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List of works by Cecilia O'Kane

A Randomized Clinical Trial of Hydroxymethylglutaryl– Coenzyme A Reductase Inhibition for Acute Lung Injury (The HARP Study)

scientific article published on 24 September 2010

A functional variant of elafin with improved anti-inflammatory activity for pulmonary inflammation

scientific article published on 5 September 2014

A potential role for keratinocyte growth factor and clarithromycin in the treatment of paraquat overdose.

scientific article published on 12 February 2010

A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung

scientific article published on 13 March 2015

A stepwise approach to justify phase III randomized clinical trials and enhance the likelihood of a positive result ⬇️

scientific article published on October 1, 2010

Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS.

scientific article published on 12 January 2017

Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis

scientific article

Benefits of statins in the critically ill: promising but not proven

scientific article published on 01 June 2011

Characterisation of eppin function: expression and activity in the lung

scientific article published on 13 July 2017

Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation.

scientific article published on 2 February 2016

Comment on "Statin administration did not influence the progression of lung injury or associated organ failures in a cohort of patients with acute lung injury"

scientific article published on 14 May 2009

Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia.

scientific article

Does MMP-12 play a role in human lung fibrosis?

scientific article published on 01 February 2008

Erratum to: Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction - a randomised placebo-controlled trial (KARE): study protocol.

scientific article published on 11 May 2017

Evidence for chemokine synergy during neutrophil migration in ARDS

scientific article published on 05 August 2016

Evolution of the inflammatory and fibroproliferative responses during resolution and repair after ventilator-induced lung injury in the rat.

scientific article published in November 2011

Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair

scientific article published on 16 January 2019

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

Innate Lymphoid Cells Are the Predominant Source of IL-17A during the Early Pathogenesis of Acute Respiratory Distress Syndrome.

scientific article published on 21 October 2015

Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial.

scientific article published on 16 May 2017

Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction--a randomised placebo-controlled trial (KARE): study protocol.

scientific article published on 18 February 2013

Keratinocyte growth factor in acute lung injury--a work in progress.

scientific article published in May 2009

Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury

scientific article

MMP expression and abnormal lung permeability are important determinants of outcome in IPF

scientific article published on 01 October 2008

Matrix metalloproteinases in acute lung injury: mediators of injury and drivers of repair.

scientific article published on 12 May 2011

Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer.

scientific article published on 9 June 2017

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS.

scientific article published on 5 April 2016

Monocyte-Dependent Fibroblast CXCL8 Secretion Occurs in Tuberculosis and Limits Survival of Mycobacteria within Macrophages

scientific article published on 01 March 2007

Monocyte-dependent oncostatin M and TNF-alpha synergize to stimulate unopposed matrix metalloproteinase-1/3 secretion from human lung fibroblasts in tuberculosis

scientific article

Mycobacterium tuberculosis up-regulates matrix metalloproteinase-1 secretion from human airway epithelial cells via a p38 MAPK switch

scientific article published in October 2005

Mycobacterium tuberculosis, but not vaccine BCG, specifically upregulates matrix metalloproteinase-1.

scientific article

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury.

scientific article published on 29 January 2018

Novel pulmonary biomarkers in the diagnosis of VAP

scientific article published on 01 March 2010

Prevention of post-operative complications by using a HMG-CoA reductase inhibitor in patients undergoing one-lung ventilation for non-cardiac surgery: study protocol for a randomised controlled trial

scientific article published on 18 December 2018

Reply to Letter: "Effect of Simvastatin on Physiological and Biological Outcomes in Patients Undergoing Esophagectomy: A Randomized Placebo-controlled Trial".

scientific article published in December 2015

Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD

scientific article

SMAD inhibition attenuates epithelial to mesenchymal transition by primary keratinocytes in vitro

scientific article published in July 2014

STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis

scientific article

Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome.

scientific article published in July 2009

Satisfaction with the decision to participate in cancer clinical trials is high, but understanding is a problem

scientific article published on 23 February 2010

Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers

scientific article published on 26 March 2009

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury.

scientific article

Simvastatin for patients with acute respiratory distress syndrome: long-term outcomes and cost-effectiveness from a randomised controlled trial ⬇️

scientific article

Statins and sepsis: potential benefit but more unanswered questions

scientific article published on 01 April 2013

Synergistic up-regulation of epithelial cell matrix metalloproteinase-9 secretion in tuberculosis.

scientific article published on 15 June 2007

Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation.

scientific article published on September 2015

Transcriptional mechanisms regulating alveolar epithelial cell-specific CCL5 secretion in pulmonary tuberculosis.

scientific article published on 26 April 2004

Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome

scientific article published on 22 May 2015

Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung

scientific article published on 01 December 2012

Where next for cell-based therapy in ARDS

scientific article published on 12 November 2018

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