List of works by Luciano De Petrocellis

(-)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels

scientific article published on 25 March 2010

3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators

scientific article published on 14 August 2013

A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up

scientific article published on 7 October 2009

A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons

scientific article

A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid

scientific article published in March 2002

Actions and Regulation of Ionotropic Cannabinoid Receptors

scientific article published on 12 June 2017

Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels

scientific article

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

scientific article

Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum

scientific article

An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery?

scientific article published on January 2011

An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors

scientific article

An introduction to the endocannabinoid system: from the early to the latest concepts

scientific article published on February 2009

Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels

scientific article

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma

scientific article (publication date: September 2006)

Arachidonic acid, protein kinase C activators and bud formation in Hydra vulgaris

article published in 1993

Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells

scientific article published on 05 March 2007

Arylboronic acids as dual-action FAAH and TRPV1 ligands

scientific article published on 25 January 2016

Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring

scientific article

Bioactive Prenylogous Cannabinoid from Fiber Hemp (Cannabis sativa)

scientific article published on 08 September 2011

Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa

scientific article

Cannabimimetic eicosanoids in cancer and inflammation: an update.

scientific article published in January 2002

Cannabimovone, a Cannabinoid with a Rearranged Terpenoid Skeleton from Hemp

Cannabinoid CB1 receptor elevation of intracellular calcium in neuroblastoma SH-SY5Y cells: interactions with muscarinic and delta-opioid receptors

scientific article

Cannabitwinol, a Dimeric Phytocannabinoid from Hemp, Cannabis sativa L., Is a Selective Thermo-TRP Modulator

scientific article published on 03 September 2020

Capsaicin-like effects of N-arachidonoyl-dopamine in the isolated guinea pig bronchi and urinary bladder

scientific article (publication date: 15 August 2003)

Cell signalling: why fasting worms age slowly

scientific article published in May 2011

Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo.

scientific article

Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.

scientific article

Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease

scientific article published on March 2003

Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes

scientific article published on May 2009

Corrigendum to Halogenation of a capsaicin analogue leads to novel vanilloid TRPVI receptor antagonists.

scientific article

Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide,

scientific article published on 4 March 2016

Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes

scientific article published on 18 October 2020

Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential

scientific article

Discovery of a Remarkable Methyl Shift Effect in the Vanilloid Activity of Triterpene Amides

scientific article published on 02 November 2020

Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands

scientific article published on 28 January 2015

Dopamides, vanillylamides, ethanolamides, and arachidonic acid amides of anti-inflammatory and analgesic drug substances as TRPV1 ligands

scientific article

Effect of acyclic monoterpene alcohols and their derivatives on TRP channels

scientific article published on 12 October 2014

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels

scientific article published on May 2014

Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems

scientific article

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes ⬇️

scientific article

Effects of curcumin and curcumin analogues on TRP channels.

scientific article published on 10 September 2017

Effects of metabolites of the analgesic agent dipyrone (metamizol) on rostral ventromedial medulla cell activity in mice.

scientific article published on 31 December 2014

Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice

scientific article published on 09 September 2018

Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists

scientific article published on 14 September 2018

Enantioselective synthesis and vanilloid activity evaluation of 1-beta-(p-methoxycinnamoyl)polygodial, an antinociceptive compound from Drymis winteri barks

scientific article published on 5 October 2007

Enantioselective synthesis of 1-(R)-hydroxypolygodial and its 9α epimer, 1-(R)-hydroxyisotadeonal

Enantioselective synthesis of 3(S)-hydroxy polygodial derivatives and evaluation of their vanilloid activity

Endocannabinoid signalling in the blood of patients with schizophrenia

scientific article

Endocannabinoids Part II: pathological CNS conditions involving the endocannabinoid system and their possible treatment with endocannabinoid-based drugs

scientific article published on 01 June 2001

Endocannabinoids and related compounds: walking back and forth between plant natural products and animal physiology

scientific article published on July 2007

Evolving visual pigments: Hints from the opsin-based proteins in a phylogenetically old “eyeless” invertebrate

scientific article published in October 2006

Exploiting nanotechnologies and TRPV1 channels to investigate the putative anandamide membrane transporter

scientific article

Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications

scientific article

Fifty years of ‘cannabinoid research’ and the need for a new nomenclature

First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands

scientific article published on 29 December 2005

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

scientific article published on October 2016

Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism

scientific article

Functional lipidomics. Calcium-independent activation of endocannabinoid/endovanilloid lipid signalling in sensory neurons by protein kinases C and A and thrombin

scientific article published on 6 February 2008

Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists

scientific article published on August 2003

Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa, as a Novel PPARγ Agonist via a Combined Computational and Functional Study

scientific article published on 03 March 2020

Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.

scientific article published on 17 July 2015

Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis

scientific article

Iodinated N-acylvanillamines: potential "multiple-target" anti-inflammatory agents acting via the inhibition of t-cell activation and antagonism at vanilloid TRPV1 channels.

scientific article published on 4 January 2006

Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids.

scientific article published on 14 December 2017

Iodine-mediated cyclization of cannabigerol (CBG) expands the cannabinoid biological and chemical space

scientific article published on 27 July 2018

Leucettamols, bifunctionalized marine sphingoids, act as modulators of TRPA1 and TRPM8 channels

scientific article published on 2 November 2012

Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels

scientific article

Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells

scientific article

Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects

scientific article

Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds

scientific article

Molecular and Functional Diversity of Visual Pigments: Clues from the Photosensitive Opsin–Like Proteins of the Animal Model Hydra

scientific article published in 2005

Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

scientific article published on 22 February 2020

N-Acyldopamines and N-Acylserotonins: From Synthetic Pharmacological Tools to Endogenous Multitarget Mediators

scholarly article published 2015

N-Acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor

scientific article

N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia

scientific article published on 4 February 2003

N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity

scientific article published on 5 January 2011

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1

scientific article

Neuroactive and Anti-inflammatory Frankincense Cembranes: A Structure-Activity Study.

scientific article published on 28 June 2016

Neuromodulatory actions neuromodulatory actions of endocannabinoids in pain and sedation.

scientific article published on January 2003

New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain

scientific article published on 21 November 2007

New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis

scientific article

New tetrazole-based selective anandamide uptake inhibitors

scientific article

Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels

scientific article

Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms

scientific article

Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action

scientific article

Novel selective and metabolically stable inhibitors of anandamide cellular uptake

scientific article published in May 2003

Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity

scientific article published on April 2006

Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature.

scientific article

Plant, synthetic, and endogenous cannabinoids in medicine

scientific article

Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8.

scientific article

Possible endocannabinoid control of colorectal cancer growth

scientific article published in September 2003

Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids

scientific article published on 18 January 2007

Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia

scientific article published on 9 May 2006

Reprint of: Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum.

scientific article published on 11 April 2018

Role of endocannabinoids and endovanilloids in Ca2+ signalling

scientific article published on 07 April 2009

Sesquiterpenoids from Common Ragweed (Ambrosia artemisiifolia L.), an Invasive Biological Polluter

Some like it pungent and vile. TRPA1 as a molecular target for the malodorous vinyl disulfides from asafoetida

scientific article

Structure-activity relationships of the prototypical TRPM8 agonist icilin

scientific article published on 16 April 2015

Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene

scientific article

Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist

scientific article published on 12 July 2014

Structure–activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The homovanillyl moiety

scientific article published on 29 September 2006

Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators

scientific article published on 31 December 2011

Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands

scientific article published on 20 October 2009

Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity

scientific article published on 20 April 2020

TRPA1 Modulating C14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba

scientific article published on 17 July 2018

TRPA1 channels as targets for resveratrol and related stilbenoids

scientific article published on 19 December 2015

TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives

scientific article published on 06 June 2015

Tetrahydro-β-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels.

scientific article published on 12 November 2012

The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system

scientific article

The 1,2,3-triazole ring as a peptido- and olefinomimetic element: discovery of click vanilloids and cannabinoids

scientific article published in January 2007

The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats

scientific article published on 20 June 2008

The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels

scientific article published on 19 January 2015

The endocannabinoid system and its therapeutic exploitation

scientific article published in September 2004

The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis

scholarly article

The endocannabinoid system: a general view and latest additions

scientific article published on 26 January 2004

The endovanilloid/endocannabinoid system: a new potential target for osteoporosis therapy.

scientific article published on 13 January 2011

The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination

scientific article published on July 2005

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