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List of works by Marc P Hübner

A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis.

scientific article published on 28 September 2015

AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litomosoides sigmodontis

scientific article published on 05 November 2010

Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis ⬇️

scientific article published on June 15, 2013

Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

scientific article published on 26 February 2019

Chronic Helminth Infection Reduces Basophil Responsiveness in an IL-10–Dependent Manner ⬇️

scientific article published on March 28, 2012

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages

scientific article

Combination of worm antigen and proinsulin prevents type 1 diabetes in NOD mice after the onset of insulitis.

scientific article published on 16 February 2016

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

scientific article

Comparative study on serum-induced arthritis in the temporomandibular and limb joint of mice

scientific article published on 21 January 2019

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections

scientific article published on 07 December 2020

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

scientific article published on 28 February 2019

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

scientific article published on 01 May 2019

Echinococcus multilocularis metacestodes modulate cellular cytokine and chemokine release by peripheral blood mononuclear cells in alveolar echinococcosis patients.

scientific article published on August 2006

Eotaxin-1 is involved in parasite clearance during chronic filarial infection

scientific article published on 01 February 2014

Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice.

scientific article

Filarial extract of Litomosoides sigmodontis induces a type 2 immune response and attenuates plaque development in hyperlipidemic ApoE-knockout mice

scientific article published on 26 February 2019

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

scientific article published in 2022

Genome-wide transcriptome induced by Porphyromonas gingivalis LPS supports the notion of host-derived periodontal destruction and its association with systemic diseases

scientific article published on 24 November 2015

Genome-wide transcriptome induced by nickel in human monocytes

scientific article published on 28 July 2016

Helminth Protection against Autoimmune Diabetes in Nonobese Diabetic Mice Is Independent of a Type 2 Immune Shift and Requires TGF-β ⬇️

scientific article published on December 14, 2011

Helminth infection is associated with decreased basophil responsiveness in human beings ⬇️

scientific article published on May 16, 2012

Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour? ⬇️

scientific article published on September 10, 2013

Histamine 1 Receptor Blockade Enhances Eosinophil-Mediated Clearance of Adult Filarial Worms

scientific article published on 23 July 2015

IL-6 is required for protective immune responses against early filarial infection

scientific article published on 01 September 2018

Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response

scientific article

Immunomodulation by helminths: Similar impact on type 1 and type 2 diabetes?

scientific article published on 10 November 2016

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis

scientific article published on 27 January 2020

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

scientific article published on 05 August 2019

Litomosoides sigmodontis: a simple method to infect mice with L3 larvae obtained from the pleural space of recently infected jirds (Meriones unguiculatus).

scientific article published on 20 May 2009

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

scientific article published on 16 January 2019

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

scientific article published on 22 December 2016

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

scientific article published on 06 July 2020

Parasitic helminths and their beneficial impact on type 1 and type 2 diabetes.

scientific article published on 25 June 2015

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

scientific article published on 01 March 2019

Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation

scientific article published on 13 November 2019

S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis

scientific article published on 27 February 2020

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

scientific article published on 20 May 2019

Transcriptome-wide analysis of filarial extract-primed human monocytes reveal changes in LPS-induced PTX3 expression levels

scientific article published on 22 February 2019

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