Search filters

List of works by Nico P Vermeulen

3,5-Disubstituted analogues of paracetamol. Synthesis, analgesic activity and cytotoxicity

scientific article published on 01 December 1995

3-Chloro-2-hydroxypropylmercapturic acid and α-chlorohydrin as biomarkers of occupational exposure to epichlorohydrin

scientific article published on 01 July 1997

4-Hydroxy-2,3-trans-nonenal stimulates microsomal lipid peroxidation by reducing the glutathione-dependent protection

scientific article published on 01 December 1987

4-Substituted 1-chloro-2-nitrobenzenes: structure-activity relationships and extension of the substrate model of rat glutathione S-transferase 4-4

scientific article published on 01 April 1997

A Comparative Linear Interaction Energy and MM/PBSA Study on SIRT1-Ligand Binding Free Energy Calculation

scientific article published on 11 September 2019

A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants

A physiologically-based pharmacokinetic(PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism

scientific article published on 01 August 2000

A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

scientific article published on 01 March 1992

A predictive substrate model for rat glutathione S-transferase 4-4

scientific article published on 01 July 1995

A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building

scientific article published on 01 June 1993

A refined substrate model for human cytochrome P450 2D6

scientific article published on 01 January 1997

A theoretical study on the metabolic activation of paracetamol by cytochrome P-450: indications for a uniform oxidation mechanism

scientific article published on 01 January 1989

A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108

scientific article published on 01 October 1996

ABSTRACTS

scientific article (publication date: March 2006)

Ab initio calculations on iron-porphyrin model systems for intermediates in the oxidative cycle of cytochrome P450s

scientific article published on March 1, 1998

Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion.

scientific article published on 5 July 2018

Activation of microsomal glutathione S-transferase and inhibition of cytochrome P450 1A1 activity as a model system for detecting protein alkylation by thiourea-containing compounds in rat liver microsomes

scientific article published on 01 May 1999

Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants

scientific article

Active site substitution A82W improves the regioselectivity of steroid hydroxylation by cytochrome P450 BM3 mutants as rationalized by spin relaxation nuclear magnetic resonance studies.

scientific article

Allylmercapturic acid as urinary biomarker of human exposure to allyl chloride ⬇️

scientific article published on September 1, 1997

An on-line post-column detection system for the detection of reactive-oxygen-species-producing compounds and antioxidants in mixtures.

scientific article published on 28 April 2007

Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites.

scientific article published on 16 June 2011

Application of a Continuous-Flow Bioassay to Investigate the Organic Solvent Tolerability of Cytochrome P450 BM3 Mutants.

scientific article published on 22 September 2015

Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity.

scientific article published on 11 January 2016

Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone.

scientific article published on 18 November 2010

Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs.

scientific article

Application of lipid peroxidation and protein oxidation biomarkers for oxidative damage in mammalian cells. A comparison with two fluorescent probes.

scientific article published on 20 February 2006

Are Automated Molecular Dynamics Simulations and Binding Free Energy Calculations Realistic Tools in Lead Optimization? An Evaluation of the Linear Interaction Energy (LIE) Method

article

Assay of pemoline in human plasma, saliva and urine by capillary gas chromatography with nitrogen-selective detection

scientific article published on 01 September 1978

Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography-mass spectrometry.

scientific article published on 19 September 2007

Automated high-performance liquid chromatographic determination of antipyrine and its main metabolites in plasma, saliva and urine, including 4,4'-dihydroxyantipyrine

scientific article published on 01 December 1983

Beta-lyase-dependent attenuation of cisplatin-mediated toxicity by selenocysteine Se-conjugates in renal tubular cell lines.

scientific article

Binding free energy predictions of farnesoid X receptor (FXR) agonists using a linear interaction energy (LIE) approach with reliability estimation: application to the D3R Grand Challenge 2.

scientific article published on 9 September 2017

Binding mode prediction of cytochrome p450 and thymidine kinase protein-ligand complexes by consideration of water and rescoring in automated docking.

scientific article published in April 2005

Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy

scientific article published in February 2006

Bioactivation of N-substituted N'-(4-imidazole-ethyl)thioureas by human FMO1 and FMO3

Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: indications for formation of both thionoacylating species and thiiranes as reactive intermediates

scientific article published on 01 October 1996

Bioactivation of dibrominated biphenyls by cytochrome P450 activity to metabolites with estrogenic activity and estrogen sulfotransferase inhibition capacity.

scientific article

Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K

scientific journal article

Biomarkers of free radical damage applications in experimental animals and in humans

scientific article published on 01 January 1999

Biomonitoring aquatic pollution with feral eel (Anguilla anguilla). III. Statistical analyses of relationships between contaminant exposure and biomarkers

article by Ron van der Oost et al published July 1997 in Aquatic Toxicology

Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme

scientific article published on 16 December 2014

Biotransformation and quantitative determination of sulfur-containing metabolites of 1,4-dibromobutane in the rat

scientific article published on 01 September 1986

Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking.

scientific article published in April 2006

Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines.

scientific article published on 26 April 2016

Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine

scientific article published on 8 October 2016

Characterization of human cytochrome P450s involved in the bioactivation of tri-ortho-cresyl phosphate (ToCP)

scientific article published on 02 March 2015

Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A-catalysed hydroxylation by sulfaphenazole

scientific article published on 26 December 2018

Characterization of thioether compounds formed from alkaline degradation products of enflurane.

scientific article published in July 2001

Chemical and glutathione conjugation-related degradation of fotemustine: formation and characterization of a glutathione conjugate of diethyl (1-isocyanatoethyl)phosphonate, a reactive metabolite of fotemustine

scientific article published on 01 May 1994

Combining substrate dynamics, binding statistics, and energy barriers to rationalize regioselective hydroxylation of octane and lauric acid by CYP102A1 and mutants

scientific article

Comparative cytotoxicity of 14 novel selenocysteine se-conjugates in rat renal proximal tubular cells

scientific article published on 01 November 1996

Comparative cytotoxicity of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices.

scientific article published in April 2004

Comparative toxicokinetics of 2,2'- and 4,4'-dichlorobiphenyls in the pond snail Lymnaea stagnalis (L.).

scientific article published on 01 July 1990

Comprehensive and Automated Linear Interaction Energy Based Binding-Affinity Prediction for Multifarious Cytochrome P450 Aromatase Inhibitors

scientific article published on 04 August 2017

Computational prediction of drug binding and rationalisation of selectivity towards cytochromes P450

scientific article published on 01 May 2008

Computer prediction and experimental validation of cytochrome P4502D6-dependent oxidation of GBR 12909

scientific article published on 01 June 1995

Contribution of 4-hydroxy-2,3-trans-nonenal to the reduction of beta-adrenoceptor function in the heart by oxidative stress

scientific article published on 01 January 1989

Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug candidates.

scientific article published on May 2011

Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats

scientific article published on 01 November 1983

Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats with a portacaval shunt.

scientific article

Correlation of apparent intrinsic clearances of simultaneously administered S (+) and d3R (-) hexobarbital in the rat

scientific article published on 01 April 1987

Cytochrome P450 2B1-mediated one-electron reduction of adriamycin: a study with rat liver microsomes and purified enzymes

scientific article published on 01 December 1993

Cytochrome P450 bio-affinity detection coupled to gradient HPLC: on-line screening of affinities to cytochrome P4501A2 and 2D6

scientific article published on 17 August 2007

Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats

scientific article published on 01 January 1996

Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases

scientific article published on 18 November 2014

Cytochrome p450 in silico: an integrative modeling approach.

scientific article

Cytotoxic and cytoprotective activities of curcumin. Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes

scientific article published on 01 June 1990

Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin.

scientific article published on July 1996

Cytotoxicity of a series of mono- and di-substituted thiourea in freshly isolated rat hepatocytes: a preliminary structure-toxicity relationship study

scientific article published on 01 February 1998

Cytotoxicity of paracetamol and 3,5-dihalogenated analogues: Role of cytochrome P-450 and formation of GSH conjugates and protein adducts.

scientific article published in February 1997

Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR.

scientific article

Determination of cisplatin and related platinum complexes in plasma ultrafiltrate and urine by high-performance liquid chromatography with on-line radioactivity detection

scientific article published on 01 June 1989

Determination of tetrahydrophtalimide and 2-thiothiazolidine-4-carboxylic acid, urinary metabolites of the fungicide captan, in rats and humans

scientific article published on 01 January 1991

Determination of two mercapturic acid metabolites of 1,3-dichloropropene in human urine with gas chromatography and sulphur-selective detection

scientific article published on 01 November 1989

Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase.

scientific article published in August 2006

Development and validation of a microsomal online cytochrome P450 bioreactor coupled to solid-phase extraction and reversed-phase liquid chromatography

scientific article published on 01 May 2005

Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography.

scientific article published in August 2005

Development of three parallel cytochrome P450 enzyme affinity detection systems coupled on-line to gradient high-performance liquid chromatography

scientific article published on 24 January 2007

Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation.

scientific article published on 28 November 2016

Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs ⬇️

scientific article published on November 26, 2011

Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors.

scientific article published in August 2017

Disposition in rat of [2-3H]-trans-4-hydroxy-2,3-nonenal, a product of lipid peroxidation

scientific article published on 01 October 1996

Disposition of 1,2-[14C]Dibromoethane in male Wistar rats

scientific article published on 01 May 1998

Disposition of allylic oxidation pathway metabolites of racemic hexobarbital in the rat

scientific article published on 01 April 1986

Disposition of hexobarbital enantiomers in the rat

scientific article published on 01 September 1983

Disposition of hexobarbitone in healthy man: kinetics of parent drug and metabolites following oral administration

scientific article

Dose-dependent pharmacokinetics of zoxazolamine in the rat

scientific article published on 01 May 1986

Dose-dependent stereoselectivity in the formation of mercapturic acids from cyclohexene oxide by the rat ⬇️

scientific article published on May 1, 1981

Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine.

scientific article published on 16 December 2017

ETAP changes

scientific article published on 01 June 2001

Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism

scientific article published in December 2017

Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.

scientific article published on 31 October 2013

Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac

scientific article

Effect of thiols on lipid peroxidation in rat liver microsomes

scientific article published on 01 January 1989

Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver

scientific article published on 01 January 1996

Effects of oxygen radical scavengers on the inactivation of SS phi X174 DNA by the semi-quinone free radical of the antitumor agent etoposide

scientific article published on 01 January 1990

Efficacy and transdermal absorption of permethrin in scabies patients.

scientific article

Enantioselective substrate binding in a monooxygenase protein model by molecular dynamics and docking.

scientific article

Endocrine disrupting chemicals-Linking internal exposure to vitellogenin levels and ovotestis in Abramis brama from Dutch surface waters.

scientific article published on 3 August 2010

Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium.

scientific article published on 7 December 2017

Enzymatic pathways of beta elimination of chemopreventive selenocysteine Se conjugates

scientific article published on 01 January 2002

Enzyme kinetics and substrate selectivities of rat glutathione S-transferase isoenzymes towards a series of new 2-substituted 1-chloro-4-nitrobenzenes.

scientific article published on February 1996

Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: comparison of three types of expression systems

scientific article published on 01 February 1999

Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies

scientific article published on 01 April 1999

Evaluation of a multi-parameter biomarker set for oxidative damage in man: increased urinary excretion of lipid, protein and DNA oxidation products after one hour of exercise.

scientific article

Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants.

scientific article

Evaluation of urinary biomarkers for radical-induced liver damage in rats treated with carbon tetrachloride

scientific article published on 01 January 1998

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

scientific article

Examination of the structure-toxicity relationships of L-cysteine-S-conjugates of halogenated alkenes and their corresponding mercapturic acids in rat renal tissue slices

scientific article published on 01 March 1993

Excretion of multiple urinary biomarkers for radical induced damage in rats treated with three different nephrotoxic compounds

scientific article published on 01 January 1998

Expression of human cytochrome P450 1A2 in Escherichia coli: a system for biotransformation and genotoxicity studies of chemical carcinogens.

scientific article published in May 1998

Extension of a predictive substrate model for human cytochrome P4502D6

scientific article published on 01 April 1997

Fish bioaccumulation and biomarkers in environmental risk assessment: a review.

scientific article published on February 2003

Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity.

scientific article published on January 2005

Free Energy Calculations Give Insight into the Stereoselective Hydroxylation of α-Ionones by Engineered Cytochrome P450 BM3 Mutants

scientific article published on 19 July 2012

Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression.

scientific article published on 2 February 2010

Gas chromatographic determination of pemoline as 5-phenyl-2,4-oxazolidinedione in human urine

scientific article published on 01 July 1977

Generic method for the absolute quantification of glutathione S-conjugates: Application to the conjugates of acetaminophen, clozapine and diclofenac

scientific article published on 06 February 2017

Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity

scientific article

Glutamine deamidation by cereal-associated lactic acid bacteria.

scientific article published in October 2007

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells.

scientific article published on 18 April 2018

Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.

scientific article

Heterologous expression of xenobiotic mammalian-metabolizing enzymes in mutagenicity tester bacteria: an update and practical considerations

scientific article

Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3

scientific article published on 08 June 2006

Hexobarbital-1',2'-epoxide: a possible intermediate in the metabolism of hexobarbital

scientific article published on 01 January 1978

High-performance liquid chromatography-based assay for glutathione transferase theta 2 activity: Application to characterize interindividual variability in human liver fractions

scientific article published on 23 April 2018

High-performance liquid chromatography-fluorescence assay of pyruvic acid to determine cysteine conjugate beta-lyase activity: application to S-1,2-dichlorovinyl-L-cysteine and S-2-benzothiazolyl-L-cysteine

scientific article published on 01 November 1992

Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.

scientific article published on January 2003

Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid

scientific article published on 26 February 2014

Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity

scientific article

Human-based alternatives to animal experiments: is ‘Replacement’ credible? ⬇️

scientific article published on January 18, 2006

Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450

scientific article published on 01 September 1998

Identification and quantitative determination of a carboxylic and a mercapturic acid metabolite of etridiazole in urine of rat and man. Potential tools for biological monitoring

scientific article published on 01 January 1991

Identification and quantitative determination of four different mercapturic acids formed from 1,3-dibromopropane and its 1,1,3,3-tetradeutero analogue by the rat

scientific article published on 01 January 1986

Identification and quantitative determination of glutathione-related urinary metabolites of fotemustine, a new anti-cancer agent

scientific article published on 01 August 1993

Identification of Critical Residues in Novel Drug Metabolizing Mutants of Cytochrome P450 BM3 Using Random Mutagenesis

scientific article published on 01 February 2007

Improving the iterative Linear Interaction Energy approach using automated recognition of configurational transitions

scientific article

In vitro bioactivation of 3-(N-phenylamino)propane-1,2-diol by human and rat liver microsomes and recombinant P450 enzymes. Implications for toxic oil syndrome

scientific article published on 03 August 2007

In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate

scientific article published on 01 July 1996

Influence of the rate of hepatic portal vein infusion on hexobarbital pharmacokinetics in the rat.

scientific article published in January 1988

Inhalation exposure to 1,3-dichloropropene in the Dutch flower-bulb culture. Part II. Biological monitoring by measurement of urinary excretion of two mercapturic acid metabolites.

scientific article published on January 1991

Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products

research work

Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations

scientific article

Integrative Modeling Strategies for Predicting Drug Toxicities at the eTOX Project

scientific article published on 11 June 2015

Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer.

scientific article published on 24 February 2016

Inter-individual variability in activity of the major drug metabolizing enzymes in liver homogenates of 20 Individuals

scientific article published on 8 January 2018

Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes

scientific article

Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants

scientific article published on 9 September 2008

Interactions of organophosphates with keratins in the cornified epithelium of human skin ⬇️

scientific article published on April 13, 2012

Interrelationships between bioaccumulation of organic trace pollutants (PCBs, organochlorine pesticides and PAHs), and MFO-induction in fish ⬇️

scientific article published on January 1, 1991

Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio

scientific article published on 01 April 1986

Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation

scientific article

Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

scientific article published on 22 August 2018

Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin

scientific article published on 17 May 2007

MX100, a new Escherichia coli tester strain for use in genotoxicity studies.

scientific article

Malleability and Versatility of Cytochrome P450 Active Sites Studied by Molecular Simulations

scientific article published on 01 February 2012

Mass spectrometric characterization of protein adducts of multiple P450-dependent reactive intermediates of diclofenac to human glutathione-S-transferase P1-1

scientific article published on 10 October 2012

Mass spectrometric identification of isocyanate-induced modifications of keratins in human skin.

scientific article

Mechanism of protection of ebselen against paracetamol-induced toxicity in rat hepatocytes

scientific article published on 01 October 1994

Mechanism of the reaction of ebselen with endogenous thiols: dihydrolipoate is a better cofactor than glutathione in the peroxidase activity of ebselen

scientific article published on 01 March 1990

Mechanisms of activation of phenacetin to reactive metabolites by cytochrome P-450: a theoretical study involving radical intermediates

scientific article published on 01 March 1990

Metabolic profiling of endocrine-disrupting compounds by on-line cytochrome p450 bioreaction coupled to on-line receptor affinity screening

scientific article

Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylamphetamines: in silico predictions and experimental validation.

scientific article

Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway.

scientific article

Metabolism of L-cysteine S-conjugates and N-(trideuteroacetyl)-L-cysteine S-conjugates of four fluoroethylenes in the rat. Role of balance of deacetylation and acetylation in relation to the nephrotoxicity of mercapturic acids

scientific article published on 01 June 1991

Metabolism ofN-substituted 7-methoxy-4-(aminomethyl) -coumarins by cytochrome P450 2D6 mutants and the indication of additional substrate interaction points

scientific article published on 01 September 2006

Metabolism related toxicity of diclofenac in yeast as model system.

scientific article published on 24 November 2010

Metabolite predictions for para-substituted anisoles based on ab initio complete active space self-consistent field calculations

scientific article published on 01 April 1995

Midazolam is a phenobarbital-like cytochrome p450 inducer in rats.

scientific article published in December 2001

Mini-dialysis tubes as tools to prepare drug-protein adducts of P450-dependent reactive drug metabolites.

scientific article published on 31 October 2014

Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate beta-lyase.

scientific article

Modeling the Active Sites of Cytochrome P450s and GlutathioneS-Transferases, two of the Most Important Biotransformation Enzymes ⬇️

scientific article published on August 1, 1997

Molecular Modeling-Guided Site-Directed Mutagenesis of Cytochrome P450 2D6

article

Molecular and biochemical mechanisms of chemically induced nephrotoxicity: a review.

scientific article published on May 1990

Molecular dynamics simulations and free energy calculations on the enzyme 4-hydroxyphenylpyruvate dioxygenase

article

Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions.

scientific article published in April 1996

Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene.

scientific article published in January 1991

Nephrotoxicity and hepatotoxicity of 1,1-dichloro-2,2-difluoroethylene in the rat. Indications for differential mechanisms of bioactivation

scientific article published on 01 December 1987

Non-linear pharmacokinetics of sparteine in the rat

scientific article published on 01 August 1986

Occurrence of a cytochrome P-450-containing mixed-function oxidase system in the pond snail, Lymnaea stagnalis

scientific article published on 01 February 1991

One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac

scientific article published on 15 November 2013

One-electron reductive bioactivation of 2,3,5,6-tetramethylbenzoquinone by cytochrome P450

scientific article published on 01 January 1992

Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures.

scientific article

Oxidative N-Dealkylation of p-Cyclopropyl-N,N-dimethylaniline. A Substituent Effect on a Radical-Clock Reaction Rationalized by Ab Initio Calculations on Radical Cation Intermediates

scientific article published on 01 November 1997

Oxygen and xenobiotic reductase activities of cytochrome P450.

scientific article published on January 1995

Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches

scientific article

Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives. Comparison of their microsomal cytochrome P-450 dependent oxidation and toxicity in freshly isolated hepatocytes

scientific article published on 01 November 1986

Paracetamol, 3-monoalkyl- and 3,5-dialkyl-substituted derivatives. Antioxidant activity and relationship between lipid peroxidation and cytotoxicity

scientific article published on 01 September 1988

Pharmacokinetics of lignocaine and bupivacaine in surgical patients following epidural administration. Simultaneous investigation of absorption and disposition kinetics using stable isotopes.

scientific article published in September 1987

Pharmacokinetics of orally administered hexobarbital in plasma and saliva of healthy subjects.

scientific article

Pharmacokinetics of pemoline in plasma, saliva and urine following oral administration ⬇️

scientific article published on November 1, 1979

Pharmacokinetics of simultaneously administered hexobarbital and heptabarbital in rats: an alternative approach to metabolic correlation studies

scientific article published on 01 June 1983

Polymorphism in the glutathione conjugation activity of human erythrocytes towards ethylene dibromide and 1,2-epoxy-3-(p-nitrophenoxy)-propane

scientific article published on 01 April 1995

Prediction of drug metabolism: the case of cytochrome P450 2D6.

scientific article

Prediction of ligand binding affinity and orientation of xenoestrogens to the estrogen receptor by molecular dynamics simulations and the linear interaction energy method.

scientific article published in February 2004

Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System.

scientific article published on 30 May 2015

Protective effects of lobenzarit against allyl alcohol-induced hepatotoxicity in mice and rats

scientific article published on 01 June 1997

Purification of glutamine transaminase K/cysteine conjugate beta-lyase from rat renal cytosol based on hydrophobic interaction HPLC and gel permeation FPLC

scientific article published on 01 December 1993

Rapid on-line profiling of estrogen receptor binding metabolites of tamoxifen

scientific article published on 01 June 2006

Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol

scientific article published on 01 June 1996

Reconstitution of the interplay between cytochrome P450 and human glutathione S-transferases in clozapine metabolism in yeast ⬇️

scientific article published on August 2, 2013

Reduced aggregation and improved specificity of G-rich oligodeoxyribonucleotides containing pyrazolo[3,4-d]pyrimidine guanine bases.

scientific article

Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations.

scientific article

Reduction of antitumour mitosenes in non-aqueous and aqueous environment. An electron spin resonance and cyclic voltammetry study

scientific article published on 01 February 1995

Reduction of cisplatin nephrotoxicity by sodium selenite. Lack of interaction at the pharmacokinetic level of both compounds

scientific article published on 01 January 1993

Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling

Relationship between paracetamol binding to and its oxidation by two cytochromes P-450 isozymes--a proton nuclear magnetic resonance and spectrophotometric study

scientific article published on 01 January 1987

Response to “The Path Forward on Endocrine Disruptors Requires Focus”.

scientific article published in February 2016

Role of Human Glutathione S-Transferases in the Inactivation of Reactive Metabolites of Clozapine ⬇️

scientific article published on September 20, 2010

Role of hepatic microsomal and purified cytochrome P-450 in one-electron reduction of two quinone imines and concomitant reduction of molecular oxygen

scientific article published on 01 March 1987

Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11 ⬇️

scientific article published on May 13, 2011

Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6.

scientific article published on 21 October 2005

Screening the oxidative potential of several mono- and di-halogenated biphenyls and biphenyl ethers in rat hepatocytes

scientific article published on 01 July 2006

Selected ion monitoring analysis of pseudoracemic hexobarbital and its major metabolites in blood and urine of rats

scientific article published on 01 September 1985

Selection of antisense oligodeoxynucleotides against glutathione S-transferase Mu.

scientific article published in December 2002

Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression

scientific journal article

Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes: analysis with a novel reverse transcriptase-polymerase chain reaction assay section sign

scientific article published on 01 November 2000

Selective reduction of cis-diamminedichloroplatinum(II) nephrotoxicity by ebselen

scientific article published on 01 November 1990

Selenium-induced protection against cis-diamminedichloroplatinum(II) nephrotoxicity in mice and rats

scientific article published on 01 June 1989

Selenoxidation by flavin-containing monooxygenases as a novel pathway for beta-elimination of selenocysteine Se-conjugates.

scientific article

Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol.

scientific article published on 13 May 2016

Simultaneous determination of blood concentrations of methohexital and its hydroxy metabolite by gas chromatography and identification of 4'-hydroxymethohexital by combined gas--liquid chromatography--mass spectrometry

scientific article published on 01 December 1981

Simultaneous determination of glutathione, glutathione disulphide, paracetamol and its sulphur containing metabolites using HPLC and electrochemical detection with on-line generated bromine

scientific article published on 01 January 1988

Simultaneous determination of tyrosine, phenylalanine and deoxyguanosine oxidation products by liquid chromatography-tandem mass spectrometry as non-invasive biomarkers for oxidative damage.

scientific article

Stereospecific analysis of racemic hexobarbital in rat blood by enantioselective capillary gas chromatography

scientific article published on 01 March 1986

Strategies to characterize the mechanisms of action and the active sites of glutathione S-transferases: a review

scientific article published on 01 August 1998

Structure-activity relationships for the glutathione conjugation of 2-substituted 1-chloro-4-nitrobenzenes by rat glutathione S-transferase 4-4

scientific article published on 01 March 1996

Synthesis of bis-spermine dimers that are potent polyamine transport inhibitors.

scientific article published in January 2002

Synthesis of novel Se-substituted selenocysteine derivatives as potential kidney selective prodrugs of biologically active selenol compounds: evaluation of kinetics of beta-elimination reactions in rat renal cytosol

scientific article published on 01 May 1996

The Use of Humanin VitroMetabolic Parameters to Explore the Risk Assessment of Hazardous Compounds: The Case of Ethylene Dibromide

scientific article published in March 1997

The cytotoxicity of mitomycin C and adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes

scientific article published on 01 July 1995

The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae

scientific article

The effect of hydrogen peroxide on beta-adrenoceptor function in the heart

scientific article published on 01 January 1988

The epoxide-diol pathway in the metabolism of hexobarbital in rat and man

scientific article published on May 1, 1979

The influence of ebselen on the toxicity of cisplatin in LLC-PK1 cells ⬇️

scientific article published on July 22, 1992

The influence of pretreatment on the urinary metabolite profile of pseudoracemic hexobarbital

scientific article published on 01 September 1986

The mechanism of interaction between cisplatin and selenite

scientific article published on 01 May 1991

The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution

scientific article (publication date: July 1987)

The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress

scientific article

The metabolic fate of 1',2'-epoxyhexobarbital in the rat.

scientific article published in August 1981

The metabolic formation of N-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-1,2-dibromoethane. relative importance of oxidation and glutathione conjugation in vivo

scientific article published on 01 September 1981

The role of lipid peroxidation in the nephrotoxicity of cisplatin

scientific article published on 01 September 1992

The role of protein plasticity in computational rationalization studies on regioselectivity in testosterone hydroxylation by cytochrome P450 BM3 mutants

scientific article

The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene.

scientific article published on July 2002

The use of macroporous microcarriers for the large-scale growth of V79 cells genetically designed to express single human cytochrome P450 isoenzymes and for the characterization of the expressed cytochrome P450

scientific article published on 01 December 1996

Thioether excretion in urine of applicators exposed to 1,3-dichloropropene: a comparison with urinary mercapturic acid excretion.

scientific article published on July 1991

Tissue distribution of cytosolic beta-elimination reactions of selenocysteine Se-conjugates in rat and human.

scientific article published in August 2002

Topological role of cytochrome P450 2D6 active site residues.

scientific article published on 23 January 2006

Towards automated binding affinity prediction using an iterative linear interaction energy approach

scientific article published on 9 January 2014

Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it.

scientific article

Toxicity of the cysteine-S-conjugates and mercapturic acids of four structurally related difluoroethylenes in isolated proximal tubular cells from rat kidney. Uptake of the conjugates and activation to toxic metabolites

scientific article published on 01 November 1989

Urinary excretion of N-acetyl-S-allyl-L-cysteine upon garlic consumption by human volunteers

scientific article published on 01 January 1996

Urinary excretion of biomarkers for radical-induced damage in rats treated with NDMA or diquat and the effects of calcium carbimide co-administration

scientific article published on 01 January 1999

Urinary excretion of biomarkers of oxidative kidney damage induced by ferric nitrilotriacetate

scientific article published on 01 June 1998

Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity.

scientific article published on 9 November 2012

Urinary metabolite profile of phenyl and o-cresyl glycidyl ether in rats: identification of a novel pathway leading to N-acetylserine O-conjugates

scientific article published on 01 February 1998

Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.

scientific article published in April 1997

Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man

scientific article published on 01 November 1984

Yeast as a humanized model organism for biotransformation-related toxicity.

scientific article published on December 2012

alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. II. Pharmacokinetics and stereoselectivity of metabolism and excretion in vivo and in the perfused liver.

scientific article published in December 1986

eTOX ALLIES: an automated pipeLine for linear interaction energy-based simulations.

scientific article published on 21 November 2017

Paulina is supported by:

About Paulina

Help