List of works - Chie Emoto

A Prospective Study of Alemtuzumab as a Second-Line Agent for Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric and Young Adult Allogeneic Hematopoietic Stem Cell Transplantation.

scientific article

Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1.

scientific article

Approach to predict the contribution of cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage: the effect of the expression of cytochrome b(5) with recombinant P450 enzymes

scientific article published on 01 September 2007

Approach to the prediction of the contribution of major cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage.

scientific article published on August 2006

Arachidonic acid with taurine enhances pulmonary absorption of macromolecules without any serious histopathological damages.

scientific article published on 13 January 2017

Causative agent of vascular pain among photodegradation products of dacarbazine.

scientific article published in August 2002

Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter.

scientific article published on 09 December 2016

Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes

scientific article published in October 2000

Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes.

scientific article published in August 2012

Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants

scientific article published on 08 August 2016

Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants.

scientific article

Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content.

scientific article published on 24 July 2013

Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children.

scientific article

Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies.

scientific article published on 16 February 2017

Discovery of 1-(β-amino substituted-β-alanyl)-N,N-dimethylindoline-2-carboxamides as novel nonpeptide antagonists of nociceptin/orphanin FQ receptor: efficient design, synthesis, and structure-activity relationship studies.

scientific article published on 25 July 2012

Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure-activity relationships for (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives

scientific article

Effects of enzyme sources on midazolam 1'-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH-cytochrome P450 reductase

scientific article

Effects of histidine-tag on recombinant human cytochrome P450 3A5 catalytic activity in reconstitution systems

scientific article published in December 2009

Evaluation of intestinal metabolism and absorption using the Ussing chamber system equipped with intestinal tissue from rats and dogs.

scientific article published on 30 September 2017

Evidence of a clinically significant drug-drug interaction between cannabidiol and tacrolimus

scientific article published on 21 May 2019

Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling

scientific article published on 28 January 2015

In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.

scientific article published in January 2003

In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A.

scientific article published in October 2005

Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study

scientific article published on 08 November 2018

Metabolism of CJ-036878, N-(3-phenethoxybenzyl)-4-hydroxybenzamide, in liver microsomes and recombinant cytochrome P450 enzymes: metabolite identification by LC-UV/MS(n) and (1)H-NMR.

scientific article published in December 2007

Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution.

scientific article published on October 2010

Model-based precision dosing of sirolimus in pediatric patients with vascular anomalies.

scientific article published on 16 May 2017

Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children

scientific article published on 13 June 2015

Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver

scientific article published on 01 March 2008

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants

scientific article published on 19 June 2018

Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients

scientific article published on 23 January 2020

Prediction of drug intestinal absorption in human using the Ussing chamber system: A comparison of intestinal tissues from animals and humans.

scientific article published on 6 October 2016

Pretransplant Absolute Lymphocyte Counts Impact the Pharmacokinetics of Alemtuzumab.

scientific article published on 12 January 2017

Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients

scientific article published on 14 June 2016

The impact of CYP3A5*3 polymorphism on sirolimus pharmacokinetics: insights from predictions with a physiologically-based pharmacokinetic model

scientific article

Use of everted sacs of mouse small intestine as enzyme sources for the study of drug oxidation activities in vitro

scientific article published in October 2000

Using a vancomycin PBPK model in special populations to elucidate case-based clinical PK observations

scientific article published on 15 February 2018

Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding.

scientific article published in March 2009

List of works by Chie Emoto

A Prospective Study of Alemtuzumab as a Second-Line Agent for Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric and Young Adult Allogeneic Hematopoietic Stem Cell Transplantation.

Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1.

Approach to predict the contribution of cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage: the effect of the expression of cytochrome b(5) with recombinant P450 enzymes

Approach to the prediction of the contribution of major cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage.

Arachidonic acid with taurine enhances pulmonary absorption of macromolecules without any serious histopathological damages.

Causative agent of vascular pain among photodegradation products of dacarbazine.

Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter.

Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes

Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes.

Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants

Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants.

Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content.

Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children.

Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies.

Discovery of 1-(β-amino substituted-β-alanyl)-N,N-dimethylindoline-2-carboxamides as novel nonpeptide antagonists of nociceptin/orphanin FQ receptor: efficient design, synthesis, and structure-activity relationship studies.

Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure-activity relationships for (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives

Effects of enzyme sources on midazolam 1'-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH-cytochrome P450 reductase

Effects of histidine-tag on recombinant human cytochrome P450 3A5 catalytic activity in reconstitution systems

Evaluation of intestinal metabolism and absorption using the Ussing chamber system equipped with intestinal tissue from rats and dogs.

Evidence of a clinically significant drug-drug interaction between cannabidiol and tacrolimus

Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling

In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.

In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A.

Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study

Metabolism of CJ-036878, N-(3-phenethoxybenzyl)-4-hydroxybenzamide, in liver microsomes and recombinant cytochrome P450 enzymes: metabolite identification by LC-UV/MS(n) and (1)H-NMR.

Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution.

Model-based precision dosing of sirolimus in pediatric patients with vascular anomalies.

Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children

Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants

Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients

Prediction of drug intestinal absorption in human using the Ussing chamber system: A comparison of intestinal tissues from animals and humans.

Pretransplant Absolute Lymphocyte Counts Impact the Pharmacokinetics of Alemtuzumab.

Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients

The impact of CYP3A5*3 polymorphism on sirolimus pharmacokinetics: insights from predictions with a physiologically-based pharmacokinetic model

Use of everted sacs of mouse small intestine as enzyme sources for the study of drug oxidation activities in vitro

Using a vancomycin PBPK model in special populations to elucidate case-based clinical PK observations

Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding.