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List of works by Stephen G Ward

Activation of phosphatidylinositol 3-kinase by interleukin-13. An inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29.

scientific article published on May 1997

Activation of the PI3K effector protein kinase B following ligation of CD28 or Fas

scientific article published on 01 November 1997

Analysis of CXCR3 and atypical variant expression and signalling in human T lymphocytes.

scientific article published in January 2010

Antagonism of the platelet activating factor-induced rise of the intracellular calcium ion concentration of U937 cells ⬇️

scientific article published on April 1, 1988

Antibody ligation of CD7 leads to association with phosphoinositide 3-kinase and phosphatidylinositol 3,4,5-trisphosphate formation in T lymphocytes

scientific article published on 01 February 1995

Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion.

scientific article published in June 1995

CD28 stimulates tyrosine phosphorylation, cellular redistribution and catalytic activity of the inositol lipid 5-phosphatase SHIP

scientific article published on 01 November 1999

CD28: a signalling perspective.

scientific article published on September 1996

Cell penetrating peptides fail to induce an innate immune response in epithelial cells in vitro: Implications for continued therapeutic use ⬇️

scientific article published on September 1, 2013

Chemokines and T lymphocytes: more than an attraction

scientific article

Chemokines: understanding their role in T-lymphocyte biology.

scientific article published on August 1998

Comparison of infrared thermography and laser speckle contrast imaging for the dynamic assessment of digital microvascular function.

scientific article

Des-gamma-carboxy prothrombin stimulates human vascular endothelial cell growth and migration.

scientific article

Development and characterisation of tetracycline-regulated phosphoinositide 3-kinase mutants: assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling.

scientific article

Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma).

scientific article published on 7 January 2005

Differential regulation of prostaglandin E biosynthesis by interferon-gamma in colonic epithelial cells

scientific article

Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors

scientific article published on November 2002

Evidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28.

scientific article published on August 1997

Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22.

scientific article

Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility

scientific article published on 14 March 2011

Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes.

scientific article

Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1.

scientific article published on 25 September 2009

Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels

scientific article published in October 2012

Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes.

scientific article

High PD-1/PD-L1 checkpoint interaction infers tumor selection and therapeutic sensitivity to anti-PD-1/PD-L1 treatment

scientific article published on 27 August 2020

Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium.

scientific article published on 19 November 2016

How does inflammation cause Barrett's metaplasia?

scientific article published on 12 October 2009

Hydrogen Peroxide Triggers a Dual Signaling Axis To Selectively Suppress Activated Human T Lymphocyte Migration.

scientific article

Inhibition by staurosporine of mitogen-induced calcium mobilisation in human T lymphoblasts

scientific article published on 01 November 1988

Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin

scientific article published on 01 February 1995

Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies.

scientific article published on October 2012

Interactions between phosphatidylinositol 3-kinase and nitric oxide: explaining the paradox.

scientific article

Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents.

scientific article

Leukocyte navigation mechanisms as targets in airway diseases.

scientific article published on 7 September 2006

Ligation of CD28 stimulates the formation of a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the g

scientific article published in January 2006

Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B.

scientific article

Long term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer.

scientific article published in April 2008

Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease

scientific article

Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.

scientific article published on February 2009

Millipede-like lymphocyte crawling: feeling the way with filopodia.

scientific article published in March 2009

Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes.

scientific article published on 14 January 2013

Modulation of P-glycoprotein activity by the substituted quinoxalinone compound QA3 in adriamycin-resistant K562/A02 cells

scientific article published in March 2010

New drug targets in inflammation: efforts to expand the anti-inflammatory armoury.

scientific article published on 4 February 2008

New insights into mechanisms of gastrointestinal inflammation and cancer

scientific article published on 24 October 2009

Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle.

scientific article

Optimal chemotactic responses of leukemic T cells to stromal cell-derived factor-1 requires the activation of both class IA and IB phosphoinositide 3-kinases.

scientific article published in April 2003

PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models.

scientific article

PI 3-kinase: a pivotal pathway in T-cell activation?

scientific article published on April 1996

PI3K comes of age

scientific article published on 01 January 2003

PI3K inhibitors as potential therapeutics for autoimmune disease

scientific article published on 13 April 2014

PI3Kgamma is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA.

scientific article published on 22 August 2007

Phosphoinositide 3-kinase alpha-dependent regulation of branching morphogenesis in murine embryonic lung: evidence for a role in determining morphogenic properties of FGF7

scientific article

Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond.

scientific article published on August 2007

Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines.

scientific article

Phosphoinositide 3-kinases in T lymphocyte activation

scientific article

Phosphoinositide 3-kinases in the gut: a link between inflammation and cancer?

scientific article

Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes

scientific article published on 10 December 2007

Protein arginine methylation: a new handle on T lymphocytes?

scientific article published on 22 February 2010

Regulatory role of phosphatidylinositol 3-kinase on TNF-alpha-induced cyclooxygenase 2 expression in colonic epithelial cells.

scientific article

Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes ⬇️

scientific article published on February 17, 2011

Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1.

scientific article published on 27 September 2011

Spotlight on new anti-inflammatory drug targets in the immune system

scientific article published on 01 August 2003

Spurs in the hunt for new immunomodulatory drug targets ⬇️

scientific article published on July 5, 2012

T lymphocytes on the move: chemokines, PI 3-kinase and beyond

scientific article

T-lymphocyte navigation and migration: beyond the PI3K paradigm

scientific article published on 01 April 2007

Targeting PI3K isoforms and SHIP in the immune system: new therapeutics for inflammation and leukemia.

scientific article published on 04 April 2012

Temporal variation in CB2R levels following T lymphocyte activation: Evidence that cannabinoids modulate CXCL12-induced chemotaxis

article

The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha.

scientific article published on October 1998

The PI3K inhibitor arsenal: choose your weapon!

scientific article published in October 2007

The Role of Ubiquitination and Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate in the Degradation of the Adrenomedullin Type I Receptor

scientific article published on 28 September 2017

Therapeutic potential of phosphoinositide 3-kinase inhibitors.

scientific article

Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma.

scientific article published on 13 October 2017

Toll-like receptors in the spotlight

scientific article published on 01 April 2003

Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases.

scientific article

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