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List of works by Blaise A Clarke

A Clinical and Molecular Phase II Trial of Oral ENMD-2076 in Ovarian Clear Cell Carcinoma (OCCC): A Study of the Princess Margaret Phase II Consortium

scientific article published on 14 August 2018

A Genomically Characterized Collection of High-Grade Serous Ovarian Cancer Xenografts for Preclinical Testing

scientific article published on 16 February 2018

A distinct innate lymphoid cell population regulates tumor-associated T cells

scientific article published on 6 February 2017

A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503).

scientific article published on 18 July 2013

A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575).

scientific article published on 05 May 2013

A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia

scientific article published on 11 March 2015

A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors

scientific article published on 17 July 2013

A triage assessment strategy for the management of women with endometrial cancer.

scientific article published on April 2013

ARID1A loss correlates with mismatch repair deficiency and intact p53 expression in high-grade endometrial carcinomas

scientific article

ARID1A/BAF250a as a prognostic marker for gastric carcinoma: a study of 2 cohorts.

scientific article published on 20 February 2014

Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes

scientific article published on 27 February 2012

Association of Ipilimumab With Safety and Antitumor Activity in Women With Metastatic or Recurrent Human Papillomavirus-Related Cervical Carcinoma.

scientific article published on 16 November 2017

Biologic rationale and clinical activity of mTOR inhibitors in gynecological cancer.

scientific article published on 29 February 2012

Biologically-targeted detection of primary and micro-metastatic ovarian cancer

scientific article published on 25 May 2013

Canadian Association of Pathologists-Association canadienne des pathologistes National Standards Committee for High Complexity Testing/Immunohistochemistry: guidelines for the preparation, release, and storage of unstained archived diagnostic tissue

scientific article

Canadian high risk endometrial cancer (CHREC) consortium: analyzing the clinical behavior of high risk endometrial cancers

scientific article published on 6 September 2015

Cancer classification using the Immunoscore: a worldwide task force

scientific article

Characterization of the Tumor-Microenvironment in Patient-Derived Cervix Xenografts (OCICx)

scientific article published on 29 August 2012

Chromosomal instability as a prognostic marker in cervical cancer

scientific article published on 6 May 2015

Clear cell (glycogen-rich) gastric adenocarcinoma.

scientific article published in April 2004

Clinical, morphological and immunohistochemical evidence that small-cell carcinoma of the ovary of hypercalcaemic type (SCCOHT) may be a primitive germ-cell neoplasm.

scientific article published on 28 January 2017

Comparison of clinical schemas and morphologic features in predicting Lynch syndrome in mutation-positive patients with endometrial cancer encountered in the context of familial gastrointestinal cancer registries.

scientific article published on 30 June 2011

Cryptococcemia Resulting in an Incomplete Abortion in an HIV-Positive Patient ⬇️

scientific article published on January 1, 2009

Current morphologic criteria perform poorly in identifying hereditary leiomyomatosis and renal cell carcinoma syndrome-associated uterine leiomyomas

scientific article published on 01 November 2014

DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors.

scientific article published on 26 June 2017

Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

scientific article

Developing a prognostic micro-RNA signature for human cervical carcinoma

scientific article published on 16 April 2015

Displaced granulosa cells within the ovarian stroma in a BRCA1 mutation carrier

scientific article published on 01 July 2014

Endometrial carcinoma: controversies in histopathological assessment of grade and tumour cell type.

scientific article published on May 2010

Endometrial giant cell carcinoma: a case series and review of the spectrum of endometrial neoplasms containing giant cells.

scientific article published on August 2010

Expanding the morphological spectrum of ovarian microcystic stromal tumour

article

Fertility sparing treatment of complex atypical hyperplasia and low grade endometrial cancer using oral progestin.

scientific article published on 19 February 2014

Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy.

scientific article published on March 2014

Genotype-matched treatment for patients with advanced type I epithelial ovarian cancer (EOC).

scientific article

Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type

scientific article published on 23 March 2014

Gynaecological neoplasms in common familial syndromes (Lynch and HBOC).

scientific article published on 26 December 2017

Gynecologic Pathology

scientific article published on 01 June 2016

Hedgehog pathway signaling in cervical carcinoma and outcome after chemoradiation

scientific article published on 25 October 2011

Histologic artifacts in abdominal, vaginal, laparoscopic, and robotic hysterectomy specimens: a blinded, retrospective review.

scientific article published on January 2011

Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study

scientific article

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.

scientific article

Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.

scientific article published on 17 September 2013

Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.

scientific article

Identifying Lynch syndrome in patients with ovarian carcinoma: the significance of tumor subtype.

scientific article

Implementing a Cervical Sentinel Lymph Node Biopsy Program: Quality Improvement in Gynaecologic Oncology.

scientific article published in August 2017

In-depth proteomics of ovarian cancer ascites: combining shotgun proteomics and selected reaction monitoring mass spectrometry.

scientific article

International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project: Guidelines From the Special Techniques and Ancillary Studies Group

scientific article published on 8 March 2018

Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type and BRCA1 loss

scientific article published on 05 December 2008

Intratumoral heterogeneity in a minority of ovarian low-grade serous carcinomas

scientific article

Isolated amoebic appendicitis.

scientific article published on 28 November 2001

Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors

scientific article published on 31 October 2018

Leiomyosarcoma of the broad ligament with osteoclast-like giant cells and rhabdoid cells.

scientific article published in September 2010

Letter to the editor regarding 'Roh MH, Lassin Y, Miron A et al. High-grade fimbrial-ovarian carcinomas are unified by p53, PTEN and PAX2 expression'

scientific article published on 01 September 2011

Loss of SMARCA4 (BRG1) protein expression as determined by immunohistochemistry in small-cell carcinoma of the ovary, hypercalcaemic type distinguishes these tumours from their mimics

scientific article published on 21 April 2016

MicroRNA-196b regulates the homeobox B7-vascular endothelial growth factor axis in cervical cancer.

scientific article published on 4 July 2013

Microsatellite analysis of early stage (Ia-IIb) uterine cervical squamous carcinoma.

scientific article

Microscopic extraovarian sex cord proliferations: an undescribed phenomenon.

scientific article published on 22 December 2014

Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas.

scientific article published in January 2013

Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer

scientific article published on 15 February 2014

Molecular profiling and clinical outcome of high-grade serous ovarian cancer presenting with low- versus high-volume ascites

scientific article

Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial.

scientific article published on 25 October 2016

Mutation ofFOXL2in Granulosa-Cell Tumors of the Ovary

scientific article published on 10 June 2009

Mutations inIDH1andIDH2are not present in sporadic ovarian sex cord-stromal tumours

scientific article published on 05 August 2014

Myxoid invasive papillary urothelial carcinoma of the bladder and urethra

scientific article published on 01 November 2001

Müllerian adenosarcomas with unusual growth patterns: staging issues.

scientific article published in July 2011

Neoadjuvant Chemotherapy of Ovarian Cancer Results in Three Patterns of Tumor-Infiltrating Lymphocyte Response with Distinct Implications for Immunotherapy

scientific article published on 6 September 2016

Neuroendocrine tumors of the gynecologic tract: select topics.

scientific article published on August 2013

No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour

scientific article published on 20 May 2014

Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin.

scientific article

Novel combinations of PI3K-mTOR inhibitors with dacomitinib or chemotherapy in PTEN-deficient patient-derived tumor xenografts.

scientific article published on 8 July 2017

Ovarian Microcystic Stromal Tumors Are Characterized by Alterations in the Beta-Catenin-APC Pathway and May be an Extracolonic Manifestation of Familial Adenomatous Polyposis

scientific article published on 26 October 2017

Ovarian hilar proliferations resembling Sertoli cell tumours: microscopic neoplasms or non-neoplastic remnants?

scientific article published on 25 July 2015

Ovarian immature teratoma: Treatment and outcome in a single institutional cohort

article

Performance characteristics of a brief Family History Questionnaire to screen for Lynch syndrome in women with newly diagnosed endometrial cancer.

scientific article published on 19 December 2014

Performance characteristics of screening strategies for Lynch syndrome in unselected women with newly diagnosed endometrial cancer who have undergone universal germline mutation testing.

scientific article published on 31 July 2014

Plexiform spitz nevus.

scientific article

Prevalence of loss of expression of DNA mismatch repair proteins in primary epithelial ovarian tumors.

scientific article published in November 2012

Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience

scientific article published on 21 June 2009

Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience

scientific article

Progesterone receptor expression is associated with longer overall survival within high-grade histotypes of endometrial carcinoma: A Canadian high risk endometrial cancer consortium (CHREC) study

scientific article published on 9 April 2016

Prognostic Significance of Human Papilloma Virus and p16 Expression in Patients with Vulvar Squamous Cell Carcinoma who Received Radiotherapy.

scientific article published on 12 February 2018

Prophylactic Gynecologic Specimens from Hereditary Cancer Carriers

scientific article published on June 2016

Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers

scientific article published on 21 December 2011

Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma

scientific article published on 31 July 2018

Review of findings in prophylactic gynaecological specimens in Lynch syndrome with literature review and recommendations for grossing

scientific article published on 16 April 2014

Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4

scientific article

Somatic BRCA1/2 Recovery as a Resistance Mechanism After Exceptional Response to Poly (ADP-ribose) Polymerase Inhibition.

scientific article published on 21 February 2017

Sorafenib Increases Tumor Hypoxia in Cervical Cancer Patients Treated With Radiation Therapy: Results of a Phase 1 Clinical Study.

scientific article published on 18 September 2015

Systemic anaplastic large cell lymphoma presenting with conjunctival involvement.

scientific article

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

scientific article published on 17 March 2011

The histomorphology of Lynch syndrome-associated ovarian carcinomas: toward a subtype-specific screening strategy

scientific article published on September 2014

Treatment related outcomes in high-risk endometrial carcinoma: Canadian high risk endometrial cancer consortium (CHREC).

scientific article published on 4 February 2016

Tubulo-squamous polyp with mucinous and goblet cell differentiation: a unique morphologic variant

scientific article published on 01 September 2011

Tumor cell type can be reproducibly diagnosed and is of independent prognostic significance in patients with maximally debulked ovarian carcinoma.

scientific article published on 7 July 2008

Use of mismatch repair immunohistochemistry and microsatellite instability testing: exploring Canadian practices.

scientific article

Uterine adenosarcomas: a dual-institution update on staging, prognosis and survival

scientific article published on 14 October 2013

VEPH1 expression decreases vascularisation in ovarian cancer xenografts and inhibits VEGFA and IL8 expression through inhibition of AKT activation

scientific article published on 16 March 2017

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