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List of works by Edoardo Spina

6-Mer Hyaluronan Oligosaccharides Modulate Neuroinflammation and α-Synuclein Expression in Neuron-Like SH-SY5Y Cells

scientific article published on 11 May 2016

A comprehensive review of swallowing difficulties and dysphagia associated with antipsychotics in adults

scientific article published on 08 February 2019

A comprehensive review of the clinical utility of and a combined analysis of the clozapine/norclozapine ratio in therapeutic drug monitoring for adult patients

scientific article published on 31 May 2019

A molecular pathway analysis informs the genetic background at risk for schizophrenia

scientific article published on 30 December 2014

A nationwide prospective study on prescribing pattern of antidepressant drugs in Italian primary care

scientific article

A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting paliperidone

scientific article published on 04 December 2018

A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting risperidone.

scientific article published on 12 July 2017

A systematic review and combined analysis of therapeutic drug monitoring studies for oral paliperidone

scientific article published on 18 June 2018

ABCB1 polymorphisms influence steady-state plasma levels of 9-hydroxyrisperidone and risperidone active moiety.

scientific article published in October 2008

Acute cerebellar ataxia following meningococcal group C conjugate vaccination.

scientific article published on 28 December 2012

Adverse Drug Reactions in Hospitalized Patients: Results of the FORWARD (Facilitation of Reporting in Hospital Ward) Study.

scientific article

Adverse drug interaction between risperidone and carbamazepine in a patient with chronic schizophrenia and deficient CYP2D6 activity.

scientific article

Age-related Changes in Pharmacodynamics: Focus on Drugs Acting on Central Nervous and Cardiovascular Systems ⬇️

scientific article published on September 1, 2011

Allele and genotype frequencies of CYP2C9, CYP2C19 and CYP2D6 in an Italian population.

scientific article

Antidepressant drugs: prevalence, incidence and indication of use in general practice of Southern Italy during the years 2003-2004.

scientific article published on May 2007

Antidepressant use in the elderly: the role of pharmacodynamics and pharmacokinetics in drug safety

scientific article

Antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia: associations with dopamine and serotonin receptor and transporter polymorphisms

scientific article published on 17 January 2007

Antipsychotics and torsadogenic risk: signals emerging from the US FDA Adverse Event Reporting System database.

scientific article

Are the safety profiles of antipsychotic drugs used in dementia the same? An updated review of observational studies.

scientific article published on July 2014

Assessing drug-drug interactions through therapeutic drug monitoring when administering oral second-generation antipsychotics.

scientific article published on 15 February 2016

Assessment and Management of Cognitive and Psychosocial Dysfunctions in Patients With Major Depressive Disorder: A Clinical Review

scholarly article by Andrea Fiorillo et al published 2018 in Frontiers in Psychiatry

Augmentation of clozapine with agomelatine in partial-responder schizophrenia: a 16-week, open-label, uncontrolled pilot study

scientific article published in August 2014

Augmentation of clozapine with ziprasidone in refractory schizophrenia: a double-blind, placebo-controlled study

scientific article published on February 2014

CYP2D6 genotype and antipsychotic-induced extrapyramidal side effects in schizophrenic patients

scientific article published on 01 December 2000

CYP2D6-related oxidation polymorphism in Italy

scientific article published on 01 April 1994

Can valproic acid be an inducer of clozapine metabolism?

scientific article

Can zinc depletion play a role in LEV-induced hair loss? Considerations from a case study

scientific article published on 09 August 2013

Changes in the prescribing pattern of antidepressant drugs in elderly patients: an Italian, nationwide, population-based study.

scientific article published on 15 January 2014

Clinical applications of CYP genotyping in psychiatry.

scientific article published on 09 September 2014

Clinical trial methodology to assess the efficacy/effectiveness of long-acting antipsychotics: Randomized controlled trials vs naturalistic studies

scientific article published on 28 November 2016

Clinically Relevant Drug Interactions with Anti-Alzheimer's Drugs.

scientific article published on 3 March 2017

Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents

scientific article published on 02 December 2020

Clinically Significant Drug Interactions with Newer Antidepressants

scientific article published on January 1, 2012

Clinically relevant drug interactions between newer antidepressants and oral anticoagulants

scientific article published on 10 December 2019

Clinically relevant drug interactions in anxiety disorders

scientific article published on 07 February 2012

Clinically relevant interactions between newer antidepressants and second-generation antipsychotics

scientific article published on 05 February 2014

Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update

scientific article

Clinically significant drug interactions with antidepressants in the elderly.

scientific article

Clinically significant pharmacokinetic drug interactions of antiepileptic drugs with new antidepressants and new antipsychotics.

scientific article published on 16 February 2016

Clozapine ultrarapid metabolism during weak induction probably exists but requires careful diagnosis. A literature review, five new cases and a proposed definition

scientific article published in 2023

Co-prescriptions with itraconazole and fluconazole as a signal for possible risk of drug-drug interactions: a four-year analysis from Italian general practice

scientific article published on 01 April 2007

Continuous apomorphine infusion (CAI) and neuropsychiatric disorders in patients with advanced Parkinson's disease: a follow-up of two years.

scientific article

Corrigendum to “Evaluation of the role of MAPK1 and CREB1 polymorphisms on treatment resistance, response and remission in mood disorder patients.” [Progress in Neuro-Psychopharmacology & Biological Psychiatry 44 (2013) 271–278]

scholarly article by Raffaella Calati et al published October 2013 in Progress in Neuro-Psychopharmacology & Biological Psychiatry

Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone

scientific article

Cytochrome P450 polymorphisms and response to antipsychotic therapy.

scientific article

Decreased plasma concentrations of imipramine and desipramine following cholestyramine intake in depressed patients

scientific article published on 01 August 1994

Determination of clozapine, desmethylclozapine and clozapine N-oxide in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection

scientific article published on 01 September 1998

Determination of olanzapine in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection

scientific article published on 01 June 2006

Determination of risperidone and its major metabolite 9-hydroxyrisperidone in human plasma by reversed-phase liquid chromatography with ultraviolet detection

scientific article published on 01 September 2000

Drug Dosage Individualization Based on a Random-Effects Linear Model ⬇️

scientific article published on January 1, 2012

Drug interactions with vortioxetine, a new multimodal antidepressant.

scientific article published on September 2015

Duloxetine as adjunctive treatment to clozapine in patients with schizophrenia

scientific article published on 01 November 2011

ECG parameters in children and adolescents treated with aripiprazole and risperidone.

scientific article published on 5 November 2013

Effect of Adjunctive Lamotrigine Treatment on the Plasma Concentrations of Clozapine, Risperidone and Olanzapine in Patients With Schizophrenia or Bipolar Disorder

scientific article published on 01 October 2006

Effect of Aripiprazole Augmentation of Serotonin Reuptake Inhibitors or Clomipramine in Treatment-Resistant Obsessive-Compulsive Disorder

scientific article published on 01 April 2011

Effect of Topiramate on Plasma Concentrations of Clozapine, Olanzapine, Risperidone, and Quetiapine in Patients With Psychotic Disorders

scientific article published on 01 March 2007

Effect of adjunctive duloxetine on the plasma concentrations of clozapine, olanzapine, and risperidone in patients with psychotic disorders.

scientific article published on October 2010

Effect of aripiprazole augmentation of clozapine in schizophrenia: A double-blind, placebo-controlled study

scientific article published on 23 January 2011

Effect of fluoxetine on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenia ⬇️

scientific article published on May 1, 1998

Effect of fluvoxamine on plasma risperidone concentrations in patients with schizophrenia.

scientific article

Effects of L'Aquila earthquake on the prescribing pattern of antidepressant and antipsychotic drugs

scientific article published on 18 September 2013

Elevation of plasma carbamazepine concentrations by ketoconazole in patients with epilepsy

scientific article published on 01 October 1997

Estimating the size of the effects of co-medications on plasma clozapine concentrations using a model that controls for clozapine doses and confounding variables.

scientific article published in May 2008

Evaluation of acute cardiovascular effects of immediate-release methylphenidate in children and adolescents with attention-deficit hyperactivity disorder

scientific article published on 8 May 2015

Evaluation of the role of MAPK1 and CREB1 polymorphisms on treatment resistance, response and remission in mood disorder patients

scientific article

Exploring low clozapine C/D ratios, inverted clozapine-norclozapine ratios and undetectable concentrations as measures of non-adherence in clozapine patients

scientific article published in 2023

Generalized versus partial reflex seizures: a review.

scientific article

Generic Olanzapine Substitution in Patients With Schizophrenia

scientific article published on 01 December 2015

Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population.

scientific article

Genetic polymorphisms of cytochrome P450 enzymes and antidepressant metabolism

scientific article published on 08 July 2011

Glutamine-supplemented total parenteral nutrition improves immunological status in anorectic patients

scientific article published in February 2010

Head-to-Head Comparison of Aripiprazole and Risperidone in the Treatment of ADHD Symptoms in Children with Autistic Spectrum Disorder and ADHD: A Pilot, Open-Label, Randomized Controlled Study

scientific article published on 8 June 2016

How frequently are contraindicated or warned against combinations of drugs prescribed to patients receiving long-term opioid therapy for chronic pain?

scientific article published on 14 November 2011

Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in mice

scientific article

Indications of newer and older anti-epileptic drug use: findings from a southern Italian general practice setting from 2005-2011.

scientific article published on June 2015

Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance.

scientific article

Inhibition of diazepam metabolism by fluvoxamine: a pharmacokinetic study in normal volunteers.

scientific article published in November 1994

Interactions between antiepileptics and second-generation antipsychotics.

scientific article published on 15 February 2012

Iron status in schizophrenic patients with acute neuroleptic-induced dystonic reactions

scientific article published on 01 September 1994

Issues in Methodology and Applications for Therapeutic Drug Monitoring of Fluoxetine and Norfluoxetine Enantiomers

scientific article published on 01 February 1998

Lack of a pharmacokinetic interaction between mirtazapine and the newer antipsychotics clozapine, risperidone and olanzapine in patients with chronic schizophrenia.

scientific article published in October 2003

Lamotrigine augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study

scientific article published on 20 February 2012

Long-Term Intravitreal Ranibizumab as a Potential Additional Risk Factor for Neurodegeneration in Parkinson's Disease: A Case Report.

scientific article

Low-Dose of Bergamot-Derived Polyphenolic Fraction (BPF) Did Not Improve Metabolic Parameters in Second Generation Antipsychotics-Treated Patients: Results from a 60-days Open-Label Study.

scientific article published on 11 April 2017

Management of women with epilepsy: from preconception to post-partum

scientific article

Melatonin treatment mimics the antidepressant action in chronic corticosterone-treated mice

scientific article published in June 2010

Melatonin's stimulatory effect on adult hippocampal neurogenesis in mice persists after ovariectomy

scientific article published on 06 June 2011

Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract.

scientific article

Metabolic drug interactions with new psychotropic agents.

scientific article published on October 2003

Metabolic drug interactions with newer antipsychotics: a comparative review.

scientific article published on January 2007

Newer and older antiepileptic drug use in Southern Italy: a population-based study during the years 2003-2005

scientific article published on 05 April 2009

Newer antipsychotics: comparative review of drug interactions.

scientific article

No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population.

scientific article

No effect of reboxetine on plasma concentrations of clozapine, risperidone, and their active metabolites.

scientific article published in December 2001

No effect of the new antidepressant reboxetine on CYP2D6 activity in healthy volunteers

scientific article published on 01 October 1999

Pharmaco-utilisation and related costs of drugs used to treat schizophrenia and bipolar disorder in Italy: the IBIS study

scientific article

Pharmacogenetic aspects in the metabolism of psychotropic drugs: pharmacokinetic and clinical implications.

scientific article published on February 1994

Pharmacogenetics of antidepressants

scientific article

Pharmacogenetics of drug-metabolizing enzymes in Italian populations.

scientific article published on June 2015

Pharmacogenomics of Depression

Pharmacokinetic and pharmacodynamic interactions between antiepileptics and antidepressants

scientific article published on 06 September 2014

Pharmacokinetic drug interaction studies must consider pharmacological heterogeneity, use of repeated dosing, and translation into a message understandable to practicing clinicians

scientific article published on 01 June 2009

Pharmacokinetic drug-drug interactions between olanzapine and valproate need to be better studied.

scientific article published on July 2010

Phenobarbital induces the 2-hydroxylation of desipramine

scientific article published on 01 February 1996

Plasma concentrations of clozapine and its major metabolites during combined treatment with paroxetine or sertraline

scientific article published on 01 November 2000

Plasma concentrations of risperidone and 9-hydroxyrisperidone: effect of comedication with carbamazepine or valproate

scientific article published on 01 August 2000

Plasma concentrations of risperidone and olanzapine during coadministration with oxcarbazepine.

scientific article published in May 2005

Plasma risperidone concentrations during combined treatment with sertraline.

scientific article published in August 2004

Possible Pharmacodynamic and Pharmacokinetic Drug-Drug Interactions That Are Likely to Be Clinically Relevant and/or Frequent in Bipolar Disorder.

scientific article published on 12 March 2018

Potentially Clinically Relevant Pharmacodynamic Interactions Between Antiepileptic Drugs And Psychotropic Drugs: An Update.

scientific article published on 9 August 2017

Prescribing pattern of anti-Parkinson drugs in Southern Italy: cross-sectional analysis in the years 2003-2005

scientific article published on 03 March 2008

Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005.

scientific article published on 26 September 2007

Progress and prospects in pharmacogenetics of antidepressant drugs

scientific article

Quetiapine versus clozapine: a preliminary report of comparative effects on dopaminergic psychosis in patients with Parkinson's disease.

scientific article

Rapid versus slow withdrawal of antiepileptic monotherapy in 2-year seizure-free adult patients with epilepsy (RASLOW) study: a pragmatic multicentre, prospective, randomized, controlled study.

scientific article published on 25 January 2016

Real World Data on the Utilization Pattern and Safety Profile of Infliximab Originator Versus Biosimilars in Italy: A Multiregional Study

article

Reboxetine adjuvant therapy in patients with schizophrenia showing a suboptimal response to clozapine: a 12-week, open-label, pilot study

scientific article published on October 2014

Red Yeast Rice (RYR) supplementation in patients treated with second-generation antipsychotics.

scientific article published on 15 March 2018

Relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics

scientific article published on 01 January 2000

Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study

scientific article published on 01 January 1997

Restless Leg Syndrome in ADHD children: levetiracetam as a reasonable therapeutic option.

scientific article published on 14 October 2010

Safety Profile of Biologics Used in Rheumatology: An Italian Prospective Pharmacovigilance Study

scientific article published on 24 April 2020

Serenoa repens as an Endocrine Disruptor in a 10-Year-Old Young Girl: A New Case Report.

scientific article published on 2 June 2015

Sertindole: pharmacological and clinical profile and role in the treatment of schizophrenia

scientific article published on 01 May 2008

Short- and long-term effects on prolactin of risperidone and olanzapine treatments in children and adolescents.

scientific article

Short-term memory loss associated with rosuvastatin.

scientific article published in August 2006

Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy

scientific article published on 01 December 1994

Small effects of valproic acid on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenic or affective disorders

scientific article published on 01 June 1999

The Effect of Safety Warnings on Antipsychotic Drug Prescribing in Elderly Persons with Dementia in the United Kingdom and Italy: A Population-Based Study.

scientific article published on 16 July 2016

The Role of Levomilnacipran in the Management of Major Depressive Disorder: A Comprehensive Review

scientific article published on 17 November 2015

The economic burden of preventable adverse drug reactions: a systematic review of observational studies

scientific article published on 03 July 2018

The effect of carbamazepine on the 2-hydroxylation of desipramine

scientific article published on 01 February 1995

The effect of clozapine on aggressive behaviour in patients with chronic schizophrenia

scientific article published on 01 January 1999

The effect of lamotrigine augmentation of clozapine in a sample of treatment-resistant schizophrenic patients: A double-blind, placebo-controlled study

scientific article published on 26 March 2007

Transient global amnesia as a presenting aura or epilepsy?

scientific article published on 01 July 2014

Use and tolerability of newer antipsychotics and antidepressants: a chart review in a paediatric setting.

scientific article published on 21 June 2007

What is needed to incorporate clinical pharmacogenetic tests into the practice of psychopharmacotherapy?

scientific article published on 18 November 2015

Ziprasidone and amisulpride effectively treat negative symptoms of schizophrenia: results of a 12-week, double-blind study.

scientific article published in May 2006

n−3 fatty acids prevent impairment of neurogenesis and synaptic plasticity in B-cell activating factor (BAFF) transgenic mice ⬇️

scientific article published on December 28, 2011

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