List of works - Benedetta Mannini

Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N ⬇️

scientific article published on April 18, 2013

Bis(indolyl)phenylmethane derivatives are effective small molecules for inhibition of amyloid fibril formation by hen lysozyme.

scientific article published on 26 August 2016

Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity

scientific article

Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers

scientific article published on 02 August 2019

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

Proteome-wide observation of the phenomenon of life on the edge of solubility

scientific article published on 31 December 2019

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

scientific article published on 03 June 2020

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

scientific article published on 25 June 2020

Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

scientific article published on 10 June 2020

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

scientific article published on 04 November 2020

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

scientific article published on 10 August 2018

Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates

scientific article published on 01 November 2021

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

scientific article

Toxic HypF-N Oligomers Selectively Bind the Plasma Membrane to Impair Cell Adhesion Capability.

scientific article published in March 2018

Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity

scientific article published on 11 August 2014

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

scientific article published on 25 September 2013

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

scientific article published on 13 August 2020

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

scientific article published in Nature Communications

List of works by Benedetta Mannini