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List of works by Mark Peakman

203 Preliminary therapeutic target validation of the IL-36 receptor in psoriasis

scholarly article by S.K. Mahil published in October 2017

3 beta hydroxysteroid dehydrogenase autoantibodies in patients with idiopathic premature ovarian failure target N- and C-terminal epitopes

scientific article published on 01 December 2001

A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding

scientific article published on 23 November 2016

A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells.

scientific article published on January 2015

A model for harmonizing flow cytometry in clinical trials

scientific article

A novel approach to tracking antigen-experienced CD4 T cells into functional compartments via tandem deep and shallow TCR clonotyping

scientific article published on 25 October 2013

A single autoimmune T cell receptor recognizes more than a million different peptides

scientific article published on 18 November 2011

A systematic review and critical evaluation of the immunology of chronic fatigue syndrome

scientific article

Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.

scientific article

An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target. ⬇️

scientific article

Anti-TNFalpha therapy--killing two birds with one stone?

scientific article published on 01 June 2010

Antibody combination therapy targeting CD25, CD70 and CD8 reduces islet inflammation and improves glycaemia in diabetic mice

scientific article published on 01 November 2012

Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs

scientific article

Antigen targets of type 1 diabetes autoimmunity

scientific article published in April 2012

Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine

scientific article published on 24 October 2018

Antigen-specific immunotherapy and influenza vaccination in type 1 diabetes: timing is everything.

scientific article published on 24 May 2017

Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential

scientific article

Antinuclear autoantibodies (ANA) in Gulf War-related illness and chronic fatigue syndrome (CFS) patients.

scientific article

Atorvastatin Fails to Prevent the Development of Autoimmune Diabetes Despite Inhibition of Pathogenic -Cell-Specific CD8 T-Cells

article

Autoantibodies to autonomic nerves associated with cardiac and peripheral autonomic neuropathy

scientific article

Autoreactive T cells in human type 1 diabetes.

scientific article published on March 2004

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes.

scientific article published on 16 July 2018

Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes

scientific article

Broadening the translational immunology landscape ⬇️

scientific article published on December 1, 2012

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

scientific article published on October 2008

Can we vaccinate against Type 1 diabetes? ⬇️

scientific article published on October 2, 2012

Cellular immune activation in Gulf War veterans

scientific article published in January 2004

Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop fo

scientific article

Characterization of the T-cell response to coxsackievirus B4: evidence that effector memory cells predominate in patients with type 1 diabetes

scientific article published in June 2002

Characterization of the autoimmune response against the nerve tissue S100β in patients with type 1 diabetes.

scientific article published on May 2015

Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells

scientific article

Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

scientific article published on 10 November 2019

Clinical improvement in chronic fatigue syndrome is not associated with lymphocyte subsets of function or activation.

scientific article published in January 1997

Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop

scientific article published on 01 December 2003

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

scientific article

Conjugation of a peptide autoantigen to gold nanoparticles for intradermally administered antigen specific immunotherapy

scientific article published on 22 March 2019

Correction: A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding

scientific article

Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment

scientific article published on 02 December 2013

Creating a "Transcampus" in diabetes research between King's College London and the Technische Universität Dresden: update on islet biology and transplantation.

scientific article published on 5 December 2014

Cytokine overproduction in healthy first degree relatives of patients with IDDM

scientific article published on 01 March 1998

Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

scientific article

Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR.

scientific article published on 4 March 2016

Diabetogenic T lymphocytes in human Type 1 diabetes

scientific article

Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations

scientific article published on 14 December 2012

Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule.

scientific article published on 30 December 2015

Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers.

scientific article published in June 2011

Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes

scientific article published on 11 December 2013

Enteroviruses and type 1 diabetes

scientific article published on November 2003

Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835-3845

scientific article published on September 2015

Establishing humanized mice using stem cells: maximizing the potential

scientific article published on 24 April 2008

Evolution of ectopic lymphoid neogenesis and in situ autoantibody production in autoimmune nonobese diabetic mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islets

scientific article published on 16 August 2010

GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells

scientific article published on 04 April 2020

Generation of human islet-specific regulatory T cells by TCR gene transfer

scientific article published on 20 January 2017

Genetically engineered human islets protected from CD8-mediated autoimmune destruction in vivo

scientific article published on 21 May 2013

HLA Class II molecules on haplotypes associated with type 1 diabetes exhibit similar patterns of binding affinities for coxsackievirus P2C peptides.

scientific article published in November 2005

Heterogeneity in the Locomotory Behavior of Human Monocyte Subsets over Human Vascular Endothelium In Vitro

scientific article

High levels of type 2 cytokine-producing cells in chronic fatigue syndrome

scientific article

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

scientific article published on 16 May 2016

How Representative Are Research Tissue Biobanks of the Local Populations? Experience of the Infectious Diseases Biobank at King's College, London, UK

scientific article

Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity

scientific article

Humoral and cellular immune responses to myelin protein peptides in chronic inflammatory demyelinating polyradiculoneuropathy

scientific article published on 17 November 2008

Hydrophobic CDR3 residues promote the development of self-reactive T cells

scientific article published on 27 June 2016

Identification and characterisation of peptide binding motifs of six autoimmune disease-associated human leukocyte antigen-class I molecules including HLA-B*39:06.

scientific article published on 25 August 2014

Identification of a naturally processed cytotoxic CD8 T-cell epitope of coxsackievirus B4, presented by HLA-A2.1 and located in the PEVKEK region of the P2C nonstructural protein

scientific article published on December 2004

Immunogenicity of human embryonic stem cell-derived beta cells.

scientific article

Immunological dysfunction, vaccination and Gulf War illness

scientific article

Immunological pathways to β‐cell damage in Type 1 diabetes ⬇️

scientific article published on February 1, 2013

In silico and ex vivo approaches indicate immune pressure on capsid and non-capsid regions of coxsackie B viruses in the human system.

scientific article published on 20 June 2018

Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

scientific article published on 01 December 2008

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy

scientific article published on 21 October 2015

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

scientific article published on 21 November 2019

Lack of association between HLA genotype and chronic fatigue syndrome

article

Level of major histocompatibility complex class I expression on endothelium in non-obese diabetic mice influences CD8 T cell adhesion and migration

scientific article published on 01 July 2009

Long-lasting T cell responses to biological warfare vaccines in human vaccinees

scientific article published on 23 May 2006

Long-term outcome of individuals treated with oral insulin: diabetes prevention trial-type 1 (DPT-1) oral insulin trial

scientific article

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes.

scientific article published on August 2017

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

scientific article

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes

scientific article published on 17 January 2018

More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers

scientific article

Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes

scientific article

Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression ⬇️

scientific article

Optimization of current and future therapy for autoimmune diseases

scientific article published on 6 January 2012

Optimized Peptide-MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells

Paraoxonase in Persian Gulf War veterans

scientific article published in July 2003

Peptide length determines the outcome of TCR/peptide-MHCI engagement

scientific article

Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations.

scientific article published on 26 February 2018

Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death

scientific journal article

Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry

scientific article published on 29 July 2015

Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture

scientific article published on 03 October 2008

Possession of human leucocyte antigen DQ6 alleles and the rate of CD4 T-cell decline in human immunodeficiency virus-1 infection

scientific article

Post-mortem analysis of islet pathology in type 1 diabetes illuminates the life and death of the beta cell

scientific article published on 01 February 2009

Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

scientific article published on 02 October 2013

Prevalence of anti-N-methyl-D-aspartate (NMDA) receptor [corrected] antibodies in patients with schizophrenia and related psychoses: a systematic review and meta-analysis

scientific article

Primary and immortalised human pancreatic islet endothelial cells: phenotypic and immunological characterisation.

scientific article published on 15 November 2005

Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells

scientific article published on 01 March 2003

Progress in immune-based therapies for type 1 diabetes

scientific article published on May 2013

Proinsulin multi-peptide immunotherapy induces antigen-specific regulatory T cells and limits autoimmunity in a humanized model.

scientific article published on 17 September 2015

Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study.

scientific article published on 20 November 2008

Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease

scientific article published on 14 October 2019

Proinsulin-mediated induction of type 1 diabetes in HLA-DR4-transgenic mice

scientific article published on 20 September 2018

Promiscuous binding of proinsulin peptides to Type 1 diabetes-permissive and -protective HLA class II molecules

scientific article published on 09 April 2003

Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers

scientific article

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity

scientific article

Reduction in CD4 central memory T-cell subset in costimulation modulator abatacept-treated patients with recent-onset type 1 diabetes is associated with slower C-peptide decline

scientific article

Regulatory T cell dysfunction in type 1 diabetes: what's broken and how can we fix it?

scientific article

Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort.

scientific article

Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

scientific article

Reversed-polarity T(reg) cell TCRs provide a shock

scientific article published on October 2015

Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.

scientific article

Stimulated urine C-peptide creatinine ratio vs serum C-peptide level for monitoring of β-cell function in the first year after diagnosis of Type 1 diabetes

scientific article published on 18 July 2016

Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

scientific article

Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes

scientific article published on 01 February 2010

Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis

scientific article published on 20 January 2020

T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes.

scientific article published on 27 November 2017

T cells in type 1 diabetes: Instructors, regulators and effectors: A comprehensive review

scientific article published on 03 September 2015

Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.

scientific article published on 17 October 2016

The challenge of modulating β-cell autoimmunity in type 1 diabetes

scientific article published on 24 October 2018

The development of new density gradient media for purifying human islets and islet-quality assessments

scientific article

The habitual, diverse and surmountable obstacles to human immunology research

scientific article published on 01 June 2008

Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.

scientific article

Understanding and preventing type 1 diabetes through the unique working model of TrialNet

scientific article published on 2 August 2017

Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes.

scientific article published on 12 August 2009

Variation of Peripheral Blood Mononuclear Cell RNA Quality in Archived Samples

scientific article

β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults

scientific article published on 30 May 2016

β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure

scientific article

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