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List of works by Blanca Rodriguez

A Comparative Study of Graph-Based, Eikonal, and Monodomain Simulations for the Estimation of Cardiac Activation Times ⬇️

scientific article published on April 4, 2012

A multiscale investigation of repolarization variability and its role in cardiac arrhythmogenesis

scientific article published on 20 December 2011

Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue

scientific article

Arrhythmogenesis in the heart: Multiscale modeling of the effects of defibrillation shocks and the role of electrophysiological heterogeneity

scientific article

Artificial intelligence for the electrocardiogram

scientific article published on 01 January 2019

Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics.

scientific article published on 8 May 2017

Balance between sodium and calcium currents underlying chronic atrial fibrillation termination: An in silico intersubject variability study.

scientific article published on 25 August 2016

Beta-cell hubs maintain Ca oscillations in human and mouse islet simulations

scientific article published on 01 January 2018

Bridging experiments, models and simulations: an integrative approach to validation in computational cardiac electrophysiology

scientific article published on 11 May 2012

Cardiac vulnerability to electric shocks during phase 1A of acute global ischemia

scientific article published on 01 December 2004

Chaste: Cancer, Heart and Soft Tissue Environment

scientific article published on 13 March 2020

Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay

scientific article published on 23 January 2020

Computational techniques for ECG analysis and interpretation in light of their contribution to medical advances

scientific article published in January 2018

Correction: Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition.

scientific article published on 17 May 2018

Corrigendum: The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

scientific article

Differences between left and right ventricular anatomy determine the types of reentrant circuits induced by an external electric shock. A rabbit heart simulation study

scientific article published on 11 July 2005

Differences between left and right ventricular chamber geometry affect cardiac vulnerability to electric shocks

scientific article

Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associate With Arrhythmic Risk Markers

scientific article published on 13 March 2018

ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk

scientific article

Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve

scientific article

Editorial: Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond.

scientific article

Effect of acute global ischemia on the upper limit of vulnerability: a simulation study

scientific article published on 29 January 2004

Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart

scientific article published on 01 August 2016

Electrocardiogram phenotypes in hypertrophic cardiomyopathy caused by distinct mechanisms: apico-basal repolarization gradients vs. Purkinje-myocardial coupling abnormalities

Electrophysiological and anatomical factors determine arrhythmic risk in acute myocardial ischaemia and its modulation by sodium current availability

scientific article published on 11 December 2020

Electrophysiological properties of computational human ventricular cell action potential models under acute ischemic conditions

scientific article published on 18 February 2017

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

scientific article published on 20 May 2013

Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition

scientific article

Exploring the parameter space of a rabbit ventricular action potential model to investigate the effect of variation on action potential and calcium transients

scientific article published on 01 January 2010

Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization

scientific article published on August 2014

From ionic to cellular variability in human atrial myocytes: an integrative computational and experimental study

scientific article published on 22 December 2017

Functional identification of islet cell types by electrophysiological fingerprinting

scientific article published on March 2017

Generation of histo-anatomically representative models of the individual heart: tools and application

scientific article

High-throughput cardiac science on the Grid

scientific article published in August 2010

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

scientific article published on 12 September 2017

Human ventricular activation sequence and the simulation of the electrocardiographic QRS complex and its variability in healthy and intraventricular block conditions

scientific article published on December 2016

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.

scientific article

In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes

scientific article

In vivo human left-to-right ventricular differences in rate adaptation transiently increase pro-arrhythmic risk following rate acceleration

scientific article

Inference of intramural wavefront orientation from optical recordings in realistic whole-heart models

scientific article

Integrated approach for the study of anatomical variability in the cardiac Purkinje system: from high resolution MRI to electrophysiology simulation

scientific article published in January 2010

Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation

scientific article

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy

scientific article published on 15 September 2015

Mechanistic enquiry into the effect of increased pacing rate on the upper limit of vulnerability.

scientific article published in June 2006

Mechanistic investigation into the arrhythmogenic role of transmural heterogeneities in regional ischaemia phase 1A.

scientific article published on November 2007

Modeling cardiac ischemia

scientific article published on October 2006

Modelling variability in cardiac electrophysiology: a moment-matching approach.

scientific article published in August 2017

Modulation of Cardiac Alternans by Altered Sarcoplasmic Reticulum Calcium Release: A Simulation Study

Modulation of shock-end virtual electrode polarisation as a direct result of 3D fluorescent photon scattering.

scientific article published in January 2006

Na/K pump regulation of cardiac repolarization: insights from a systems biology approach

scientific article published on 15 May 2013

Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated Guinea Pig ventricular myocytes

scientific article

Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach.

scientific article published on 26 July 2017

Photon scattering effects in optical mapping of propagation and arrhythmogenesis in the heart

scientific article published on November 2007

Population of computational rabbit-specific ventricular action potential models for investigating sources of variability in cellular repolarisation

scientific article (publication date: 2014)

Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability

scientific article published on 18 August 2017

Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia

scientific article published on 16 June 2016

Rabbit-specific ventricular model of cardiac electrophysiological function including specialized conduction system

scientific article

Reentry in survived subepicardium coupled to depolarized and inexcitable midmyocardium: insights into arrhythmogenesis in ischemia phase 1B

scientific article

Reply to the Editor-On misuse of null hypothesis testing: Analysis of biophysical model simulations.

scientific article

Role of cellular uncoupling in arrhythmogenesis in ischemia phase 1B.

scientific article published in January 2006

Scientific and regulatory evaluation of mechanistic <i>in silico</i> drug and disease models in drug development: Building model credibility

scientific article published in 2021

Slow adaptation of ventricular repolarization as a cause of arrhythmia?

scientific article published on 9 May 2014

Strategies of data layout and cache writing for input-output optimization in high performance scientific computing: Applications to the forward electrocardiographic problem

scientific article published in PLoS ONE

Synthesis of voltage-sensitive optical signals: application to panoramic optical mapping

scientific article

The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

scientific article

The Na+/K+ pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue

scientific article published on 23 December 2011

The ischemic heart: what causes ectopic beating?

scientific article published in January 2005

The role of photon scattering in optical signal distortion during arrhythmia and defibrillation

scientific article

The role of transmural ventricular heterogeneities in cardiac vulnerability to electric shocks

scientific article

The systems biology approach to drug development: application to toxicity assessment of cardiac drugs

scientific article published on 02 June 2010

Transmural electrophysiological heterogeneities in action potential duration increase the upper limit of vulnerability

scientific article published on 01 January 2006

Unlocking data sets by calibrating populations of models to data density: A study in atrial electrophysiology

scientific article published on 10 January 2018

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

scientific article

Upper limit of vulnerability in a defibrillation model of the rabbit ventricles

scientific article published in January 2003

Validation and models in computational biomedical sciences: Philosophy, science, engineering

scientific article published in October 2017

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

scientific article published on 14 December 2015

Vulnerability to electric shocks in the regionally-ischemic ventricles

article

What have we learned from mathematical models of defibrillation and postshock arrhythmogenesis? Application of bidomain simulations

scientific article published on 22 April 2006

mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study

scientific article

β-Adrenergic receptor stimulation inhibits proarrhythmic alternans in postinfarction border zone cardiomyocytes: a computational analysis

scientific article published on 26 May 2017

δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin.

scientific article

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