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List of works by Oliver N Keene

Adaptive designs for pivotal trials: discussion points from the PSI Adaptive Design Expert Group.

scientific article published on January 2006

Alternatives to the hazard ratio in summarizing efficacy in time-to-event studies: an example from influenza trials

scientific article published on 01 December 2002

Analysis of exacerbation rates in asthma and chronic obstructive pulmonary disease: example from the TRISTAN study

scientific article published on 01 April 2007

Asthma Exacerbations Associated with Lung Function Decline in Patients with Severe Eosinophilic Asthma.

scientific article published in February 2018

Blood eosinophil counts predict treatment response in patients with severe eosinophilic asthma.

scientific article published on 17 July 2015

Common noncompartmental pharmacokinetic variables: are they normally or log-normally distributed?

scientific article published on 01 March 1997

Comparative pharmacokinetics of bismuth from ranitidine bismuth citrate (GR122311X), a novel anti-ulcerant and tripotassium dicitrato bismuthate (TDB)

scientific article published on 01 January 1994

Design and analysis of trials with rare outcomes: examples from trials in herpes transmission and influenza prophylaxis

scientific article published on 01 June 2005

Does tachyphylaxis occur to the non-pulmonary effects of salmeterol?

scientific article published on February 1994

Effect of sumatriptan, a new selective 5HT1-like agonist, on liquid gastric emptying in man

scientific article published on 01 December 1992

Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections. GG167 Influenza Study Group.

scientific article

Evaluation of different indirect measures of rate of drug absorption in comparative pharmacokinetic studies

scientific article published on 01 February 1994

Evaluation of different metrics as indirect measures of rate of drug absorption from extended release dosage forms at steady-state

scientific article published on 01 January 1995

Evaluation of different partial AUCs as indirect measures of rate of drug absorption in comparative pharmacokinetic studies

scientific article published on 01 October 1998

Impact of zanamivir on antibiotic use for respiratory events following acute influenza in adolescents and adults.

scientific article

Inhaled zanamivir versus rimantadine for the control of influenza in a highly vaccinated long-term care population.

scientific article

Intent-to-treat analysis in the presence of off-treatment or missing data

scientific article

Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma

scientific article

Methods for therapeutic trials in COPD: lessons from the TORCH trial.

scientific article published in November 2009

Missing data sensitivity analysis for recurrent event data using controlled imputation

scientific article

Number needed to treat in COPD: exacerbations versus pneumonias

scientific article published on 15 March 2013

Number needed to treat: enigmatic results for exacerbations in COPD

scientific article published on 01 January 2016

Statistical analysis of COPD exacerbations.

scientific article published in November 2008

Statistical analysis of exacerbation rates in COPD: TRISTAN and ISOLDE revisited

article

Statistical resource needs to be increased in the European regulatory agencies.

scientific article published in March 2011

Strategies for composite estimands in confirmatory clinical trials: Examples from trials in nasal polyps and steroid reduction

scientific article published on 29 October 2018

Subgroups: time to go back to basic statistical principles?

scientific article published on January 2014

Temporal clustering of exacerbations in chronic obstructive pulmonary disease

scientific article published on 01 October 2010

The log transformation is special ⬇️

scientific article published on April 30, 1995

The pharmacokinetic and pharmacodynamic interaction between lacidipine and propranolol in healthy volunteers

scientific article published on 01 January 1991

Treatment policy estimands for recurrent event data using data collected after cessation of randomised treatment

scientific article published on 08 November 2018

What matters most? Different stakeholder perspectives on estimands for an invented case study in COPD

scientific article published on 09 January 2020

Zanamivir for treatment of symptomatic influenza A and B infection in children five to twelve years of age: a randomized controlled trial.

scientific article

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