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List of works by Steven H Sacks

A double-blind randomised controlled investigation into the efficacy of Mirococept (APT070) for preventing ischaemia reperfusion injury in the kidney allograft (EMPIRIKAL): study protocol for a randomised controlled trial

scientific article

Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA.

scientific article published on October 1999

Accumulation of immune complexes in glomerular disease is independent of locally synthesized c3

scientific article published on 01 February 2006

Allograft immune response with sCR1 intervention

scientific article published on 01 March 1996

Allograft rejection: effect of local synthesis of complement.

scientific article

Altered distribution of intraglomerular immune complexes in C3-deficient mice

scientific article published on 01 July 1999

An antibody combination that targets activated T cells extends graft survival in sensitized recipients.

scientific article published on 10 September 2008

Analysis of complement C4 loci in Caucasoids and Japanese with idiopathic membranous nephropathy

scientific article published on 01 October 1992

Apical proteins stimulate complement synthesis by cultured human proximal tubular epithelial cells

scientific article published on 01 January 1999

Autoimmune renal injury in C3- and C4-deficient mice: a histological and functional study

scientific article published on 01 January 2004

C3 and C4 gene expression and interferon-gamma-mediated regulation in human glomerular mesangial cells

scientific article published on 01 September 1993

C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation.

scientific article published on 22 July 2013

C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli

scientific article published on 21 December 2017

CD46 (membrane cofactor protein) acts as a human epithelial cell receptor for internalization of opsonized uropathogenic Escherichia coli.

scientific article published on August 2006

CD59a deficiency exacerbates ischemia-reperfusion injury in mice

scientific article

Characteristics and outcome of membranous nephropathy in older patients.

scientific article

Coexpression of donor peptide/recipient MHC complex and intact donor MHC: evidence for a link between the direct and indirect pathways

scientific article published on 14 March 2011

Collectin-11 (CL-11) Is a Major Sentinel at Epithelial Surfaces and Key Pattern Recognition Molecule in Complement-Mediated Ischaemic Injury

scientific article published on 06 September 2018

Collectin-11 Promotes the Development of Renal Tubulointerstitial Fibrosis.

scientific article published on 15 November 2017

Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury

scientific article published on 18 April 2016

Compartmental localization of complement component transcripts in the normal human kidney

scientific article published on 01 January 1998

Complement C3 gene expression and regulation in human glomerular epithelial cells.

scientific article

Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy.

scientific article published on 26 December 2017

Complement Recognition Pathways in Renal Transplantation.

scientific article published on 29 June 2017

Complement activation regulates the capacity of proximal tubular epithelial cell to stimulate alloreactive T cell response

article

Complement in organ transplantation.

scientific article

Complement inhibition as a novel strategy in renal transplantation.

scientific article published in July 2013

Contribution of renal secreted complement C3 to the circulating pool in humans

scientific article published on 01 April 1999

Control of innate immunological mechanisms as a route to drug minimization.

scientific article

Controlling the generation and function of human CD8+ memory T cells in vitro with immunosuppressants

scientific article published on 01 November 2006

Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation.

scientific article published on 23 September 2008

Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2.

scientific article

Deficiency of C5aR prolongs renal allograft survival.

scientific article

Dendritic cell function in allostimulation is modulated by C5aR signaling.

scientific article

Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype

scientific article published on 01 March 2006

Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples

scientific article published on 02 March 2019

Donor specific transplant tolerance is dependent on complement receptors.

scientific article published on 20 November 2012

Dynamics of the expression of the interleukin-2 (IL-2) receptor in rat renal allografts analyzed by immunohistology, autoradiography, and nuclear imaging using radioiodinated IL-2 probes

scientific article published on 01 December 1994

Effect of symptomless bacteriuria in childhood on subsequent pregnancy

scientific article published on 01 October 1987

Endogenous complement C3 synthesis in immune complex nephritis

scientific article published on 01 November 1993

Endogenous ligands for TLR2 and TLR4 are not involved in renal injury following ureteric obstruction

scientific article published on 28 April 2010

Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli

scientific article published on 01 July 2001

Evidence for increased synthesis of complement C4 in the renal epithelium of rats with passive Heymann nephritis

scientific article published on 01 February 1997

Evidence linking familial thrombosis with a defective antithrombin III gene in two British kindreds.

scientific article

Expression and tissue localization of donor-specific complement C3 synthesized in human renal allografts

scientific article published on 01 April 1995

Expression of complement components, receptors and regulators by human dendritic cells.

scientific article

Expression of tissue type plasminogen activator and type 1 plasminogen activator inhibitor, and persistent fibrin deposition in chronic renal allograft failure

scientific article published on 01 August 1997

Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice

scientific article

Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade.

scientific article published on 14 September 2003

Footprints of humoral rejection

scientific article published on 01 November 2002

Gene microarrays in transplantation

scientific article published on 01 November 2003

Haplotype analysis of tumour necrosis factor receptor genes in 1p36: no evidence for association with systemic lupus erythematosus

article

Homeostatic proliferation of lymphocytes results in augmented memory-like function and accelerated allograft rejection.

scientific article published in March 2008

Human blood group isoantigen expression on normal and malignant gastric epithelium studied with anti-A and anti-B monoclonal antibodies

scientific article published on 01 April 1983

Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress

scientific article published on 7 November 2017

Independent pathways of P-selectin and complement-mediated renal ischemia/reperfusion injury.

scientific article published on January 2004

Influence of complement on the allospecific antibody response to a primary vascularized organ graft

scientific article published on 01 November 1997

Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury

scientific article published on 31 October 2011

Interferon-gamma regulation of C4 gene expression in cultured human glomerular epithelial cells

scientific article published on 01 October 1993

Intraglomerular C3 synthesis in rats with passive Heymann nephritis.

scientific article published on November 1997

Intrarenal synthesis of complement.

scientific article

Kinetics of mast cell migration during transplantation tolerance

scientific article published on 18 October 2014

Late strut fracture in a Björk-Shiley valve prosthesis (current series).

scientific article published on May 1984

Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2.

scientific article published on 10 February 2017

Licenced to transplant: UK overkill on EU Organ Directive provides golden opportunity for research

scientific article published on 08 August 2012

Local extravascular pool of C3 is a determinant of postischemic acute renal failure

scientific article published on 01 February 2006

Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction

scientific article published on 04 December 2007

Local synthesis of complement component C3 regulates acute renal transplant rejection

scientific article published on 01 June 2002

Local transcription of complement C3 in human allograft rejection. Evidence for a pathogenic role and correlation to histology and outcome

scientific article published on 01 September 1994

Locally produced and activated complement as a mediator of alloreactive T cells.

scientific article published on June 2009

Locally produced complement and its role in renal allograft rejection.

scientific article

Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study

scientific article published in February 2018

Long-term tacrolimus versus long-term ciclosporin in renal transplant recipients with poor graft function

scientific article published on 16 September 2008

Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells

scientific article published on 22 November 2005

Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4.

scientific article published on 27 May 2014

Mechanisms of disease: the complement system in renal injury--new ways of looking at an old foe.

scientific article published on May 2007

Mechanisms of rejection: role of complement

scientific article published on February 2014

Minireview: functions of the renal tract epithelium in coordinating the innate immune response to infection.

scientific article published in October 2004

Molecular analysis of C3 allotypes related to transplant outcome in human renal allografts

scientific article published on 01 December 1995

Molecular mapping of the HLA class II region in HLA-DR3 associated idiopathic membranous nephropathy.

scientific article published on January 1993

Monoclonal anti-A and anti-B on Groupamatic

scientific article published on 01 January 1983

Monoclonal anti-A and anti-B: development as cost-effective reagents

scientific article published on 01 April 1982

Monoclonal anti-A from a hybrid-myeloma: evaluating as a blood grouping reagent

scientific article published on 01 September 1980

Monoclonal anti-B as a new blood-typing reagent

scientific article published on 01 February 1981

Multiple signals regulate the intracellular trafficking of HLA-DM in B-lymphoblastoid cells.

scientific article published on April 1998

Natural killer-cell activity after human renal transplantation in relation to killer immunoglobulin-like receptors and human leukocyte antigen mismatch1

scientific article published on 01 October 2003

Non-Invasive whole-body detection of complement activation using radionuclide imaging in a mouse model of myocardial ischaemia-reperfusion injury.

scientific article published on 23 November 2017

Noninvasive Imaging of Activated Complement in Ischemia-Reperfusion Injury Post-Cardiac Transplant

scientific article

Nontransgenic Hyperexpression of a Complement Regulator in Donor Kidney Modulates Transplant Ischemia/Reperfusion Damage, Acute Rejection, and Chronic Nephropathy ⬇️

scientific article published on October 1, 2003

Outcome of pregnancy in an Oxford-Cardiff cohort of women with previous bacteriuria

scientific article published on 01 July 1992

Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction

scientific article published on 16 June 2010

Predominant role for C5b-9 in renal ischemia/reperfusion injury.

scientific article

Protection against anti-glomerular basement membrane (GBM)-mediated nephritis in C3- and C4-deficient mice

scientific article published on 01 December 1997

RNA interference--a new experimental and therapeutic tool

scientific article published on 01 November 2005

Rapamycin at subimmunosuppressive levels inhibits mesangial cell proliferation and extracellular matrix production.

scientific article

Rapid rejection of HLA-A2 transgenic skin graft due to indirect allorecognition.

scientific article

Recombinant complement receptor 2 radiolabeled with [99mTc(CO)3]+: a potential new radiopharmaceutical for imaging activated complement

scientific article

Role of complement in tubulointerstitial injury from proteinuria.

scientific article

Role of the complement system in rejection.

scientific article

Role of the lectin complement pathway in kidney transplantation.

scientific article

SPECT/CT lymphoscintigraphy of heterotopic cardiac grafts reveals novel sites of lymphatic drainage and T cell priming.

scientific article published on 10 January 2011

Sparing of first dose effect of monovalent anti-CD3 antibody used in allograft rejection is associated with diminished release of pro-inflammatory cytokines

scientific article published on 01 December 1994

Strategies for targeting complement inhibitors in ischaemia/reperfusion injury.

scientific article

Structural and functional diversity of collectins and ficolins and their relationship to disease.

scientific article published on 11 September 2017

Systematic assessment of the influence of complement gene polymorphisms on kidney transplant outcome.

scientific article published on 12 December 2015

TLR2 stimulation of intrinsic renal cells in the induction of immune-mediated glomerulonephritis.

scientific article

TNF-alpha regulation of C3 gene expression and protein biosynthesis in rat glomerular endothelial cells

scientific article published on 01 March 1997

Targeting complement at the time of transplantation.

scientific article published on January 2013

Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.

scientific article

Tertiary lymphoid organs in renal allografts can be associated with donor-specific tolerance rather than rejection

scientific article published on 11 November 2010

The allogeneic T and B cell response is strongly dependent on complement components C3 and C4

scientific article published on 01 October 2001

The classical complement pathway plays a critical role in the opsonisation of uropathogenic Escherichia coli.

scientific article published on 17 September 2007

The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis

scientific article published on 28 June 2016

The effect of locally synthesised complement on acute renal allograft rejection.

scientific article

The membrane attack complex, C5b-9, up regulates collagen gene expression in renal tubular epithelial cells.

scientific article published in April 2004

The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies.

scientific article published on September 2007

The role of complement in regulating the alloresponse.

scientific article published on February 2009

The role of complement in the early immune response to transplantation.

scientific article published on 25 May 2012

Therapeutic strategy with a membrane-localizing complement regulator to increase the number of usable donor organs after prolonged cold storage

scientific article published on 01 March 2006

Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation

scientific article

Thrombalexins: Cell-Localized Inhibition of Thrombin and Its Effects in a Model of High-Risk Renal Transplantation.

scientific article published on 4 July 2016

Tissue synthesis of complement as an immune regulator.

scientific article published on July 1995

To breast feed or not to breast feed. A survey of primiparae

scientific article published on 01 February 1976

Toll-like receptor 2 agonists exacerbate accelerated nephrotoxic nephritis

scientific article published on 31 May 2006

Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody-mediated glomerulonephritis via CXCL1 and CXCL2

scientific article published on 25 April 2007

Toll-like receptors TLR2 and TLR4 initiate the innate immune response of the renal tubular epithelium to bacterial products.

scientific article

Transferrin but not albumin mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells

scientific article published on 01 January 2001

Triptolide is a potent suppressant of C3, CD40 and B7h expression in activated human proximal tubular epithelial cells.

scientific article published in October 2002

Ultra-localization of Foxp3+ T cells within renal allografts shows infiltration of tubules mimicking rejection.

scientific article

Up-regulation of type 1 plasminogen activator inhibitor messenger RNA with thrombotic changes in renal grafts

scientific article published on 01 March 1996

Urinary tract infections: new insights into a common problem.

scientific article published on February 2005

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