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List of works by Paul K Witting

3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for alpha-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation

scientific article published on 01 December 1996

A DNA oligonucleotide-hemin complex cleaves t-butyl hydroperoxide through a homolytic mechanism.

scientific article

A role for reduced coenzyme Q in atherosclerosis?

scientific article

Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.

scientific article

Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress.

scientific article

Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system?

scientific article published on 7 July 2005

Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease

scientific article

Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice

scientific article published on 01 August 2000

Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y

scientific article published on 28 November 2018

Assessment of prooxidant activity of vitamin E in human low-density lipoprotein and plasma

scientific article published on 01 January 1999

Beneficial effects of the synthetic antioxidant tert-butyl bisphenol on the hepatic microcirculation in a rat model of diabetes mellitus

scientific article

Catalase-Like Antioxidant Activity is Unaltered in Hypochlorous Acid Oxidized Horse Heart Myoglobin

scientific article published on 18 September 2019

Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease

scientific article published on 01 November 2012

Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults.

scientific article

Coenzyme Q(10) supplementation inhibits aortic lipid oxidation but fails to attenuate intimal thickening in balloon-injured New Zealand white rabbits.

scientific article published in August 2003

Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl)carboxamide in a cell model of myoglobinuria

scientific article published on May 2011

Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits

scientific article published in August 2002

Conjugates of desferrioxamine B (DFOB) with derivatives of adamantane or with orally available chelators as potential agents for treating iron overload

scientific article published in February 2010

Corrigendum to "Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis" [Free Radic. Biol. Med.

scientific article published on 20 September 2018

Corrigendum to: “Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy” [Free Radic Biol Med. 50 (2011) 1546–1555]

scientific article published on 29 August 2013

Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis ⬇️

scientific article published on February 15, 2012

Cytosolic phospholipase A2α sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells

scientific article published on 14 March 2013

Dissociation of atherogenesis from aortic accumulation of lipid hydro(pero)xides in Watanabe heritable hyperlipidemic rabbits.

scientific article

Effects of 8 weeks of CPAP on lipid-based oxidative markers in obstructive sleep apnea: a randomized trial

scientific article published on 22 December 2014

Effects of hydrogen peroxide and apolipoprotein E isoforms on apolipoprotein E trafficking in HepG2 cells.

scientific article published on 28 September 2009

Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts

scientific article

Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer's disease

scientific article published on 01 August 2018

Expression of human myoglobin in H9c2 cells enhances toxicity to added hydrogen peroxide

article

Glutathione Enhances Antibiotic Efficiency and Effectiveness of DNase I in Disrupting Pseudomonas aeruginosa Biofilms While Also Inhibiting Pyocyanin Activity, Thus Facilitating Restoration of Cell Enzymatic Activity, Confluence and Viability

scientific article published on 14 December 2017

High-Density Lipoprotein (HDL) Inhibits Serum Amyloid A (SAA)-Induced Vascular and Renal Dysfunctions in Apolipoprotein E-Deficient Mice

scientific article published on 15 February 2020

Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide.

scientific article published on 10 January 2005

Human indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions: implications for the inhibition of dioxygenase activity by hydrogen peroxide.

scientific article published on 3 December 2012

Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability

scientific article published on 01 January 2007

Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin

scientific article published on 19 June 2008

Inhibition of copper- and peroxyl radical-induced LDL lipid oxidation by ebselen: antioxidant actions in addition to hydroperoxide-reducing activity

scientific article published on 01 September 1996

Inverse deuterium kinetic isotope effect for peroxidation in human low-density lipoprotein (LDL): a simple test for tocopherol-mediated peroxidation of LDL lipids

scientific article published on 01 November 1995

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

scientific article

Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet.

scientific article published on 28 February 2006

Lipid oxidation in human low-density lipoprotein induced by metmyoglobin/H2O2: involvement of alpha-tocopheroxyl and phosphatidylcholine alkoxyl radicals

scientific article published on 01 December 1999

Measuring redox-active species in cells and tissues. Focus on "A case of mistaken identity: are reactive oxygen species actually reactive sulfide species?".

scientific article published on 17 February 2016

Metabolism of selenite in human lung cancer cells: X-ray absorption and fluorescence studies.

scientific article published on 20 October 2011

Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling

scientific article published in April 2003

Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II

scientific article

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

scientific article published on 12 March 2011

Molecular changes to the rat renal cotransporters PEPT1 and PEPT2 due to ageing

scientific article published on 17 July 2018

Molecules in focus: cytosolic phospholipase A2-alpha.

scientific article published on 08 August 2008

Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease.

scientific article published on 13 March 2018

Myoglobin induces oxidative stress and decreases endocytosis and monolayer permissiveness in cultured kidney epithelial cells without affecting viability.

scientific article published on 8 January 2008

NFκB Inhibition Mitigates Serum Amyloid A-Induced Pro-Atherogenic Responses in Endothelial Cells and Leukocyte Adhesion and Adverse Changes to Endothelium Function in Isolated Aorta ⬇️

article

Neuroglobin overexpression in cultured human neuronal cells protects against hydrogen peroxide insult via activating phosphoinositide-3 kinase and opening the mitochondrial K(ATP) channel.

scientific article published on September 2010

Neutrophils recruited to the myocardium after acute experimental myocardial infarct generate hypochlorous acid that oxidizes cardiac myoglobin.

scientific article

Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle.

scientific article published on 25 September 2009

Nitroxides Mitigate Neutrophil-Mediated Damage to the Myocardium after Experimental Myocardial Infarction in Rats

scientific article published on 16 October 2020

Optimal Preparation of Formalin Fixed Samples for Peptide Based Matrix Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Workflows.

scientific article published on 16 January 2018

Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine

scientific article published on 23 May 2006

Oxidation of Free Fatty Acids in Low Density Lipoprotein by 15-Lipoxygenase Stimulates Nonenzymic, α-Tocopherol-mediated Peroxidation of Cholesteryl Esters

scientific article published in Journal of Biological Chemistry

Oxidation of high density lipoproteins. I. Formation of methionine sulfoxide in apolipoproteins AI and AII is an early event that accompanies lipid peroxidation and can be enhanced by alpha-tocopherol

scientific article published on 01 March 1998

Oxidation of high density lipoproteins. II. Evidence for direct reduction of lipid hydroperoxides by methionine residues of apolipoproteins AI and AII

scientific article published on 01 March 1998

Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product?

scientific article published on January 2013

Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction

scientific article published on 05 July 2011

Pitfalls in the use of arachidonic acid oxidation products to assign lipoxygenase activity in cancer cells.

scientific article

Pleiotropic, heart rate-independent cardioprotection by ivabradine.

scientific article published on 21 July 2015

Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice.

scientific article published on 16 April 2008

Pre-treatment with the synthetic antioxidant T-butyl bisphenol protects cerebral tissues from experimental ischemia reperfusion injury

scientific article published on 6 June 2014

Probucol protects against hypochlorite-induced endothelial dysfunction: identification of a novel pathway of probucol oxidation to a biologically active intermediate.

scientific article

Protective Role for Antioxidants in Acute Kidney Disease

scientific article

Protective effects of probucol in two animal models of atherosclerosis

scientific article published on 01 January 2000

Rat models of myocardial infarction. Pathogenetic insights and clinical relevance

scientific article published on 01 November 2006

Reaction of human myoglobin and H2O2. Electron transfer between tyrosine 103 phenoxyl radical and cysteine 110 yields a protein-thiyl radical.

scientific article

Reaction of human myoglobin and H2O2. Involvement of a thiyl radical produced at cysteine 110

scientific article published on 01 July 2000

Reaction of human myoglobin and peroxynitrite: characterizing biomarkers for myoglobin-derived oxidative stress.

scientific article

Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities.

scientific article published on October 2008

Regio- and stereo-chemical oxidation of linoleic acid by human myoglobin and hydrogen peroxide: Tyr(103) affects rate and product distribution.

scientific article published on July 2004

Regulation of vascular tone by S-nitroso-myoglobin

scientific article published on 01 January 2004

Retraction. The significance of neuroglobin in the brain

scientific article published on 01 January 2010

Role of alpha-tocopheroxyl radical in the initiation of lipid peroxidation in human low-density lipoprotein exposed to horse radish peroxidase

scientific article published on 01 February 1997

Role of tyrosine-103 in myoglobin peroxidase activity: kinetic and steady-state studies on the reaction of wild-type and variant recombinant human myoglobins with H(2)O(2).

scientific article published in September 2002

Selective inhibition of the master regulator transcription factor Egr-1 with catalytic oligonucleotides reduces myocardial injury and improves left ventricular systolic function in a preclinical model of myocardial infarction

scientific article published on 31 July 2013

Selenite-mediated production of superoxide radical anions in A549 cancer cells is accompanied by a selective increase in SOD1 concentration, enhanced apoptosis and Se-Cu bonding

scientific article published on 15 February 2014

Selenium inhibits renal oxidation and inflammation but not acute kidney injury in an animal model of rhabdomyolysis

scientific article published on 16 October 2012

Selenium metabolism in cancer cells: the combined application of XAS and XFM techniques to the problem of selenium speciation in biological systems

scientific article published on 21 May 2013

Serum amyloid A induction of cytokines in monocytes/macrophages and lymphocytes

scientific article published on 21 May 2009

Serum amyloid A may potentiate prothrombotic and proinflammatory events in acute coronary syndromes.

scientific article

Serum amyloid A receptor blockade and incorporation into high-density lipoprotein modulates its pro-inflammatory and pro-thrombotic activities on vascular endothelial cells

scientific article published on 15 May 2015

Serum amyloid A stimulates cultured endothelial cells to migrate and proliferate: inhibition by the multikinase inhibitor BIBF1120.

scientific article published in September 2013

Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells

scientific article

Site-specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b5-mediated heme reduction

scientific article published on 2 October 2009

Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.

scientific article published on 17 February 2009

Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen.

scientific article

Targeting of cytosolic phospholipase A2α impedes cell cycle re-entry of quiescent prostate cancer cells

scientific article published on 24 September 2015

The acute-phase protein serum amyloid A induces endothelial dysfunction that is inhibited by high-density lipoprotein

scientific article published on 04 July 2011

The endothelium-derived hyperpolarizing factor, H2O2, promotes metal-ion efflux in aortic endothelial cells: elemental mapping by a hard X-ray microprobe

scientific article published in October 2006

The nitroxide 4-methoxy TEMPO inhibits neutrophil-stimulated kinase activation in H9c2 cardiomyocytes.

scientific article

The significance of neuroglobin in the brain.

scientific article published on January 2010

The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction

scientific article published on 01 January 2014

The synthetic polyphenol tert-butyl-bisphenol inhibits myoglobin-induced dysfunction in cultured kidney epithelial cells.

scientific article published in August 2010

Therapeutic inflammatory monocyte modulation using immune-modifying microparticles

scientific article

Tissue vibration induces carotid artery endothelial dysfunction: a mechanism linking snoring and carotid atherosclerosis?

scientific article

Vitamin E Analogues Inhibit Angiogenesis by Selective Induction of Apoptosis in Proliferating Endothelial Cells: The Role of Oxidative Stress

scientific article published on 01 December 2007

Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway.

scientific article

XAS and XFM studies of selenium and copper speciation and distribution in the kidneys of selenite-supplemented rats

scientific article published in September 2014

XAS studies of Se speciation in selenite-fed rats

scientific article

α-Tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids ⬇️

scientific article published on July 22, 1997

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