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List of works by Avril A.B. Robertson

A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome

scientific article

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

scientific article

An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes

scientific article published on 25 November 2017

An optimized whole blood assay measuring expression and activity of NLRP3-, NLRC4 and AIM2-inflammasomes.

scientific article published on 28 September 2015

Antimicrobial octapeptin C4 analogues active against Cryptococcus species.

scientific article

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome ⬇️

scientific article published on 06 February 2020

Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration

scientific article published on 10 February 2020

Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling

scientific article published in Scientific Reports

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

scientific article

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.

scientific article published on 30 May 2017

Efficient synthesis of anacardic acid analogues and their antibacterial activities.

scientific article published on 29 January 2013

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis.

scientific article published on 23 April 2018

GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans.

scientific article

High-performance liquid chromatographic separation of natural and synthetic desulphoglucosinolates and their chemical validation by UV, NMR and chemical ionisation-MS methods

scientific article published on 01 July 2001

Human Monocytes Engage an Alternative Inflammasome Pathway

scientific article published on 28 March 2016

Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950.

scientific article published on 27 September 2016

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice.

scientific article published on 23 June 2015

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

scientific article published on 01 October 2018

Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung

scientific article published on 04 October 2019

Inflammasomes in the lung.

scientific article published on 24 January 2017

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.

scientific article published on 18 December 2016

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

scientific article published on 13 May 2019

Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection

scientific article published on 04 August 2020

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.

scientific article published on 9 May 2017

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.

scientific article published on 14 July 2015

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.

scientific article published on 3 February 2017

Natural product and natural product derived drugs in clinical trials.

scientific article

PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome.

scientific article

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.

scientific article published on 31 January 2017

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

scientific article published on 28 June 2017

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

scientific article published on 17 March 2022

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

scientific article published on 10 June 2016

Small-Molecule Inhibitors of the SOX18 Transcription Factor.

scientific article

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

scientific article

Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli

scientific article

Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors.

scientific article

Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950.

scientific article published on 26 December 2017

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

scientific article

The Bohlmann–Rahtz route to functionalised pyridine scaffolds and their use in library synthesis

article published in 2003

The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals

scientific article published on 25 May 2016

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype ⬇️

scientific article published on 13 October 2016

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