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List of works by Seth G. Grant

A brain-wide atlas of synapses across the mouse lifespan

scientific article published on 11 June 2020

A general basis for cognition in the evolution of synapse signaling complexes.

scientific article published on 02 December 2009

A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia

scientific article published on 12 September 2017

A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability

scientific journal article

A novel role for PSD-95 in mediating ethanol intoxication, drinking and place preference.

scientific article

A novel role for cyclic guanosine 3',5'monophosphate signaling in synaptic plasticity: a selective suppressor of protein kinase A-dependent forms of long-term potentiation.

scientific article published on 23 March 2006

ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex

scientific article published on 19 September 2016

Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons.

scientific article published in March 1993

Altered thalamocortical development in the SAP102 knockout model of intellectual disability

scientific article published on 27 July 2016

An anatomically comprehensive atlas of the adult human brain transcriptome

scientific article (publication date: 20 September 2012)

Analysis of NMDA receptor mediated synaptic plasticity using gene targeting: roles of Fyn and FAK non-receptor tyrosine kinases.

scientific article published in January 1996

Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence. ⬇️

scientific article published in October 2017

Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

scientific article

Architecture of the Mouse Brain Synaptome

scientific article published on 02 August 2018

Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndrome

scientific journal article

Beta-adrenergic receptor activation rescues theta frequency stimulation-induced LTP deficits in mice expressing C-terminally truncated NMDA receptor GluN2A subunits.

scientific article

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene

scientific article

CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation

scientific journal article

Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference.

scientific article published on 11 January 2017

Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns

scientific article published on 23 July 2015

Cell-type specific visualization and biochemical isolation of endogenous synaptic proteins in mice

Cell-type-specific visualisation and biochemical isolation of endogenous synaptic proteins in mice

scientific article published on 06 November 2019

Characterization of the proteome, diseases and evolution of the human postsynaptic density.

scientific article published on 19 December 2010

Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1+/− mice

scientific article published on 23 June 2018

Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder

scientific article

Clustered gene expression changes flank targeted gene loci in knockout mice.

scientific article

Clustering of neuronal potassium channels is independent of their interaction with PSD-95.

scientific article

Cognitive components in mice and humans: Combining genetics and touchscreens for medical translation ⬇️

scientific article published on June 22, 2013

Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins

scientific article

Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice

scientific article published on 19 July 2019

Computational geometry analysis of dendritic spines by structured illumination microscopy

scientific article published on 20 March 2019

Confirmed rare copy number variants implicate novel genes in schizophrenia

scientific article

Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice

scientific article

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.

scientific article

De novo mutations in schizophrenia implicate synaptic networks

scientific article

Defective reflex responses to impeded breathing during quiet sleep or anesthesia in thiamine-deficient kittens and puppies.

scientific article published in January 1980

Differential expression of two NMDA receptor interacting proteins, PSD-95 and SynGAP during mouse development.

scientific article published in January 2005

Discovering genes involved in alcohol dependence and other alcohol responses: role of animal models ⬇️

scientific article published on January 1, 2012

Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability

scientific article

Durable fear memories require PSD-95.

scientific article published on 16 December 2014

Dynamic distribution of endoplasmic reticulum in hippocampal neuron dendritic spines.

scientific article

Early invasiveness characterizes metastatic carcinoid tumors in transgenic mice ⬇️

scientific article published on September 15, 1991

Enhanced cognition and dysregulated hippocampal synaptic physiology in mice with a heterozygous deletion of PSD-95.

scientific article published on 13 December 2017

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

scientific article

Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior

scientific article

Evolution of complexity in the zebrafish synapse proteome.

scientific article published on 02 March 2017

Evolutionary expansion and anatomical specialization of synapse proteome complexity.

scientific article published on 8 June 2008

Expression of AMPA receptor subunits at synapses in laminae I-III of the rodent spinal dorsal horn.

scientific article published on 23 January 2008

FAK is required for axonal sorting by Schwann cells

scientific article

Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice

scientific article published on 01 August 1995

Fyn tyrosine kinase is required for normal amygdala kindling

scientific article published on 01 October 1995

G2Cdb: the Genes to Cognition database.

scientific article published on 4 November 2008

Genome variation and complexity in the autism spectrum.

scientific article published in July 2010

Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation

scientific article

Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes. ⬇️

scientific article published on 28 April 2017

High throughput protein expression screening in the nervous system--needs and limitations.

scientific article published on 22 June 2006

Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins.

scientific article published on 07 January 2014

Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes

scientific article

Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn.

scientific article published on 16 September 2003

Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity

scientific journal article

Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment

scientific article published on 27 January 2016

Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice

scientific article published on December 18, 1992

In vivo STED microscopy visualizes PSD95 sub-structures and morphological changes over several hours in the mouse visual cortex.

scientific article published on 9 January 2018

In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93

scientific article

Integrating synapse proteomics with transcriptional regulation.

scientific article published on 15 September 2006

Integrin-mediated axoglial interactions initiate myelination in the central nervous system

scientific article published on May 2009

Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels

scientific article published in December 1997

Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus.

scientific article published on 23 September 2008

Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro

scientific article

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors ⬇️

scientific article published on October 10, 1991

Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome

scientific article (publication date: April 2006)

Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95

scientific article published on March 2014

Multiprotein complex signaling and the plasticity problem.

scientific article published in June 2001

Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background

article

NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840

scientific article

NMDA receptor modulation of glutamate release in activated neutrophils

scientific article published on 08 August 2019

NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism

scientific article published on 21 March 2015

NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation ⬇️

scientific article published on 27 April 2016

Nanostructural Diversity of Synapses in the Mammalian Spinal Cord

scientific article published on 18 May 2020

Neonatal hepatitis induced by alpha 1-antitrypsin: a transgenic mouse model

scientific article published on 01 December 1988

Network activity-independent coordinated gene expression program for synapse assembly.

scholarly article

Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways.

scientific article published on 2 May 2015

Neuroligin 1 is dynamically exchanged at postsynaptic sites.

scientific article

Neurotransmitters drive combinatorial multistate postsynaptic density networks.

scientific article published on 28 April 2009

Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption.

scientific article published on 10 October 2013

Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity.

scientific article published on 20 October 2008

Overexpression of an Aplysia shaker K+ channel gene modifies the electrical properties and synaptic efficacy of identified Aplysia neurons ⬇️

scientific article published on February 1, 1992

PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits

scientific article

Pharmacological and genetic approaches to the analysis of tyrosine kinase function in long-term potentiation

scientific article published on January 1, 1992

Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase-Independent Mechanisms ⬇️

scientific article (publication date: May 2003)

Phosphoproteomic Analysis of the Mouse Brain Cytosol Reveals a Predominance of Protein Phosphorylation in Regions of Intrinsic Sequence Disorder

scientific article

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

scientific article

Probing the Modulation of Acute Ethanol Intoxication by Pharmacological Manipulation of the NMDAR Glycine Co‐Agonist Site ⬇️

scientific article published on August 30, 2012

Proteomic analysis of NMDA receptor-adhesion protein signaling complexes

scientific article (publication date: July 2000)

Proteomic analysis of in vivo phosphorylated synaptic proteins.

scientific article published on 30 November 2004

Proteomic analysis of postsynaptic proteins in regions of the human neocortex

scientific article published on 4 December 2017

Proteomics in neuroscience: from protein to network.

scientific article

Proteomics in postgenomic neuroscience: the end of the beginning.

scientific article published on May 2004

Proteomics of multiprotein complexes: answering fundamental questions in neuroscience.

scientific article

Proteomics of the nervous system.

scientific article

Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures.

scientific article published on 28 January 2015

Rapid homeostatic downregulation of LTP by extrasynaptic GluN2B receptors

scientific article published on 15 August 2018

Regional Diversity in the Postsynaptic Proteome of the Mouse Brain

scientific article published on 01 August 2018

Robust enrichment of phosphorylated species in complex mixtures by sequential protein and peptide metal-affinity chromatography and analysis by tandem mass spectrometry.

scientific article published on 23 August 2005

Robust nanoscopy of a synaptic protein in living mice by organic-fluorophore labeling

article published in the Proceedings of the National Academy of Sciences of the United States of America

Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

scientific article published on 02 March 2019

Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling.

scholarly article

SnapShot: Organizational principles of the postsynaptic proteome.

scientific article published in October 2013

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

scientific article published on December 2004

Standardized experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds.

scientific article published on 25 November 2016

Supramolecular organization of NMDA receptors and the postsynaptic density ⬇️

scientific article published on 31 May 2017

Supramolecular signalling complexes in the nervous system.

scientific article published on January 2007

SynGAP isoforms exert opposing effects on synaptic strength

scientific article

SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor

scientific journal article

Synapse diversity and synaptome architecture in human genetic disorders

scientific article published on 01 November 2019

Synapse molecular complexity and the plasticity behaviour problem

scientific article published on 01 January 2018

Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases.

scientific article

Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies.

scientific article

Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.

scientific article

Synaptic scaffold evolution generated components of vertebrate cognitive complexity.

scientific article

Synaptopathies: diseases of the synaptome.

scientific article published on 10 March 2012

Synaptopathy--From Biology to Therapy

scientific article

Systems biology in neuroscience: bridging genes to cognition.

scientific article published on October 2003

TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function

scientific article published on October 2012

Targeted TAP tags, phosphoproteomes and the biology of thought

scientific article published on 01 April 2010

Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins

scientific journal article

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences

article

The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data

scientific article (publication date: February 2004)

The Synaptomic Theory of Behavior and Brain Disease

scientific article published on 01 January 2018

The mas proto-oncogene is developmentally regulated in the rat central nervous system

scientific article published on July 24, 1992

The molecular evolution of the vertebrate behavioural repertoire

scientific article

The origin and evolution of synapses.

scientific article published on 09 September 2009

The role of DNA copy number variation in schizophrenia.

scientific article published on 12 September 2009

The role of neuronal complexes in human X-linked brain diseases

scientific article

Tolerance to ethanol intoxication after chronic ethanol: role of GluN2A and PSD-95.

scientific article

Toward a molecular catalogue of synapses.

scientific article published on 22 May 2007

Transplantation of β cells from transgenic mice into nude athymic diabetic rats restores glucose regulation ⬇️

scientific article published on December 1, 1991

alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A- and NR2B-containing N-methyl-d-aspartate receptors in hippocampus.

scientific article published on 12 October 2007

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