List of works - Jonathan Grimes

A mechanism for initiating RNA-dependent RNA polymerization

scientific article

A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus

scientific article published on 15 December 2014

The atomic structure of the bluetongue virus core

scientific article

A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

scientific article (publication date: June 2005)

What does structure tell us about virus evolution?

scientific article

Lysine methylation as a routine rescue strategy for protein crystallization

scientific article (publication date: November 2006)

The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation

scientific article

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

scientific article

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation

scientific article

Insights into assembly from structural analysis of bacteriophage PRD1.

scientific article published in November 2004

Detection of a fourth orbivirus non-structural protein

scientific article (publication date: 2011)

Structure Unifies the Viral Universe

scientific article published on 05 April 2012

Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein

scientific article

The highly ordered double-stranded RNA genome of bluetongue virus revealed by crystallography.

scientific article published in May 1999

Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2

scientific article

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

scientific article

An in-depth analysis of original antigenic sin in dengue virus infection

scientific article

Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation

scientific article

The nsp9 replicase protein of SARS-coronavirus, structure and functional insights

scientific article

The crystal structure of bluetongue virus VP7

scientific article

In situ macromolecular crystallography using microbeams

scientific article published on 17 April 2012

The structure of a cypovirus and the functional organization of dsRNA viruses.

scientific article

Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element

scientific article

Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

scientific article

Crystal Structure and Carbohydrate Analysis of Nipah Virus Attachment Glycoprotein: a Template for Antiviral and Vaccine Design

scientific article

Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry

scientific article

Membrane structure and interactions with protein and DNA in bacteriophage PRD1.

scientific article published on November 2004

Insights into virus evolution and membrane biogenesis from the structure of the marine lipid-containing bacteriophage PM2

scientific article

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus

scientific article

An atomic model of the outer layer of the bluetongue virus core derived from X-ray crystallography and electron cryomicroscopy

scientific article

Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization

scientific article

Bluetongue virus VP4 is an RNA-capping assembly line

scientific article

Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein

scientific article

More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules

scientific article

Structural Analysis of a Dengue Cross-Reactive Antibody Complexed with Envelope Domain III Reveals the Molecular Basis of Cross-Reactivity

scientific article

The Structure of an RNAi Polymerase Links RNA Silencing and Transcription

scientific article

The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.

scientific article published on July 2006

Translocation portals for the substrates and products of a viral transcription complex: the bluetongue virus core.

scientific article

How vaccinia virus has evolved to subvert the host immune response.

scientific article published on 17 March 2011

Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1

scientific article published on 16 September 2014

Insights into the Evolution of a Complex Virus from the Crystal Structure of Vaccinia Virus D13

scientific article published on July 13, 2011

Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence

scientific article

Structure and Function of A41, a Vaccinia Virus Chemokine Binding Protein

scientific article

Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data

scientific article

Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).

scientific article published on 25 August 2010

A revised partiality model and post-refinement algorithm for X-ray free-electron laser data

scientific article

Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues

scientific article

Rhabdovirus Matrix Protein Structures Reveal a Novel Mode of Self-Association

scientific article

Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.

scientific article published on 7 April 2011

The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase

scientific article

List of works by Jonathan Grimes

A mechanism for initiating RNA-dependent RNA polymerization

A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus

The atomic structure of the bluetongue virus core

A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

What does structure tell us about virus evolution?

Lysine methylation as a routine rescue strategy for protein crystallization

The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation

Insights into assembly from structural analysis of bacteriophage PRD1.

Detection of a fourth orbivirus non-structural protein

Structure Unifies the Viral Universe

Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein

The highly ordered double-stranded RNA genome of bluetongue virus revealed by crystallography.

Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

An in-depth analysis of original antigenic sin in dengue virus infection

Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation

The nsp9 replicase protein of SARS-coronavirus, structure and functional insights

The crystal structure of bluetongue virus VP7

In situ macromolecular crystallography using microbeams

The structure of a cypovirus and the functional organization of dsRNA viruses.

Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element

Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

Crystal Structure and Carbohydrate Analysis of Nipah Virus Attachment Glycoprotein: a Template for Antiviral and Vaccine Design

Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry

Membrane structure and interactions with protein and DNA in bacteriophage PRD1.

Insights into virus evolution and membrane biogenesis from the structure of the marine lipid-containing bacteriophage PM2

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus

An atomic model of the outer layer of the bluetongue virus core derived from X-ray crystallography and electron cryomicroscopy

Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization

Bluetongue virus VP4 is an RNA-capping assembly line

Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein

More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules

Structural Analysis of a Dengue Cross-Reactive Antibody Complexed with Envelope Domain III Reveals the Molecular Basis of Cross-Reactivity

The Structure of an RNAi Polymerase Links RNA Silencing and Transcription

The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.

Translocation portals for the substrates and products of a viral transcription complex: the bluetongue virus core.

How vaccinia virus has evolved to subvert the host immune response.

Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1

Insights into the Evolution of a Complex Virus from the Crystal Structure of Vaccinia Virus D13

Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence

Structure and Function of A41, a Vaccinia Virus Chemokine Binding Protein

Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data

Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).

A revised partiality model and post-refinement algorithm for X-ray free-electron laser data

Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues

Rhabdovirus Matrix Protein Structures Reveal a Novel Mode of Self-Association

Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.

The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase