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List of works by Ira Pastan

A Recombinant Immunotoxin against the Tumor-Associated Antigen Mesothelin Reengineered for High Activity, Low Off-Target Toxicity, and Reduced Antigenicity ⬇️

scientific article published on November 6, 2012

A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake

scientific article

A model for obesity and gigantism due to disruption of the Ankrd26 gene

scientific journal article

A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene

scientific article published on 13 March 2013

A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice

scientific article

A novel high-affinity human monoclonal antibody to mesothelin.

scientific article

A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity

scientific article

A primate-specific POTE-actin fusion protein plays a role in apoptosis

scientific article

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity.

scientific article published on 17 November 2011

A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice.

scientific article

ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells

scientific article

Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo

scientific article

An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

scholarly article

An improved recombinant Fab-immunotoxin targeting CD22 expressing malignancies

scientific article

Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts

scientific journal article

Anoctamin and transmembrane channel-like proteins are evolutionarily related.

scientific article published on July 2009

Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models

scientific article published on 19 February 2019

Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial

scientific article

Antibody Fusion Proteins: Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox ⬇️

scientific article published on October 15, 2011

BL22 and lymphoid malignancies

scientific article published on January 2006

Bortezomib reduces pre-existing antibodies to recombinant immunotoxins in mice

scientific article

Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy

scientific article

Characterization of CD22 expression in acute lymphoblastic leukemia

scientific article published on March 2015

Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy

scientific article published on 14 July 2016

Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers

scientific article (publication date: May 2002)

Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter

scientific article (publication date: August 2003)

Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins

scientific article

Class II human leucocyte antigen DRB1*11 in hairy cell leukaemia patients with and without haemolytic uraemic syndrome

scientific article

Cloning, molecular characterization, and expression analysis of Copine 8.

scientific article

Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anticancer Immunity

scientific article

Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma

scientific article

Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity

scientific article published on 13 February 2019

Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer

scientific article

Development of Recombinant Immunotoxins for Hairy Cell Leukemia

scientific article published on 03 August 2020

Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins

scientific article

Display and selection of scFv antibodies on HEK-293T cells

scientific article

Domain II of Pseudomonas Exotoxin Is Critical for Efficacy of Bolus Doses in a Xenograft Model of Acute Lymphoblastic Leukemia.

scientific article

Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity

scientific article published on 04 May 2016

Effect of antigen shedding on targeted delivery of immunotoxins in solid tumors from a mathematical model

scientific article

Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo

scientific article

Enhanced efficacy of mesothelin-targeted immunotoxin LMB-100 and anti-PD-1 antibody in patients with mesothelioma and mouse tumor models

scientific article published on 01 July 2020

Evolution and expression of chimeric POTE-actin genes in the human genome

scholarly article

Exotoxin Immunotoxins and Anti-Tumor Immunity: From Observations at the Patient's Bedside to Evaluation in Preclinical Models

scientific article published on 05 January 2019

Expression of POTE protein in human testis detected by novel monoclonal antibodies

scientific article

Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases

scholarly article

Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths

scientific article published on August 2004

HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity.

scientific article published on February 2005

High expression of a cytokeratin-associated protein in many cancers

scientific article

High-density Functional Display of Proteins on Bacteriophage Lambda ⬇️

scientific article published on November 21, 2003

Identification and characterization of fully human anti-CD22 monoclonal antibodies

scientific article

Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE.

scientific article

Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemia

scientific article published on April 2006

Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4).

scientific article published on August 2007

Immunobiological treatments of hairy-cell leukaemia

scientific article

Immunoconjugates in the management of hairy cell leukemia

scientific article

Immunogenicity of therapeutic recombinant immunotoxins

scientific article published on March 2016

Immunoglobulin superfamily receptor translocation associated 2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies

scientific article

Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine

scientific article published on 02 March 2020

Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs

scientific article

Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy ⬇️

scientific article published on April 16, 2012

Immunotoxin treatment of cancer

scientific article

Immunotoxins in the treatment of hematologic malignancies

scientific article published on October 2006

Immunotoxins in the treatment of refractory hairy cell leukemia

scientific article published on October 2006

Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display.

scientific article

Improving the in vivo efficacy of an anti-Tac (CD25) immunotoxin by Pseudomonas exotoxin A domain II engineering

scientific article published on 25 April 2018

In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma

scientific article published on February 2004

In vitro antibody affinity maturation targeting germline hotspots

scientific article

In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin

scientific article

Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning

scientific article published in February 2007

Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors

scientific article published on 10 April 2008

Isolation of anti-CD22 Fv with high affinity by Fv display on human cells

scientific article published on 8 June 2006

Lipoprotein modulation of proteinuric renal injury

scientific article published on 24 April 2019

Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor

scientific article

Low-Dose Methotrexate Prevents Primary and Secondary Humoral Immune Responses and Induces Immune Tolerance to a Recombinant Immunotoxin.

scientific article published on 5 February 2018

MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer

scientific article

Mammalian cell display for antibody engineering

scientific article

Mechanisms of Resistance to Immunotoxins Containing Pseudomonas Exotoxin A in Cancer Therapy

scientific article published on 30 June 2020

Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice

scientific article

Mesothelin expression in human lung cancer

scientific article published on March 2007

Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats

scientific article

Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells

scientific article

Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors

scientific article

Mesothelin: a new target for immunotherapy

scientific article

Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8.

scientific article published on 13 August 2013

Multiple proteases are involved in mesothelin shedding by cancer cells

scientific article published on 01 December 2020

Mutants of immunotoxin anti-Tac(dsFv)-PE38 with variable number of lysine residues as candidates for site-specific chemical modification. 1. Properties of mutant molecules

scientific article published in March 2003

NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate

scientific article

NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells.

scientific article published on February 2007

New gene expressed in prostate: a potential target for T cell-mediated prostate cancer immunotherapy

scientific article published on 04 June 2009

New high affinity monoclonal antibodies recognize non-overlapping epitopes on mesothelin for monitoring and treating mesothelioma

scientific article

New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA.

scientific article published on August 2005

Non-AUG translational initiation of a short CAPC transcript generating protein isoform

scientific article

Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments

scientific article published on July 2002

PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity

scientific article

PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach

scientific article

POTE paralogs are induced and differentially expressed in many cancers.

scientific article published on January 2006

POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells ⬇️

scientific article published on January 3, 2012

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer

scientific article

PRAC2: A new gene expressed in human prostate and prostate cancer ⬇️

scientific article published on July 1, 2003

Palmitoylation of POTE family proteins for plasma membrane targeting

scientific article

Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts ⬇️

scientific article published on April 26, 2011

Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia

scientific article

Poor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A.

scientific article

Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits

scientific article published on 27 May 2019

Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malig

scientific article published in October 2003

Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A.

scientific article published on 25 July 2016

Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells

scientific article

Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors

scientific article

Rational design of low immunogenic anti CD25 recombinant immunotoxin for T cell malignancies by elimination of T cell epitopes in PE38.

scientific article published on 5 January 2017

Recognition of Mesothelin by the Therapeutic Antibody MORAb-009: STRUCTURAL AND MECHANISTIC INSIGHTS

scientific article

Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes.

scientific article

Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes

scientific article

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

scientific article

Recombinant immunotoxins for treating cancer

scientific article published on April 2004

Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins

scientific article published on 18 May 2016

Removing T-cell epitopes with computational protein design.

scientific article

SS1P Immunotoxin Induces Markers of Immunogenic Cell Death and Enhances the Effect of the CTLA-4 Blockade in AE17M Mouse Mesothelioma Tumors

scholarly article by Yasmin Leshem et al published 14 November 2018 in Toxins

Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera

scientific article

Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells.

scientific article

Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers ⬇️

scientific article published on April 1, 2012

Site-Specific PEGylation of Anti-Mesothelin Recombinant Immunotoxins Increases Half-life and Antitumor Activity

scientific article published on 23 December 2019

Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study

scientific article published on January 2005

Synergistic antitumor activity of anti-CD25 recombinant immunotoxin LMB-2 with chemotherapy.

scientific article published on 8 November 2011

TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates

scientific journal article

TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma.

scientific article published on January 2005

Targeted cytotoxic therapy kills persisting HIV infected cells during ART

scientific article (publication date: 2014)

Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin

scientific article published in June 2002

Targeting TARP, a novel breast and prostate tumor-associated antigen, with T cell receptor-like human recombinant antibodies

scientific article published on June 2008

The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sperm-associated protein

scientific article

The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria

scientific article

The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion.

scientific article

The improvement of an anti-CD22 immunotoxin: conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan

scientific article published on September 2011

Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts.

scientific article

Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level

scientific article published on August 2008

Toxin-Based Targeted Therapy for Malignant Brain Tumors ⬇️

scientific article published on February 9, 2012

Treatment of Hematologic Malignancies with Immunotoxins and Antibody-Drug Conjugates ⬇️

scientific article published on October 15, 2011

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