List of works by Michele Perni

Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation

scientific article published on 16 October 2019

C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis

scientific article published on 27 December 2019

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

scientific article published on 20 July 2021

Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification

scientific article published on 19 July 2019

Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans

scientific article published on 27 June 2019

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery

scientific article published on 13 February 2018

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies

scientific article published on 14 May 2019

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

scientific article published on 03 June 2020

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

scientific article published on 04 November 2020

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

scientific article published on 10 August 2018

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

scientific article

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

scientific article published on 13 August 2020

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

scientific article published in Nature Communications

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