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Authors whose works are in public domain in at least one jurisdiction

List of works by Charles W Roberts

A first-generation pediatric cancer dependency map

scientific article published on 22 March 2021

A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers

scientific article

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection

scientific article published in December 2017

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice.

scientific article

ARID1A mutations in cancer: another epigenetic tumor suppressor?

scientific article

ARID1B is a specific vulnerability in ARID1A-mutant cancers. ⬇️

scientific article

Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors.

scientific article published on 19 September 2012

Abstract LB-126: ARID1B is a specific vulnerability in ARID1A-mutant cancers

Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5.

scientific article published on 25 February 2013

Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies

scientific article published on 10 January 2016

Author Correction: BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

scientific article published on 26 September 2019

Author Correction: PGBD5 promotes site-specific oncogenic mutations in human tumors

scientific article published on 11 September 2020

BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

article

CARMA: CARM1 methylation of SWI/SNF in breast cancer.

scientific article published on January 2014

CHD7 in charge of neurogenesis.

scientific article published in July 2013

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

scientific article published on 4 December 2017

Cancer-fighting Smurf

scientific article published on 06 February 2012

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

scientific article

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

scientific article published on 27 December 2018

Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia ⬇️

scientific article (publication date: 5 July 1991)

Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation

scientific article

Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors.

scientific article published on 15 May 2012

Epigenetics and cancer without genomic instability.

scientific article

Epigenetics and cancer: altered chromatin remodeling via Snf5 loss leads to aberrant cell cycle regulation.

scientific article

Erratum: PGBD5 promotes site-specific oncogenic mutations in human tumors.

scientific article published in September 2017

Establishment and characterization of MRT cell lines from genetically engineered mouse models and the influence of genetic background on their development.

scientific article published on 27 December 2012

Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences

scientific article

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity

scientific article

Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors

scientific article

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

scientific article

Functionally distinct patterns of nucleosome remodeling at enhancers in glucocorticoid-treated acute lymphoblastic leukemia

scientific article published on 02 December 2015

Genetic causes of familial risk in rhabdoid tumors

scientific article published on 01 September 2006

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

scientific article published on 3 June 2016

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice

scientific journal article

High Frequency of Ovarian Cyst Development in Vhl2B/+;Snf5+/- Mice

scientific article published on 20 April 2018

Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5

scientific article published on 01 November 2002

Hox11 controls the genesis of the spleen

scientific article published in Nature

Inactivation of SNF5 cooperates with p53 loss to accelerate tumor formation in Snf5(+/-);p53(+/-) mice

scientific article

Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation.

scientific article

Integrated genetic and pharmacologic interrogation of rare cancers

scientific article

Linking the SWI/SNF complex to prostate cancer.

scientific article published in November 2013

Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.

scientific article

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.

scientific article

MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

scientific article published on 12 February 2019

Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth.

scientific article

Metagene projection for cross-platform, cross-species characterization of global transcriptional states

scholarly article

Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor

scientific article published on 4 December 2015

Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.

scientific article published on 11 October 2013

Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study.

scientific article published on 28 January 2016

Mutational heterogeneity in cancer and the search for new cancer-associated genes

scientific article

Mutational processes shape the landscape of TP53 mutations in human cancer.

scientific article

On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(-)/-) mutant mice.

scientific article

Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.

scientific article published on 29 September 2009

PGBD5 promotes site-specific oncogenic mutations in human tumors

scientific article published on 15 May 2017

Partitioning of Chemotherapeutics into Nuclear Condensates-Opening the Door to New Approaches for Drug Development

scientific article published on 01 August 2020

Renal Medullary Carcinoma: Establishing Standards in Practice

scientific article published on July 2017

Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation

scientific article

Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine

scientific article published on 06 July 2020

Rhabdoid tumors: an initial clue to the role of chromatin remodeling in cancer

scientific article published on March 2013

SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation

scientific article

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity

scientific article published on 20 May 2009

SWI/SNF nucleosome remodellers and cancer.

scientific article published on 09 June 2011

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

scientific article

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

scientific article published on 01 August 2019

Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters

scientific article published on 30 May 2013

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.

scientific article published on 8 February 2017

TCR-dependent transformation of mature memory phenotype T cells in mice

scientific article

TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer

scientific article published on 01 October 2018

Targeting EZH2 in cancer

scientific article

The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers

scientific article

The SWI/SNF complex in cancer - biology, biomarkers and therapy

scientific article published on 17 April 2020

The SWI/SNF complex--chromatin and cancer.

scientific article published on February 2004

The SWI/SNF tumor suppressor complex: Regulation of promoter nucleosomes and beyond

scientific article published on 30 September 2013

The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors ⬇️

scientific article published on January 1, 2002

The role of SMARCB1/INI1 in development of rhabdoid tumor.

scientific article published on 29 March 2009

Toward understanding and exploiting tumor heterogeneity

scientific article

Tumor-specific cooperation of retinoblastoma protein family and Snf5 inactivation

scientific article published on 01 April 2007

Vulnerabilities of mutant SWI/SNF complexes in cancer.

scientific article published on September 2014

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

scientific article published on 01 February 2019

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