List of works - Cheng Zhu

2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system.

scientific article published on 20 October 2013

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

A FRET-Based Biosensor for Imaging SYK Activities in Living Cells

scientific article published on December 2011

A TCR mechanotransduction signaling loop induces negative selection in the thymus

scientific article published on 12 November 2018

A generalizable, tunable microfluidic platform for delivering fast temporally varying chemical signals to probe single-cell response dynamics.

scientific article

A model for cyclic mechanical reinforcement

scientific article published on 27 October 2016

A model for single-substrate trimolecular enzymatic kinetics.

scientific article

A modified Boyden chamber assay for tumor cell transendothelial migration in vitro

scientific article published on 01 July 1999

A thermodynamic and biomechanical theory of cell adhesion. Part I: General formulism.

scientific article published on May 1991

Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling.

scientific article published on April 2014

Accumulation of serial forces on TCR and CD8 frequently applied by agonist antigenic peptides embedded in MHC molecules triggers calcium in T cells

scientific article

Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds.

scientific article published on 4 March 2013

An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation

scientific article published on 25 March 2019

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis

scientific article published in Nature Communications

Author Correction: Mechanosensing through immunoreceptors

scientific article published on 01 December 2019

Bending rigidities of cell surface molecules P-selectin and PSGL-1

scientific article published on 13 January 2009

Binary Time Series Modeling with Application to Adhesion Frequency Experiments

scientific article published on September 2008

Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor.

scientific article published on 19 June 2019

Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment

scientific article published in Nature Communications

Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets.

scientific article published on 14 March 2018

Concurrent binding to multiple ligands: kinetic rates of CD16b for membrane-bound IgG1 and IgG2

scientific article

Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets.

scientific article published on 06 June 2016

Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals.

scientific article published on 19 July 2016

DNA-based digital tension probes reveal integrin forces during early cell adhesion.

scientific article

Demonstration of catch bonds between an integrin and its ligand.

scientific article published on June 2009

Diffusion of microspheres in shear flow near a wall: use to measure binding rates between attached molecules.

scientific article

Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow.

scientific article

Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis.

scientific article

Effects of anchor structure and glycosylation of Fcγ receptor III on ligand binding affinity

scientific article published on 31 August 2016

Flow induces loop-to-beta-hairpin transition on the beta-switch of platelet glycoprotein Ib alpha

scientific article

Flow-Enhanced Stability of Rolling Adhesion through E-Selectin.

scientific article

Flow-enhanced adhesion regulated by a selectin interdomain hinge.

scientific article

Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells.

scientific article

Force-history dependence and cyclic mechanical reinforcement of actin filaments at the single molecular level

scientific article published on 04 February 2019

From cellular to molecular mechanobiology

scientific article published on 14 February 2020

Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.

scientific article published on 23 December 2016

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

scientific article published on 16 May 2016

Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor.

scientific article

In situ and in silico kinetic analyses of programmed cell death-1 (PD-1) receptor, programmed cell death ligands, and B7-1 protein interaction network.

scientific article published on 6 March 2017

Insights from in situ analysis of TCR-pMHC recognition: response of an interaction network

scientific article published on January 2013

Kinetic measurements of cell surface E-selectin/carbohydrate ligand interactions

scientific article published on 01 November 2001

Kinetics of MHC-CD8 interaction at the T cell membrane.

scientific article published in December 2007

L-selectin mechanochemistry restricts neutrophil priming in vivo.

scientific article

Local Cellular and Cytokine Cues in the Spleen Regulate In Situ T Cell Receptor Affinity, Function, and Fate of CD8+ T Cells.

scientific article published on November 2016

MHC variant peptide-mediated anergy of encephalitogenic T cells requires SHP-1.

scientific article published in November 2008

Measuring diffusion and binding kinetics by contact area FRAP.

scientific article published on 4 April 2008

Mechanical regulation of T-cell functions

scientific article

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity.

scientific article published on 11 April 2016

Mechanochemical coupling of formin-induced actin interaction at the level of single molecular complex

scientific article published on 21 January 2020

Mechanochemitry: a molecular biomechanics view of mechanosensing.

scientific article published on 05 September 2013

Mechanosensing through immunoreceptors

scientific article published on 18 September 2019

Molecular force spectroscopy on cells

scientific article published on 12 January 2015

Molecular mechanisms of mechanotransduction in integrin-mediated cell-matrix adhesion.

scientific article

Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases.

scientific article published on 11 September 2017

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.

scientific article published on 2 March 2017

Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells.

scientific article

P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces

scientific article

Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.

scientific article

Pre-TCR ligand binding impacts thymocyte development before αβTCR expression.

scientific article published on 8 June 2015

Probabilistic modeling of rosette formation.

scientific article

Programmable Multivalent DNA-Origami Tension Probes for Reporting Cellular Traction Forces

scientific article published on 05 July 2018

Quantifying the impact of membrane microtopology on effective two-dimensional affinity

scientific article published on 29 January 2001

Regulation of actin catch-slip bonds with a RhoA-formin module

scientific article published on 12 October 2016

Regulatory and T Effector Cells Have Overlapping Low to High Ranges in TCR Affinities for Self during Demyelinating Disease

scientific article

Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation

scientific article published on 31 May 2018

T cell triggering: insights from 2D kinetics analysis of molecular interactions

scientific article published on 07 August 2012

T cells like a firm molecular handshake

scholarly article

The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex

scientific article published on 22 May 2015

The differential effect of endothelial cell factors on in vitro motility of malignant and non-malignant cells.

scientific article published on 9 April 2008

The membrane anchor influences ligand binding two-dimensional kinetic rates and three-dimensional affinity of FcgammaRIII (CD16)

scientific article published on 01 April 2000

Thermo-mechanical responses of a surface-coupled AFM cantilever.

scientific article published in December 2005

Transport governs flow-enhanced cell tethering through L-selectin at threshold shear.

scientific article

Triphasic force dependence of E-selectin/ligand dissociation governs cell rolling under flow.

scientific article

Tyrosine replacement in P-selectin glycoprotein ligand-1 affects distinct kinetic and mechanical properties of bonds with P- and L-selectin.

scientific article published on November 1999

List of works by Cheng Zhu

2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

A FRET-Based Biosensor for Imaging SYK Activities in Living Cells

A TCR mechanotransduction signaling loop induces negative selection in the thymus

A generalizable, tunable microfluidic platform for delivering fast temporally varying chemical signals to probe single-cell response dynamics.

A model for cyclic mechanical reinforcement

A model for single-substrate trimolecular enzymatic kinetics.

A modified Boyden chamber assay for tumor cell transendothelial migration in vitro

A thermodynamic and biomechanical theory of cell adhesion. Part I: General formulism.

Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling.

Accumulation of serial forces on TCR and CD8 frequently applied by agonist antigenic peptides embedded in MHC molecules triggers calcium in T cells

Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds.

An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis

Author Correction: Mechanosensing through immunoreceptors

Bending rigidities of cell surface molecules P-selectin and PSGL-1

Binary Time Series Modeling with Application to Adhesion Frequency Experiments

Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor.

Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment

Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets.

Concurrent binding to multiple ligands: kinetic rates of CD16b for membrane-bound IgG1 and IgG2

Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets.

Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals.

DNA-based digital tension probes reveal integrin forces during early cell adhesion.

Demonstration of catch bonds between an integrin and its ligand.

Diffusion of microspheres in shear flow near a wall: use to measure binding rates between attached molecules.

Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow.

Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis.

Effects of anchor structure and glycosylation of Fcγ receptor III on ligand binding affinity

Flow induces loop-to-beta-hairpin transition on the beta-switch of platelet glycoprotein Ib alpha

Flow-Enhanced Stability of Rolling Adhesion through E-Selectin.

Flow-enhanced adhesion regulated by a selectin interdomain hinge.

Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells.

Force-history dependence and cyclic mechanical reinforcement of actin filaments at the single molecular level

From cellular to molecular mechanobiology

Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor.

In situ and in silico kinetic analyses of programmed cell death-1 (PD-1) receptor, programmed cell death ligands, and B7-1 protein interaction network.

Insights from in situ analysis of TCR-pMHC recognition: response of an interaction network

Kinetic measurements of cell surface E-selectin/carbohydrate ligand interactions

Kinetics of MHC-CD8 interaction at the T cell membrane.

L-selectin mechanochemistry restricts neutrophil priming in vivo.

Local Cellular and Cytokine Cues in the Spleen Regulate In Situ T Cell Receptor Affinity, Function, and Fate of CD8+ T Cells.

MHC variant peptide-mediated anergy of encephalitogenic T cells requires SHP-1.

Measuring diffusion and binding kinetics by contact area FRAP.

Mechanical regulation of T-cell functions

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity.

Mechanochemical coupling of formin-induced actin interaction at the level of single molecular complex

Mechanochemitry: a molecular biomechanics view of mechanosensing.

Mechanosensing through immunoreceptors

Molecular force spectroscopy on cells

Molecular mechanisms of mechanotransduction in integrin-mediated cell-matrix adhesion.

Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases.

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.

Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells.

P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces

Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.

Pre-TCR ligand binding impacts thymocyte development before αβTCR expression.

Probabilistic modeling of rosette formation.

Programmable Multivalent DNA-Origami Tension Probes for Reporting Cellular Traction Forces

Quantifying the impact of membrane microtopology on effective two-dimensional affinity

Regulation of actin catch-slip bonds with a RhoA-formin module

Regulatory and T Effector Cells Have Overlapping Low to High Ranges in TCR Affinities for Self during Demyelinating Disease

Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation

T cell triggering: insights from 2D kinetics analysis of molecular interactions

T cells like a firm molecular handshake

The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex

The differential effect of endothelial cell factors on in vitro motility of malignant and non-malignant cells.

The membrane anchor influences ligand binding two-dimensional kinetic rates and three-dimensional affinity of FcgammaRIII (CD16)

Thermo-mechanical responses of a surface-coupled AFM cantilever.

Transport governs flow-enhanced cell tethering through L-selectin at threshold shear.

Triphasic force dependence of E-selectin/ligand dissociation governs cell rolling under flow.

Tyrosine replacement in P-selectin glycoprotein ligand-1 affects distinct kinetic and mechanical properties of bonds with P- and L-selectin.