List of works - Klaus Richter

A Grp on the Hsp90 mechanism

scientific article published on October 2007

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation

scientific article published on 21 May 2015

A network of genes connects polyglutamine toxicity to ploidy control in yeast

scientific article published on January 2013

AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control

scientific article

Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90.

scientific article published on 20 September 2016

Analysis of the regulation of the molecular chaperone Hsp26 by temperature-induced dissociation: the N-terminal domail is important for oligomer assembly and the binding of unfolding proteins

scientific article published on 13 January 2004

Artificial Accelerators of the Molecular Chaperone Hsp90 Facilitate Rate-Limiting Conformational Transitions

scholarly article by Bettina K. Zierer et al published 22 September 2014 in Angewandte Chemie International Edition

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

scientific article published on 01 February 2010

Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network

scientific article

Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites

scientific article

Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors

scientific article published on 29 September 2010

Chaperone-interacting TPR proteins in Caenorhabditis elegans

scientific article published on 29 May 2013

Closely related receptor complexes differ in their ABA selectivity and sensitivity

scientific article published on 21 September 2009

Closing In on the Hsp90 Chaperone-Client Relationship

scientific article published on 01 April 2011

Cns1 is an activator of the Ssa1 ATPase activity

scientific article

Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation

scientific article published on 01 February 2012

Conserved conformational changes in the ATPase cycle of human Hsp90.

scientific article published on 9 April 2008

Construction and evaluation of yeast expression networks by database-guided predictions

scientific article published on 21 April 2016

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.

scientific article published on 22 February 2009

Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegans

scientific article

Energetics by NMR: site-specific binding in a positively cooperative system

scientific article

Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes

scientific article

Formation of She2p tetramers is required for mRNA binding, mRNP assembly, and localization

scientific article published on 26 August 2009

Hsp90 in non-mammalian metazoan model systems

scientific article published on 22 September 2011

Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules

scientific article published on 8 April 2015

Hsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes

scientific article published on 27 October 2017

Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites

scientific article published on 28 October 2015

Identification of a tissue-selective heat shock response regulatory network

scientific article

Importance of cycle timing for the function of the molecular chaperone Hsp90.

scientific article published on 10 October 2016

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

scientific article published on 10 February 2013

Intrinsic inhibition of the Hsp90 ATPase activity

scientific article published on 6 February 2006

Ligand-induced formation of a transient tryptophan synthase complex with αββ subunit stoichiometry

scientific article published on 6 December 2010

Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle

scientific article

Monomeric myosin V uses two binding regions for the assembly of stable translocation complexes

scholarly article

N-terminal residues regulate the catalytic efficiency of the Hsp90 ATPase cycle

scientific article

NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol

scientific article published in September 2003

Nematode Sgt1-homologue D1054.3 binds open and closed conformations of Hsp90 via distinct binding sites

scientific article

Nucleotide-Free sB-Raf is Preferentially Bound by Hsp90 and Cdc37 In Vitro

scientific article published on 9 September 2016

Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects

scientific article

Protein folding, misfolding and quality control: the role of molecular chaperones

scientific article published on 01 January 2014

Regulation of the Hsp90 system

scientific article published on 18 March 2018

Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association

scientific article

Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism

scientific article

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

scientific article

Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle

scientific article

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.

scientific article published on 4 September 2011

Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB.

scientific article

Subunit Interactions and cooperativity in the microtubule-severing AAA ATPase spastin

scientific article published on 27 May 2012

The Co-chaperone Sba1 connects the ATPase reaction of Hsp90 to the progression of the chaperone cycle

scientific article published in October 2004

The Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain: CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTIONS

scientific article

The Hsp90 chaperone machinery

scientific article

The activation mechanism of Hsp26 does not require dissociation of the oligomer

scientific article published in July 2005

The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90

scientific journal article

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

scientific article

The balanced regulation of Hsc70 by DNJ-13 and UNC-23 is required for muscle functionality.

scientific article

The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function

scientific article

The charged linker region is an important regulator of Hsp90 function

scientific article published on 24 June 2009

The heat shock response: life on the verge of death

scientific article published on October 2010

The lid domain of Caenorhabditis elegans Hsc70 influences ATP turnover, cofactor binding and protein folding activity.

scientific article

The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90.

scientific article published on 25 June 2009

The prion curing agent guanidinium chloride specifically inhibits ATP hydrolysis by Hsp104.

scientific article published on 10 December 2003

The rod-shaped conformation of Starmaker

scientific article published on 25 July 2009

Unique Proline-Rich Domain Regulates the Chaperone Function of AIPL1

scientific article published on 13 March 2013

daf-41/p23: A Small Protein Heating Up Lifespan Regulation

scientific article published on 6 July 2015

hsp90: twist and fold.

scientific article

List of works by Klaus Richter

A Grp on the Hsp90 mechanism

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation

A network of genes connects polyglutamine toxicity to ploidy control in yeast

AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control

Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90.

Analysis of the regulation of the molecular chaperone Hsp26 by temperature-induced dissociation: the N-terminal domail is important for oligomer assembly and the binding of unfolding proteins

Artificial Accelerators of the Molecular Chaperone Hsp90 Facilitate Rate-Limiting Conformational Transitions

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network

Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites

Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors

Chaperone-interacting TPR proteins in Caenorhabditis elegans

Closely related receptor complexes differ in their ABA selectivity and sensitivity

Closing In on the Hsp90 Chaperone-Client Relationship

Cns1 is an activator of the Ssa1 ATPase activity

Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation

Conserved conformational changes in the ATPase cycle of human Hsp90.

Construction and evaluation of yeast expression networks by database-guided predictions

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.

Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegans

Energetics by NMR: site-specific binding in a positively cooperative system

Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes

Formation of She2p tetramers is required for mRNA binding, mRNP assembly, and localization

Hsp90 in non-mammalian metazoan model systems

Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules

Hsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes

Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites

Identification of a tissue-selective heat shock response regulatory network

Importance of cycle timing for the function of the molecular chaperone Hsp90.

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

Intrinsic inhibition of the Hsp90 ATPase activity

Ligand-induced formation of a transient tryptophan synthase complex with αββ subunit stoichiometry

Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle

Monomeric myosin V uses two binding regions for the assembly of stable translocation complexes

N-terminal residues regulate the catalytic efficiency of the Hsp90 ATPase cycle

NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol

Nematode Sgt1-homologue D1054.3 binds open and closed conformations of Hsp90 via distinct binding sites

Nucleotide-Free sB-Raf is Preferentially Bound by Hsp90 and Cdc37 In Vitro

Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects

Protein folding, misfolding and quality control: the role of molecular chaperones

Regulation of the Hsp90 system

Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association

Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.

Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB.

Subunit Interactions and cooperativity in the microtubule-severing AAA ATPase spastin

The Co-chaperone Sba1 connects the ATPase reaction of Hsp90 to the progression of the chaperone cycle

The Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain: CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTIONS

The Hsp90 chaperone machinery

The activation mechanism of Hsp26 does not require dissociation of the oligomer

The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

The balanced regulation of Hsc70 by DNJ-13 and UNC-23 is required for muscle functionality.

The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function

The charged linker region is an important regulator of Hsp90 function

The heat shock response: life on the verge of death

The lid domain of Caenorhabditis elegans Hsc70 influences ATP turnover, cofactor binding and protein folding activity.

The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90.

The prion curing agent guanidinium chloride specifically inhibits ATP hydrolysis by Hsp104.

The rod-shaped conformation of Starmaker

Unique Proline-Rich Domain Regulates the Chaperone Function of AIPL1

daf-41/p23: A Small Protein Heating Up Lifespan Regulation

hsp90: twist and fold.