List of works - Ian Chambers

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal

scientific journal article

A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis.

scientific article

A new twist to Sin3 complexes in pluripotent cells

scientific article published on 28 June 2017

An Oct4-centered protein interaction network in embryonic stem cells

scientific article

BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3

scientific article (publication date: 31 October 2003)

Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice.

scientific article published in May 2005

Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis

scientific article published on 01 July 1996

Derivation of germline competent embryonic stem cells with a combination of interleukin-6 and soluble interleukin-6 receptor

scientific article published on 01 November 1994

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

scientific article

Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function

scientific article published on 6 December 2016

Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs

scientific article (publication date: 14 April 2016)

Distinct SoxB1 networks are required for naïve and primed pluripotency

scientific article published on 19 December 2017

Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through Fgf4/Fgfr2 signalling in preimplantation mouse embryos

scientific article published on 27 February 2018

Effect of selenium status on mRNA levels for glutathione peroxidase in rat liver

scientific article published on 01 June 1988

Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker

scientific article published on 03 October 2019

Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles.

scientific article published on 10 March 2003

Esrrb Complementation Rescues Development of Nanog-Null Germ Cells

scientific article published in January 2018

Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation

scientific article published on 01 October 2018

Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression

scientific journal article

Expression of alternative forms of differentiation inhibiting activity (DIA/LIF) during murine embryogenesis and in neonatal and adult tissues.

scientific article published in January 1993

Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells ⬇️

scientific article published on 19 August 2009

Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

scientific article

Functional Antagonism between OTX2 and NANOG Specifies a Spectrum of Heterogeneous Identities in Embryonic Stem Cells

scientific article

Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells

scientific article published on 19 July 2018

Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells

scientific article (publication date: 30 May 2003)

Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation

scientific article published on 25 November 2002

Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity ⬇️

scientific article

Lessons in learning: An effective process for engaging 12- to 14-year-olds in stem cell biology

scientific article

Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways

scientific article published on 01 February 1994

Molecular coupling of Xist regulation and pluripotency.

scientific article

Nanog is the gateway to the pluripotent ground state.

scientific article

Nanog promotes transfer of pluripotency after cell fusion

scientific article

Nanog retrotransposed genes with functionally conserved open reading frames.

scientific article published on 14 July 2006

Nanog safeguards pluripotency and mediates germline development

scientific article (publication date: 20 December 2007)

OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.

scientific article published on 23 November 2012

Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells.

scientific article published on March 2002

Quantification of Pluripotency Transcription Factor Levels in Embryonic Stem Cells by Flow Cytometry ⬇️

scientific article published on December 1, 2011

Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog

scientific article published on May 2013

Reprogramming Roadblocks Are System Dependent

scientific article

Segregation of the mouse germline and soma

scientific article published on 04 October 2019

Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.

scientific article

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

scientific article

Self-renewal of teratocarcinoma and embryonic stem cells.

scientific article published in September 2004

Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells.

scientific article

Stem cell powwow in Squaw Valley.

scientific article published on July 2012

Structure of the mouse leukaemia inhibitory factor receptor gene: regulated expression of mRNA encoding a soluble receptor isoform from an alternative 5' untranslated region.

scientific article published in December 1997

The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells.

scientific article

The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression ⬇️

scientific article published on July 1, 2012

The evolving biology of cell reprogramming.

scientific article published on August 2011

The homeodomain protein Nanog and pluripotency in mouse embryonic stem cells

scientific article

The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells

scientific article published on 28 April 2016

The pluripotency rheostat Nanog functions as a dimer

scientific article

The pluripotent genome in three dimensions is shaped around pluripotency factors

scientific article published on 24 July 2013

Transcription factor heterogeneity and epiblast pluripotency.

scientific article

Transcriptional up-regulation of the mouse cytosolic glutathione peroxidase gene in erythroid cells is due to a tissue-specific 3' enhancer containing functionally important CACC/GT motifs and binding sites for GATA and Ets transcription factors.

scientific article published on October 1993

List of works by Ian Chambers

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal

A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis.

A new twist to Sin3 complexes in pluripotent cells

An Oct4-centered protein interaction network in embryonic stem cells

BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3

Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice.

Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis

Derivation of germline competent embryonic stem cells with a combination of interleukin-6 and soluble interleukin-6 receptor

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function

Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs

Distinct SoxB1 networks are required for naïve and primed pluripotency

Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through Fgf4/Fgfr2 signalling in preimplantation mouse embryos

Effect of selenium status on mRNA levels for glutathione peroxidase in rat liver

Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker

Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles.

Esrrb Complementation Rescues Development of Nanog-Null Germ Cells

Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation

Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression

Expression of alternative forms of differentiation inhibiting activity (DIA/LIF) during murine embryogenesis and in neonatal and adult tissues.

Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells ⬇️

Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

Functional Antagonism between OTX2 and NANOG Specifies a Spectrum of Heterogeneous Identities in Embryonic Stem Cells

Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells

Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells

Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation

Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity ⬇️

Lessons in learning: An effective process for engaging 12- to 14-year-olds in stem cell biology

Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways

Molecular coupling of Xist regulation and pluripotency.

Nanog is the gateway to the pluripotent ground state.

Nanog promotes transfer of pluripotency after cell fusion

Nanog retrotransposed genes with functionally conserved open reading frames.

Nanog safeguards pluripotency and mediates germline development

OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.

Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells.

Quantification of Pluripotency Transcription Factor Levels in Embryonic Stem Cells by Flow Cytometry ⬇️

Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog

Reprogramming Roadblocks Are System Dependent

Segregation of the mouse germline and soma

Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

Self-renewal of teratocarcinoma and embryonic stem cells.

Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells.

Stem cell powwow in Squaw Valley.

Structure of the mouse leukaemia inhibitory factor receptor gene: regulated expression of mRNA encoding a soluble receptor isoform from an alternative 5' untranslated region.

The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells.

The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression ⬇️

The evolving biology of cell reprogramming.

The homeodomain protein Nanog and pluripotency in mouse embryonic stem cells

The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells

The pluripotency rheostat Nanog functions as a dimer

The pluripotent genome in three dimensions is shaped around pluripotency factors

Transcription factor heterogeneity and epiblast pluripotency.

Transcriptional up-regulation of the mouse cytosolic glutathione peroxidase gene in erythroid cells is due to a tissue-specific 3' enhancer containing functionally important CACC/GT motifs and binding sites for GATA and Ets transcription factors.