List of works - Clifford C Taggart

A functional variant of elafin with improved anti-inflammatory activity for pulmonary inflammation

scientific article published on 5 September 2014

A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung

scientific article published on 13 March 2015

A secretory leukocyte protease inhibitor variant with improved activity against lung infection

scientific article published on 16 September 2015

Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency.

scientific article published on May 2004

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.

scientific article published on 4 September 2008

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway. VOLUME 283 (2008) PAGES 31736-31744.

scientific article published in April 2009

Activity of innate antimicrobial peptides and ivacaftor against clinical cystic fibrosis respiratory pathogens.

scientific article published on 27 June 2017

Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations.

scientific article published on 16 January 2008

Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.

scientific article

Alpha-1-antitrypsin deficiency: current concepts

scientific article published on 12 June 2007

Altered Toll-like receptor 2-mediated endotoxin tolerance is related to diminished interferon beta production.

scientific article published on 24 June 2011

Altered intracellular pH regulation in neutrophils from patients with cystic fibrosis

scientific article published on 01 July 2000

Ambient pCO2 modulates intracellular pH, intracellular oxidant generation, and interleukin-8 secretion in human neutrophils.

scientific article

Anti-apoptotic effects of Z alpha1-antitrypsin in human bronchial epithelial cells.

scientific article published on 19 October 2009

Anti-proteinase 3 antibody activation of neutrophils can be inhibited by alpha1-antitrypsin.

scientific article published in June 2001

Antimicrobial efficacy of tobramycin polymeric nanoparticles for Pseudomonas aeruginosa infections in cystic fibrosis: formulation, characterisation and functionalisation with dornase alfa (DNase).

scientific article published on 4 December 2014

Antimicrobial proteins and polypeptides in pulmonary innate defence

scientific article

Antiproteases as therapeutics to target inflammation in cystic fibrosis.

scientific article published on 30 March 2010

Biomarkers to monitor exacerbations in cystic fibrosis

scientific article published on 16 March 2017

Characterisation of eppin function: expression and activity in the lung

scientific article published on 13 July 2017

Clearance of intracellular Klebsiella pneumoniae infection using gentamicin-loaded nanoparticles.

scientific article

Cystic fibrosis epithelial cells are primed for apoptosis as a result of increased Fas (CD95).

scientific article published on 24 February 2018

Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation

scientific article

Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradation

scientific article published on September 2009

Effect of different carbon sources on heterologous expression levels in the yeast S. cerevisiae BJ2168

scientific article published on 01 February 1994

Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor.

scientific article published on 4 October 2006

Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway.

scientific article

Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis

scientific article published on 17 September 2008

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis

scientific article published on 15 March 2018

Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease.

scientific article

Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo.

scientific article

Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases.

scientific article

Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.

scientific article published on 8 December 2011

High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations

scientific article published on 15 December 2010

Impaired Immune Tolerance to Porphyromonas gingivalis Lipopolysaccharide Promotes Neutrophil Migration and Decreased Apoptosis ⬇️

scientific article published on August 2, 2010

Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins

scientific article

Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8

scientific article published on 01 January 2000

Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in preclinical models of non-small cell lung cancer (NSCLC) radiotherapy.

scientific article

Innate host defense functions of secretory leucoprotease inhibitor.

scientific article published on December 2007

Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury

scientific article

Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis.

scientific article

Matrix metalloproteinases 2 and 9 in human atherosclerotic and non-atherosclerotic cerebral aneurysms

article

Nanodelivery strategies for the treatment of multidrug-resistant bacterial infections

scientific article published on 04 September 2018

Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium

scientific article

Neutrophil elastase increases airway epithelial nonheme iron levels

scientific article

Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells.

scientific article

Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4.

scientific article

Preclinical Evaluation of Dose-Volume Effects and Lung Toxicity Occurring In and Out-of-Field

scientific article published on 12 December 2018

Protean proteases: at the cutting edge of lung diseases

scientific article published on 8 February 2017

Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease

scientific article published on 28 August 2018

Protein Phosphatase 2A Reduces Cigarette Smoke-induced Cathepsin S and Loss of Lung Function

scientific article published on 01 July 2019

Regulated nuclear localisation of the yeast transcription factor Ace2p controls expression of chitinase (CTS1) in Saccharomyces cerevisiae

scientific article published on 01 September 1999

Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide

scientific article

Respiratory syncytial virus infections enhance cigarette smoke induced COPD in mice

scientific article (publication date: 2014)

Respiratory viral infection: a potential "missing link" in the pathogenesis of COPD

scientific article published on 14 March 2019

Role of IL-18 in CD4+ T lymphocyte activation in sarcoidosis

scientific article published on 01 October 2000

SLPI and elafin: multifunctional antiproteases of the WFDC family.

scientific article published on October 2011

Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression.

scientific article

Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding

scientific article

Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination.

scientific article published on 25 June 2002

Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers

scientific article published on 26 March 2009

TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells.

scientific article published on February 2005

Targeting of cathepsin S reduces cystic fibrosis-like lung disease

scientific article published on 28 March 2019

Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad.

scientific article

The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity

scientific article published on 12 July 2015

The effect of liposome encapsulation on the pharmacokinetics of recombinant secretory leukocyte protease inhibitor (rSLPI) therapy after local delivery to a guinea pig asthma model

scientific article published on 7 June 2011

The effect of recombinant human lactoferrin on growth and the antibiotic susceptibility of the cystic fibrosis pathogen Burkholderia cepacia complex when cultured planktonically or as biofilms

scientific article published on 26 June 2007

The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma

scholarly article by Akane Tanaka et al published June 2018 in The Journal of Allergy and Clinical Immunology

The prevalence of alpha-1 antitrypsin deficiency in Ireland

scientific article

The role of dietary cholesterol in the regulation of postprandial apolipoprotein B48 levels in diabetes ⬇️

scientific article published on December 1, 1997

The role of whey acidic protein four-disulfide-core proteins in respiratory health and disease

scientific article published on 8 December 2016

Tumor necrosis factor-alpha-converting enzyme: its role in community-acquired pneumonia.

scientific article published on 14 November 2002

Type-I interferons induce lung protease responses following respiratory syncytial virus infection via RIG-I-like receptors.

scientific article

Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis

scientific article published on 23 July 2011

miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production

scientific article

List of works by Clifford C Taggart

A functional variant of elafin with improved anti-inflammatory activity for pulmonary inflammation

A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung

A secretory leukocyte protease inhibitor variant with improved activity against lung infection

Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency.

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway. VOLUME 283 (2008) PAGES 31736-31744.

Activity of innate antimicrobial peptides and ivacaftor against clinical cystic fibrosis respiratory pathogens.

Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations.

Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.

Alpha-1-antitrypsin deficiency: current concepts

Altered Toll-like receptor 2-mediated endotoxin tolerance is related to diminished interferon beta production.

Altered intracellular pH regulation in neutrophils from patients with cystic fibrosis

Ambient pCO2 modulates intracellular pH, intracellular oxidant generation, and interleukin-8 secretion in human neutrophils.

Anti-apoptotic effects of Z alpha1-antitrypsin in human bronchial epithelial cells.

Anti-proteinase 3 antibody activation of neutrophils can be inhibited by alpha1-antitrypsin.

Antimicrobial efficacy of tobramycin polymeric nanoparticles for Pseudomonas aeruginosa infections in cystic fibrosis: formulation, characterisation and functionalisation with dornase alfa (DNase).

Antimicrobial proteins and polypeptides in pulmonary innate defence

Antiproteases as therapeutics to target inflammation in cystic fibrosis.

Biomarkers to monitor exacerbations in cystic fibrosis

Characterisation of eppin function: expression and activity in the lung

Clearance of intracellular Klebsiella pneumoniae infection using gentamicin-loaded nanoparticles.

Cystic fibrosis epithelial cells are primed for apoptosis as a result of increased Fas (CD95).

Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation

Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradation

Effect of different carbon sources on heterologous expression levels in the yeast S. cerevisiae BJ2168

Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor.

Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway.

Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis

Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease.

Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo.

Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases.

Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.

High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations

Impaired Immune Tolerance to Porphyromonas gingivalis Lipopolysaccharide Promotes Neutrophil Migration and Decreased Apoptosis ⬇️

Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins

Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8

Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in preclinical models of non-small cell lung cancer (NSCLC) radiotherapy.

Innate host defense functions of secretory leucoprotease inhibitor.

Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury

Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis.

Matrix metalloproteinases 2 and 9 in human atherosclerotic and non-atherosclerotic cerebral aneurysms

Nanodelivery strategies for the treatment of multidrug-resistant bacterial infections

Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium

Neutrophil elastase increases airway epithelial nonheme iron levels

Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells.

Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4.

Preclinical Evaluation of Dose-Volume Effects and Lung Toxicity Occurring In and Out-of-Field

Protean proteases: at the cutting edge of lung diseases

Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease

Protein Phosphatase 2A Reduces Cigarette Smoke-induced Cathepsin S and Loss of Lung Function

Regulated nuclear localisation of the yeast transcription factor Ace2p controls expression of chitinase (CTS1) in Saccharomyces cerevisiae

Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide

Respiratory syncytial virus infections enhance cigarette smoke induced COPD in mice

Respiratory viral infection: a potential "missing link" in the pathogenesis of COPD

Role of IL-18 in CD4+ T lymphocyte activation in sarcoidosis

SLPI and elafin: multifunctional antiproteases of the WFDC family.

Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression.

Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding

Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination.

Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers

TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells.

Targeting of cathepsin S reduces cystic fibrosis-like lung disease

Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad.

The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity

The effect of liposome encapsulation on the pharmacokinetics of recombinant secretory leukocyte protease inhibitor (rSLPI) therapy after local delivery to a guinea pig asthma model

The effect of recombinant human lactoferrin on growth and the antibiotic susceptibility of the cystic fibrosis pathogen Burkholderia cepacia complex when cultured planktonically or as biofilms

The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma

The prevalence of alpha-1 antitrypsin deficiency in Ireland

The role of dietary cholesterol in the regulation of postprandial apolipoprotein B48 levels in diabetes ⬇️

The role of whey acidic protein four-disulfide-core proteins in respiratory health and disease

Tumor necrosis factor-alpha-converting enzyme: its role in community-acquired pneumonia.

Type-I interferons induce lung protease responses following respiratory syncytial virus infection via RIG-I-like receptors.

Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis

miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production