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List of works by Jonathan Grimes

3D Correlative Cryo-Structured Illumination Fluorescence and Soft X-ray Microscopy Elucidates Reovirus Intracellular Release Pathway ⬇️

scientific article published on 27 June 2020

A Mechanism for the Activation of the Influenza Virus Transcriptase

scholarly article by Itziar Serna Martin published in October 2018

A Mechanism for the Activation of the Influenza Virus Transcriptase.

scientific article

A mechanism for initiating RNA-dependent RNA polymerization

scientific article

A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus

scientific article published on 15 December 2014

A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

scientific article (publication date: June 2005)

A revised partiality model and post-refinement algorithm for X-ray free-electron laser data

scientific article

An In-Depth Analysis of Original Antigenic Sin in Dengue Virus Infection.

scientific article published in November 2011

An atomic model of the outer layer of the bluetongue virus core derived from X-ray crystallography and electron cryomicroscopy

scientific article

An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1

scientific article

An in-depth analysis of original antigenic sin in dengue virus infection

scientific article

Antigenic Switching of Hepatitis B Virus by Alternative Dimerization of the Capsid Protein

scientific article

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens.

scientific article published on 19 September 2006

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens. Corrigendum

scholarly article published in Acta Crystallographica Section D: Biological Crystallography

Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation

scientific article

Back-priming mode of 6 RNA-dependent RNA polymerase

scientific article published on 01 February 2005

Bacteriophage P23-77 Capsid Protein Structures Reveal the Archetype of an Ancient Branch from a Major Virus Lineage

scientific article

Bluetongue virus VP4 is an RNA-capping assembly line

scientific article

Bluetongue virus: the role of synchrotron radiation

Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients

scientific article published on 08 June 2020

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

scientific article published on 04 September 2020

Calcium-controlled conformational choreography in the N-terminal half of adseverin

scientific article

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

scientific article published on 15 October 2018

Complementing crystallography: the role of cryo-electron microscopy in structural biology.

scientific article published on October 1999

Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).

scientific article published on 25 August 2010

Corrigendum: A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus

scientific article published in June 2015

Corrigendum: A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus

scientific article

Crystal Structure and Carbohydrate Analysis of Nipah Virus Attachment Glycoprotein: a Template for Antiviral and Vaccine Design

scientific article

Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

scientific article

Crystal lattice as biological phenotype for insect viruses

scientific article published on 9 September 2005

Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues

scientific article

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus

scientific article

Crystal structure of the top domain of African horse sickness virus VP7: comparisons with bluetongue virus VP7

scientific article

Crystallization and preliminary X-ray analysis of the core particle of bluetongue virus

scientific article published in June 1995

Crystallization and preliminary X-ray crystallographic studies on the bacteriophage Φ6 RNA-dependent RNA polymerase

scientific article published on 01 November 2000

Crystallization and preliminary crystallographic analysis of the major capsid proteins VP16 and VP17 of bacteriophage P23-77.

scientific article

Crystallization of the membrane-containing bacteriophage PRD1 in quartz capillaries by vapour diffusion

scientific article published on 21 February 2003

Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region

scientific article published on 30 October 2019

Detection of a fourth orbivirus non-structural protein

scientific article (publication date: 2011)

Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics

scientific article published on 19 November 2020

Diffraction quality crystals of PRD1, a 66-MDa dsDNA virus with an internal membrane.

scientific article published in August 2002

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

scientific article

Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases

scientific article published on 22 April 2020

Expression, purification and crystallization of a lyssavirus matrix (M) protein

scientific article

Expression, purification and crystallization of the ectodomain of the envelope glycoprotein E2 from Bovine viral diarrhoea virus

scientific article

Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein ⬇️

scientific article

Gene silencing pathway RNA-dependent RNA polymerase of Neurospora crassa: yeast expression and crystallization of selenomethionated QDE-1 protein

article

Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev.

scientific article

Genomics and structure/function studies of Rhabdoviridae proteins involved in replication and transcription.

scientific article published on 25 February 2010

Going soft and SAD with manganese

scientific article published on 17 December 2004

High-resolution crystal structure of arthropod Eiger TNF suggests a mode of receptor engagement and altered surface charge within endosomes

scientific article published on 06 August 2019

Host ANP32A mediates the assembly of the influenza virus replicase

scientific article published on 18 November 2020

How vaccinia virus has evolved to subvert the host immune response.

scientific article published on 17 March 2011

Hybrid vigor: hybrid methods in viral structure determination

scientific article

Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element

scientific article

In situ macromolecular crystallography using microbeams

scientific article published on 17 April 2012

In vitro activities of the multifunctional RNA silencing polymerase QDE-1 of Neurospora crassa

scientific article published on 20 July 2010

Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence

scientific article

Insights from the crystal structure of the chicken CREB3 bZIP suggest that members of the CREB3 subfamily transcription factors may be activated in response to oxidative stress

scientific article published on 06 February 2019

Insights into assembly from structural analysis of bacteriophage PRD1.

scientific article published in November 2004

Insights into the Evolution of a Complex Virus from the Crystal Structure of Vaccinia Virus D13 ⬇️

scientific article published on July 13, 2011

Insights into the pre-initiation events of bacteriophage phi 6 RNA-dependent RNA polymerase: towards the assembly of a productive binary complex.

scientific article published on 7 January 2009

Insights into virus evolution and membrane biogenesis from the structure of the marine lipid-containing bacteriophage PM2

scientific article

Large unit cells and cellular mechanics

scientific article published on August 1, 1998

Lysine methylation as a routine rescue strategy for protein crystallization

scientific article (publication date: November 2006)

Macromolecular assemblies: greater than their parts.

scientific article

Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies

scientific article published on 11 January 2022

Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.

scientific article published on 7 April 2011

Mechanisms of Yersinia YopO kinase substrate specificity.

scientific article published on 04 January 2017

Membrane structure and interactions with protein and DNA in bacteriophage PRD1.

scientific article published on November 2004

More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules

scientific article

Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus

scientific article published on 29 May 2019

Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils

scientific article published on 04 July 2018

Noncatalytic Ions Direct the RNA-Dependent RNA Polymerase of Bacterial Double-Stranded RNA Virus  6 from De Novo Initiation to Elongation

scientific article

Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein

scientific article

Order and disorder in crystals of hexameric NTPases from dsRNA bacteriophages

scientific article published on 27 November 2003

Overcoming the false-minima problem in direct methods: structure determination of the packaging enzyme P4 from bacteriophage phi13.

scientific article

Plate Tectonics of Virus Shell Assembly and Reorganization in Phage Φ8, a Distant Relative of Mammalian Reoviruses

scientific article

Preliminary crystallographic analysis of the major capsid protein P2 of the lipid-containing bacteriophage PM2.

scientific article published on 30 July 2005

Production, crystallization and preliminary X-ray crystallographic studies of the bacteriophage phi 12 packaging motor

scientific article published on 25 February 2004

Pushing the limits of sulfur SAD phasing:de novostructure solution of the N-terminal domain of the ectodomain of HCV E1

scientific article

RNA-dependent RNA polymerases of dsRNA bacteriophages

scientific article published on April 2004

Rhabdovirus Matrix Protein Structures Reveal a Novel Mode of Self-Association

scientific article

Selenomethionine labeling of large biological macromolecular complexes: probing the structure of marine bacterial virus PM2.

scientific article published in November 2007

Semi-automated microseeding of nanolitre crystallization experiments

scientific article

Solution and Crystallographic Structures of the Central Region of the Phosphoprotein from Human Metapneumovirus

scientific article

Structural Analysis of a Dengue Cross-Reactive Antibody Complexed with Envelope Domain III Reveals the Molecular Basis of Cross-Reactivity

scientific article

Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2

scientific article

Structural basis of mechanochemical coupling in a hexameric molecular motor

scientific article

Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization

scientific article

Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering

scientific article published in November 2017

Structural explanation for the role of Mn2+ in the activity of  6 RNA-dependent RNA polymerase

scientific article

Structural insights into RNA polymerases of negative-sense RNA viruses

scientific article

Structural insights into the human metapneumovirus glycoprotein ectodomain.

scientific article published on 16 July 2014

Structural studies of orbivirus particles

scientific article

Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

scientific article

Structure Unifies the Viral Universe ⬇️

scientific article published on 05 April 2012

Structure and Function of A41, a Vaccinia Virus Chemokine Binding Protein

scientific article

Structure and Self-Assembly of the Calcium Binding Matrix Protein of Human Metapneumovirus

scientific article

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

scientific article

Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data

scientific article

Structure of CrmE, a virus-encoded tumour necrosis factor receptor

scientific article

Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry

scientific article

Structure of a VP1-VP3 Complex Suggests How Birnaviruses Package the VP1 Polymerase

scientific article

Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Å resolution

scientific article

Structure of the Nucleoprotein Binding Domain of Mokola Virus Phosphoprotein

scientific article

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation

scientific article

Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization

scientific article

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

scientific article published on 04 September 2019

Structures of orbivirus VP7: implications for the role of this protein in the viral life cycle

scientific article published on 01 July 1997

SynchLink: an iOS app for ISPyB.

scientific article published on 4 September 2014

The C-terminal priming domain is strongly associated with the main body of bacteriophage ϕ6 RNA-dependent RNA polymerase

scientific article

The N-Terminus of the RNA Polymerase from Infectious Pancreatic Necrosis Virus Is the Determinant of Genome Attachment

scientific article

The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly

scientific article published on 31 May 2016

The Structure of an RNAi Polymerase Links RNA Silencing and Transcription

scientific article

The VIZIER project: preparedness against pathogenic RNA viruses

scientific article

The atomic structure of the bluetongue virus core

scientific article

The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA.

scientific article published on 3 April 2017

The core of bluetongue virus binds double-stranded RNA

scientific article

The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.

scientific article published on July 2006

The crystal structure of bluetongue virus VP7

scientific article

The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation

scientific article

The highly ordered double-stranded RNA genome of bluetongue virus revealed by crystallography.

scientific article published in May 1999

The matrix protein of rabies virus binds to RelAp43 to modulate NF-κB-dependent gene expression related to innate immunity

scientific article published on 21 December 2016

The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure

article

The nsp9 replicase protein of SARS-coronavirus, structure and functional insights

scientific article

The role of gelsolin domain 3 in familial amyloidosis (Finnish type)

scientific article published on 26 June 2019

The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase

scientific article

The structure and function of the outer coat protein VP9 of Banna virus

scientific article

The structure of a cypovirus and the functional organization of dsRNA viruses.

scientific article

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins

scientific article published on 19 February 2019

The structure of the nucleoprotein binding domain of lyssavirus phosphoprotein reveals a structural relationship between the N-RNA binding domains of Rhabdoviridae and Paramyxoviridae

scientific article published on 27 May 2010

The use of low-resolution phasing followed by phase extension from 7.6 to 2.5 Å resolution with noncrystallographic symmetry to solve the structure of a bacteriophage capsid protein

scientific article

Towards in cellulo virus crystallography

scientific article published on 28 February 2018

Tracking in atomic detail the functional specializations in viral RecA helicases that occur during evolution ⬇️

scientific article

Translocation portals for the substrates and products of a viral transcription complex: the bluetongue virus core.

scientific article

Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1

scientific article published on 16 September 2014

Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein

scientific article

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

scientific article

Virus crystallography.

scientific article

What does structure tell us about virus evolution?

scientific article

Where is crystallography going?

scientific article published in February 2018

X-ray structure and activities of an essential Mononegavirales L-protein domain

scientific article

Yersinia effector YopO uses actin as bait to phosphorylate proteins that regulate actin polymerization

scientific article published on 9 February 2015

Yersinia effector protein (YopO)-mediated phosphorylation of host gelsolin causes calcium-independent activation leading to disruption of actin dynamics.

scientific article

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