List of works - Alexander L Breeze

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

scientific article

Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release.

scientific article published in January 1984

Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3

Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation

scientific article

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System ⬇️

scientific article published on 16 February 2018

Evaluation of 15N-detected H-N correlation experiments on increasingly large RNAs ⬇️

scientific article

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies ⬇️

scientific article

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures

scientific article

Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data. ⬇️

scientific article published on 11 May 2018

Fragment screening to predict druggability (ligandability) and lead discovery success.

scientific article published on 16 February 2011

Interactions between discrete neuronal membrane binding sites for the putative K+-channel ligands beta-bungarotoxin, dendrotoxin and mast-cell-degranulating peptide

scientific article published on 01 January 1989

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use. ⬇️

scientific article

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence ⬇️

scientific article published on 12 November 2015

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 1 ⬇️

scientific article published on January 17, 2013

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074. ⬇️

scientific article published on 26 March 2018

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

scientific article published on 30 June 2021

Real-time monitoring of New Delhi metallo-β-lactamase activity in living bacterial cells by 1H NMR spectroscopy ⬇️

scientific article published on 23 January 2014

Secondary structure and backbone dynamics of human granulocyte colony-stimulating factor in solution

scientific article published on 01 June 1994

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation ⬇️

scientific article

Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction ⬇️

scientific article

Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.

scientific article

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase ⬇️

scientific article published on 23 July 2015

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4

scientific article

Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase

scientific article

Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting ⬇️

scientific article published in 2018

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

scientific article published in May 2005

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups ⬇️

scientific article

Target-based whole-cell screening by ¹H NMR spectroscopy ⬇️

scientific article published on 18 February 2015

The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs ⬇️

scientific article published on 01 February 2019

Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics ⬇️

scientific article published on 24 March 2016

¹H, ¹³C and ¹⁵N resonance assignment for the human K-Ras at physiological pH.

scientific article published on 12 August 2012

List of works by Alexander L Breeze

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release.

Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3

Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System ⬇️

Evaluation of 15N-detected H-N correlation experiments on increasingly large RNAs ⬇️

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies ⬇️

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures

Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data. ⬇️

Fragment screening to predict druggability (ligandability) and lead discovery success.

Interactions between discrete neuronal membrane binding sites for the putative K+-channel ligands beta-bungarotoxin, dendrotoxin and mast-cell-degranulating peptide

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use. ⬇️

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence ⬇️

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 1 ⬇️

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074. ⬇️

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

Real-time monitoring of New Delhi metallo-β-lactamase activity in living bacterial cells by 1H NMR spectroscopy ⬇️

Secondary structure and backbone dynamics of human granulocyte colony-stimulating factor in solution

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation ⬇️

Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction ⬇️

Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase ⬇️

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4

Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase

Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting ⬇️

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups ⬇️

Target-based whole-cell screening by ¹H NMR spectroscopy ⬇️

The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs ⬇️

Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics ⬇️

¹H, ¹³C and ¹⁵N resonance assignment for the human K-Ras at physiological pH.