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List of works by Matthew G Vander Heiden

A Metabolomics Analysis of Adiposity and Advanced Prostate Cancer Risk in the Health Professionals Follow-Up Study

scientific article published on 10 March 2020

A framework for examining how diet impacts tumour metabolism

scientific article published on 17 September 2019

A metastasis map of human cancer cell lines

scientific article published on 09 December 2020

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

scientific article published on 2 October 2017

Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth

scientific article published in 2021

Aspartate is an endogenous metabolic limitation for tumour growth

scientific article published on 25 June 2018

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

scientific article published in 2022

Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity

scientific article published on 16 November 2019

Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation

scientific article published on 16 September 2019

Circulating Metabolites and Survival Among Patients With Pancreatic Cancer

scientific article published on 11 January 2016

Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance

scientific article published on 04 September 2019

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

scientific article published on 10 July 2020

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

scientific article

Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

scientific article published on 01 February 2020

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

scientific article published on 15 August 2017

Erratum: Metabolic targets for cancer therapy

scholarly article published in Nature Reviews Drug Discovery

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

article

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS

scientific article published on 01 April 2021

Gene Expression Pathways in Prostate Tissue Associated with Vigorous Physical Activity in Prostate Cancer

scientific article published on 26 January 2021

Gene expression profiling of prostate tissue identifies chromatin regulation as a potential link between obesity and lethal prostate cancer

scientific article published on 12 July 2017

Identification of DHODH as a therapeutic target in small cell lung cancer

scientific article published on 01 November 2019

Increased PHGDH expression promotes aberrant melanin accumulation

scientific article published on 22 July 2019

Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1

scientific article published on 08 June 2020

Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate

scientific article published in Journal of Biological Chemistry

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

scientific article published on 22 June 2020

MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme

scientific article published on 24 September 2020

Metabolic targets for cancer therapy

scientific article published on 11 October 2013

Methionine synthase is essential for cancer cell proliferation in physiological folate environments

scientific article published on 18 November 2021

Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies

scientific article published on 07 August 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division

scientific article published on 05 October 2020

Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression

scientific article published on 30 October 2020

PKM2, cancer metabolism, and the road ahead

scientific article published on 17 November 2016

Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer

scientific article published on 18 September 2019

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

scientific article

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

scientific article published on 16 April 2019

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

scientific article published on 09 November 2020

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

scientific article published on 06 December 2019

The role of tumor metabolism as a driver of prostate cancer progression and lethal disease: results from a nested case-control study

scientific article published on 07 December 2016

Transcriptional activation of macropinocytosis by the Hippo pathway following nutrient limitation

scientific article published on 01 October 2020

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

scientific article published on 22 October 2018

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