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List of works by Lars Rönnstrand

3,4-Diarylmaleimides-a novel class of kinase inhibitors-effectively induce apoptosis in FLT3-ITD-dependent cells

scientific article published on 01 September 2011

30 Purification of platelet-derived growth factor β receptor from porcine uterus

scientific article published on 01 January 1991

A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML.

scientific article

A tyrosine residue in the juxtamembrane segment of the platelet-derived growth factor beta-receptor is critical for ligand-mediated endocytosis

scientific article published on 01 February 1994

A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex

scientific article

ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.

scientific article published on 10 January 2017

Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML.

scientific article published on 21 March 2016

Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF.

scientific article published on February 2001

BEX1 acts as a tumor suppressor in acute myeloid leukemia.

scientific article published on 26 May 2015

Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis

scientific article published on 01 November 2000

Brain-Expressed X-linked (BEX) proteins in human cancers.

scientific article published on 23 September 2015

Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma

scientific article published on 16 July 2018

C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation

scientific article

Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF beta R fusion protein

scientific article published on 01 November 1999

Characterization of the receptor for platelet-derived growth factor on human fibroblasts. Demonstration of an intimate relationship with a 185,000-Dalton substrate for the platelet-derived growth factor-stimulated kinase

scientific article published on 01 August 1983

Characterization of two monoclonal antibodies reactive with the external domain of the platelet-derived growth factor receptor

scientific article published on 01 July 1988

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

scientific article published on March 2003

Co expression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanism.

scientific article published on April 2006

Correction: The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia

scientific article published on 25 July 2019

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

scientific article published on 2 May 2018

Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors

scientific article

Deregulation of protein phosphatase expression in acute myeloid leukemia ⬇️

scientific article published on February 26, 2013

Differential activity of c-KIT splice forms is controlled by extracellular peptide insert length.

scientific article published on 21 July 2013

Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors

scientific article (publication date: 24 March 2000)

Dysfunctionality of a tobacco mosaic virus movement protein mutant mimicking threonine 104 phosphorylation

scientific article published in March 2003

EPO-independent functional EPO receptor in breast cancer enhances estrogen receptor activity and promotes cell proliferation

scientific article published on 3 February 2014

Enhanced SOX10 and KIT expression in cutaneous melanoma.

scientific article published on 26 June 2013

Expression of GADS enhances FLT3-induced mitogenic signaling.

scientific article published in March 2016

Expression of Platelet-Derived Growth Factor Receptors is Induced on Connective Tissue Cells During Chronic Synovial Inflammation

scientific article published on 01 March 1988

FLT3 mutations in patients with childhood acute lymphoblastic leukemia (ALL).

scientific article

FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia

scientific article published on 29 November 2012

FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

scientific article published on 01 July 2019

FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia.

scientific article published on 2 February 2016

Functional co-operation between the subunits in heterodimeric platelet-derived growth factor receptor complexes.

scientific article published on August 1999

HIF-2α Expression Is Suppressed in SCLC Cells, Which Survive in Moderate and Severe Hypoxia When HIF-1α Is Repressed ⬇️

scientific article published on November 21, 2011

HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells.

scientific article published on 03 February 2016

Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation.

scientific article published on 30 November 2006

Identification of Novel Phosphorylation Sites in Hormone-sensitive Lipase That Are Phosphorylated in Response to Isoproterenol and Govern Activation Properties in Vitro ⬇️

scientific article published on January 2, 1998

Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins

scientific article

Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2

scientific article published on 09 May 2006

Identification of protein tyrosine phosphatases associating with the PDGF receptor

scientific article

Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells

scientific journal article

Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol

scientific article published on 01 May 1996

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases ⬇️

scientific article published on June 1, 1993

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

scientific journal article

Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.

scientific article

Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing.

scientific article

Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD.

scientific article

Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor.

scientific article

Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation

scientific article

Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.

scientific article published on August 1997

Irreversible pan-ERBB inhibitor canertinib elicits anti-leukaemic effects and induces the regression of FLT3-ITD transformed cells in mice

scientific article published on 16 August 2011

Keratin 19 expression correlates with poor prognosis in breast cancer

scientific article published on 26 August 2014

Metallopeptidase inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer

scientific article published on 24 October 2019

Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C

scientific journal article

Molecular Basis for the Dominant White Phenotype in the Domestic Pig ⬇️

scientific article published on August 1, 1998

Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis.

scientific article published on July 1999

PDGF-induced phosphorylation of Tyr28 in the N-terminus of Fyn affects Fyn activation.

scientific article published on December 1997

PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner

scientific article published on 4 June 2015

Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant

scientific journal article

Phosphorylation of the potyvirus capsid protein by protein kinase CK2 and its relevance for virus infection.

scientific article published in September 2003

Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296.

scientific article published on May 1997

Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block.

scientific article

Platelet-derived growth factor receptors in the kidney--upregulated expression in inflammation.

scientific article published in December 1989

Platelet-derived growth factor: mechanism of action and relation to oncogenes.

scientific article

Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia.

scientific article published on 31 October 2013

Protein kinase C expression is deregulated in chronic lymphocytic leukemia.

scientific article

Protein-tyrosine Phosphatase DEP-1 Controls Receptor Tyrosine Kinase FLT3 Signaling ⬇️

scientific article published on January 24, 2011

Purification of the transforming growth factor-beta (TGF-beta) binding proteoglycan betaglycan ⬇️

scientific article published on December 5, 1991

Purification of transforming growth factor-beta 1 binding proteins from porcine uterus membranes.

scientific article published in November 1991

Receptor association and tyrosine phosphorylation of S6 kinases.

scientific article published on May 2006

Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.

scientific article published on 13 March 2015

SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis

scientific article published on 01 June 1999

SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor

scientific article (publication date: 14 March 2002)

SOCS proteins in regulation of receptor tyrosine kinase signaling

scientific article published on 05 April 2014

SOCS6 is a selective suppressor of receptor tyrosine kinase signaling

scientific article

SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation

scientific article published on 23 April 2018

Ser-474 is the major target of insulin-mediated phosphorylation of protein kinase B beta in primary rat adipocytes.

scientific article

Signal transduction via platelet-derived growth factor receptors ⬇️

scientific article published on August 19, 1998

Signal transduction via the stem cell factor receptor/c-Kit

scientific article

Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.

scientific article

Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling

scientific article published on 21 July 2016

Src-like-adaptor protein (SLAP) differentially regulates normal and oncogenic c-Kit signaling.

scientific article published on 27 November 2013

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications ⬇️

scientific article published on October 1, 2012

Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells.

scientific article published on October 2008

Stimulation of tyrosine phosphorylation by platelet-derived growth factor

scientific article published on 01 October 1984

Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis.

scientific article published on March 1996

Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling ⬇️

scientific article published on March 19, 2013

The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia

scholarly article by Sausan A Moharram et al published 15 January 2019 in Blood Cancer Journal

The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.

scientific article published on 11 November 2013

The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.

scientific article published on 9 September 2015

The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation

scientific article published on 23 October 2017

The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V.

scientific article

The basic helix-loop-helix (bHLH) proteins in breast cancer progression ⬇️

scientific article published on July 23, 2013

The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit.

scientific article

The characterization of epithelial and stromal subsets of candidate stem/progenitor cells in the human adult prostate.

scientific article

The presence or absence of IL-3 during long-term culture of Flt3-ITD and c-Kit-D816V expressing Ba/F3 cells influences signaling outcome.

scientific article published on 22 March 2013

The role of HOXB2 and HOXB3 in acute myeloid leukemia.

scientific article published on 16 October 2015

The role of SRC family kinases in FLT3 signaling

scientific article published on 12 December 2018

The stem cell factor receptor/c-Kit as a drug target in cancer

scientific article

The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling ⬇️

scientific article published on May 21, 2013

Tissue distribution of macrophages, class II transplantation antigens, and receptors for platelet-derived growth factor in normal and rejected human kidneys

scientific article published on 01 October 1987

Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

scientific article

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD.

scientific article published on 7 March 2017

Why and how to investigate the role of protein phosphorylation in ZIP and ZnT zinc transporter activity and regulation

scientific article published on 19 February 2020

XK-related protein 5 (XKR5) is a novel negative regulator of KIT/D816V-mediated transformation.

scientific article published on 18 June 2018

p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils

scientific article

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