobacter capsulatus is more similar to its eukaryotic counterparts than to prokaryotic molybdenum enzymes.

scientific article

Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes

scientific article published on June 2015

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