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List of works by John M Mariadason

A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells.

scientific article

ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types.

scientific article published on 13 June 2017

Aberrant DNA Methylation in Colorectal Cancer: What Should We Target?

scientific article published on 12 September 2017

Altered dynamics of intestinal cell maturation in Apc1638N/+ mice.

scientific article

An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression

scientific article published on 29 September 2009

Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity.

scientific article published on 20 February 2014

Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction.

scientific article published on 12 January 2010

Application of gene expression profiling to colon cell maturation, transformation and chemoprevention.

scientific article

Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment.

scientific article published on 06 April 2010

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

scientific article published on 24 April 2019

BRAF inhibitor-driven tumor proliferation in a KRAS-mutated colon carcinoma is not overcome by MEK1/2 inhibition.

scientific article published on 4 November 2013

Biomarkers of 5-FU response in colon cancer ⬇️

scientific article published on April 15, 2011

Brush border myosin Ia has tumor suppressor activity in the intestine.

scientific article published on 18 January 2012

Brush border myosin Ia inactivation in gastric but not endometrial tumors

scientific article

By moonlighting in the nucleus, villin regulates epithelial plasticity.

scientific article

Carcinoma of the colon in an adult with intestinal malrotation.

scientific article published on 29 July 2013

Cell Line Models of Molecular Subtypes of Colorectal Cancer

scientific article published on 01 January 2018

Colorectal Cancer Cell Line Proteomes are Representative of Primary Tumors and Predict Drug Sensitivity

scientific article

Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues.

scientific article

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer

scientific article published on 22 April 2014

Customizing chemotherapy for colon cancer: the potential of gene expression profiling.

scientific article published in June 2004

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.

scientific article

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

scientific article published on 22 November 2019

Dietary components modify gene expression: implications for carcinogenesis.

scientific article

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

scientific article published on 16 March 2016

Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer

scientific article

ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer

scientific article published on 30 August 2018

EPHB4 and survival of colorectal cancer patients.

scientific article published on September 2006

Enhanced Solubility, Permeability and Anticancer Activity of Vorinostat Using Tailored Mesoporous Silica Nanoparticles

scientific article published on 17 December 2018

Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin

scientific article published on 17 September 2019

Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer.

scientific article

FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis

scientific article

FunRich: An open access standalone functional enrichment and interaction network analysis tool

scientific article

Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets

scientific article published on 31 October 2019

Genomic and biological characterization of exon 4 KRAS mutations in human cancer

scientific article

Global protein profiling reveals anti-EGFR monoclonal antibody 806-modulated proteins in A431 tumor xenografts

scientific article published on 20 August 2013

HDAC4 promotes growth of colon cancer cells via repression of p21.

scientific article published on 16 July 2008

Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment

scientific article published on 5 May 2015

Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer.

scientific article

Interaction of genetic and dietary factors in mouse intestinal tumorigenesis

scientific article published on 01 October 2006

Interleukin 33 signaling restrains sporadic colon cancer in an interferon-gamma-dependent manner.

scientific article published on 20 February 2018

Intestinal epithelial-specific PTEN inactivation results in tumor formation

scientific article published on 11 August 2011

K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines

scientific article published on 24 May 2017

Kaiso-deficient mice show resistance to intestinal cancer

scientific article

Loss of the EPH receptor B6 contributes to colorectal cancer metastasis

scientific article published on 06 March 2017

Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer Cells

scientific article

Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.

scientific article

Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer

scientific article published on 5 December 2017

Meta-analysis of microarray studies reveals a novel hematopoietic progenitor cell signature and demonstrates feasibility of inter-platform data integration

scientific article published on 13 August 2008

Molecular imaging of death receptor 5 occupancy and saturation kinetics in vivo by humanized monoclonal antibody CS-1008.

scientific article published on 17 September 2013

Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells.

scientific article published on November 2004

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy

scientific article

Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT

scientific article

Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan

scientific article published on May 2014

Overexpression of TP53 protein is associated with the lack of adjuvant chemotherapy benefit in patients with stage III colorectal cancer

scientific article published on 30 August 2019

PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation

scientific article published on 28 June 2017

PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity.

scientific article published on 17 March 2014

PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer.

scientific article

Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer

scientific article

Phase II study of everolimus (RAD001) monotherapy as first-line treatment in advanced biliary tract cancer with biomarker exploration: the RADiChol Study.

scientific article published on 12 March 2018

Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer

scientific article

Prediction and testing of biological networks underlying intestinal cancer

scientific article

Protective role of the epithelium of the small intestine and colon ⬇️

scientific article published on January 1, 1996

Proteomic changes during intestinal cell maturation in vivo

scientific article

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer.

scientific article

ROS1 and ALK fusions in colorectal cancer, with evidence of intratumoral heterogeneity for molecular drivers.

scientific article

Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing

scientific article

Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents ⬇️

scientific article published on December 18, 2012

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

scientific article

Short chain fatty acids and colon cancer

scientific article published on 01 December 2002

Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer

scientific article published on 20 November 2014

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner

scientific article

The prognostic impact of consensus molecular subtypes (CMS) and its predictive effects for bevacizumab benefit in metastatic colorectal cancer: molecular analysis of the AGITG MAX clinical trial

scientific article published on 01 November 2018

The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.

scientific article

Vascular endothelial growth factor D expression is a potential biomarker of bevacizumab benefit in colorectal cancer

scientific article

Villin expression is frequently lost in poorly differentiated colon cancer.

scientific article

Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells

scientific article

c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression

scientific article published in July 2007

c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis.

scientific article published on November 2003

β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

scientific article

β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

scientific article

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